Lundgreen, Peter unter Mitarbeit von Jürgen Schallmann: Die Lehrer an den Schulen in der Bundesrepublik Deutschland 1949-2009, Datenhandbuch zur deutschen Bildungsgeschichte, Band XI, Göttingen: Vandenhoeck & Ruprecht 2013 [...] [Sammelrezension]

Sammelrezension: 1. Lundgreen, Peter unter Mitarbeit von Jürgen Schallmann: Die Lehrer an den Schulen in der Bundesrepublik Deutschland 1949-2009, Datenhandbuch zur deutschen Bildungsgeschichte, Band XI, Göttingen: Vandenhoeck & Ruprecht 2013, (352 S.; ISBN 978-3-525-36388-5; 89,99 EUR) 2. András Németh / Ehrenhardt Skiera (Hrsg.): Lehrerbildung in Europa, Geschichte, Struktur und Reform, (Erziehung in Wissenschaft und Praxis; Bd. 9), Frankfurt am Main: Peter Lang 2012 (340 S.; ISBN 978-3-631-62454-8; 51,95 EUR)

A common polymorphism in the oxygen-dependent degradation (ODD) domain of hypoxia inducible factor-1alpha (HIF-1alpha) does not impair Pro-564 hydroxylation

The hypoxia-inducible factor (HIF) transcription complex, which is activated by low oxygen tension, controls a diverse range of cellular processes including angiogenesis and erythropoiesis. Under normoxic conditions, the alpha subunit of HIF is rapidly degraded in a manner dependent on hydroxylation of two conserved proline residues at positions 402 and 564 in HIF-1alpha in the oxygen-dependent degradation (ODD) domain. This allows subsequent recognition by the von Hippel-Lindau (VHL) tumor suppressor protein, which targets HIF for degradation by the ubiquitin-proteasome pathway. Under hypoxic conditions, prolyl hydroxylation of HIF is inhibited, allowing it to escape VHL-mediated degradation. The transcriptional regulation of the erythropoietin gene by HIF raises the possibility that HIF may play a role in disorders of erythropoiesis, such as idiopathic erythrocytosis (IE).

Spectrally bounded operators from von Neumann algebras

We prove that every unital spectrally bounded operator from a properly infinite von Neumann algebra onto a semisimple Banach algebra is a Jordan homomorphism.