Os papéis dos RNAs não codificantes no desenvolvimento embrionário: um panorama geral

The genome of multicellular organisms shows a ruge index of RNA transcripts that are not protein coding. These ncRNAs act in housekeeping and genic regulation, as well in signaling and cell differentiation, crucial events to embryonic and ontogenetic development. Moreover, another events require the orderly expression these transcripts, as in cromossomic inactivation and genomic imprinting process, and their fail may cause several syndromes, malformations, illness and even death of affected individual. This review focus is to present the main acting pathways of ncRNAs already studied, as well to introduce the actual landscape of Dapper gene cluster and its performance in vertebrate development.

Concentração de tensões em peças e componentes estruturais - uma abordagem através do método dos elementos finitos

Any failure process that may occur in a part probably is located where the stress exceeded the level of resistance. When a part or component has a sharp change in geometry, such as slots, holes, grooves, bumps or other irregularities, there is an increased concentration of stress at a specific location of the part. The objective of this study is to determine the maximum stresses in structural parts and components using the equations of elasticity theory in conjunction with the stress concentration factor experiment and compare them with results obtained by finite element method

Pediculose na escola - uma oportunidade para aprender e ensinar

O piolho de cabeça atualmente é um problema mundial e não está relacionado à pobreza, falta de higiene, desleixo. Sua prevalência é alta na idade escolar de três a doze anos de idade. Quando uma criança o adquire tem um sentimento de vergonha, deixa de ir à escola e raramente é encaminhada para cuidados médicos. Geralmente para o controle, as famílias utilizam substâncias tóxicas, inseticidas domiciliares, produtos inflamáveis e ervas na cabeça das crianças. E ainda, acreditam que o piolho pode ser transmissor de doenças. Há uma falta de informação e neste caso, a educação se faz necessária. O objetivo deste trabalho foi elaborar um instrumento de avaliação de professores das séries iniciais do ensino fundamental I, da rede pública de ensino, da cidade de Botucatu – SP, relacionado à pediculose. Esta análise ocorreu através de um questionário constituído de 10 perguntas abertas e 14 fechadas (concordo e discordo) com abordagem educacional (ensino sobre piolho - conhecimento, atitude e prática) e com uma abordagem didática sobre biologia, diagnóstico, prevenção, tratamento, transmissão sobre o piolho de cabeça. Este trabalho foi realizado em 9 escolas da rede pública do ensino fundamental I com 108 professores.Todos os dados foram tabulados no programa Microsoft Excel 2000 versões 7.0 e as análises foram realizadas com base na estatística descritiva, não – paramétrica, segundo o método estatístico que consiste em técnica de análise de variância não paramétrica para o modelo com um fator – Teste de Kruskal-Wallis e por tabelas de freqüência. A análise estatística dos dados obtidos dos questionários mostrou como resultados mais pertinentes a posição de 100% dos professores que nunca deixam de falar sobre piolho em sala de aula, nunca proíbem o aluno... (Resumo completo, clicar acesso eletrônico abaixo)

Efeito do treinamento com pesos nos distúrbios do sono e na qualidade de vida de pacientes com demência de Alzheimer

The Alzheimer's dementia (AD) is the most prevalent form of dementia in the elderly. Among the harmful changes arising from the DA, there may be sleep disturbance and impaired quality of life. Physical activity is an important non-pharmacological feature that would provide positive effects for the treatment of disease. However, there are still few studies that clarify the effects of resistance training in this population. Thus, the present study has as objective analyzes the effects of the resistance training in sleep disturbance and quality of life of patients with AD. Participated in this study 22 patients with clinical diagnosis of AD divided into two groups: Training Group (TG) and Social Interaction Group (SIG). The subjects of TG underwent a resistance training protocol, appropriate to the individual conditions, during three days no consecutive in the week, with duration of 60 minutes each session, for 16 weeks. The SIG won't participate in any systematized physical activity, but they realized other activities, such as reading, poetry, hiking and painting, among others. This protocol also was realized three times in week for 16 weeks, with duration of 60 minutes each session. Both groups were assessed at the beginning of the program and after 16 weeks. For the assessment of sleep disturbance was used the Mini Sleep Questionnaire and to assess of quality of life was used the Scale for Assessment of Quality of Life in Alzheimer's disease (QL), versions: patient, caregiver, family and the final score. Due to the scalar nature of the data and small sample, all variables were analyzed by nonparametric statistics. The U-Mann Whitney test, Wilcoxon test and Spearman correlation test was used, except for the Modified Baecke... (Complete abstract click electronic access below)

