Joseph P. Chamberlain Papers 1933-1951

Correspondence, memoranda, reports and printed matter relating to Chamberlain's work with the following organizations: American Christian Committee for Refugees; Fort Ontario Refugee Shelter, Oswego, N.Y.; German Jewish Children's Aid; Intergovernmental Committee on Refugees; National Coordinating Committee; National Refugee Service; President's Advisory Committee on Political Refugees; War Refugee Board. Topics include Chamberlain's involvement with individual cases, visas, sponsorship, German-Jewish scholars, Intergovernmental Committee on Refugees at Evian, Bermuda Conference, Capital Transfer Plan for German-Austrian Refugees. Of particular interest are the minutes of the President's Advisory Committee, 1938-1943. Materials on settlement projects relating to Alaska, Argentina, Bolivia, Brazil, British Guiana, California, China, Colombia, Dominican Republic, Ecuador, Venezuela. Correspondents include Dean Acheson, Paul Baerwald, Joseph Beck, Francis K. Biddle, Bernard Dubin, Dwight D. Eisenhower, Felix Frankfurter, Cordell Hull, James Houghteling, Joseph C. Hyman, Ruth Learned, James G. McDonald, Clarence E. Pickett, Leland Robinson, William Rosenwald, Joseph F. Rummel, E.J. Shaughnessy, Felix Warburg, George L. Warren.

Julius Bisno collection, undated, 1780, 1801-1980.

Jewish organization executive. Primarily autographs, photos, writings, speeches, and biographical material, collected by Bisno, relating to ca. 120 Jews who have attained prominence in American public life; together with papers (1923-32) from Congregation Talmud Torah of Los Angeles, letters (1928-37) relating to other Jewish organizations in Los Angeles, and 3 letters of Stephen S. Wise, dealing with the general Jewish situation in Europe in 1933 and with the question of Jewish participation in the 1936 Olympic games. Persons represented include Benjamin N. Cardozo, Abe Fortas, Felix Frankfurter, Henry Horner, Herbert H. Lehman, and Lewis L. Strauss.

Judah P. Benjamin collection, undated, 1838-1942.

The collection consists of 25 letters written by Benjamin between 1838 and 1881 on a variety of subjects, four Confederate notes and two bonds bearing his picture, miscellaneous items about Benjamin (1893-1942), nine issues of the Congressional globe with speeches by Benjamin, as well as separate copies of his printed speeches, and a photostatic copy of the "Diary of Events" (400 pp.) kept by Benjamin, the original of which is in the Library of Congress (1862-1864).

Mount Scopus Lodge Malden, Massachusetts collection, 1930-1940, 1942

Mount Scopus Lodge in Malden, Massachusetts was a Masonic Lodge established in 1930 by Bertram E. Green and George Kramer. Named for the mountain from which Roman legions and crusaders conducted their assaults on Jerusalem, the Lodge had a strong following in the first ten years of their existence. This collection contains by-laws, concert programs, and a booklet with a historical sketch.

Address to George Clinton

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Letter of K.K. Beth Elohim Charleston, regarding address to George Washington

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Hebrew hymns and prayers after an earthquake, during the reign of George II (1727-1760)

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Letter from Manuel Josephson to K.K.S.I. regarding joint letter to George Washington

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Oath of allegiance to George II by Jews in American colonies

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Valkoisen talon kappalaiset : Yhdysvaltain presidentti-instituution viralliset puheet retorisena kansalaisuskontona

