M??s de cien mentiras : Quijote y Sabina confabulados

Publicaci??n que conmemora el IV aniversario de la primera edici??n de El Quijote y que ha reunido a un grupo de profesores de ??reas distintas (biolog??a, compensatoria, ingl??s, educaci??n f??sica, historia, integraci??n, lat??n y lengua) del IES Manuel T??rrega Escribano de la Regi??n de Murcia. Se trata de un proyecto literario y creativo que tras la lectura de El Quijote se propone a los alumnos para que inventasen relatos breves en los que se jugar?? con la mentira, la ficci??n o la paradoja. En casi todos los relatos hay predominio del tema amoroso. El acercamiento al lenguaje barroco les ha llevado a recrear el estilo cervantino y a utilizar los recursos literarios de la ??poca. Al juntar el Quijote a Sabina se ha avivado la creaci??n y excitado la imaginaci??n desencadanada por la canci??n de ??ste ??ltimo titulada 'Es mentira'.

IV Congreso Nacional de Escuelas Oficiales de Idiomas : diversidad, cultura y did??ctica de las lenguas

El IV Congresos de Escuelas Oficiales de Idiomas celebrado en Murcia en abril de 2005 bajo el lema: Diversidad, Cultura y Did??ctica de las Lenguas refleja las preocupaciones e inquietudes de un profesorado que se mueve entre la innovaci??n did??ctica, la tradicional relaci??n de los idiomas con la cultura, y los cambios derivados de la implantaci??n de los nuevos curr??culos de las ense??anzas y del creciente uso de las tecnolog??as de la informaci??n y comunicaci??n en las aulas..

Educaci??n y personas mayores

La educaci??n de personas mayores se hace necesaria en base a potenciar el intelecto de estas y trabajar por la continuidad y desarrollo de sus capacidades mentales. Se trata de poner en pr??ctica una intervenci??n socioeducativa centrada en la animaci??n sociocultural, motivaci??n por el aprendizaje y el desarrollo personal, detectando necesidades y aportando recursos que las satisfagan de la forma m??s ??ptima posible para lo que se precisa la definici??n de un marco pedag??gico espec??fico..

La participaci??n familiar en los planes de convivencia escolar : estudio de los centros p??blicos de educaci??n primaria y secundaria de la Regi??n de Murcia

La escuela es el lugar id??neo para la socializaci??n, sin embargo, como instituci??n que agrupa a gran n??mero de sujetos con roles bien definidos, resulta ser un escenario propicio para el conflicto. El presente trabajo es fruto de una investigaci??n que tiene como objetivos: conocer la opini??n en materia de convivencia escolar, de padres, profesores, directivos y orientadores de centros de educaci??n infantil y primaria y centros de educaci??n secundaria de la Regi??n de Murcia; analizar la participaci??n de las familias en los Planes de Convivencia Escolar; constatar el conocimiento de la normativa vigente, valorar el estado actual de la convivencia en los centros y elaborar propuestas de actuaci??n para la mejora del clima escolar. El an??lisis realizado se fundamenta en la normativa sobre convivencia escolar dictada por la Consejer??a de Educaci??n de la Regi??n de Murcia, as?? como las instrucciones en relaci??n con situaciones de acoso escolar en los centros docentes.

The Audiomomma Music Recommendation System

We design and implement a system that recommends musicians to listeners. The basic idea is to keep track of what artists a user listens to, to find other users with similar tastes, and to recommend other artists that these similar listeners enjoy. The system utilizes a client-server architecture, a web-based interface, and an SQL database to store and process information. We describe Audiomomma-0.3, a proof-of-concept implementation of the above ideas.

Measuring Value in Product Development

“What is value in product development?” is the key question of this paper. The answer is critical to the creation of lean in product development. By knowing how much value is added by product development (PD) activities, decisions can be more rationally made about how to allocate resources, such as time and money.

