Atividades biológicas de extratos salinos de sementes de plantas da caatinga contra Aedes Aegypti e investigação da participação de proteínas bioativas

Dengue fever, currently the most important arbovirus, is transmitted by the bite of the Aedes aegypti mosquito. Given the absence of a prophylactic vaccine, the disease can only be controlled by combating the vector insect. However, increasing reports of resistance and environmental damage caused by insecticides have led to the urgent search for new safer alternatives. Twenty - um plant s eed extracts from the Caatinga were prepared , tested and characterized . Sodium phosphate ( 50 mM pH 8.0) was used as extractor. All extracts showed larvicidal and ovipositional deterrence activity . Extracts of D. grandiflora, E. contortisiliquum, A. cearenses , C. ferrea and C. retusa were able to attract females for posture when in low co ncentration . In the attractive concentrations, the CE of E. contortisiliquum and A. cearenses were able to kill 52% and 100% of the larvae respectively . The extracts of A. cearenses , P. viridiflora, E. velutina, M. urundeuva and S. brasiliensis were also pupicides, while extracts of P. viridiflora, E. velutina, E. contortisiliquum , A. cearenses, A. colubrina, D. grandiflora , B. cheilantha , S. spectabilis, C. pyramidalis, M. regnelli e G. americana displayed adulticidal activity. All extracts were toxic to C. dubia zooplankton . The EB of E. velutina and E. contortisiliquum did not affect the viability of fibroblasts . In all extracts were identified at least two potential insecticidal proteins such as enzyme inhibitors, lectins and chitin - binding proteins and components of secondary metabolism . Considering all bioassays , the extracts from A. cearenses, P. viridiflora, E. contortisiliquum , S. brasiliensis, E. velutina and M. urundeuva were considered the most promising . The E. contortisiliquum extracts was the only one who did not show pupicida activity, indicating that its mechanism of action larvicide and adulticidal is related only to the ingesti on of toxic compounds by insect , so it was selected to be fragmenting. As observed for the CE , th e protein fractions of E. contortisiliquum also showed larvicidal activity, highlighting that F2 showed higher larvicidal activity and lower en vironmental toxicity than the CE source. The reduction in the proteolytic activity of larvae fed with crude extra ct and fractions of E. contortisiliquum suggest ed that the trypsin inhibitors ( ITEc) would be resp onsible for larvicidal activity . However the increase in the purification of this inhibitor resulted in loss of larvicidal activity , but the absence of trypsin inhibitor reduced the effectiveness of the fractions , indicating that the ITEC contributes to the larvicidal activity of this extract. Not been observed larvicidal activity and adulticide in rich fraction vicilin, nor evidence of the contribution o f this molecule for the larvicidal activity of the extract. The results show the potential of seeds from plant extracts of Caatinga as a source of active molecules against insects A. aegypti at different stages of its development cycle, since they are comp osed of different active compounds, including protein nature, which act on different mechanisms should result in the death of insec

Das palavras à vida: o prazer em Max Weber

The thesis has as its goal the discussion over the pleasure as an intellectual and personal subject for Max Weber. The main references are The Sociology of Religion, Science as a Vocation and Politics as a Vocation, Bureaucracy, The sense of "Axiological Neutrality" in Social and Economic Sciences. Many authors were researched for information about his life, with a highlight to the biography written by his wife Marianne Weber, for its great number of excerpts from letters and informal conversations. The subject "pleasure" was developed by taking into consideration the complexity of this phenomenon which happens in an ambivalent and multiple ways. In order to do that, we started from the paradigm of the complexity according to Edgar Morin's view, Georges Bataille's discussions on erotism and the antinomic comprehension of Lepegneur and Onfray, who define pleasure as a phenomenon with ambiguities, and the historical references of Peter Gay, Nobert Elias, Wolf Lepenies. In Max Weber, pleasure presents, also, this ambiguity, as his scientific approach is registering the absence of pleasure for the rise of a protestant ethic and, besides that, to support with a process of disenchantment of the world which leads us to a meaningless life. Weber goes through great changes in the last years of his life. In this period he includes in his comments the subjects "erotism" and "arts" with the possibility of escaping from modem everyday routine that affects the individual's existential freedom. However, his ambiguous position about these possibilities take him to consider that a situation o f personal confrontation, considered heroical, once, in his opinion, each one accepts the consequences o f their acts and builds their values to give a meaning to their own existence. The pleasure in Weber is, above ali aspects, intellectual and existential: side by side with the routine, bureaucracy and disenchantment ofthe world was the possibility of charisma, vocation and passion. However, always he related these characteristics to the discomfort that the modem world presented to men, he, as a scientist, was ethical. This is the main argument ofthis thesis

