On Walkup's class K (d) and a minimal triangulation of (S-3 (sic) S-1)(#3)

For d >= 2, Walkup's class K (d) consists of the d-dimensional simplicial complexes all whose vertex-links are stacked (d - 1)-spheres. Kalai showed that for d >= 4, all connected members of K (d) are obtained from stacked d-spheres by finitely many elementary handle additions. According to a result of Walkup, the face vector of any triangulated 4-manifold X with Euler characteristic chi satisfies f(1) >= 5f(0) - 15/2 chi, with equality only for X is an element of K(4). Kuhnel observed that this implies f(0)(f(0) - 11) >= -15 chi, with equality only for 2-neighborly members of K(4). Kuhnel also asked if there is a triangulated 4-manifold with f(0) = 15, chi = -4 (attaining equality in his lower bound). In this paper, guided by Kalai's theorem, we show that indeed there is such a triangulation. It triangulates the connected sum of three copies of the twisted sphere product S-3 (sic) S-1. Because of Kuhnel's inequality, the given triangulation of this manifold is a vertex-minimal triangulation. By a recent result of Effenberger, the triangulation constructed here is tight. Apart from the neighborly 2-manifolds and the infinite family of (2d + 3)-vertex sphere products Sd-1 X S-1 (twisted for d odd), only fourteen tight triangulated manifolds were known so far. The present construction yields a new member of this sporadic family. We also present a self-contained proof of Kalai's result. (C) 2011 Elsevier B.V. All rights reserved.

A family of Runge-Kutta based explicit methods for rotational dynamics

The present paper develops a family of explicit algorithms for rotational dynamics and presents their comparison with several existing methods. For rotational motion the configuration space is a non-linear manifold, not a Euclidean vector space. As a consequence the rotation vector and its time derivatives correspond to different tangent spaces of rotation manifold at different time instants. This renders the usual integration algorithms for Euclidean space inapplicable for rotation. In the present algorithms this problem is circumvented by relating the equation of motion to a particular tangent space. It has been accomplished with the help of already existing relation between rotation increments which belongs to two different tangent spaces. The suggested method could in principle make any integration algorithm on Euclidean space, applicable to rotation. However, the present paper is restricted only within explicit Runge-Kutta enabled to handle rotation. The algorithms developed here are explicit and hence computationally cheaper than implicit methods. Moreover, they appear to have much higher local accuracy and hence accurate in predicting any constants of motion for reasonably longer time. The numerical results for solutions as well as constants of motion, indicate superior performance by most of our algorithms, when compared to some of the currently known algorithms, namely ALGO-C1, STW, LIEMID[EA], MCG, SUBCYC-M.

An infinite family of tight triangulations of manifolds

We give explicit construction of vertex-transitive tight triangulations of d-manifolds for d >= 2. More explicitly, for each d >= 2, we construct two (d(2) + 5d + 5)-vertex neighborly triangulated d-manifolds whose vertex-links are stacked spheres. The only other non-trivial series of such tight triangulated manifolds currently known is the series of non-simply connected triangulated d-manifolds with 2d + 3 vertices constructed by Kuhnel. The manifolds we construct are strongly minimal. For d >= 3, they are also tight neighborly as defined by Lutz, Sulanke and Swartz. Like Kuhnel complexes, our manifolds are orientable in even dimensions and non-orientable in odd dimensions. (c) 2013 Elsevier Inc. All rights reserved.

Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity

Predicting clinical response to anticancer drugs remains a major challenge in cancer treatment. Emerging reports indicate that the tumour microenvironment and heterogeneity can limit the predictive power of current biomarker-guided strategies for chemotherapy. Here we report the engineering of personalized tumour ecosystems that contextually conserve the tumour heterogeneity, and phenocopy the tumour microenvironment using tumour explants maintained in defined tumour grade-matched matrix support and autologous patient serum. The functional response of tumour ecosystems, engineered from 109 patients, to anticancer drugs, together with the corresponding clinical outcomes, is used to train a machine learning algorithm; the learned model is then applied to predict the clinical response in an independent validation group of 55 patients, where we achieve 100% sensitivity in predictions while keeping specificity in a desired high range. The tumour ecosystem and algorithm, together termed the CANScript technology, can emerge as a powerful platform for enabling personalized medicine.

