Study of interaction between drug enantiomers and serum albumin by capillary electrophoresis

The interaction between drugs and human serum albumin (HSA) was investigated by capillary electrophoresis (CE). It involves stereoselectivity, drug displacement and synergism effects. Under protein-drug binding equilibrium, the unbound concentrations of drug enantiomers were measured by frontal analysis (FA). The stereoselectivity of verapamil (VER) binding to HSA was proved by the different free fractions of two enantiomers. In physiological pH (7.4, ionic strength 0.17 phosphate buffer) when 300 mu M (+/-) VER were equilibrated with 500 mu M HSA, the concentration of unbound S-VER was about 1.7 times its antipode. The binding constants of two enantiomers, KR-VER and KS-VER, were 2670 and 850 M-1, respectively. However, no obvious stereoselective binding of propranolol (PRO) to HSA was observed. Trimethyl-beta-cyclodextrin (45 mM) was used as a chiral selector in pH 2.5 phosphate buffer. Several drug systems were studied by the method. When ibuprofen (IBU) was added into VER-HSA solution. R-VER was partially displaced while S-VER was not displaced at all. A binding synergism effect between bupivacaine (BUP) and verapamil was observed and further study suggested that verapamil and bupivacaine occupy different binding site of HSA (site II and site III, respectively).

Sublimation of snow from confierous forests in a climate model

Essery, R L H, Pomeroy, J W, Parvianen, J & Storck, P, Sublimation of snow from confierous forests in a climate model. Journal of Climate 16, pp 1855-1864 (2003).

Adaptive capacity and learning to learn as leverage for social-ecological resilience

Ioan Fazey, John A. Fazey, Joern Fischer, Kate Sherren, John Warren, Reed F. Noss, Stephen R. Dovers (2007) Adaptive capacity and learning to learn as leverage for social?ecological resilience. Frontiers in Ecology and the Environment 5(7),375-380. RAE2008

C 225 INST-D 2013. 386 Talleres de carpintería con sus dotaciones de equipos y herramientas tradicionales y modernas.

30 fotografías a color

In Memoriam REv. Archibald Campbell Foss

Memorial address.

Alexander Mackay : missionary hero of Uganda.

http://www.archive.org/details/alexandermackay00unknuoft/

Genom Norra Amerikas Fèorenta Stater. Reseskildringar af P. Waldenstrèom.

http://www.archive.org/details/genomnorramer00waldrich

Dix-huit ans chez les sauvages : voyages et missions de Mgr Henry Faraud, áevãeque d'Anemour, vicaire apostolique de Mackensie dans l'extrãeme nord de l'Amerique britannique : d'apráes les documents de Mgr l'evãque d'Anemour / par Fernand-Michel.

http://www.archive.org/details/dixhuitanschezle00fararich

Seven years among the Freedmen [electronic resource] / M. Waterbury

http://www.archive.org/details/sevenyearsamong00waterich/

A missionary heroine / by Carrie S. Cooper.

http://www.archive.org/details/missionaryheroin00cooprich

James Evans : inventor of the syllabic system of the Cree language / by John McLean ... (Robin Rustler).

http://www.archive.org/details/jamesevans00maclrich

By canoe and dog-train among the Cree and Salteaux Indians / by Egerton Ryerson Young ; with an introduction by Mark Guy Pearse.

http://www.archive.org/details/bycanoedogtraina00younrich

Ancient peoples at new tasks

http://www.archive.org/details/ancientpeoplesat00pricuoft

The story of the Fuh-Kien mission of the Church missionary society, by Eugene Stock ...

http://www.archive.org/details/thestoryofthefuh00stocuoft