Identificação das políticas de incentivo ao desenvolvimento da energia eólica no Rio Grande do Norte (RN)

Energy is a vital resource for social and economic development. In the present scenario, the search for alternative energy sources has become fundamental, especially after the oil crises between 1973 and 1979, the Chernobyl nuclear accident in 1986 and the Kyoto Protocol in 1997. The demand for the development of new alternative energy sources aims to complement existing forms allows to meet the demand for energy consumption with greater security. Brazil, with the guideline of not dirtying the energy matrix by the fossil fuels exploitation and the recent energy crisis caused by the lack of rains, directs energy policies for the development of other renewable energy sources, complementing the hydric. This country is one of the countries that stand out for power generation capacity from the winds in several areas, especially Rio Grande do Norte (RN), which is one of the states with highest installed power and great potential to be explored. In this context arises the purpose of this work to identify the incentive to develop policies of wind energy in Rio Grande do Norte. The study was conducted by a qualitative methodology of data analysis called content analysis, oriented for towards message characteristics, its informational value, the words, arguments and ideas expressed in it, constituting a thematic analysis. To collect the data interviews were conducted with managers of major organizations related to wind energy in Brazil and in the state of Rio Grande do Norte. The identification of incentive policies was achieved in three stages: the first seeking incentives policies in national terms, which are applied to all states, the second with the questionnaire application and the third to research and data collection for the development of the installed power of the RN as compared to other states. At the end, the results demonstrated hat in Rio Grande do Norte state there is no incentive policy for the development of wind power set and consolidated, specific actions in order to optimize the bureaucratic issues related to wind farms, especially on environmental issues. The absence of this policy hinders the development of wind energy RN, considering result in reduced competitiveness and performance in recent energy auctions. Among the perceived obstacles include the lack of hand labor sufficient to achieve the reporting and analysis of environmental licenses, the lack of updating the wind Atlas of the state, a shortfall of tax incentives. Added to these difficulties excel barriers in infrastructure and logistics, with the lack of a suitable port for large loads and the need for reform, maintenance and duplication of roads and highways that are still loss-making. It is suggested as future work the relationship of the technology park of energy and the development of wind power in the state, the influence of the technology park to attract businesses and industries in the wind sector to settle in RN and a comparison of incentive policies to development of wind energy in the Brazilian states observing wind development in the same states under study.

Três alternativas estocásticas para modelar morbimortalidade por doenças respiratórias e cardiovasculares via variáveis atmosféricas

Climate and air pollution, among others, are responsible factors for increase of health vulnerability of the populations that live in urban centers. Climate changes combined with high concentrations of atmospheric pollutants are usually associated with respiratory and cardiovascular diseases. In this sense, the main objective of this research is to model in different ways the climate and health relation, specifically for the children and elderly population which live in São Paulo. Therefore, data of meteorological variables, air pollutants, hospitalizations and deaths from respiratory and cardiovascular diseases a in 11-year period (2000-2010) were used. By using modeling via generalized estimating equations, the relative risk was obtained. By dynamic regression, it was possible to predict the number of deaths through the atmospheric variables and the betabinomial-poisson model was able to estimate the number of deaths and simulate scenarios. The results showed that the risk of hospitalizations due to asthma increases approximately twice for children exposed to high concentrations of particulate matter than children who are not exposed. The risk of death by acute myocardial infarction in elderly increase in 3%, 6%, 4% and 9% due to high concentrations CO, SO2, O3 and PM10, respectively. Regarding the dynamic regression modeling, the results showed that deaths by respiratory diseases can be predicted consistently. The beta-binomial-poisson model was able to reproduce an average number of deaths by heart insufficiency. In the region of Santo Amaro the observed number was 2.462 and the simulated was 2.508, in the Sé region 4.308 were observed and 4.426 simulated, which allowed for the generation of scenarios that may be used as a parameter for decision. Making with these results, it is possible to contribute for methodologies that can improve the understanding of the relation between climate and health and proved support to managers in environmental planning and public health policies.

