Estimação e previsão no processo INARCH(2)

In the last decades the study of integer-valued time series has gained notoriety due to its broad applicability (modeling the number of car accidents in a given highway, or the number of people infected by a virus are two examples). One of the main interests of this area of study is to make forecasts, and for this reason it is very important to propose methods to make such forecasts, which consist of nonnegative integer values, due to the discrete nature of the data. In this work, we focus on the study and proposal of forecasts one, two and h steps ahead for integer-valued second-order autoregressive conditional heteroskedasticity processes [INARCH (2)], and in determining some theoretical properties of this model, such as the ordinary moments of its marginal distribution and the asymptotic distribution of its conditional least squares estimators. In addition, we study, via Monte Carlo simulation, the behavior of the estimators for the parameters of INARCH(2) processes obtained using three di erent methods (Yule- Walker, conditional least squares, and conditional maximum likelihood), in terms of mean squared error, mean absolute error and bias. We present some forecast proposals for INARCH(2) processes, which are compared again via Monte Carlo simulation. As an application of this proposed theory, we model a dataset related to the number of live male births of mothers living at Riachuelo city, in the state of Rio Grande do Norte, Brazil.

Inibição dos efeitos locais induzidos pelas peçonhas das serpentes Bothrops erythromelas e Bothrops jararaca pelo extrato aquoso das folhas de Jatropha mollissima (Pohl) Bail

Snakebites are a serious public health problem in tropical and subtropical countries and Bothrops genus is responsible for the accidents in Brazil and throughout Latin America (90% of cases). The local effects (pain, edema, hemorrhage and myonecrosis) and systemic (cardiovascular alterations, shock and blood clotting disorders) caused by the venom of Bothrops are due to the numerous protein and non-protein components, which are part of the constitution of the poison. The only form of therapy is scientifically validated antivenom serum therapy which, however, is not effective with respect to local effects produced, risk of immunological reactions, high cost and difficult access in some regions. Thus, the search for new alternatives to serum therapy becomes important, and in this context, many medicinal plants have been highlighted by the popular use as antiophidic. Among these plants, we can mention the species Jatropha mollissima (Euphorbiaceae) which has popular use in traditional medicine as antiophidic, anti-inflammatory, antimicrobial and antipyretic. Therefore, this study aims to evaluate the neutralizing potential of local effects induced by the venom of Bothrops erythromelas and Bothrops jararaca with the aqueous extract of the leaves of J. mollissima. The leaf extracts were prepared by decoction, fractionated (by liquid-liquid partition) and characterized by thin layer chromatography (TLC) and High Performance Liquid Chromatography (HPLC). Antiophidic activity of the extract was evaluated in model of paw edema, peritonitis, bleeding and myotoxicity induced by venoms of B. jararaca and B. erythromelas. In all models, the extract was evaluated by intraperitoneal route at the doses of 50, 100 and 200 mg/kg, administered 30 minutes prior to injection of the venom (pretreatment protocol). Stains suggestive of the presence of flavonoids: apigenin, luteolin, orientin, isoorientin, vitexin and vitexin-2-O-rhamnoside were detected in the extract by co-CCD. By means of HPLC were identified isoorientin, orientin, vitexin and isovitexin. All tested doses of J. mollissima extract reduced the paw edema induced by the venom with intensity similar to dexamethasone. The aqueous extract of J. mollissima leaves on all evaluated doses, inhibited cell migration induced by B. jararaca and B. erythromelas promoting inhibition of recruitment of mononuclear cells and the polymorphonuclear cells. Local bleeding induced by B. jararaca venom was significantly inhibited by the extract. Both venoms were inhibited by the extract in myotoxic activity. These results indicate that the aqueous extract of J. mollissima leaves have snakebite potential, particularly with respect to local effects, which may justify the use of this plant in traditional medicine and complementary therapy as anti-venom serum.

Inibição dos efeitos locais induzidos pelas peçonhas das serpentes Bothrops erythromelas e Bothrops jararaca pelo extrato aquoso das folhas de Jatropha mollissima (Pohl) Bail