Robust Glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI Family Member Protein, Is Critical for Oxidative Stress Resistance in Saccharomyces cerevisiae

Methylglyoxal (MG) is a reactive metabolic intermediate generated during various cellular biochemical reactions, including glycolysis. The accumulation of MG indiscriminately modifies proteins, including important cellular antioxidant machinery, leading to severe oxidative stress, which is implicated in multiple neurodegenerative disorders, aging, and cardiac disorders. Although cells possess efficient glyoxalase systems for detoxification, their functions are largely dependent on the glutathione cofactor, the availability of which is self-limiting under oxidative stress. Thus, higher organisms require alternate modes of reducing the MG-mediated toxicity and maintaining redox balance. In this report, we demonstrate that Hsp31 protein, a member of the ThiJ/DJ-1/PfpI family in Saccharomyces cerevisiae, plays an indispensable role in regulating redox homeostasis. Our results show that Hsp31 possesses robust glutathione-independent methylglyoxalase activity and suppresses MG-mediated toxicity and ROS levels as compared with another paralog, Hsp34. On the other hand, glyoxalase-defective mutants of Hsp31 were found highly compromised in regulating the ROS levels. Additionally, Hsp31 maintains cellular glutathione and NADPH levels, thus conferring protection against oxidative stress, and Hsp31 relocalizes to mitochondria to provide cytoprotection to the organelle under oxidative stress conditions. Importantly, human DJ-1, which is implicated in the familial form of Parkinson disease, complements the function of Hsp31 by suppressing methylglyoxal and oxidative stress, thus signifying the importance of these proteins in the maintenance of ROS homeostasis across phylogeny.

Caracterización y evaluación preliminar del Teocinte anual (Zea lexurians D.) recolectado en la zona norte de Chinandega, Nicaragua

Este trabajo trata sobre la caracterización y evaluación preliminar del posible ancestro del maíz, el teocintle anual (Zea luxurians Durie), el cual fue recolectado en la región Nor-occidental de Nicaragua (Villanueva, Chinandega). El experimento se llevó a efecto en el área experimental del Programa Recursos Genéticos Nicaragüenses (REGEN), adscrito a la Universidad Nacional Agraria (UNA), ubicado en el Km 12 1/2 carretera Norte. Dicha investigación se realizó en el periodo comprendido de Enero a Octubre de 1995. los meses de Enero y Febrero no fueron evaluados debido al fuerte acame de las plantas, y el mes de Octubre no se evaluó debido al deficiente crecimiento y desarrollo. El diseño empleado fue un bifactorial en parcelas divididas con dos bloques. En las parcelas grandes se ubicaron los tratamientos épocas de siembra (meses), y en las parcelas pequeñas se realizó el control de malezas (con maleza y sin maleza en todo el ciclo de la planta. Se utilizaron 45 descriptores, de los cuales cuantitativos y 11 son cualitativos. Según el realizado se observó diferencia significativa 34 son ANDEVA en los caracteres cuantitativos, a excepción de los caracteres de grano. Las mayores alturas de plantas se obtuvieron en las primeras fechas de siembra, sobrepasando los 3m de altura y en cuanto al rendimiento los mayores promedios se presentaron bajo el tratamiento sin maleza. Esta especie responde al fotoperiodo, ya que la floración se produjo entre los meses de Noviembre y Diciembre para los meses de Enero hasta Septiembre y la época de siembra del mes de Octubre se registró entre Diciembre y Enero. De los resultados obtenidos se elaboró un catálogo (valores máximos,medios, mínimos, desviación estándar y coeficiente de variación para los descriptores cuantitativos) para los diferentes tratamientos.Debido a la importancia que esta especie representa se debe tomar en cuenta la caracterización In situ y declarar zona protegida el área de origen por riesgos de erosión genética.

El Conde de Portugal D. Henrique : ambición y lealtad

Resumen: La presente investigación reivindica la persona de D. Henrique de Borgoña, padre del primer rey de Portugal, como inspirador de la política separatista que hizo del condado portugalense un reino reconocido de la Europa cristiana. Igualmente se pone de relieve la importancia del parentesco y relaciones familiares para conseguir ese éxito diplomático.

Symmetrical 2-D Hermite-Gaussian square launch for high bit rate transmission in multimode fiber links

A 2-D Hermite-Gaussian square launch is demonstrated to show improved systems capacity over multimode fiber links. It shows a bandwidth improvement over both center and offset launches and exhibits ±5 μm misalignment tolerance. © 2011 Optical Society of America.

