Plan af Jyväskylä stad utgifven 1840 af C. W. Gyldén

Claes Wilhelm Gyldén (1802-1872) oli maanmittauksen ja metsänhoidon ylihallituksen ylitirehtööri vuosina 1854-72. Ylitirehtööri omisti paljon aikaansa metsänhoidon ja maanjakotoiminnan lisäksi myös maamme kartastotoiminnalle. Hän julkaisi vuonna 1853 Suomenmaan korko-kartan, joka on maailman ensimmäisiä korkeusvyöhykekarttoja. Myös Suomen yleiskartan 1:400 000 (Karta över Finland) ensimmäisen painoksen karttalehdet painettiin vuosina 1864-1872 hänen johtajakaudellaan. Vuosina 1837-1843 toimiessaan maanmittausinsinöörinä maanmittaushallituksessa C. W. Gyldén julkaisi Suomen kaikkien silloisten kaupunkien kaupunkikartat, yhteensä 31 karttalehteä. Nämä asemakaavakartat painettiin kaikki samassa koossa 50,8 x 65,9 cm. Tästä johtuen karttojen mittakaavat vaihtelivat asteikkojen 1:3200 – 1:10000 välillä. Kaupungin asemakaavan lisäksi jokaisessa kartassa on yleissilmäyskartta, julkisten rakennusten luettelo sekä niiden sijainti. Lisäksi hän julkaisi vuonna 1844 näiden kaupunkien historiaa ja tilastotietoja kuvaavan selityskirjan.

Plan af Nycarleby utgifven 1841 af C. W. Gyldén

Uusikaarlepyyn kartta. 1 kartta : vär. ; 40,9 x 54,9 cm, lehti 45 x 60 cm. - Sisältää luettelon julkisista rakennuksista. - Mittakaava: [1:3200]

Plan af Raumo utgifven 1841 af C. W. Gyldén

Rauman kartta. - 1 kartta : vär. ; 40,7 x 54,4 cm, lehti 45 x 60 cm. - Mittakaava [1:4000]. - Sisältää luettelon julkisista rakennuksista.

Effect of iodide on Fas, Fas-ligand and Bcl-w mRNA expression in thyroid of NOD mice pretreated with methimazole

Nonobese diabetic (NOD) mice and a derived strain, NOD.H.2h4, have been used as a model for experimental spontaneous thyroiditis and thyroiditis induced by iodide excess after a goiter-inducing period. Some authors have proposed that iodide, given after methimazole or propylthiouracil, is capable of inducing apoptosis in thyroid cells and that anti-thyroid drugs can modulate the expression of apoptosis components such as Fas and its ligand (Fas-L). Here we evaluated the effect of potassium iodide (20 µg/animal for 4 days, ip) given to NOD mice at the 10th week of life after exposure to methimazole (1 mg/ml) in drinking water from the 4th to the 10th week of life. Fas, Fas-L and Bcl-w expression were analyzed semiquantitatively by RT-PCR immediately after potassium iodide administration (group MI44D) or at week 32 (MI32S). Control groups were added at 10 (C10) and 32 weeks (C32), as well as a group that received only methimazole (CM10). An increase in the expression of Fas-L and Bcl-w (P<0.01, ANOVA) was observed in animals of group MI44D, while Fas was expressed at higher levels (P = 0.02) in group C32 (72.89 ± 47.09 arbitrary units) when compared to group C10 (10.8 ± 8.55 arbitrary units). Thus, the analysis of Fas-L and Bcl-w expression in the MI44D group and Fas in group C32 allowed us to detect two different patterns of expression of these apoptosis components in thyroid tissue of NOD mice.

Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease

High levels of von Willebrand factor (vWF) have been associated with cardiovascular disease. The A allele of the -1185A/G polymorphism in the 5'-regulatory region of the vWF gene was associated with the highest plasma vWF levels in a normal population. To examine the association between -1185A/G polymorphism and coronary artery disease (CAD), 173 Brazilian Caucasian subjects submitted to coronary angiography were studied. Of these, 57 (33%) had normal coronary arteries (control group) and 116 (67%) had CAD (patient group). Plasma vWF levels were higher in patients (145 U/dl) than in controls (130 U/dl), but the differences were significant only for O blood group subjects. Polymerase chain reaction amplification of the 864-bp vWF promoter region followed by AccII restriction digestion was used to identify the -1185A/G genotypes. The -1185A allele frequency was 43.1% in patients and 44.7% in controls. Allele and genotype frequencies were not significantly different between patients and controls. No association was observed between the -1185A/G genotypes and plasma vWF levels in patients or controls. These results suggest that -1185A/G polymorphism is not an independent risk factor for CAD.