A hora da alfabetização: atores, ideias e instituições na construção do PAIC-CE

The objective of this thesis is to understand how a certain social condition becomes relevant enough to be regarded as an issue worthy of government action and how certain proposed initiatives prevail while others are discarded. More specifically, the goal is to discuss public policy for education and check whether the analytical models employed are significant enough to explain how the literacy issue became part of the policy agenda of the government of the State of Ceará in Brazil, and how the Literacy Program at the Right Age (PAIC) developed over time. From the empirical perspective about public policy for education in Brazil, this is a relevant case when one takes into account that, historically, the literacy policies are focused on teenagers and adults, implying a lack of specific initiatives towards children at the proper age of learning to read and write. In order to understand what drove this issue to the top of the state government agenda, this thesis is primarily based on the literature about public policy analysis, with focus on the agenda setting process and development of proposals. A hybrid approach is used, combining analytical tools from Kingdon’s Multiple Streams Model (1995), the Advocacy Coalition Framework by Sabatier and Jenkins Smith (1993) and the historical new institutionalism lens. The research method is qualitative and based on the single case study method. The data set was assembled from institutional PAIC-related documents, tachygraphy notes from sessions at Ceará’s State House of Representatives, press clippings, academic studies and interviews with key participants from several organizations. The conclusion of this thesis is that, given the complexity of the case in point, the combination of the three analytical methods is adequate and necessary to understanding the multiple drivers for this issue to have entered Ceará’s state government agenda and the design of the PAIC itself. Particularly relevant are the ideas and the policy entrepreneurs, the processes of problem recognition for the composition of a wide coalition and for the specification of alternatives, and the path dependence of the education policy in Ceará. This study adds, as a result, to a better understanding of the stages that make up the agenda setting in public policy, in particular in the field of education.

A hora da alfabetização: atores, ideias e instituições na construção do PAIC-CE

The objective of this thesis is to understand how a certain social condition becomes relevant enough to be regarded as an issue worthy of government action and how certain proposed initiatives prevail while others are discarded. More specifically, the goal is to discuss public policy for education and check whether the analytical models employed are significant enough to explain how the literacy issue became part of the policy agenda of the government of the State of Ceará in Brazil, and how the Literacy Program at the Right Age (PAIC) developed over time. From the empirical perspective about public policy for education in Brazil, this is a relevant case when one takes into account that, historically, the literacy policies are focused on teenagers and adults, implying a lack of specific initiatives towards children at the proper age of learning to read and write. In order to understand what drove this issue to the top of the state government agenda, this thesis is primarily based on the literature about public policy analysis, with focus on the agenda setting process and development of proposals. A hybrid approach is used, combining analytical tools from Kingdon’s Multiple Streams Model (1995), the Advocacy Coalition Framework by Sabatier and Jenkins Smith (1993) and the historical new institutionalism lens. The research method is qualitative and based on the single case study method. The data set was assembled from institutional PAIC-related documents, tachygraphy notes from sessions at Ceará’s State House of Representatives, press clippings, academic studies and interviews with key participants from several organizations. The conclusion of this thesis is that, given the complexity of the case in point, the combination of the three analytical methods is adequate and necessary to understanding the multiple drivers for this issue to have entered Ceará’s state government agenda and the design of the PAIC itself. Particularly relevant are the ideas and the policy entrepreneurs, the processes of problem recognition for the composition of a wide coalition and for the specification of alternatives, and the path dependence of the education policy in Ceará. This study adds, as a result, to a better understanding of the stages that make up the agenda setting in public policy, in particular in the field of education.

