Photoperiod modulation of aggressive behavior is independent of androgens in a tropical cichlid fish

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Tonic modulation of anxiety-like behavior by corticotropin-releasing factor (CRF) type 1 receptor (CRF1) within the medial prefrontal cortex (mPFC) in male mice: Role of protein kinase A (PKA)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Effects of dexmedetomidine on pulse pressure variation changes induced by hemorrhage followed by volume replacement in isoflurane-anesthetized dogs

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Desenvolvimento de software para exibição de exames de eletrocardiograma

The main objective is to create a software, using C++ language, for reading and exhibiting in a graphic an Electrocardiogram (ECG) wave. The data is recorded as a FM modulated signal and compressed using Adaptive Differential Pulse Code Modulation (ADPCM). The signal have this characteristics because it was acquired using an experimental equipment, this equipment is the result of research made by the professor who supervised this work. FM demodulation techniques in discrete time, discrete filters and digital signal processing are some of the topics that can be found in this essay. Some concepts about the human heart and about ECG waves are also briefly introduced. These concepts are necessary for understanding the final evaluation of the software performance. The development is partly made using MATLAB. Most of the functions that are used on the software are first tested and designed in MATLAB environment. In the end, an evaluation is done comparing the results that are expected with the ones that MATLAB presents and the ones that the developed software presents

PROD and BROD modulation in Nile tilapia after exposure to 17 beta-estradiol

The activities of 7-ethoxyresorufin-O-deetylase (EROD), 7-benzyloxyresorufin-O-debenzylase (BROD), 7-pentoxyresorufin-O-depentilase (PROD), and glutathione S-transferase (GST) were measured in Nile tilapias exposed for 7 days of 5 and 15 μg/L 17 β-estradiol. EROD and GST activities were unchanged. PROD activity increased in animals exposed to the higher dose of the hormone, while BROD was increased after 7 exposure days to both doses of the compound. These results indicate the usefulness of these enzymes as biomarkers for 17 β-estradiol exposure.

Modulation of the activity and selectivity of the immobilized lipases by surfactants and solvents

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Controlador PID utilizando microcontrolador PIC

This monograph proposes the implementation of a low cost PID controller utilizing a PIC microcontroller, and its application in a positioning system previously controlled by a dedicated integrated circuit for a positioning system. Applying the closed-loop PID control, the system instability was reduced, and its response was smoother, eliminating vibrations and mechanical wear compared to its response with the dedicated integrated circuit, which has a very limited control action. The actuator of the system is a DC motor, whose speed is controlled by the Pulse Width Modulation (PWM) technique, using a Full-Bridge circuit, allowing the shift of direction of rotation. The utilized microcontroller was the PIC16F684, which has an enhanced PWM module, with its analog converters used as reference and position feedback. The positioning sensor is a multiturn potentiometer coupled to the motor axis by gears. The possibility of programming the PID coefficients in the microcontroller, as well as the adjustment of the sampling rate, allows the implemented system achieving high level of versatility

Chaveamento de cargas intermitentes usando sensor de corrente

Due to concerns about rational use of energy, several alternative technologies of power generation appeared, including the conversion of solar energy into electrical energy by photovoltaic panels. In low-income households, the refrigerator represents considerable impact on the electric bill, since it requires constant power given its use in food preservation. It is possible to reduce this share, with the use of an alternative energy source. This work presents a timed switching electronic system, which allows commercial equipment that is not affected by short interruptions in the power supply to use a photovoltaic panel as a source of alternative energy, which usually do not provide energy continuously. Switching is made automatically in case of low incidence of sunlight, and without any form of energy storage. Between each switching, there is a dead time without power supply, therefore preventing the use of synchronizers circuits between the photovoltaic panel and the public power grid. A circuit containing a 80C31 microcontroller is used to control the system’s switching. The photovoltaic panel’s voltage inverter is in H bridge configuration, and is also controlled by the microcontroller through Pulse Width Modulation, which makes use of preprogrammed tables to generate the control signals of the power transistors. Through the use of software simulations, the proposed system was tested, which is capable of supplying intermittent single-phase loads. The simulations indicates that the project developed in this paper can be assembled into a prototype and be tested under real operating conditions, as long as the scaling of components, the characteristics of the photovoltaic panel to be used, and the project involved load are taken into account

Modulation of Immune Response by RAGE and TLR4 Signalling in PBMCs of Diabetic and Non-Diabetic Patients

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Activation of the brain melanocortin system is required for leptin-induced modulation of chemorespiratory function

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Neurochemical and electrical modulation of the locus coeruleus: contribution to CO2drive to breathe

The locus coeruleus (LC) is a dorsal pontine region, situated bilaterally on the floor of the fourth ventricle. It is considered to be the major source of noradrenergic innervation in the brain. These neurons are highly sensitive to CO2/pH, and chemical lesions of LC neurons largely attenuate the hypercapnic ventilatory response in unanesthetized adult rats. Developmental dysfunctions in these neurons are linked to pathological conditions such as Rett and sudden infant death syndromes, which can impair the control of the cardio-respiratory system. LC is densely innervated by fibers that contain glutamate, serotonin, and adenosine triphosphate, and these neurotransmitters strongly affect LC activity, including central chemoreflexes. Aside from neurochemical modulation, LC neurons are also strongly electrically coupled, specifically through gap junctions, which play a role in the CO2 ventilatory response. This article reviews the available data on the role of chemical and electrical neuromodulation of the LC in the control of ventilation.

Down-regulation of SLC8A1 as a putative apoptosis evasion mechanism by modulation of calcium levels in penile carcinoma

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Biotransformed soybean extract induces cell death of estrogen-dependent breast cancer cells by modulation of apoptotic proteins

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)