Effect of hydroxyurea on G gamma chain fetal hemoglobin synthesis by sickle-cell disease patients

Hydroxyurea is used for sickle-cell disease patients in order to increase fetal hemoglobin synthesis and consequently decrease the severity of pain episodes. Fetal hemoglobin, which is formed by gamma-globin chains A and G, is present in a constant composition throughout fetal development: about 75% of Ggamma and 25% of Agamma. In contrast, adult red cells contain about 40% of Ggamma and 60% of Agamma. In the present study, we analyzed the effect of hydroxyurea induction on the gamma chain composition of fetal hemoglobin in 31 sickle-cell disease patients treated with hydroxyurea. The control group was composed of 30 sickle-cell disease patients not treated with hydroxyurea in clinical steady state. The patients were older than 13 years and were not matched for age. All patients were seen at Hemocentro/UNICAMP and Boldrini Infantile Center, Campinas, SP, Brazil. The levels of total hemoglobin were significantly higher in patients treated with hydroxyurea (mean ± SD, 9.6 ± 2.16 g/dl) than in untreated patients (8.07 ± 0.91 g/dl). Fetal hemoglobin levels were also higher in treated patients (14.16 ± 8.31%) than in untreated patients (8.8 ± 4.09%), as was the Ggamma/Agamma ratio (1.45 ± 0.78 vs 0.98 ± 0.4, P < 0.005). The increase in the Ggamma/Agamma ratio in patients treated with hydroxyurea suggests the prevalence of a pattern of fetal hemoglobin synthesis, whereas patients not treated with hydroxyurea maintain the adult pattern of fetal hemoglobin synthesis. Because no correlation was observed between the Ggamma/Agamma ratio and total hemoglobin or fetal hemoglobin levels, the increase in Ggamma chain synthesis may not imply a higher production of hemoglobin.

Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma

It is well established that interleukin-6 (IL-6) is an essential growth factor for multiple myeloma (MM) and patients with increased IL-6 levels have a poor prognosis. In healthy subjects, the presence of the C allele at a polymorphic site (-174 G/C) of the IL-6 gene is related to low IL-6 levels. In view of the potential association of this particular polymorphism with IL-6 concentration, and the relevance of IL-6 in MM pathogenesis, the objective of the present study was to investigate the prevalence of IL-6 (-174 G/C) promoter polymorphism and its association with development of MM in Brazilian individuals. We investigated the prevalence of these alleles in 52 patients and 60 healthy subjects (matched by age, sex, and race) of a Brazilian population. Thirty patients were male (42.4%), 24 (46.2%) were white and the median age at diagnosis was 58.5 years (range: 28 to 84 years). To determine the IL-6 (-174 G/C) polymorphism, molecular analysis was performed by polymerase chain reaction followed by endonuclease restriction digestion. The genotype distributions observed in the group of patients were 4% CC, 42% GC and 54% GG. The C allele frequency was 0.25. These results were similar to the control group, suggesting no impact of this polymorphism on the susceptibility to MM.

Finsk språklära i sammandrag af G. E. Eurén

Imprimatur: C. A. Sanmark.

Förteckning öfver böcker tillgänglige vid A. W. Edgrens och J. E. Reuters lånbibliothek i Åbo

Imprimatur: L. Heimbürger.

Suomalainen laina-kirjasto Uudessakaupungissa, perustettu w. 1861

Sisältää myös kirjaston käyttösäännöt.

Ny elementar- eller Abc-bok enligt rit-, skrif- och läsmetoderna: i förening med åskådningsundervisning, förstånds- och talöfningar af J. O. I. Rancken och C. W. Rancken

Taulukkoliite: Tabell för de fyra räknesätten med hela tal från 1 till 25.

[Orphée et Eurydice]. Airs de ballet / Christoph Willilbald Glück, comp. ; orchestre de Chambre de la Société des Concerts de Versailles ; G. Cloez, dir.

Titre uniforme : [Orphée et Eurydice. W 41]. Choix

J.W. Spencer fonds, 1866, 1881-1921

Joseph William Winthrop Spencer (commonly known as J.W. Spencer) was a geologist and geomorphologist best known for his work on the geology of southern Ontario and the Great Lakes. He was born in Dundas, Upper Canada in 1851, but moved to Hamilton, Ontario in 1867. In 1871, he began studies in geology at McGill College in Montreal. In 1875 he worked in the Michigan copper mines and shortly afterwards prepared a thesis on the copper deposits. He submitted this thesis to the University of Gottingen in Germany in 1877 and was awarded a doctorate in geology, the second Canadian to earn a doctorate in this field. In 1880, he became a professor of geology and chemistry at King’s College in Windsor, N.S. Subsequently, he taught at the University of Missouri, and then the University of Georgia, but moved to Washington, D.C. in 1894, where he worked as a consultant geologist. Spencer spent much of his life studying preglacial river valleys in Ontario and the origins of the Great Lakes, as well as the Niagara River and Falls. In 1907, he published a book titled The Falls of Niagara: their evolution and varying relations to the Great Lakes. His opinions in these areas differed from some of his contemporaries, namely the American geologist Grove Karl Gilbert. Gilbert published a review of the The Falls of Niagara that exposed some flaws and inaccuracies in Spencer’s estimate of the age of the falls. Spencer’s studies also took him to the Caribbean and Central America. In 1920 he moved back to Canada, but died the following year.

Residence of James W. House, Esq. - Vignette

A vignette of the residence of James W. House, Esq., Lot 123 Stamford.