Crowded Rosselia ichnofabric in the Early Devonian of Brazil: An example of strategic behavior

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Structure and post-translational modifications of the web silk protein spidroin-1 from Nephila spiders

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Leaf synchrony and insect herbivory among tropical tree habitat specialists

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Vertical transmission of hepatitis C virus: A tale of multiple outcomes

Globally, hepatitis C virus (HCV) infection affects approximately 130 million people and 3 million new infections occur annually. HCV is also recognized as an important cause of chronic liver disease in children. The absence of proofreading properties of the HCV RNA polymerase leads to a highly error prone replication process, allowing HCV to escape host immune response. The adaptive nature of HCV evolution dictates the outcome of the disease in many ways. Here, we investigated the molecular evolution of HCV in three unrelated children who acquired chronic HCV infection as a result of mother-to-child transmission, two of whom were also coinfected with HIV-1. The persistence of discrete HCV variants and their population structure were assessed using median joining network and Bayesian approaches. While patterns of viral evolution clearly differed between subjects, immune system dysfunction related to HIV coinfection or persistent HCV seronegativity stand as potential mechanisms to explain the lack of molecular evolution observed in these three cases. In contrast, treatment of HCV infection with PegIFN, which did not lead to sustained virologic responses in all 3 cases, was not associated with commensurate variations in the complexity of the variant spectrum. Finally, the differences in the degree of divergence suggest that the mode of transmission of the virus was not the main factor driving viral evolution. (C) 2013 Elsevier B. V. All rights reserved.

The median raphe nucleus in anxiety revisited

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Tradução comentada de Peregrinaciones de una alma triste de Juana Manuela Gorriti

Pós-graduação em Letras - FCLAS

Estudo da maturação de células dendríticas em indivíduos portadores de hanseníase

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Association between pharyngeal residue and posterior oral spillage with penetration and aspiration in Stroke

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Três trajetórias e uma mesma estrada

The process of migration of the rural northeast workers toward the cities of the south of Brazil in search of work and better living conditions reached millions of individuals and constituted the basis of our industrialization and modernization, especially since the 1930s. The Cinema has not ignored this vast phenomenon and, as much as the literature put the question in debate, particularly since 1960, when our seventh art was assumed as part of the national intelligence. In this article, we observed three narratives that thematize the escape from rural to urban from the northeastern hinterland: Vidas Secas (1963), by Nelson Pereira dos Santos, Trópicos (BR / ITA, 1967), by Gianni Amico, and O Caminho das Nuvens (2003), by Vicente Amorim. Participants of the politicized cinema, Vidas Secas and Trópicos draw the political impasses of the period in the form of movies and in the aesthetic choices, trying to understand the role of these migrants in Brazilian life. Already in O Caminho das Núvens, performed four decades later, the narrative is assumed as part of the cinema of entertainment, thinking the process of migration as a choice, as stated the form of this artwork of the called cinema of the resumption.

Violência, imaginário e educação escolar: um olhar antropológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Vivencias de sujetos en procesos transexualizadores y sus relaciones con el espacio urbano de Santiago de Chile

Pós-graduação em Geografia - FCT

Água-mãe na produção romanesca de José Lins do Rego

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Next-generation sequencing reveals large connected networks of intra-host HCV variants

Background: Next-generation sequencing (NGS) allows for sampling numerous viral variants from infected patients. This provides a novel opportunity to represent and study the mutational landscape of Hepatitis C Virus (HCV) within a single host.Results: Intra-host variants of the HCV E1/E2 region were extensively sampled from 58 chronically infected patients. After NGS error correction, the average number of reads and variants obtained from each sample were 3202 and 464, respectively. The distance between each pair of variants was calculated and networks were created for each patient, where each node is a variant and two nodes are connected by a link if the nucleotide distance between them is 1. The work focused on large components having > 5% of all reads, which in average account for 93.7% of all reads found in a patient. The distance between any two variants calculated over the component correlated strongly with nucleotide distances (r = 0.9499; p = 0.0001), a better correlation than the one obtained with Neighbour-Joining trees (r = 0.7624; p = 0.0001). In each patient, components were well separated, with the average distance between (6.53%) being 10 times greater than within each component (0.68%). The ratio of nonsynonymous to synonymous changes was calculated and some patients (6.9%) showed a mixture of networks under strong negative and positive selection. All components were robust to in silico stochastic sampling; even after randomly removing 85% of all reads, the largest connected component in the new subsample still involved 82.4% of remaining nodes. In vitro sampling showed that 93.02% of components present in the original sample were also found in experimental replicas, with 81.6% of reads found in both. When syringe-sharing transmission events were simulated, 91.2% of all simulated transmission events seeded all components present in the source.Conclusions: Most intra-host variants are organized into distinct single-mutation components that are: well separated from each other, represent genetic distances between viral variants, robust to sampling, reproducible and likely seeded during transmission events. Facilitated by NGS, large components offer a novel evolutionary framework for genetic analysis of intra-host viral populations and understanding transmission, immune escape and drug resistance.

Contos de fadas: recurso educativo para crianças com deficiência intelectual

Studies show the psychological contribution of fairy tales regarding the child's development as one of the best plumbers of existential problems, appeasing it by acting as an outlet for their anguish, anxieties, and fears, engendering greater emotional balance. Thus, through researches in the literature, it was established as objective to seek information about the functionality of the fairy tales in the educational process of students with intellectual disabilities who presents challenging behaviors. Among the tales, the Brothers Grimm are suggested to be used as an educational resource. It was possible to say that, through the symbolic mediation in the imaginary of children with intellectual disabilities, educational work with fairy tales evokes significant benefits.

O uso do geoprocessamento para mapear as áreas verdes urbanas como indicador de qualidade ambiental no município de Americana/SP

The style of life in the cities deprives the man of the contact with nature. As a way to escape from the turbulent reality of the urban system, the urban planning provides areas that allow the contact between man and nature like botanical gardens, parks, leafy squares, etc. These places, through specific analysis, are also called green areas. Thus, the main purpose of this research is to outline and analyze, through geoprocessing techniques, green areas of Americana, São Paulo considering them as indicators of urban environmental quality. This evaluation will be based on the methodology adapted by Bargos (2010) where products of remote sensing were used (aerial photos and satellite images) and it will be also based on field work and calculation of the amount of green areas. The software ESRI ArcGIS® will be used to create thematic maps connected with city’s green areas. Based on the results achieved in this study, it’s expected to contribute to the government of the city of Americana in order to provide benefits of analysis for decision makers in the context of urban planning aiming an improvement in the urban environmental quality, thus benefiting its entire population