Audit report on the City of Monticello, Iowa for the year ended June 30, 2011

Audit report on the City of Monticello, Iowa for the year ended June 30, 2011

Audit report on the City of Red Oak, Iowa for the year ended June 30, 2011

Audit report on the City of Red Oak, Iowa for the year ended June 30, 2011

Audit report on the City of Solon, Iowa for the year ended June 30, 2011

Audit report on the City of Solon, Iowa for the year ended June 30, 2011

Audit report on the City of Carlisle, Iowa for the year ended June 30, 2011

Audit report on the City of Carlisle, Iowa for the year ended June 30, 2011

Long-Term Community Recovery Strategy, Iowa City, IA, December 2008

Long-Term Community Recovery Targeted Technical Assistance Strategy is an outcome of the coordinated effort of the city, Rebuild Iowa Office and Federal Emergency Management Agency Emergency Support Function. In partnership with City officials and RIO and informed by community outreach efforts, provided Targeted Technical Assistance to the community. This support helped the community identify and provide visibility to recovery issues, needs and opportunities that when addressed can result in a more effective long-term recovery for the community.

Audit report on the City of Nevada, Iowa for the year ended June 30, 2011

Audit report on the City of Nevada, Iowa for the year ended June 30, 2011

Audit report on the City of Keota, Iowa for the year ended June 30, 2011

Audit report on the City of Keota, Iowa for the year ended June 30, 2011

Les pneumopathies interstitielles diffuses chroniques: un mariage de raison entre pathologiste, clinicien et radiologue [Diffuse parenchymal lung disease, multidisciplinary approach and role of pathology]

The diagnostic approach to diffuse parenchymal lung disease (DPLD) and especially to the idiopathic interstitial pneumonias has changed over the last two decades, mostly thanks to the development of high resolution CT. Though far from replacing pathology, this additional tool has contributed to the definition of new and more precise diagnostic criteria especially for idiopathic interstitial pneumonias, integrating data provided by the three main contributors: lung specialist, radiologist and pathologist. The purpose of this article is to review the role of histopathology in the multidisciplinary approach of the diagnosis of DPLD and idiopathic interstitial pneumonias.

Audit report on the City of Atlantic, Iowa for the year ended June 30, 2011

Audit report on the City of Atlantic, Iowa for the year ended June 30, 2011

Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma.

A key element for the development of suitable anti-cancer drugs is the identification of cancer-specific enzymatic activities that can be therapeutically targeted. Mucosa-associated lymphoid tissue transformation protein 1 (MALT1) is a proto-oncogene that contributes to tumorigenesis in diffuse large B-cell lymphoma (DLBCL) of the activated B-cell (ABC) subtype, the least curable subtype of DLBCL. Recent data suggest that MALT1 has proteolytic activity, but it is unknown whether this activity is relevant for tumor growth. Here we report that MALT1 is constitutively active in DLBCL lines of the ABC but not the GCB subtype. Inhibition of the MALT1 proteolytic activity led to reduced expression of growth factors and apoptosis inhibitors, and specifically affected the growth and survival of ABC DLBCL lines. These results demonstrate a key role for the proteolytic activity of MALT1 in DLBCL of the ABC subtype, and provide a rationale for the development of pharmacological inhibitors of MALT1 in DLBCL therapy.

Hereditary diffuse leukoencephalopathy with axonal spheroids: More than just a rare disease.

Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a progressive white matter disease with a wide range of clinical symptoms including dementia, behavioral changes, seizures, pyramidal signs, ataxia, and parkinsonism.(1-3) Affected individuals develop symptoms in their early 40s with an average survival time of 10 years. HDLS is inherited as an autosomal dominant trait. Recently, mutations in the colony-stimulating factor 1 receptor gene (CSF-1R) were identified as the genetic cause of HDLS.(4) White matter lesions, easily demonstrated on MRI studies, involve predominantly the frontal lobes and corpus callosum with subsequent cortical atrophy. MRI abnormalities are present prior to symptom onset.(5,6) Histopathology shows widespread myelin and axon destruction with axonal dilations termed spheroids, as well as pigmented macrophages.

Audit report on the City of Shenandoah, Iowa for the year ended June 30, 2011

Audit report on the City of Shenandoah, Iowa for the year ended June 30, 2011

Report on a special investigation of the City of Dexter for the period July 1, 2004 through August 31, 2010

Report on a special investigation of the City of Dexter for the period July 1, 2004 through August 31, 2010

Audit report on the City of Dyersville, Iowa for the year ended June 30, 2011

Audit report on the City of Dyersville, Iowa for the year ended June 30, 2011