Report of the 2004 Workshop on In Situ Iron Enrichment Experiments in the Eastern and Western Subarctic Pacific

Foreword 1. BACKGROUND AND OBJECTIVES (pdf, 0.1 Mb) 2. 2004 WORKSHOP SUMMARY (pdf, < 0.1 Mb) 2.1. What have we learned from the enrichment experiments? 2.2 What are the outstanding questions? 2.3 Recommendations for SEEDS-II 3. EXTENDED ABSTRACTS OF THE 2004 WORKSHOP 3.1 Synthesis of the Iron Enrichment Experiments: SEEDS and SERIES (pdf, 0.5 Mb) Iron fertilization experiment in the western subarctic Pacific (SEEDS) by Atsushi Tsuda The response of N and Si to iron enrichment in the Northeast Pacific Ocean: Results from SERIES by David Timothy, C.S. Wong, Yukihiro Nojiri, Frank A. Whitney, W. Keith Johnson and Janet Barwell-Clarke 3.2 Biological and Physiological Responses (pdf, 0.2 Mb) Zooplankton responses during SEEDS by Hiroaki Saito Phytoplankton community response to iron and temperature gradient in the NW and NE subarctic Pacific Ocean by Isao Kudo, Yoshifumi Noiri, Jun Nishioka, Hiroshi Kiyosawa and Atsushi Tsuda SERIES: Copepod grazing on diatoms by Frank A. Whitney, Moira Galbraith, Janet Barwell-Clarke and Akash Sastri The Southern Ocean Iron Enrichment Experiment: The nitrogen uptake response by William P. Cochlan and Raphael M. Kudela 3.3 Biogeochemical Responses (pdf, 0.5 Mb) What have we learned regarding iron biogeochemistry from iron enrichment experiments? by Jun Nishioka, Shigenobu Takeda and W. Keith Johnson Iron dynamics and temporal changes of iron speciation in SERIES by W. Keith Johnson, C.S. Wong, Nes Sutherland and Jun Nishioka Dissolved organic matter dynamics during SEEDS and SERIES experiments by Takeshi Yoshimura and Hiroshi Ogawa Formation of transparent exopolymer particles during the in-situ iron enrichment experiment in the western subarctic Pacific (SEEDS) by Shigenobu Takeda, Neelam Ramaiah, Ken Furuya and Takeshi Yoshimura Atmospheric measurement by Mitsuo Uematsu 3.4 Prediction from Models (pdf, 0.3 Mb) Modelling iron limitation in the North Pacific by Kenneth L. Denman and M. Angelica Peña A proposed model of the SERIES iron fertilization patch by Debby Ianson, Christoph Voelker and Kenneth L. Denman 4. LIST OF PARTICIPANTS FOR THE 2004 WORKSHOP (pdf, < 0.1 Mb) APPENDIX 1 Report of the 2000 Planning Workshop on Designing the Iron Fertilization Experiment in the Subarctic Pacific (pdf, 1 Mb) APPENDIX 2 Terms of Reference for the Advisory Panel on Iron fertilization experiment in the subarctic Pacific Ocean (pdf, < 0.1 Mb) APPENDIX 3 Historical List of Advisory Panel Members on Iron fertilization experiment in the subarctic Pacific Ocean (pdf, < 0.1 Mb) APPENDIX 4 IFEP-AP Annual Reports (pdf, 0.1 Mb) APPENDIX 5 PICES Press Articles (pdf, 0.6 Mb) (194 page document)

STREAM Journal, Vol. 2, No. 4, pp 1-18. October-December 2003

CONTENTS: An experience with group formation in Jabarrah, West Bengal, by Amar Prasad, Virendra Singh, Binay Sahay and Gautum Dutta. Aquaculture self-help groups in rural West Bengal, by Satyendra Tripathi, Graham Haylor and William Savage in consultation with Jagdish Gangwar, Virendra Singh, Gautam Dutta and Prabhat Pathak. Lessons learned for Fulwar Toli from an exposure visit to Jabarrah Bhim Nayak and Rubu Mukherjee. Livelihood intervention by Fish Farmers Development Agency: a success story from Mayurbhanj, Orissa, by G.B. Parida. Understanding of assets-based livelihoods through participatory rural appraisal to eliminate hunger, by Binay Sahay. Poverty ranking tools in PRA: experiences of EIRFP in addressing vulnerability, by Binay Sahay.

STREAM Journal, Vol. 4, No. 2, pp 1-17. April-June 2005

CONTENTS: Changes in Jabarrah, by Satyendra D. Tripathi, as told by Thanda Mahato. Palu Hijau in the Banggai Islands Jabarrah: using knowledge for change, by Akhdary Dj Supu, translated by Abigail Moore. Banggai Islands case study: building foundations for action, by Samliok Ndobe, translated by Abigail Moore. Three stories from Nepal, by Ghanshayam Poudel, Suraj, Ramesh Gautam, Pashupati Chaudhary, Anil Subedi, Muralidhar Mishara and Chet Nath Adhikari. Me and my work, by Sheryll Alcazar. Livelihoods approaches: skills learned, applied and shared, by Monica Piquero-Tan.