Uma nova proposta de fluidos de perfuração aquosos à base de polímeros vinílicos e bentonita para poços de alta temperatura e pressão

The advance of drilling in deeper wells has required more thermostable materials. The use of synthetic fluids, which usually have a good chemical stability, faces the environmental constraints, besides it usually generate more discharge and require a costly disposal treatment of drilled cuttings, which are often not efficient and require mechanical components that hinder the operation. The adoption of aqueous fluids generally involves the use of chrome lignosulfonate, used as dispersant, which provides stability on rheological properties and fluid loss under high temperatures and pressures (HTHP). However, due to the environmental impact associated with the use of chrome compounds, the drilling industry needs alternatives that maintain the integrity of the property and ensure success of the operation in view of the strong influence of temperature on the viscosity of aqueous fluids and polymers used in these type fluids, often polysaccharides, passives of hydrolysis and biological degradation. Therefore, vinyl polymers were selected for this study because they have predominantly carbon chain and, in particular, polyvinylpyrrolidone (PVP) for resisting higher temperatures and partially hydrolyzed polyacrylamide (PHPA) and clay by increasing the system's viscosity. Moreover, the absence of acetal bonds reduces the sensitivity to attacks by bacteria. In order to develop an aqueous drilling fluid system for HTHP applications using PVP, HPAM and clay, as main constituents, fluid formulations were prepared and determined its rheological properties using rotary viscometer of the Fann, and volume filtrate obtained by filtration HTHP following the standard API 13B-2. The new fluid system using polyvinylpyrrolidone (PVP) with high molar weight had higher viscosities, gels and yield strength, due to the effect of flocculating clay. On the other hand, the low molecular weight PVP contributed to the formation of disperse systems with lower values in the rheological properties and fluid loss. Both systems are characterized by thermal stability gain up to around 120 ° C, keeping stable rheological parameters. The results were further corroborated through linear clay swelling tests.

Uma nova proposta de fluidos de perfuração aquosos à base de polímeros vinílicos e bentonita para poços de alta temperatura e pressão

The advance of drilling in deeper wells has required more thermostable materials. The use of synthetic fluids, which usually have a good chemical stability, faces the environmental constraints, besides it usually generate more discharge and require a costly disposal treatment of drilled cuttings, which are often not efficient and require mechanical components that hinder the operation. The adoption of aqueous fluids generally involves the use of chrome lignosulfonate, used as dispersant, which provides stability on rheological properties and fluid loss under high temperatures and pressures (HTHP). However, due to the environmental impact associated with the use of chrome compounds, the drilling industry needs alternatives that maintain the integrity of the property and ensure success of the operation in view of the strong influence of temperature on the viscosity of aqueous fluids and polymers used in these type fluids, often polysaccharides, passives of hydrolysis and biological degradation. Therefore, vinyl polymers were selected for this study because they have predominantly carbon chain and, in particular, polyvinylpyrrolidone (PVP) for resisting higher temperatures and partially hydrolyzed polyacrylamide (PHPA) and clay by increasing the system's viscosity. Moreover, the absence of acetal bonds reduces the sensitivity to attacks by bacteria. In order to develop an aqueous drilling fluid system for HTHP applications using PVP, HPAM and clay, as main constituents, fluid formulations were prepared and determined its rheological properties using rotary viscometer of the Fann, and volume filtrate obtained by filtration HTHP following the standard API 13B-2. The new fluid system using polyvinylpyrrolidone (PVP) with high molar weight had higher viscosities, gels and yield strength, due to the effect of flocculating clay. On the other hand, the low molecular weight PVP contributed to the formation of disperse systems with lower values in the rheological properties and fluid loss. Both systems are characterized by thermal stability gain up to around 120 ° C, keeping stable rheological parameters. The results were further corroborated through linear clay swelling tests.