Comparação do efeito da fadiga muscular no andar livre e adaptativo entre adultos jovens e idosos

A fadiga muscular é definida como uma falha no sistema neuromuscular na capacidade de gerar uma força requerida ou esperada. Quanto maior a idade do indivíduo, maior é a probabilidade de chegar à fadiga, aumentando o risco de quedas. Dessa forma, a fadiga pode influenciar no andar dos indivíduos, causando prejuízos no controle postural e podendo causar lesões músculo-esqueléticas A partir dos estudos realizados, percebe-se que a fadiga muscular pode prejudicar o desempenho do andar, sendo ele adaptativo ou não. O objetivo do estudo foi analisar e comparar a influência da fadiga muscular sobre os parâmetros cinemáticos do andar livre e adaptativo entre adultos jovens e idosos. Participaram do estudo 20 indivíduos, distribuídos em dois grupos etários: Adulto Jovem - 20 a 40 anos; e Idoso - a partir de 60 anos. Os participantes realizaram o andar livre e adaptativo percorrendo uma distância retilínea de 8 metros sobre um carpete de borracha com 1,4m de largura. Foram realizadas 6 tentativas para cada condição experimental. Para a coleta dos dados cinemáticos dos ciclos do andar definidos foi utilizado um sistema tridimensional (3D) optoeletrônico de análise do movimento (OPTOTRAK Certus – 3D Motion Measurement System, NDI), com precisão de 0,1 mm, posicionado no plano frontal, face anterior, ao movimento do participante, com frequência de 100 Hz. A indução a fadiga será através da tarefa de sentar e levantar. Para a comparação entre os dois grupos foram analisados as seguintes variáveis espaciais e temporais do andar livre e adaptativo: comprimento de cada passo, largura de cada passo, velocidade média do andar, distância horizontal pé-obstáculo antes da ultrapassagem, distância horizontal depois do obstáculo e distância vertical péobstáculo. Estas variáveis foram analisadas durante o ciclo do andar antes e após fadiga muscular.

Modelos matemáticos e computacionais em dengue

This work was developed starting the study of traditionals mathematical models that describe the epidemiology of infectious díseases by direct or indirect transmission. We did the classical approach of equilibrium solutions search, its analysis of stability analytically and by numerical solutions. After, we applied these techniques in a compartimental model of Dengue transmission that consider the mosquito population (susceptible vector Vs and 'infected vector VI), human population (suseeptíble humans S, infected humans I and recovered humans R) and just one sorotype floating in this population. We found the equilibrium solutions and from their analises, it was possible find the reprodution rate of dísease and which define if the disease will be endemic or not in the population.- ext, we used the method described a..~, [1] to study the infíuence of seasonalíty at vírus transmission, when it just acts on one of rates related with the vector. Lastly, we made de modeling considering the periodicity of alI rates, thereby building, a modeI with temporal dependence that permits to study periodicity of transmission through of the approach of parametrical ressonance and genetic algorithm

Estudo de falhas por fadiga em caldeiras

In recent years, increasing demand for energy has led to studies to increase the amount of electricity produced. Due to this fact, more and more boilers are becoming important sources of electricity generation. To raise the efficiency of energy generated in the boilers is necessary to raise the steam pressure and temperature to values previously unimaginable. The use of more resistant materials and maintenance practices and most appropriate operation made it possible. The objective of this study is to test the main types of failure in a chemical recovery boiler, in particular due to fatigue in the superheater, because it is a component subjected to high temperatures and thus more subject to different failures. In this manner this study aims to reduce the incidence of unscheduled maintenance shutdowns, increasing the operation time under appropriate conditions. Modeling performed in this study, the failure did not occur, because we considered only the mechanical stress. Under normal conditions, mechanical stress in combination with thermal stresses can cause cracks in the tubes due to cyclical stresses, leading to fatigue failure

