998 resultados para PL248.F34 Z7412 1891


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1891 (T16,N1)- (T16,N10).

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PURPOSE: To characterize perifoveal intraretinal cavities observed around full-thickness macular holes (MH) using en face optical coherence tomography and to establish correlations with histology of human and primate maculae. DESIGN: Retrospective nonconsecutive observational case series. METHODS: Macular en face scans of 8 patients with MH were analyzed to quantify the areas of hyporeflective spaces, and were compared with macular flat mounts and sections from 1 normal human donor eye and 2 normal primate eyes (Macaca fascicularis). Immunohistochemistry was used to study the distribution of glutamine synthetase, expressed by Müller cells, and zonula occludens-1, a tight-junction protein. RESULTS: The mean area of hyporeflective spaces was lower in the inner nuclear layer (INL) than in the complex formed by the outer plexiform (OPL) and the Henle fiber layers (HFL): 5.0 × 10(-3) mm(2) vs 15.9 × 10(-3) mm(2), respectively (P < .0001, Kruskal-Wallis test). In the OPL and HFL, cavities were elongated with a stellate pattern, whereas in the INL they were rounded and formed vertical cylinders. Immunohistochemistry confirmed that Müller cells followed a radial distribution around the fovea in the frontal plane and a "Z-shaped" course in the axial plane, running obliquely in the OPL and HFL and vertically in the inner layers. In addition, zonula occludens-1 co-localized with Müller cells within the complex of OPL and HFL, indicating junctions in between Müller cells and cone axons. CONCLUSION: The dual profile of cavities around MHs correlates with Müller cell morphology and is consistent with the hypothesis of intra- or extracellular fluid accumulation along these cells.

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1891 (A16,N14 (DOUBLE))-1892.

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1888 (N13,A13)-1891 (N13,A15).

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1888 (N13,A13,DOUBLE)-1891 (N13,A15).

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1891 (A11,N12)- (A12,N12).

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1891 (A16,N14)-1892.

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1891/07/05 (A23,T2)-1891/11/29.

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1891/01/04 (A23,T1)-1891/06/28.

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1891 (A23).

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1891 (A4).

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1891/09/17 (A4,N165)-1891/09/23.

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1891/09/03 (A4,N163)-1891/09/09.