Snakebites are a serious public health problem in tropical and subtropical countries and Bothrops genus is responsible for the accidents in Brazil and throughout Latin America (90% of cases). The local effects (pain, edema, hemorrhage and myonecrosis) and systemic (cardiovascular alterations, shock and blood clotting disorders) caused by the venom of Bothrops are due to the numerous protein and non-protein components, which are part of the constitution of the poison. The only form of therapy is scientifically validated antivenom serum therapy which, however, is not effective with respect to local effects produced, risk of immunological reactions, high cost and difficult access in some regions. Thus, the search for new alternatives to serum therapy becomes important, and in this context, many medicinal plants have been highlighted by the popular use as antiophidic. Among these plants, we can mention the species Jatropha mollissima (Euphorbiaceae) which has popular use in traditional medicine as antiophidic, anti-inflammatory, antimicrobial and antipyretic. Therefore, this study aims to evaluate the neutralizing potential of local effects induced by the venom of Bothrops erythromelas and Bothrops jararaca with the aqueous extract of the leaves of J. mollissima. The leaf extracts were prepared by decoction, fractionated (by liquid-liquid partition) and characterized by thin layer chromatography (TLC) and High Performance Liquid Chromatography (HPLC). Antiophidic activity of the extract was evaluated in model of paw edema, peritonitis, bleeding and myotoxicity induced by venoms of B. jararaca and B. erythromelas. In all models, the extract was evaluated by intraperitoneal route at the doses of 50, 100 and 200 mg/kg, administered 30 minutes prior to injection of the venom (pretreatment protocol). Stains suggestive of the presence of flavonoids: apigenin, luteolin, orientin, isoorientin, vitexin and vitexin-2-O-rhamnoside were detected in the extract by co-CCD. By means of HPLC were identified isoorientin, orientin, vitexin and isovitexin. All tested doses of J. mollissima extract reduced the paw edema induced by the venom with intensity similar to dexamethasone. The aqueous extract of J. mollissima leaves on all evaluated doses, inhibited cell migration induced by B. jararaca and B. erythromelas promoting inhibition of recruitment of mononuclear cells and the polymorphonuclear cells. Local bleeding induced by B. jararaca venom was significantly inhibited by the extract. Both venoms were inhibited by the extract in myotoxic activity. These results indicate that the aqueous extract of J. mollissima leaves have snakebite potential, particularly with respect to local effects, which may justify the use of this plant in traditional medicine and complementary therapy as anti-venom serum.

Análise de falhas em rolamentos por análise de vibração aplicado a aerogeradores

With the heavy use of bearings in various segments of the industry, there are a large number of necessary interruptions in industrial processes to perform maintenance on these devices, with the case study wind turbines. The growth of the wind energy sector, encouraged to conduct research that helps to solve this problem. To contribute to predictive maintenance has been carried out a signal analysis using techniques which allow detection and location of the problem in order to prevent accidents caused and losses due to unexpected equipment failures, whereas low system rotation complicates the detection of the failure. To work around this problem, there was the indication of standard signals for defects in the bearings, making diagnosis of possible failures. With this diagnosis can be performed predictive maintenance, identifying the failure of the system that were tested, such as the introduction of grains of sand in the bearing, wear on the outer race of the bearing and bearing rust. By processing signals it is possible to construct graphs developing a mapping of defects by different peaks in the frequency band.

Magnitude da morbidade relacionada ao trabalho no Rio Grande do Norte

Diseases and disorders related to work sets up an important public health problem in Brazil and worldwide. However, the reality of these diseases still constitutes a gap with regard to its characterization and epidemiological situation, especially in Brazil. In this context, this study aims to analyze the magnitude of morbidity related to work from the injuries and illnesses reported by Health the Diseases Notifiable of Health of the State Public River Health Department worker Reference Center Information System services Grande do Norte from 2007 to 2014. It is ecological study, quantitative cross-sectional study in which the analysis unit of the municipalities of Rio Grande do Norte. Data were collected from the state base of Diseases Notifiable Information System Centre of the Secretariat of State Workers' Health Reference Public Health of Rio Grande do Norte, between March and June 2015, after the approval of the Committee of Ethics in Research of the Federal University of Rio Grande do Norte, Opinion 014/2014. The population was represented by the universe of cases of diseases and disorders related to work that were reported and shut down the system from 2007 to 2014. Data were analyzed using descriptive and inferential statistics, presented in tables, graphs, charts and figures. For this, we used the Microsoft Excel 2007 and SPSS version 20.0. To check the significance level we opted for the application of the chi-square or Fisher tests. We adopted the significance level of p <0.05. Of the 10,161 cases of diseases related to the reported work, the biological work accidents had the highest percentage (52.84%) followed by serious occupational accidents (37.49%). For diseases, the highlights were musculoskeletal (4.82%), mental disorders (2.19%) and exogenous intoxication (1.97%). Among men, there was a predominance of major accidents (91.80%), mental disorders (70.00%) and exogenous poisoning (52.84%). Women were most affected by biological accidents (77.50%) and musculoskeletal diseases (64.10%). Among workers who have suffered injuries predominated mulatto (%), mean age of 35.86 years, low education (%) and workers in the formal sector (%). Among the accidents, biological (n = 5,369) accounted for 52.84% of cases occurred predominantly among nursing professionals (48.31%). The percutaneous exposure was the most frequent (73.05%) and the occurrence of circumstances was improper disposal of sharps (45.28%), the needle the most common agent (66.62%) and the organic material was blood (72.99%). Most injured workers were vaccinated against hepatitis B (68.13%), but no information as to the assessment of the vaccine response. In the course of the disease predominated ignored the situation with loss of monitoring of clinical follow-up (55.62%). There was also an increase in the notification of serious industrial accidents predominantly male (91.80%) workers aged 25-44 years (54.3%) and typical accidents (76.3%). The temporary disability was the most common outcome (55.53%) and hand the most affected part (33.00%); the mining and construction industry had the highest number of cases (25.1%) in registered employee (34.2%). The findings of this study show a positive result in relation to increased mandatory reporting of injuries and illnesses related to work together to health services that meet victimized workers, towards the occurrence of knowledge of these accidents for decision making in public plans and policies of health. However, the information system still needs improvement in both the coverage and the quality of the data to demonstrate with greater reliability the magnitude of events to support the planning of workers' health into shares in the state.