Biological Routes to Gold Nanoplates

Much effort has been devoted to the synthesis of gold nanoparticles with different shapes, including the zero-dimensional nanospheres, one dimensional nanorods, and two-dimensional nanoplates. Compared to zero or one dimensional nanostructures, the synthesis of two-dimensional nanostructures in high yield has always been more involved, often requiring complex and time-consuming steps such as morphology transformation from the nanospheres, or the seeded growth process. Herein we report a high yield method for gold nanoplate synthesis using the extract of unicellular green alga Chlorella vulgaris, which can be carried out under ambient conditions. More than 90% of the total nanoparticle population is of the platelet morphology, surpassing the previously reported value of 45%. The control of the anisotropic growth of different planes; as well as the lateral size, has also been partially optimized.

Core-Shell Assisted Bimetallic Assembly of Pt and Ru Nanoparticles by DNA Hybridization

We have discovered that the current protocols to assemble Au nanoparticles based on DNA hybridization do not work well with the small metal nanoparticles (e.g. 5 nm Au, 3.6 nm Pt and 3.2 nm Ru particles). Further investigations revealed the presence of strong interaction between the oligonucleotide backbone and the surface of the small metal nanoparticles. The oligonucleotides in this case are recumbent on the particle surface and are therefore not optimally oriented for hybridization. The nonspecific adsorption of oligonucleotides on small metal nanoparticles must be overcome before DNA hybridization can be accepted as a general assembly method. Two methods have been suggested as possible solutions to this problem. One is based on the use of stabilizer molecules which compete with the oligonucleotides for adsorption on the metal nanoparticle surface. Unfortunately, the reported success of this approach in small Au nanoparticles (using K₂BSPP) and Au films (using 6-mercapto-1-hexanol) could not be extended to the assembly of Pt and Ru nanoparticles by DNA hybridization. The second approach is to simply use larger metal particles. Indeed most reports on the DNA hybridization induced assembly of Au nanoparticles have made use of relatively large particles (>10 nm), hinting at a weaker non-specific interaction between the oligonucleotides and large Au nanoparticles. However, most current methods of nanoparticle synthesis are optimized to produce metal nanoparticles only within a narrow size range. We find that core-shell nanoparticles formed by the seeded growth method may be used to artificially enlarge the size of the metal particles to reduce the nonspecific binding of oligonucleotides. We demonstrate herein a core-shell assisted growth method to assemble Pt and Ru nanoparticles by DNA hybridization. This method involves firstly synthesizing approximately 16 nm core-shell Ag-Pt and 21 nm core-shell Au-Ru nanoparticles from 9.6 nm Ag seeds and 17.2 nm Au seeds respectively by the seed-mediated growth method. The core-shell nanoparticles were then functionalized by complementary thiolated oligonucleotides followed by aging in 0.2 M PBS buffer for 6 hours. The DNA hybridization induced bimetallic assembly of Pt and Ru nanoparticles could then be carried out in 0.3 M PBS buffer for 10 hours.

Protein Microarray: "Theory" to "Real Practice"

Fueled by ever-growing genomic information and rapid developments of proteomics–the large scale analysis of proteins and mapping its functional role has become one of the most important disciplines for characterizing complex cell function. For building functional linkages between the biomolecules, and for providing insight into the mechanisms of biological processes, last decade witnessed the exploration of combinatorial and chip technology for the detection of bimolecules in a high throughput and spatially addressable fashion. Among the various techniques developed, the protein chip technology has been rapid. Recently we demonstrated a new platform called “Spacially addressable protein array” (SAPA) to profile the ligand receptor interactions. To optimize the platform, the present study investigated various parameters such as the surface chemistry and role of additives for achieving high density and high-throughput detection with minimal nonspecific protein adsorption. In summary the present poster will address some of the critical challenges in protein micro array technology and the process of fine tuning to achieve the optimum system for solving real biological problems.