Tutkimuksen aihepiirinä on viimeaikaisen (1997-2004) Yhdysvaltain presidentti-instituution uskonnollinen retoriikka William J. Clintonin ja George W. Bushin virkakausina. Tutkimuksen tehtävä on selvittää, miten presidentti-instituutio hyödyntää uskonnollista retoriikkaa legimitaationa virallisissa poliittisissa linjanvetopuheissaan, kuten virkaanastujais- ja liittovaltion tila -puheissaan. Tutkimustehtävä jakautuu seuraaviin alakysymyksiin: 1) Millaisilla kansalaisuskonnollisilla käsityksillä ja keinoilla legimitaatiota yritetään tuottaa? 2) Ovatko kansalaisuskonnon keinot viimeaikaisten presidenttien keskeisintä työvälineistöä identifioinnissa ja erottautumisissa? 3) Ovatko kansalaisuskonnolliset teemat naturalisoituneet, luonnollistuneet? Tiivistetysti on tarkoitus tutkia viimeaikaisten presidenttien virallisista puheiden kautta, kuinka uskonto ja valtio liittyvät toisiinsa. Perusolettamukseni on, että presidentit hyödyntävät keskeisesti kansalaisuskonnollista retoriikkaa vakuuttaakseen yleisönsä ja politiikkansa. Tutkimusaineisto koostuu koostuu kahden Yhdysvaltain presidentin William J. Clintonin (1993-2001) ja George W. Bushin (2001-) presidenttien virallisista puheista, jotka on pidetty vuosina 1997-2004. Viralliset puheet ovat virkaanastujais- (Inaugural Address) ja vuosittaiset liittovaltion tila -puheet (Address Before a Joint Session of the Congress on the State of the Union). Puheita on kymmenen ja niiden pituus on keskimäärin viisi sivua. Tutkielman teoreettinen viitekehys tukeutuu kanadalaisen uskontososiologin Marcela Cristin uudenlaiselle käsitykselle (2001) kansalaisuskonnosta poliittisena uskontona. Tämä hyödyntää kansalaisuskonnon durkheimilaista taustaa yhdistäen Jean-Jacques Rousseuaun religion civile-teesiä. Cristin mukaan kansalaisuskonto manifestoituu kahdella tavalla: sekä durkheimilaisena kulttuurisena kansalaismuotona (civil) ja rousseualaisena ideologiana (political). Nämä eivät hänen mukaansa ole toisilleen vastakohtia, vaan yhden jatkumon osia. Tutkielman metodologinen lähestymistapa on uusretorinen analyysi ja teoreettis-medologisena viitekehyksenä on sosiaalinen konstruktivismi. Analyysin perusolettamus on, että presidentti-instituution luomassa merkityksen rakennetaan sosiaalisesta todellisuutta. Instituution retoriikka suuntautuu tiettyyn sosiaaliseen yhteisöön yrittäen legimitoida mahdollisimman laajaa joukkoa politiikkansa taakse. Analyysin tuloksena huomattiin, että presidentti-instituutio hyödyntää aktiivisesti kansalaisuskonnollisia teemoja. Molempien presidentti-instituutioiden uskonnollisessa nationalismissa hyödynnetään kansalaisuskonnollisuuden sekä protestanttis-puritaanista että valistuksellista taustaa. Kyse on oikeastaan siitä,kuinka nämä puolet saavat painotuksensa. Selvää on, että molemmat presidentit hyödyntävät kaikkia kansalaisuskonnollisuuden kolmea ulottuvuutta. Molemmilta löytyy retorinen tukeutuminen transsendenssiin, moraalistinen yhteisöllisyyden vaatimus. Clintonin uskonnollinen retoriikkaa jakaantuu kahteen ulkoisesti ristiriitaiseen käsitteelliseen linssiin: lupauksellisuus ja perustajallisuus. Ne yhdistyvät hänen nimittämisissään millenniaaliseksi yhteisöksi. Bushin uskonnollinen retoriikka tukeutuu transsendenttiseen ulottuvuuteen. Hänen käsitteelisiä linssejä ovat aktiivisen Jumalan monet roolit ja ajan siunauksellisuus. (Ks. luku 8. johtopäätökset ja jatkotutkimus.) Avainsanat: Yhdysvallat, presidentti-instituutio, kansalaisuskonto, uskonnollinen retoriikka, William J. Clinton, George W.Bush

Sermon by Jacques Judah Lyons on the death of President William Henry Harrison

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Analysis of body composition in individuals with high bone mass reveals a marked increase in fat mass in women but not men

Context: High bone mass (HBM), detected in 0.2% of dual-energy x-ray absorptiometry (DXA) scans, is characterized by raised body mass index, the basis for which is unclear. Objective: To investigate why body mass index is elevated in individuals with HBM, we characterized body composition and examined whether differences could be explained by bone phenotypes, eg, bone mass and/or bone turnover. Design, Setting, and Participants: We conducted a case-control study of 153 cases with unexplained HBM recruited from 4 UK centers by screening 219 088 DXA scans. Atotal of 138 first-degree relatives (of whom 51 had HBM) and 39 spouses were also recruited. Unaffected individuals served as controls. Main Outcome Measures: We measured fat mass, by DXA, and bone turnover markers. Results: Amongwomen, fat mass was inversely related to age in controls (P<.01), but not in HBM cases (P<.96) in whom mean fat mass was 8.9 [95% CI 4.7, 13.0] kg higher compared with controls (fully adjusted mean difference, P<.001). Increased fat mass in male HBM cases was less marked (gender interaction P = .03). Compared with controls, lean mass was also increased in female HBM cases (by 3.3 [1.2, 5.4] kg; P<.002); however, lean mass increases wereless marked than fat mass increases, resulting in 4.5% lower percentage lean mass in HBM cases (P<.001). Osteocalcin was also lower in female HBM cases compared with controls (by 2.8 [0.1, 5.5]μg/L; P = .04). Differences in fat mass were fully attenuated after hip bone mineral density (BMD) adjustment (P = .52) but unchanged after adjustment for bone turnover (P < .001), whereas the greater hip BMD in female HBM cases was minimally attenuated by fat mass adjustment (P<.001). Conclusions: HBM is characterized by a marked increase in fat mass in females, statistically explained by their greater BMD, but not by markers of bone turnover. Copyright © 2013 by The Endocrine Society.

