Jewish Winterhilfe Berlin; Kueche Klopstock-Strasse Jewish Institutions

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Jewish Winterhilfe Berlin; Kueche Blumen-Strasse Jewish Institutions

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Jewish Winterhilfe Berlin; Kueche Blumen-Strasse Jewish Institutions

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Jewish Winterhilfe Berlin; Kueche Britzer-Strasse Jewish Institutions

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Jewish Winterhilfe Berlin; Kueche Choriner-Strasse Jewish Institutions

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Jewish Winterhilfe Berlin; Kueche Choriner-Strasse Jewish Institutions

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Jewish Winterhilfe Berlin; Kueche Mosel-Strasse Jewish Institutions

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Jewish Winterhilfe Berlin; Teitelkueche Jewish Institutions

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Jewish Winterhilfe Berlin; Sonntagskueche Joachimsthaler Strasse Jewish Institutions

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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and approximately 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-)(8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

Paraxial schematic eye models for 7- and 14-year-old Chinese children

Purpose.: To develop three-surface paraxial schematic eyes with different ages and sexes based on data for 7- and 14-year-old Chinese children from the Anyang Childhood Eye Study. Methods.: Six sets of paraxial schematic eyes, including 7-year-old eyes, 7-year-old male eyes, 7-year-old female eyes, 14-year-old eyes, 14-year-old male eyes, and 14-year-old female eyes, were developed. Both refraction-dependent and emmetropic eye models were developed, with the former using linear dependence of ocular parameters on refraction. Results.: A total of 2059 grade 1 children (boys 58%) and 1536 grade 8 children (boys 49%) were included, with mean age of 7.1 ± 0.4 and 13.7 ± 0.5 years, respectively. Changes in these schematic eyes with aging are increased anterior chamber depth, decreased lens thickness, increased vitreous chamber depth, increased axial length, and decreased lens equivalent power. Male schematic eyes have deeper anterior chamber depth, longer vitreous chamber depth, longer axial length, and lower lens equivalent power than female schematic eyes. Changes in the schematic eyes with positive increase in refraction are decreased anterior chamber depth, increased lens thickness, decreased vitreous chamber depth, decreased axial length, increased corneal radius of curvature, and increased lens power. In general, the emmetropic schematic eyes have biometric parameters similar to those arising from regression fits for the refraction-dependent schematic eyes. Conclusions.: The paraxial schematic eyes of Chinese children may be useful for myopia research and for facilitating comparison with other children with the same or different racial backgrounds and living in different places.

Opening concert 1937-1938; Juedische Winterhilfe; Berlin Jewish Institutions

Caption: "Eroeffnung"

Symbol of Juedische Winterhilfe der Juedische Gemeinde; Berlin Jewish Institutions

"Aus der Arbeit der Juedische Winterhilfe der Juedische Gemeinde"

Document collage of correspondence and press materials; Juedische Winterhilfe der Juedische Gemeinde; Berlin Jewish Institutions

"die Firmen-Werbung setztein"

Reproduction of document collage; Juedische Winterhilfe der Juedische Gemeinde; Berlin Jewish Institutions

"auch 8000 Angestellte wurden geworben"