MARCAS ORGANIZACIONAIS E A AGREGAÇÃO DE VALOR INSTITUCIONAL POR MEIO DO INVESTIMENTO EM AÇÕES SOCIAIS ALTERNATIVAS

Em um cenário de mercado com alta competitividade e saturação, marcas e seus valores podem ter um papel decisivo na diferenciação e decisão de compra por parte dos consumidores. As marcas devem entender a necessidade da responsabilidade social e se preocuparem com questões sociais e ambientais, caso contrário, podem ser vistas com negatividade, isto é, como corporações que só desejam lucrar. Para compreender o espaço das marcas organizacionais na sociedade contemporânea, esta pesquisa apresenta um resgate de evoluções históricas, sobretudo nas últimas décadas, para mostrar os consideráveis progressos no modo de pensar em relação aos valores das marcas, ao relacionamento com públicos interessados e à sociedade em geral. É a partir destas análises que se apresenta a importância do investimento em causas sociais não como obrigação ou autopromoção, mas como abordagem que deve se tornar premissa básica e parte da cultura das organizações. O recorte desta pesquisa volta-se ao estudo de causas sociais menos difundidas ou de menor reper- cussão midiática, procurando verificar se o investimento nessas causas podem se refletir em valores para marcas, assim como se espera do apoio a causas mais conhe- cidas, como por exemplo, o câncer, a pobreza ou a fome. O estudo se complementa a partir de entrevistas em profundidade com executivos do Grupo Abril e da Volkswagen do Brasil para avaliar como estas organizações se posicionam frente à possibilidade de investir em causas menos conhecidas, como o daltonismo

De ángel del hogar a diablesa: la persistencia de los estereotipos de género en las sexualidades alternativas

Las sexualidades alternativas (swinger1 y bdsm2) se muestran como espacios libremente elegidos por mujeres y hombres para desarrollar una sexualidad no hegemónica en términos de total igualdad y consentimiento de las mujeres. El trabajo cuestiona estos presupuestos con la información obtenida a través de entrevistas realizadas a informantes clave, debates en foros de Internet, grupos de discusión y búsqueda y análisis básico de datos en diferentes páginas web. Se profundiza en las vivencias y experiencias de mujeres y hombres practicantes, con énfasis en la sexualidad femenina. Se analiza el mito de la mujer perversa en la dominación femenina3 como objeto de fantasía sexual masculina. La reformulación del personaje en términos de género, proponiéndola a las mujeres como posibilidad, es un elemento importante en el trabajo. Las conclusiones a las que se llega evidencian la fuerte persistencia de los estereotipos de género y la reproducción de forma masiva y sistemática de los roles de género en el juego sexual. Las vivencias de la sexualidad de las mujeres están impregnadas del sistema sexo/género y de su tradicional opresión. La subyugación femenina aparece, sin embargo, en un escenario de posibilidades y oportunidades para desarrollar una sexualidad genuinamente libre e igualitaria en aparente contradicción.

Internet, movimientos sociales y políticas alternativas : Estrategias ante el avance de las empresas transnacionales y el deterioro del medio ambiente

La siguiente ponencia se propone como problemática general abordar la articulación entre sociedad, tecnología y espacio en el mundo actual. Desde esta perspectiva se intenta analizar el rol de las tecnologías de información y comunicación(TIC) como instrumento de comunicación, difusión y coordinación, en relación específicamente al movimiento social de vecinos autoconvocados de Esquel, que a partir de su presencia en internet ve potenciadas sus capacidades organizativas, y tienen la posibilidad de hacer trascender sus movilizaciones y denuncias desde el ámbito regional o local al ámbito nacional primeramente, intentando llegar luego a la comunidad global. Este movimiento social de vecinos autoconvocados de Esquel, quienes principalmente conforman el objeto de estudio de este trabajo, lograron concretar su objetivo principal de evitar que una empresa transnacional, avalada por la legislación nacional, sobre todo pensando en leyes o modificaciones de éstas ocurridas durante la década del '90, pero que siguen vigentes aún en la actualidad, explote una mina de oro a cielo abierto en la región. Estos actores utilizan y han utilizado internet como medio de difusión alternativo para sus propuestas, logrando romper con el aislamiento de sus luchas particulares. Este movimiento de vecinos, puede insertarse perfectamente en el grupo de movimientos sociales ambientalistas, así como también pueden pertenecer a los movimientos de defensa de los derechos humanos, e inclusive, puede tomarse como un movimiento político que posee la intención de valorizar los valores democráticos, y que confía en el cambio a partir de la participación activa por parte de los integrantes de la sociedad civil