Elevated circulating sclerostin concentrations in individuals with high bone mass, with and without LRP5 mutations

CONTEXT: The role and importance of circulating sclerostin is poorly understood. High bone mass (HBM) caused by activating LRP5 mutations has been reported to be associated with increased plasma sclerostin concentrations; whether the same applies to HBM due to other causes is unknown. OBJECTIVE: Our objective was to determine circulating sclerostin concentrations in HBM. DESIGN AND PARTICIPANTS: In this case-control study, 406 HBM index cases were identified by screening dual-energy x-ray absorptiometry (DXA) databases from 4 United Kingdom centers (n = 219 088), excluding significant osteoarthritis/artifact. Controls comprised unaffected relatives and spouses. MAIN MEASURES: Plasma sclerostin; lumbar spine L1, total hip, and total body DXA; and radial and tibial peripheral quantitative computed tomography (subgroup only) were evaluated. RESULTS: Sclerostin concentrations were significantly higher in both LRP5 HBM and non-LRP5 HBM cases compared with controls: mean (SD) 130.1 (61.7) and 88.0 (39.3) vs 66.4 (32.3) pmol/L (both P < .001, which persisted after adjustment for a priori confounders). In combined adjusted analyses of cases and controls, sclerostin concentrations were positively related to all bone parameters found to be increased in HBM cases (ie, L1, total hip, and total body DXA bone mineral density and radial/tibial cortical area, cortical bone mineral density, and trabecular density). Although these relationships were broadly equivalent in HBM cases and controls, there was some evidence that associations between sclerostin and trabecular phenotypes were stronger in HBM cases, particularly for radial trabecular density (interaction P < .01). CONCLUSIONS: Circulating plasma sclerostin concentrations are increased in both LRP5 and non-LRP5 HBM compared with controls. In addition to the general positive relationship between sclerostin and DXA/peripheral quantitative computed tomography parameters, genetic factors predisposing to HBM may contribute to increased sclerostin levels.

The effects of height and BMI on prostate cancer incidence and mortality: A Mendelian randomization study in 20,848 cases and 20,214 controls from the PRACTICAL consortium

Background Epidemiological studies suggest a potential role for obesity and determinants of adult stature in prostate cancer risk and mortality, but the relationships described in the literature are complex. To address uncertainty over the causal nature of previous observational findings, we investigated associations of height- and adiposity-related genetic variants with prostate cancer risk and mortality. Methods We conducted a case–control study based on 20,848 prostate cancers and 20,214 controls of European ancestry from 22 studies in the PRACTICAL consortium. We constructed genetic risk scores that summed each man’s number of height and BMI increasing alleles across multiple single nucleotide polymorphisms robustly associated with each phenotype from published genome-wide association studies. Results The genetic risk scores explained 6.31 and 1.46 % of the variability in height and BMI, respectively. There was only weak evidence that genetic variants previously associated with increased BMI were associated with a lower prostate cancer risk (odds ratio per standard deviation increase in BMI genetic score 0.98; 95 % CI 0.96, 1.00; p = 0.07). Genetic variants associated with increased height were not associated with prostate cancer incidence (OR 0.99; 95 % CI 0.97, 1.01; p = 0.23), but were associated with an increase (OR 1.13; 95 % CI 1.08, 1.20) in prostate cancer mortality among low-grade disease (p heterogeneity, low vs. high grade <0.001). Genetic variants associated with increased BMI were associated with an increase (OR 1.08; 95 % CI 1.03, 1.14) in all-cause mortality among men with low-grade disease (p heterogeneity = 0.03). Conclusions We found little evidence of a substantial effect of genetically elevated height or BMI on prostate cancer risk, suggesting that previously reported observational associations may reflect common environmental determinants of height or BMI and prostate cancer risk. Genetically elevated height and BMI were associated with increased mortality (prostate cancer-specific and all-cause, respectively) in men with low-grade disease, a potentially informative but novel finding that requires replication.

Directional dominance on stature and cognition in diverse human populations

Homozygosity has long been associated with rare, often devastating, Mendelian disorders1, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness2. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power3, 4. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10−300, 2.1 × 10−6, 2.5 × 10−10 and 1.8 × 10−10, respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months’ less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples5, 6, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection7, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.