SCAPA (Spacially Addressable Protein Array) – a Novel Protein Array for the Differential Profiling of Ligand-receptor Induced Signalling

While protein microarray technology has been successful in demonstrating its usefulness for large scale high-throughput proteome profiling, performance of antibody/antigen microarrays has been only moderately productive. Immobilization of either the capture antibodies or the protein samples on solid supports has severe drawbacks. Denaturation of the immobilized proteins as well as inconsistent orientation of antibodies/ligands on the arrays can lead to erroneous results. This has prompted a number of studies to address these challenges by immobilizing proteins on biocompatible surfaces, which has met with limited success. Our strategy relates to a multiplexed, sensitive and high-throughput method for the screening quantification of intracellular signalling proteins from a complex mixture of proteins. Each signalling protein to be monitored has its capture moiety linked to a specific oligo ‘tag’. The array involves the oligonucleotide hybridization-directed localization and identification of different signalling proteins simultaneously, in a rapid and easy manner. Antibodies have been used as the capture moieties for specific identification of each signaling protein. The method involves covalently partnering each antibody/protein molecule with a unique DNA or DNA derivatives oligonucleotide tag that directs the antibody to a unique site on the microarray due to specific hybridization with a complementary tag-probe on the array. Particular surface modifications and optimal conditions allowed high signal to noise ratio which is essential to the success of this approach.

Tubular Organization of SnO₂ Nanocrystallites for Improved Lithium Ion Battery Anode Performance

Porous tin oxide nanotubes were obtained by vacuum infiltration of tin oxide nanoparticles into porous aluminum oxide membranes, followed by calcination. The porous tin oxide nanotube arrays so prepared were characterized by FE-SEM, TEM, HRTEM, and XRD. The nanotubes are open-ended, highly ordered with uniform cross-sections, diameters and wall thickness. The tin oxide nanotubes were evaluated as a substitute anode material for the lithium ion batteries. The tin oxide nanotube anode could be charged and discharged repeatedly, retaining a specific capacity of 525 mAh/g after 80 cycles. This capacity is significantly higher than the theoretical capacity of commercial graphite anode (372 mAh/g) and the cyclability is outstanding for a tin based electrode. The cyclability and capacities of the tin oxide nanotubes were also higher than their building blocks of solid tin oxide nanoparticles. A few factors accounting for the good cycling performance and high capacity of tin oxide nanotubes are suggested.

Possible solution of some essential zero problems in compositional data analysis

One of the tantalising remaining problems in compositional data analysis lies in how to deal with data sets in which there are components which are essential zeros. By an essential zero we mean a component which is truly zero, not something recorded as zero simply because the experimental design or the measuring instrument has not been sufficiently sensitive to detect a trace of the part. Such essential zeros occur in many compositional situations, such as household budget patterns, time budgets, palaeontological zonation studies, ecological abundance studies. Devices such as nonzero replacement and amalgamation are almost invariably ad hoc and unsuccessful in such situations. From consideration of such examples it seems sensible to build up a model in two stages, the first determining where the zeros will occur and the second how the unit available is distributed among the non-zero parts. In this paper we suggest two such models, an independent binomial conditional logistic normal model and a hierarchical dependent binomial conditional logistic normal model. The compositional data in such modelling consist of an incidence matrix and a conditional compositional matrix. Interesting statistical problems arise, such as the question of estimability of parameters, the nature of the computational process for the estimation of both the incidence and compositional parameters caused by the complexity of the subcompositional structure, the formation of meaningful hypotheses, and the devising of suitable testing methodology within a lattice of such essential zero-compositional hypotheses. The methodology is illustrated by application to both simulated and real compositional data

