Sign of the Times, February 2009

Newsletter produced by Deaf Services Commission of Iowa

Sign of the Times, April 2009

Newsletter produced by Deaf Services Commission of Iowa

Sign of the Times, July 2009

Newsletter produced by Deaf Services Commission of Iowa

Orientation Center Newsletter, Vol. 28, no. 2, November-December 2008

The Orientation Center newsletter is produced three times a year, and includes articles written by students, staff, and former students. It also contains news about what is happening to other students who have been in the Center.

Mètriques barrier walkthrough per a persones sordes

En aquest article es presenta un conjunt de mètriques manuals, les mètriques BAW, per avaluar l'accessibilitat web d'una pàgina dins d'un context específic i ofereix la possibilitat de quantificar el grau d'accessibilitat amb una fórmula.

Recurrent deletions and reciprocal duplications of 10q11.21q11.23 including CHAT and SLC18A3 are likely mediated by complex low-copy repeats.

We report 24 unrelated individuals with deletions and 17 additional cases with duplications at 10q11.21q21.1 identified by chromosomal microarray analysis. The rearrangements range in size from 0.3 to 12 Mb. Nineteen of the deletions and eight duplications are flanked by large, directly oriented segmental duplications of >98% sequence identity, suggesting that nonallelic homologous recombination (NAHR) caused these genomic rearrangements. Nine individuals with deletions and five with duplications have additional copy number changes. Detailed clinical evaluation of 20 patients with deletions revealed variable clinical features, with developmental delay (DD) and/or intellectual disability (ID) as the only features common to a majority of individuals. We suggest that some of the other features present in more than one patient with deletion, including hypotonia, sleep apnea, chronic constipation, gastroesophageal and vesicoureteral refluxes, epilepsy, ataxia, dysphagia, nystagmus, and ptosis may result from deletion of the CHAT gene, encoding choline acetyltransferase, and the SLC18A3 gene, mapping in the first intron of CHAT and encoding vesicular acetylcholine transporter. The phenotypic diversity and presence of the deletion in apparently normal carrier parents suggest that subjects carrying 10q11.21q11.23 deletions may exhibit variable phenotypic expressivity and incomplete penetrance influenced by additional genetic and nongenetic modifiers.

Sign of the Times, August 2009

Newsletter produced by Deaf Services Commission of Iowa

Sign of the Times, September 2009

Newsletter produced by Deaf Services Commission of Iowa

Sign of the Times, October 2009

Newsletter produced by Deaf Services Commission of Iowa

Sign of the Times, November 2009

Newsletter produced by Deaf Services Commission of Iowa

Sign of the Times, December 2009

Newsletter produced by Deaf Services Commission of Iowa

Sign of the Times, January 2010

Newsletter produced by Deaf Services Commission of Iowa

Sign of the Times, February 2010

Newsletter produced by Deaf Services Commission of Iowa

Sign of the Times, March 2010

Newsletter produced by Deaf Services Commission of Iowa