Hillsborough County, New Hampshire, 1858 (Image 1 of 4) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of Hillsboro Co., New Hampshire, from actual surveys by J. Chace, Jr. It was published by Smith, Mason & Co. in 1858. Scale [ca. 1:53,000]. This layer is image 1 of 4 total images, representing the northwest portion of the four sheet source map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the New Hampshire State Plane coordinate system (NAD 1983 in Feet) (Fipszone 2800). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), private buildings with names of property owners, town and school district boundaries, and more. Relief shown by hachures. Includes table of distances, agricultural goods, religious affiliations, business directory, statistics of education and other information, and a list of county officers.This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and map purposes.

Hillsborough County, New Hampshire, 1858 (Image 2 of 4) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of Hillsboro Co., New Hampshire, from actual surveys by J. Chace, Jr. It was published by Smith, Mason & Co. in 1858. Scale [ca. 1:53,000]. This layer is image 2 of 4 total images, representing the southwest portion of the four sheet source map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the New Hampshire State Plane coordinate system (NAD 1983 in Feet) (Fipszone 2800). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), private buildings with names of property owners, town and school district boundaries, and more. Relief shown by hachures. Includes table of distances, agricultural goods, religious affiliations, business directory, statistics of education and other information, and a list of county officers.This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and map purposes.

Hillsborough County, New Hampshire, 1858 (Image 3 of 4) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of Hillsboro Co., New Hampshire, from actual surveys by J. Chace, Jr. It was published by Smith, Mason & Co. in 1858. Scale [ca. 1:53,000]. This layer is image 3 of 4 total images, representing the southeast portion of the four sheet source map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the New Hampshire State Plane coordinate system (NAD 1983 in Feet) (Fipszone 2800). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), private buildings with names of property owners, town and school district boundaries, and more. Relief shown by hachures. Includes table of distances, agricultural goods, religious affiliations, business directory, statistics of education and other information, and a list of county officers.This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and map purposes.

Hillsborough County, New Hampshire, 1858 (Image 4 of 4) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of Hillsboro Co., New Hampshire, from actual surveys by J. Chace, Jr. It was published by Smith, Mason & Co. in 1858. Scale [ca. 1:53,000]. This layer is image 4 of 4 total images, representing the northeast portion of the four sheet source map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the New Hampshire State Plane coordinate system (NAD 1983 in Feet) (Fipszone 2800). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), private buildings with names of property owners, town and school district boundaries, and more. Relief shown by hachures. Includes table of distances, agricultural goods, religious affiliations, business directory, statistics of education and other information, and a list of county officers.This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and map purposes.

Essex County, Massachusetts, 1856 (Image 3 of 4) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: A topographical map of Essex County, Massachusetts : based upon the trigonometrical survey of the state the details, from actual surveys under the direction of H.F. Walling, superintendent of state map ; engd. by Geo. Worley & Wm. Bracher. It was published by Smith and Morley in 1856. Scale [ca. 1:50,000]. This layer is image 3 of 4 total images, representing the southwest portion of the four sheet source map.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), private buildings with names of property owners, town and school district boundaries, and more. Relief shown by hachures. It includes many cadastral insets of individual county towns and villages. It also includes illustrations, business directories, and tables of statistics and distances.This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Essex County, Massachusetts, 1856 (Image 2 of 4) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: A topographical map of Essex County, Massachusetts : based upon the trigonometrical survey of the state the details, from actual surveys under the direction of H.F. Walling, superintendent of state map ; engd. by Geo. Worley & Wm. Bracher. It was published by Smith and Morley in 1856. Scale [ca. 1:50,000]. This layer is image 2 of 4 total images, representing the southeast portion of the four sheet source map.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), private buildings with names of property owners, town and school district boundaries, and more. Relief shown by hachures. It includes many cadastral insets of individual county towns and villages. It also includes illustrations, business directories, and tables of statistics and distances.This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Lynn to Halibut Point, Rockport, Massachusetts, Atlantic Coast, 1873 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Eldridge's new chart from Lynn to Halibut Point : with the harbors of Salem, Beverly, Marblehead, Manchester, Gloucester & Rockport, compiled from the latest surveys, [by George Eldridge] ; G.W. Boynton, sc. It was published by S. Thaxter & Son, 1873. Scale [ca. 1:58,370]. This map is a nautical chart covering the Atlantic Coast of Massachusetts from Lynn to Halibut Point, Rockport, Massachusetts. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows coastal features such as lighthouses, buoys, beacons, rocks, channels, points, coves, islands, and more. Depths are shown by soundings and shading. Includes sailing directions and table of tides. This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Essex County, Massachusetts, 1825 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: The county of Essex, made by John G. Hales ; engraved by J.V.N. Throop. It was published June 19th, 1825. Scale [ca. 1:90,000]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, drainage, public buildings, churches, industry locations (e.g. mills, factories, mines, etc.), individual dwellings, town and county boundaries and more. Relief is shown by hachures. This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Boston and vicinity, Massachusetts, 1776 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: An accurate map of the country round Boston in New England. It was originally published by Archibald Hamilton in Town and country magazine (London), Jan. 16, 1776. Scale [ca. 1:362,500]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, drainage, selected public buildings, town boundaries and more. Relief is shown by hachures. Includes ancillary map: A plan of Boston and Charlestown, from a drawing made in 1771, with index to points of interest. This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Gloucester, Massachusetts 15 Minute Digital Raster Graphic