Estimação de densidades e aplicação em segmentação de imagens

The aim of this work is to study some of the density estimation tec- niques and to apply to the segmentation of medical images. Medical images are used to help the diagnostic of tumor diseases as well as to plan and deliver treatment. A computer image is an array of values representing colors in some scale. The smallest element of the image to which it is possible to assign a value is called pixel. Segmen- tation is the process of dividing the image in portions through the classi¯cation of each pixel. The simplest way of classi¯cation is by thresholding, given the number of portions and the threshold values. Another method is constructing a histogram of the pixel values and assign a portion to each pike. The threshold is the mean between two pikes. As the histogram does not form a smooth curve it is di±cult to discern between true pikes and random variation. Density estimation methods allow the estimation of a smooth curve. Image data can be considered as mixture of different densities. In this project parametric and nonparametric methods for density estimation will be addressed and some of them are applied to CT image data

Efeito de diferentes espessuras, técnicas de aplicação e protocolos de resfriamento na resistência à fratura da cerâmica de cobertura aplicada sobre infraestrutura de y-tzp

Pós-graduação em Odontologia Restauradora - ICT

Estresse oxidativo em cães com doença renal crônica

Pós-graduação em Medicina Veterinária - FCAV

Localização de descargas parciais em transformadores de potência imersos em óleo mineral por meio de cápsulas piezelétricas de baixo custo e sistemas inteligentes

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Eficiência das companhias aéreas brasileiras: uma análise envoltória de dados

Studies about efficiency have gained dimension, in Brazil, since the early 90’s. Same decade that the Civil Aviation System suffers important changes in terms of regulations. Such transformations have echoed effects currently, with some significant trend for international standards. This paper focuses on one of the agents from the Brazilian Civil Aviation System, the airlines companies, which aimed on analyze and evaluate both passengers and cargo air transport, by using data envelopment analysis (DEA), during the period of 2005 to 2010. The yearbooks of ANAC, corresponding at the period from 2005 to 2010, were used as data base in this present study. The technique was applied to 14 companies, which through Stepwise process of variables validation was possible to compose a compact, but complete model, that could translate the reality of companies. This model was composed by one output, Total Income, and by four inputs, Total Costs, Total Domestic Passenger, Total Cargo and Total International Passengers. However, this approach has some flaws. Therefore in order to remedy it, it was required to apply the method Frontier Inverted, one of the alternatives proposed in the literature, which ensured an improvement in the context of efficiencies due to biggest discrimination of airlines. As a result of the DEA-BCC process, oriented by output, TAM 2005 was considered the most efficient company, however GOL and Webjet companies concentrated in 2007 their worst levels

Gestão da Manutenção Centrada na Confiabilidade em Pontes Rolantes

The objective of this work is to perform a study applying the methodology of Reliability Centered Maintenance - MCC to a group of cranes belonging to Amsted -Maxion in Cruzeiro - SP. The work consists of a presentation of maintenance, the reasons why more and more people worry about maintenance, making a presentation on the types of maintenance, its peculiar characteristics and then do a study where you identified the functionality required by the equipment under study, identified failure modes and their probable causes, and then detail the effects and consequences of these failures. With that evaluate the criticality of these failures and identify the most significant consequences that affect safety, availability or cost of equipment operation and allow a selection of the most appropriate tasks for the identified failure modes. We will also present best crane equipment, its main components, verify that there was or not improvement in the machine after the application of MCC and make a current analysis of maintenance in Amsted -Maxion

Estudo comparativo entre ressecção e eletrocoagulação endometrial em paciebtes com sangramento uterino anormal

Pós-graduação em Ginecologia, Obstetrícia e Mastologia - FMB

Fadiga em compósitos 5HS carbono/epóxi processados via RTM: relação entre cargas axiais no plano e modos de delaminação

Pós-graduação em Engenharia Mecânica - FEG