Measuring Value in Product Development

“What is value in product development?” is the key question of this paper. The answer is critical to the creation of lean in product development. By knowing how much value is added by product development (PD) activities, decisions can be more rationally made about how to allocate resources, such as time and money. In order to apply the principles of Lean Thinking and remove waste from the product development system, value must be precisely defined. Unfortunately, value is a complex entity that is composed of many dimensions and has thus far eluded definition on a local level. For this reason, research has been initiated on “Measuring Value in Product Development.” This paper serves as an introduction to this research. It presents the current understanding of value in PD, the critical questions involved, and a specific research design to guide the development of a methodology for measuring value. Work in PD value currently focuses on either high-level perspectives on value, or detailed looks at the attributes that value might have locally in the PD process. Models that attempt to capture value in PD are reviewed. These methods, however, do not capture the depth necessary to allow for application. A methodology is needed to evaluate activities on a local level to determine the amount of value they add and their sensitivity with respect to performance, cost, time, and risk. Two conceptual tools are proposed. The first is a conceptual framework for value creation in PD, referred to here as the Value Creation Model. The second tool is the Value-Activity Map, which shows the relationships between specific activities and value attributes. These maps will allow a better understanding of the development of value in PD, will facilitate comparison of value development between separate projects, and will provide the information necessary to adapt process analysis tools (such as DSM) to consider value. The key questions that this research entails are: · What are the primary attributes of lifecycle value within PD? · How can one model the creation of value in a specific PD process? · Can a useful methodology be developed to quantify value in PD processes? · What are the tools necessary for application? · What PD metrics will be integrated with the necessary tools? The research milestones are: · Collection of value attributes and activities (September, 200) · Development of methodology of value-activity association (October, 2000) · Testing and refinement of the methodology (January, 2001) · Tool Development (March, 2001) · Present findings at July INCOSE conference (April, 2001) · Deliver thesis that captures a formalized methodology for defining value in PD (including LEM data sheets) (June, 2001) The research design aims for the development of two primary deliverables: a methodology to guide the incorporation of value, and a product development tool that will allow direct application.

Coherent forecasting of multiple-decrement life tables: a test using Japanese cause of death data

Planners in public and private institutions would like coherent forecasts of the components of age-specic mortality, such as causes of death. This has been di cult to achieve because the relative values of the forecast components often fail to behave in a way that is coherent with historical experience. In addition, when the group forecasts are combined the result is often incompatible with an all-groups forecast. It has been shown that cause-specic mortality forecasts are pessimistic when compared with all-cause forecasts (Wilmoth, 1995). This paper abandons the conventional approach of using log mortality rates and forecasts the density of deaths in the life table. Since these values obey a unit sum constraint for both conventional single-decrement life tables (only one absorbing state) and multiple-decrement tables (more than one absorbing state), they are intrinsically relative rather than absolute values across decrements as well as ages. Using the methods of Compositional Data Analysis pioneered by Aitchison (1986), death densities are transformed into the real space so that the full range of multivariate statistics can be applied, then back-transformed to positive values so that the unit sum constraint is honoured. The structure of the best-known, single-decrement mortality-rate forecasting model, devised by Lee and Carter (1992), is expressed in compositional form and the results from the two models are compared. The compositional model is extended to a multiple-decrement form and used to forecast mortality by cause of death for Japan

Los alimentos

Este material se edita dentro de HABITAR, programa did??ctico para el estudio del medio, que ofert?? el Ayuntamiento de Gij??n a la comunidad educativa. El documento en s??, viene precedido por la presentaci??n de los principios educativos y otros principios de procedimiento que guian el programa.En concreto en el tema 'Los alimentos' existen dos partes diferenciadas: por un lado el aspecto del proceso productivo de los alimentos y por otro lado el aspecto de la alimentaci??n humana, de la nutrici??n. La t??cnica de trabajo es la de 'seguir la pista' con objeto de integrar los diferentes aspectos de la producci??n de alimentos facilitando la puesta en relaci??n de este proceso con las caracter??sticas de los alumnos y su importancia en la nutrici??n humana. Se proponen una serie de actividades como juegos (veo-veo, la habitaci??n vac??a, b??squeda del tesoro, el mercado en clase, platos t??picos, etc.) y otras cuyos materiales se ofrecen agrupados en: 1.-Los alimentos que nos dan los alimentos 2.-En la caseria se producen alimentos 3.-El casta??o y el manzano 4.-Del trigo al pan 6.- La compra equilibrada. Finalmente se ofrecen las gu??as para las visitas a una caser??a, el mercado y una panificadora.