This layer is a digital raster graphic of the historic 15-minute USGS topographic map of the Gloucester, Massachusetts quadrangle. The survey date (ground condition) of this map is 1886, the edition date is August, 1893 and the map was reprinted in January 1898. A digital raster graphic (DRG) is a scanned image of a U.S. Geological Survey (USGS) standard series topographic map, including all map collar information. The image inside the map neatline is geo-referenced to the surface of the earth and fit to the Universal Transverse Mercator projection. The horizontal positional accuracy and datum of the DRG matches the accuracy and datum of the source map. The names of quadrangles which border this one appear on the map collar in their respective positions (N,S,E,W) in relation to this map.

Salem, Massachusetts 15 Minute Digital Raster Graphic

This layer is a digital raster graphic of the historic 15-minute USGS topographic map of the Salem, Massachusetts quadrangle. The survey date (ground condition) of the original paper map is 1886, the edition date is October, 1893 and this map has a reprint date of December, 1897. A digital raster graphic (DRG) is a scanned image of a U.S. Geological Survey (USGS) standard series topographic map, including all map collar information. The image inside the map neatline is geo-referenced to the surface of the earth and fit to the Universal Transverse Mercator projection. The horizontal positional accuracy and datum of the DRG matches the accuracy and datum of the source map.

Transient Activation of Meox1 Is an Early Component of the Gene Regulatory Network Downstream of Hoxa2

Hox genes encode transcription factors that regulate morphogenesis in all animals with bilateral symmetry. Although Hox genes have been extensively studied, their molecular function is not clear in vertebrates, and only a limited number of genes regulated by Hox transcription factors have been identified. Hoxa2 is required for correct development of the second branchial arch, its major domain of expression. We now show that Meox1 is genetically downstream from Hoxa2 and is a direct target. Meox1 expression is downregulated in the second arch of Hoxa2 mouse mutant embryos. In chromatin immunoprecipitation (ChIP), Hoxa2 binds to the Meox1 proximal promoter. Two highly conserved binding sites contained in this sequence are required for Hoxa2-dependent activation of the Meox1 promoter. Remarkably, in the absence of Meox1 and its close homolog Meox2, the second branchial arch develops abnormally and two of the three skeletal elements patterned by Hoxa2 are malformed. Finally, we show that Meox1 can specifically bind the DNA sequences recognized by Hoxa2 on its functional target genes. These results provide new insight into the Hoxa2 regulatory network that controls branchial arch identity.

The Argentine as a market;

Mode of access: Internet.

Correspondence and speeches of Mr. Peter Rylands, M. P., with a sketch of his career.

vol. I. Life and correspondence.--vol. II. Speeches.

Standardized reporting using CODES (Crash Outcome Data Evaluation System).

National Highway Traffic Safety Administration, Washington, D.C.