Internet, movimientos sociales y políticas alternativas : Estrategias ante el avance de las empresas transnacionales y el deterioro del medio ambiente

La siguiente ponencia se propone como problemática general abordar la articulación entre sociedad, tecnología y espacio en el mundo actual. Desde esta perspectiva se intenta analizar el rol de las tecnologías de información y comunicación(TIC) como instrumento de comunicación, difusión y coordinación, en relación específicamente al movimiento social de vecinos autoconvocados de Esquel, que a partir de su presencia en internet ve potenciadas sus capacidades organizativas, y tienen la posibilidad de hacer trascender sus movilizaciones y denuncias desde el ámbito regional o local al ámbito nacional primeramente, intentando llegar luego a la comunidad global. Este movimiento social de vecinos autoconvocados de Esquel, quienes principalmente conforman el objeto de estudio de este trabajo, lograron concretar su objetivo principal de evitar que una empresa transnacional, avalada por la legislación nacional, sobre todo pensando en leyes o modificaciones de éstas ocurridas durante la década del '90, pero que siguen vigentes aún en la actualidad, explote una mina de oro a cielo abierto en la región. Estos actores utilizan y han utilizado internet como medio de difusión alternativo para sus propuestas, logrando romper con el aislamiento de sus luchas particulares. Este movimiento de vecinos, puede insertarse perfectamente en el grupo de movimientos sociales ambientalistas, así como también pueden pertenecer a los movimientos de defensa de los derechos humanos, e inclusive, puede tomarse como un movimiento político que posee la intención de valorizar los valores democráticos, y que confía en el cambio a partir de la participación activa por parte de los integrantes de la sociedad civil

Internet, movimientos sociales y políticas alternativas : Estrategias ante el avance de las empresas transnacionales y el deterioro del medio ambiente

La siguiente ponencia se propone como problemática general abordar la articulación entre sociedad, tecnología y espacio en el mundo actual. Desde esta perspectiva se intenta analizar el rol de las tecnologías de información y comunicación(TIC) como instrumento de comunicación, difusión y coordinación, en relación específicamente al movimiento social de vecinos autoconvocados de Esquel, que a partir de su presencia en internet ve potenciadas sus capacidades organizativas, y tienen la posibilidad de hacer trascender sus movilizaciones y denuncias desde el ámbito regional o local al ámbito nacional primeramente, intentando llegar luego a la comunidad global. Este movimiento social de vecinos autoconvocados de Esquel, quienes principalmente conforman el objeto de estudio de este trabajo, lograron concretar su objetivo principal de evitar que una empresa transnacional, avalada por la legislación nacional, sobre todo pensando en leyes o modificaciones de éstas ocurridas durante la década del '90, pero que siguen vigentes aún en la actualidad, explote una mina de oro a cielo abierto en la región. Estos actores utilizan y han utilizado internet como medio de difusión alternativo para sus propuestas, logrando romper con el aislamiento de sus luchas particulares. Este movimiento de vecinos, puede insertarse perfectamente en el grupo de movimientos sociales ambientalistas, así como también pueden pertenecer a los movimientos de defensa de los derechos humanos, e inclusive, puede tomarse como un movimiento político que posee la intención de valorizar los valores democráticos, y que confía en el cambio a partir de la participación activa por parte de los integrantes de la sociedad civil

¿Es posible explorar nuevas alternativas para la formación de creencias en la decisión de invertir en capital humano?

Es imposible negar el sentimiento de fastidio por parte de uno que otro economista frente a la teoría clásica. Fastidio que nace cuando insistentemente se compara el supuesto de racionalidadperfecta y la manera como el ser humano en realidad se comporta. Pero, no sólo ha sido la insatisfacción de muchos economistas frente a dicha construcción teórica, sino tambiénlos intentos por reemplazar el modelo básico del hombre racional,los que han hecho que surjan una serie de propuestas para modelar el problema de la toma de decisiones de una manera diferente. Así como muchos han expresado su disconformidad,este artículo tendrá como propósito hacer lo mismo. Es decir, intentará explorar una nueva alternativa para entender cómo y por qué los agentes toman la decisión de invertir en capital humano.