STREAM Journal, Vol. 5, No. 1, pp 1-18. January-March 2006

CONTENTS: Policy development as a theme and policy briefs as a genre, by Graham Haylor and William Savage. Decriminalizing Cambodian family-scale fishers through a livelihoods approach to law reform, by Nao Thuok and Chun Sopha. Longer pond leases in Orissa, by Reshmee Guha and Rubu Mukherjee. One-stop aqua shop: a “one-window delivery” service center for aqua-farmers and fishers, by S.D. Tripathi, Rubu Mukherjee and Kuddus Ansary. Fisheries and aquaculture policy formulation process in Pakistan, by Muhammad Junaid Wattoo and Dr. Muhammad Hayat. Improving the international marine ornamental fish trade to sustain and improve the livelihoods of poor people involved in the trade, by Aniza Suspita, Michael J. Phillips and Samliok Ndobe.

Epistolas Varias que Consagra a la Catolica Magestad Del Rey D. Carlos Segundo, N.S. Monarca de las Espanas y del Nuevo Mundo, Don Felix de Lucio Espinosa y Malo, su autor, doctor en ambos derechos, con privilegio

Félix de Lúcio Espinosa y Maio, escritor e historiador espanhol, nasceu em Zaragoza, em 1646, e morreu em Palermo, Itália, em 1691. Doutorou-se em Direito na Universidade de Nápoles, foi Secretário do Conselho de Sua Majestade e Secretário de Estado e Guerra, no reino da Sicília. Cronista do reino de Aragão, das Índias e de Castela e Leão. Distinguiu-se por seu talento e sua cultura. ‘Epistolas varias...’ traz composições poéticas em forma de cartas, descrevendo entre outras coisas: ‘Del origem de las estatuas’, ‘De los sepulcros antigos’, ‘Del origem de las monedas’, ‘De la causa dei terremoto’, ‘Descripcion de la fiesta de toros de Madrid���, ‘De la velocidad dei tiempo’, ‘Consolatoria en la muerte’, ‘De la pintura, y alguns inventores’, ‘La paz y la union’, ‘Sobre eI origen de la poesia en varias naciones’

Biological survey of the Panama Canal Zone

exhaustive biological survey of the Panama Canal Zone-will be undertaken in the winter of 1910-11. A part of the fresh-water streams of the Isthmus of Panama empty into the Atlantic Ocean and others into the Pacific Ocean. It is known that a certain number of animals and plants in the streams on the Atlantic side are different from those of the Pacific side, but as no exact biological survey has ever been undertaken the extent and magnitude of these differences have yet to be learned. When the canal is completed the organisms of the various watersheds will be offered a ready means of mingling together, the natural distinctions now existing will be obliterated....

Reactions of small molecules facilitated by metal-acceptor interactions

The role of metal-acceptor interactions arising from M–BR3 and M–PR3 bonding is discussed with respect to reactions between first-row transition metals and N2, H2, and CO. Thermally robust, S = 1/2 (TPB)Co(H2) and (TPB)Co(N2) complexes (TPB = tris(2- (diisopropylphosphino)phenyl)borane) are described and the energetics of N2 and H2 binding are measured. The H2 and N2 ligands are bound more weakly in the (TPB)Co complexes than in related (SiP3)M(L) complexes (SiP3 = tris(2- (diisopropylphosphino)phenyl)silyl). Comparisons within and between these two ligand platforms allow for the factors that affect N2 (and H2) binding and activation to be delineated. The characterization and reactivity of (DPB)Fe complexes (DPB = bis(2- (diisopropylphosphino)phenyl)phenylborane) in the context of N2 functionalization and E–H bond addition (E = H, C, N, Si) are described. This platform allows for the one-pot transformation of free N2 to an Fe hydrazido(-) complex via an Fe aminoimide intermediate. The principles learned from the N2 chemistry using (DPB)Fe are applied to CO reduction on the same system. The preparation of (DPB)Fe(CO)2 is described as well as its reductive functionalization to generate an unprecedented Fe dicarbyne. The bonding in this highly covalent complex is discussed in detail. Initial studies of the reactivity of the Fe dicarbyne reveal that a CO-derived olefin is released upon hydrogenation. Alternative approaches to uncovering unusual reactivity using metal- acceptor interactions are described in Chapters 5 and 6, including initial studies on a new π-accepting tridentate diphosphinosulfinyl ligand and strategies for designing ligands that undergo site-selective metallation to generate heterobimetallic complexes.