Ms. hebr. oct. 142 - [Sammelband in 2 Teilen: Handschriftenkonvolut]

Vorbesitzer: שלום יחייא; Hirsch Scheuer; Abraham Merzbacher

Ḥinnûk qāṭān : undzi seifer muser šraibn dś jdr faṭr un muṭr zain meḥuyev ria leine kindr tzu gwinn loišn koideš ...

Digitalisat der Ausg. [S.l.], [ca. 1750]

Sēfer Neṭaʿ šaʿašûʿîm : enṭhelṭ zaiṭṭen lehren

ešer ḥibbēr avî ... Hirš ...

Progressive multifocal leukoencephalopathy in common variable immunodeficiency: mitigated course under mirtazapine and mefloquine.

Demonstration of survival and outcome of progressive multifocal leukoencephalopathy (PML) in a 56-year-old patient with common variable immunodeficiency, consisting of severe hypogammaglobulinemia and CD4+ T lymphocytopenia, during continuous treatment with mirtazapine (30 mg/day) and mefloquine (250 mg/week) over 23 months. Regular clinical examinations including Rankin scale and Barthel index, nine-hole peg and box and block tests, Berg balance, 10-m walking tests, and Montreal Cognitive Assessment (MoCA) were done. Laboratory diagnostics included complete blood count and JC virus (JCV) concentration in cerebrospinal fluid (CSF). The noncoding control region (NCCR) of JCV, important for neurotropism and neurovirulence, was sequenced. Repetitive MRI investigated the course of brain lesions. JCV was detected in increasing concentrations (peak 2568 copies/ml CSF), and its NCCR was genetically rearranged. Under treatment, the rearrangement changed toward the archetype sequence, and later JCV DNA became undetectable. Total brain lesion volume decreased (8.54 to 3.97 cm(3)) and atrophy increased. Barthel (60 to 100 to 80 points) and Rankin (4 to 2 to 3) scores, gait stability, and box and block (7, 35, 25 pieces) and nine-hole peg (300, 50, 300 s) test performances first improved but subsequently worsened. Cognition and walking speed remained stable. Despite initial rapid deterioration, the patient survived under continuous treatment with mirtazapine and mefloquine even though he belongs to a PML subgroup that is usually fatal within a few months. This course was paralleled by JCV clones with presumably lower replication capability before JCV became undetectable. Neurological deficits were due to PML lesions and progressive brain atrophy.

The swiss transplant cohort study: lessons from the first 6 years.

Prospective cohort studies significantly contribute to answering specific research questions in a defined population. Since 2008, the Swiss Transplant Cohort Study (STCS) systematically enrolled >95 % of all transplant recipients in Switzerland, collecting predefined data at determined time points. Designed as an open cohort, the STCS has included >3900 patients to date, with a median follow-up of 2.96 years (IQR 1.44-4.73). This review highlights some relevant findings in the field of transplant-associated infections gained by the STCS so far. Three key general aspects have crystallized: (i) Well-run cohort studies are a powerful tool to conduct genetic studies, which are crucially dependent on a meticulously described phenotype. (ii) Long-term real-life observations are adding a distinct layer of information that cannot be obtained during randomized studies. (iii) The systemic collection of data, close interdisciplinary collaboration, and continuous analysis of some key outcome data such as infectious diseases endpoints can improve patient care.

Le-yôm rîšôn šel Rôš haš-šānā

Digitalisat der Ausg. Ofenbach, [1817/18]

Le-yôm šēnî šel Rôš haš-šānā

Digitalisat der Ausg. Ofenbach, [1817/18]

Le-Yôm Kippûr

Digitalisat der Ausg.

Le-ʿarvît Yôm Kippûr

Digitalisat der Ausg. Ofenbach, [1811/12]

PTX3 Polymorphisms and Invasive Mold Infections after Solid Organ Transplantation

Donor PTX3 polymorphisms were shown to influence the risk of invasive aspergillosis among hematopoietic stem cell transplant recipients. Here, we show that PTX3 polymorphisms are independent risk factors for invasive mold infection among 1101 solid organ transplant recipients, thereby strengthening their role in mold infection pathogenesis and patient's risk stratification.

Le-yôm rîšôn we-šēnî šel Sukkôt

Digitalisat der Ausg. Ofenbach, [1827/28]

Li-Šmînî-ʿAṣeret we-Śimḥat Tōrā

Digitalisat der Ausg. Ofenbach, [i.e. circa 1810]

Le-yôm rîšôn we-šēnî šel Pesaḥ

Digitalisat der Ausg. Ofenbach, [1811/12]