Field behavior of chemical, biological, and radiological agents.

April 1969

The atom in the South: story of leadership and achievement; report to Southern Governors' Conference, Hollywood-by-the-Sea, Florida, October 4, 1962.

Mode of access: Internet.

A glossary of terms in nuclear science and technology.

Preliminary ed. published in 1950-52 under title: Glossary of nuclear energy terms.

Control and reduction of armaments : hearings before a subcommittee of the Committee on Foreign Relations, United States Senate, Eighty-fourth Congress, second session [-Eighty-fifth Congress, second session].

Includes index (pt.[18]).

Nuclear data : a collection of experimental values of half-lives, radiation energies, relative isotopic abundances, nuclear moments, and cross sections.

sup. 1. January to July 1950 -- sup. 2. July 1950 to January 1951 -- sup. 3. January to July 1951.

Scientific and technical aspects of the control of atomic energy; the full text of the First report of the Scientific and Technical Committee of the Atomic Energy Commission, the background of the report, a glossary of scientific terms and biographical notes.

Mode of access: Internet.

[Hearings, reports and prints of the Joint Committee on Atomic Energy].

Mode of access: Internet.

International commercial nuclear reactor safety : hearing before the Subcommittee on Nuclear Regulation of the Committee on Environment and Public Works, United States Senate, One Hundred Second Congress, first session ....

"November 21, 1991" -- Pt. 2.

Nuclear safety : concerns with nuclear facilities and other sources of radiation in the Former Soviet Union : report to the Honorable Bob Graham, U.S. Senate /

"B-261612"--P. 1.

Department of Energy's civilian Nuclear Waste Program : hearing before the Committee on Energy and Natural Resources, United States Senate, One Hundred Second Congress ....

Shipping list no.: 91-436-P (pt. [1]).

Conservation of freshwater thermal habitats for Pacific salmon in a changing climate

Thesis (Ph.D.)--University of Washington, 2016-06

The Epstein-Barr virus nuclear antigen-6 protein co-localizes with EBNA-3 and survival of motor neurons protein

The Epstein-Barr virus nuclear antigen (EBNA)-6 protein is essential for Epstein-Barr virus (EBV)-induced immortalization of primary human B-lymphocytes in vitro. In this study, fusion proteins of EBNA-6 with green fluorescent protein (GFP) have been used to characterize its nuclear localization and organization within the nucleus. EBNA-6 associates with nuclear structures and in immunofluorescence demonstrate a punctate staining pattern. Herein, we show that the association of EBNA-6 with these nuclear structures was maintained throughout the cell cycle and with the use of GFP-E6 deletion mutants, that the region amino acids 733-808 of EBNA-6 contains a domain that can influence the association of EBNA-6 with these nuclear structures. Co-immunofluorescence and confocal analyses demonstrated that EBNA-6 and EBNA-3 co-localize in the nucleus of cells. Expression of EBNA-6, but not EBNA-3, caused a redistribution of nuclear survival of motor neurons protein (SMN) to the EBNA-6 containing nuclear structures resulting in co-localization of SMN with EBNA-6. (C) 2003 Elsevier Inc. All rights reserved.

The ins and outs of transcriptional control: nucleocytoplasmic shuttling in development and disease

Recent findings relating to SOX transcription factors indicate that defects in organogenesis can be caused not only by impairment of the biochemical properties of transcription factors but also, in some cases, by deficient nuclear import. In addition, experimentally interfering with the nuclear export signals of some SOX factors has now been found to cause developmental defects. Controlling the balance of nuclear import and export might be a common means by which transcription factor activity can be regulated during development, and defects in these processes might underlie a broader spectrum of inherited developmental disorders.

The impact of prolonged fasting during aestivation on the structure of the small intestine in the green-striped burrowing frog, Cyclorana alboguttata

The effects of short-term fasting and prolonged fasting during aestivation on the morphology of the proximal small intestine and associated organs were investigated in the green-striped burrowing frog, Cyclorana alboguttata (Anura: Hylidae). Animals were fasted for 1 week while active or for 3-9 months during aestivation. Short-duration fasting (1 week) had little effect on the morphology of the small intestine, whilst prolonged fasting during aestivation induced marked enteropathy including reductions in intestinal mass, length and diameter, longitudinal fold height and tunica muscularis thickness. Enterocyte morphology was also affected markedly by prolonged fasting: enterocyte cross-sectional area and microvillous height were reduced during aestivation, intercellular spaces were visibly reduced and the prevalence of lymphocytes amongst enterocytes was increased. Mitochondria and nuclei were also affected by 9 months of aestivation with major disruptions to mitochondrial cristae and increased clumping of nuclear material and increased infolding of the nuclear envelope. The present study demonstrates that the intestine of an aestivating frog responds to prolonged food deprivation during aestivation by reducing in size, presumably to reduce the energy expenditure of the organ.

Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherin

Fibroblast growth factor (FGF) receptors (FGFRs) signal to modulate diverse cellular functions, including epithelial cell morphogenesis. In epithelial cells, E-cadherin plays a key role in cell-cell adhesion, and its function can be regulated through endocytic trafficking. In this study, we investigated the location, trafficking, and function of FGFR1 and E-cadherin and report a novel mechanism, based on endocytic trafficking, for the coregulation of E-cadherin and signaling from FGFR1. FGF induces the internalization of surface FGFR1 and surface E-cadherin, followed by nuclear translocation of FGFR1. The internalization of both proteins is regulated by common endocytic machinery, resulting in cointernalization of FGFR1 and E-cadherin into early endosomes. By blocking endocytosis, we show that this is a requisite, initial step for the nuclear translocation of FGFR1. Overexpression of E-cadherin blocks both the coendocytosis of E-cadherin and FGFR1, the nuclear translocation of FGFR1 and FGF-induced signaling to the mitogen-activated protein kinase pathway. Furthermore, stabilization of surface adhesive E-cadherin, by overexpressing p120(ctn), also blocks internalization and nuclear translocation of FGFR1. These data reveal that conjoint endocytosis and trafficking is a novel mechanism for the coregulation of E-cadherin and FGFR1 during cell signaling and morphogenesis.