Determinants of pregnancy, and induced and spontaneous abortion in a jointly determined framework: Evidence from a country wide district level household survey in India

This study provides evidence on the principal determinants of pregnancy and abortion in India using a large country-wide district-level data set (DLHS 2007). The paper provides an economic framework for the analysis of pregnancy and abortion. The study distinguishes between induced and spontaneous abortion and compares the effects of their determinants.

The results show that there are wide differences between induced and spontaneous abortions in terms of the sign and magnitude of the estimated effects of several of their determinants, most notably wealth, the woman’s age and her desire for children. The study makes a methodological contribution by proposing a trivariate probit estimation framework that recognizes the joint dependence of pregnancy and induced and spontaneous abortion, and provides evidence in support of this joint dependence.

The study reports an inverted U-shaped effect of a woman’s age on her pregnancy and both forms of abortion. The turning point in each case is quite robust to the estimation framework. A significant effect of contextual variables, at the village level, constructed from the individual responses, on a woman’s pregnancy is found. The effects are weaker in the case of induced abortion, and insignificant in the case of spontaneous abortion. The results are shown to be fairly robust. This paper extends the literature on the relation between son preference and fertility by examining the link between mother’s son preference and desire for more children with abortion rates.

Spontaneous judgements of health related-risk

In health psychology, individuals’ judgements about health risks have almost exclusively been investigated by explicitly soliciting such judgements. Five novel methodologies were used to examine risk judgements that are made spontaneously, without prompting. The findings suggest that spontaneous risk judgements can differ in important ways from researcher solicited ones.

Doctoral work as boundary-riding and boundary-breaking

This chapter considers the tension between candidates being ‘disciplined in the discipline of the discipline’ and producing significant original knowledge to earn their doctorate. That is, learning about the disciplinary boundaries within which their doctorates are conducted, and learning how to ‘push’ those boundaries with sufficient originality in order to be ‘doctored’. For the purposes of this chapter, ‘doctoral work’ embraces all those forms of work and their workers that contribute to doctoral process. Supervisors (advisers) and candidates (students) are the obvious workers, but then there are those whose work it is to support doctoral work; in particular, administrators, counsellors, postgraduate students’ associations, and those ‘scholarly friends’ the librarians.

Applications of symbolic computing for symmetry analysis of differential equations

 This thesis presents a number of applications of symbolic computing to the study of differential equations. In particular, three packages have been produced for the computer algebra system MAPLE and used to find a variety of symmetries (and corresponding invariant solutions) for a range of differential systems.

Breaking up prolonged sitting reduces resting blood pressure in overweight/obese adults

To compare the effect of 7 h of prolonged sitting on resting blood pressure with a similar duration of sitting combined with intermittent brief bouts of light-intensity or moderate-intensity physical activity.

Tumour but not stromal expression of β3 integrin is essential, and is required early, for spontaneous dissemination of bone-metastatic breast cancer.

Although many preclinical studies have implicated β3 integrin receptors (αvβ3 and αIIbβ3) in cancer progression, β3 inhibitors have shown only modest efficacy in patients with advanced solid tumours. The limited efficacy of β3 inhibitors in patients could arise from our incomplete understanding of the precise function of β3 integrin and, consequently, inappropriate clinical application. Data from animal studies are conflicting and indicate heterogeneity with respect to the relative contributions of β3-expressing tumour and stromal cell populations in different cancers. Here we aimed to clarify the function and relative contributions to metastasis of tumour versus stromal β3 integrin in clinically relevant models of spontaneous breast cancer metastasis, with particular emphasis on bone metastasis. We show that stable down-regulation of tumour β3 integrin dramatically impairs spontaneous (but not experimental) metastasis to bone and lung without affecting primary tumour growth in the mammary gland. Unexpectedly, and in contrast to subcutaneous tumours, orthotopic tumour vascularity, growth and spontaneous metastasis were not altered in mice null for β3 integrin. Tumour β3 integrin promoted migration, protease expression and trans-endothelial migration in vitro and increased vascular dissemination in vivo, but was not necessary for bone colonization in experimental metastasis assays. We conclude that tumour, rather than stromal, β3 expression is essential and is required early for efficient spontaneous breast cancer metastasis to bone and soft tissues. Accordingly, differential gene expression analysis in cohorts of breast cancer patients showed a strong association between high β3 expression, early metastasis and shorter disease-free survival in patients with oestrogen receptor-negative tumours. We propose that β3 inhibitors may be more efficacious if used in a neoadjuvant setting, rather than after metastases are established. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Small-sample improved seasonal unit root tests for trending and breaking series

In this article three unit root tests that allow for a break in both the seasonal mean and linear trend of the data are proposed. The tests, which can be seen as small-sample corrected versions of already known asymptotic tests, are shown to perform very well in simulations, and much better than their asymptotic counterparts.