Efficacy and adverse effects of venlafaxine in children and adolescents with ADHD : a systematic review of non-controlled and controlled trials

Attention deficit hyperactivity disorder (ADHD) is a common psychiatric disorder in children and adolescents. Stimulants are commonly prescribed for ADHD management. There is clinical trial evidence that some medications with noradrenergic properties such as atomoxetine are effective. It is of theoretical and practical importance if other agents with noradrenergic properties display a comparable pattern of efficacy.
This paper is a systematic review of the efficacy and safety of venlafaxine for treating children and adolescents with ADHD. MEDLINE, Google scholar, Scopus, and Web of science (ISI) databases were electronically searched in July 2012, updated on November 2012. Time and language of publication were not exclusion criteria. Efficacy outcomes were assessed by a valid and reliable parent- and/or teacher-reported instrument to evaluate clinical symptoms. Adverse effects were also evaluated.

There were three uncontrolled trials and only two double blind controlled clinical trials. Venlafaxine appeared effective for treating ADHD. The rates of some adverse effects of venlafaxine were less than those documented for methylphenidate.

While one of the two small controlled trials did not find difference between venlafaxine ad methylphenidate, the other trial reported lower efficacy for venlafaxine. Headache, insomnia, and nausea were among the most common adverse effects.

This systematic review provides preliminary support that venlafaxine may have short term utility in treating ADHD in children and adolescents. However, before recommending venlafaxine for treatment, more robust and larger clinical trials, in particular providing evidence of its long-term efficacy, safety and tolerability are required.

Workplace human rights reporting: a study of Australian garment and retail companies

The opening of the Australian economy in a globalised world has led to Australian garment and retail corporations moving their manufacturing overseas and acquiring goods from overseas providers. This is usually better for the corporations’ bottom-line, as they can purchase goods overseas at a fraction of their local cost, partly due to cheap labour. Australia is one of the many OECD countries not to have a well regulated environment for workplace human rights. This study examines 18 major Australian retail and garment manufacturing corporations and finds that workplace human rights reporting is poor, based on content analysis of their annual reports, corporate social responsibility reports and websites. This is probably due to the failure of the Australian Government to provide adequate oversight by promulgating mandatory reporting standards for both local and overseas operations of Australian companies. This permits corporations to avoid reporting their workplace human rights standards and breaches.

The importance and significance of heritage conservation of ex-tin mining landscape in Perak, the Abode of Grace

The thematic history of tin mining in Perak reveals the evolution of tin production, technology, infrastructure, transportation, social and the state economic development. The mining expansion that spread from Larut district to Kinta at the end of nineteenth century has distinctively impact on it's landscape. The surviving evidences that spread over Kinta demonstrates the importance and significance of conservation of ex-tin mining places. These surviving evidences are testimony of the past history and legacy for the present and future generations.

Developing a dialysis centre foot screening culture

Foot lesions are common in the dialysis population and contribute to increased morbidity and mortality (Broersma 2004). lmportantly, patients on dialysis with and without diabetes are at increased risk of foot ulcers (Jones et al. 2012) and lower limb amputation (Kaminski, Frescos & Tucker 2012). Simple foot screening in dialysis centres can identify those at risk of foot complications and the presence of foot ulcers (Ahmad 2009; Ng et al. 2003). Valid and reliable foot screening tools have been developed in the dialysis context to identify those at risk and those with actual ulcers (Murphy et al. 2012).ln 2011, following the completion of a Diabetes and Renal Pilot Study and staff education, Moorabbin Haemodialysis Unit and Southern Health, identified the need to formalise foot screening for all patients and increase the rate at which these were conducted. The aim of this report is to present a summary of the audit evaluation of foot health screens and referrals in our dialysis centre.

The pharmaceutical industry, intellectual property rights and access to medicines in Pakistan

The pharmaceutical industry in Pakistan is worth around US$ l.18 billion, with annual growth in 2010 approaching 10 per cent (Khan, 2012). There are more than 650 registered companies, including 31 multinationals, which in 2006 had a market share in value terms of 53.3 per cent, with national firms controlling the remaining 46.7 per cent (IMS Health, 2007). In 2007 medicines worth about US$100 million were exported. Medicines are a vital component of healthcare, and Pakistan spends around three-quarters of its healthcare budget on medicines (WHO, 2004). This chapter provides an overview, from a public health perspective, of the national pharmaceutical market and the development of drug policies and regulation. Pakistan adopted a Trade Related Aspects of Intellectual Property Rights (TRIPS) compliant patent regime in 2000, and the intersection between patents and public health is a central policy challenge. This chapter highlights key issues related to intellectual property, Free Trade Agreements (FTAs), and production and access to medicines.

An integrated management systems approach to corporate social responsibility

A great deal of research has emphasized the strategic management of corporate social responsibility (CSR). However, gaps remain on how CSR can be effectively integrated with existing business processes. One key question remaining is how to design business processes so that they accommodate stakeholder requirements in an integrated manner. The purpose of this paper is to present a framework that can be used to integrate CSR into business processes. The framework highlights the concept of simultaneous ‘top-down integration’ and ‘bottom-up community-related indicators development’ approaches to CSR. These two approaches are elaborated with the help of two cases. The top-down approach focuses on building CSR into existing business initiatives through an integrated management systems (IMS) approach. This paper concludes that an IMS approach provides the infrastructure for the integration of CSR. The bottom-up approach focuses on the development of indicators linked to community initiatives. Examples of best practice for both the top-down and bottom-up approaches are provided in two case studies.

Minimizing impact of bounded uncertainty on McNaughton's scheduling algorithm via interval programming

Uncertainty of data affects decision making process as it increases the risk and the costs of the decision. One of the challenges in minimizing the impact of the bounded uncertainty on any scheduling algorithm is the lack of information, as only the upper bound and the lower bound are provided without any known probability or membership function. On the contrary, probabilistic uncertainty can use probability distributions and fuzzy uncertainty can use the membership function. McNaughton's algorithm is used to find the optimum schedule that minimizes the makespan taking into consideration the preemption of tasks. The challenge here is the bounded inaccuracy of the input parameters for the algorithm, namely known as bounded uncertain data. This research uses interval programming to minimise the impact of bounded uncertainty of input parameters on McNaughton’s algorithm, it minimises the uncertainty of the cost function estimate and increase its optimality. This research is based on the hypothesis that doing the calculations on interval values then approximate the end result will produce more accurate results than approximating each interval input then doing numerical calculations.

Recognising user identity in twitter social networks via text mining

Social networks have become a convenient and effective means of communication in recent years. Many people use social networks to communicate, lead, and manage activities, and express their opinions in supporting or opposing different causes. This has brought forward the issue of verifying the owners of social accounts, in order to eliminate the effect of any fake accounts on the people. This study aims to authenticate the genuine accounts versus fake account using writeprint, which is the writing style biometric. We first extract a set of features using text mining techniques. Then, training of a supervised machine learning algorithm to build the knowledge base is conducted. The recognition procedure starts by extracting the relevant features and then measuring the similarity of the feature vector with respect to all feature vectors in the knowledge base. Then, the most similar vector is identified as the verified account.

Recalling yesterday, predicting tomorrow : revisit South Australia conservation practice for heritage mining places, a practical guide for Malaysia

Mining started in South Australia in the early 1840s with the discovery of silver-lead ore at Glen Osmond in 1841 and later copper in Kapunda in 1842 and Burra in 1845; all these discoveries greatly contributed to South Australia's economic development. South Australia entered the mining era at the time when the Cornish engine was at the peak of its development, and the horizontal engine was beginning its rise in popularity. These South Australian historic mining sites contain extensive extant evidence of technology, innovation and human endeavours that previously went into the mining activity. This paper seeks to critically review items for inclusion on the South Australian State Heritage Register, the character of mining heritage places, enforcement by legislation, interpretation of the heritage assessment and how these practices could guide Malaysia in recognizing industrial heritage as a significant part of its cultural heritage that needs to be conserved, restored and managed as a legacy for present and future generations.