Colectivos sociales y ciborgs: hacia una lectura feminista de los drones

Este artículo analiza el papel de los drones en la emergencia de nuevas formas de participación política e impugnación del poder por parte de colectivos sociales. El artículo plantea una lectura feminista de los drones como ciborgs (humanos-máquinas) para explorar las agencias distribuidas entre actores humanos y no humanos con el propósito de visibilizar las relaciones de poder y analizar la configuración de contra-realidades. Se presentan ocho casos de colectivos sociales que, con la ayuda de un dron, disputan el poder de gobiernos, empresas transnacionales además de desempeñar innovadoras intervenciones públicas.

Poor communication skills means high risk for aviation safety

Este artigo analisa diferentes tipos de comunicação no ambiente de negócios da aviação civil. Para tanto, utilizou-se uma abordagem qualitativa, delineada por análise documental dos relatórios das agencias governamentais. A comunicação é um sistema complexo que consiste em comunicação verbal, não verbal, escrita, falada e eletrônica. Na aviação, ela é um fator crucial ao enfrentamento de situações de alto risco. Os resultados obtidos indicam que lacunas de comunicação entre os indivíduos que atuam nas operações aeronáuticas e aeroviárias contribuem para a maior parte dos acidentes e incidentes ocorridos. As conclusões pontuam que as habilidades de comunicação são tão importantes quanto às habilidades técnicas e enfatizam a emergência do treinamento em habilidades de comunicação aos profissionais da aviação, possibilitando-os detectar ameaças e comunicar claramente a necessidade de apoio para o enfrentamento de riscos. É imperativo adotar as ações requeridas pela filosofia do Sistema de Gestão de Segurança, visando gerar comportamento seguro.

Comunicação e comportamento em organizações de alta confiabilidade: uma análise da comunicação em atividades complexas

As organizações de alta confiabilidade são caracterizadas pelo alto nível de complexidade e de exposição contínua a riscos. Sob esse ambiente, observa-se o surgimento de estresse e de conflitos interpessoais que, para adequada gestão, demandam habilidades de comunicação. Esta pesquisa tem por objeto de estudo a comunicação documentada nos casos de incidentes e acidentes ocorridos na Aviação Civil, investigados pela Federal Aviation Administration e pelo Centro de Investigação e Prevenção de Acidentes Aeronáuticos. De acordo com dados das agências, deficiências na comunicação respondem por aproximadamente 80% das ocorrências. Contudo, os resultados da pesquisa, confirmam não haver carga horária suficiente de treinamento de habilidades de comunicação para atendimento específico de situações de extremo risco e de contínua pressão. O treinamento é mais focado em habilidades técnicas do que em habilidades sociais.

Gestão do Acidentado de Trânsito em São Vicente: a pertinência de um Enfermeiro Urgentista no atendimento pré-hospitalar

A incidência dos acidentes de trânsitos em Cabo Verde acompanha a tendência mundial, sendo uma das primeiras causas de morte nos jovens; nos anos 2010 a 2012. Este estudo tem como objetivo caraterizar o atendimento pré-hospitalar às vítimas de trauma, decorrentes de acidentes de trânsito, em São Vicente, no que se refere ao perfil das ocorrências, identificando a inserção da enfermagem nesse campo. O trabalho de pesquisa carateriza-se como um estudo de carater qualitativo, descritivo e exploratório. Durante a sua realização, os dados foram obtidos por meio de entrevistas semi-estruturadas, dirigidas a seis (6) dos enfermeiros do serviço de Banco de Urgência do Adulto do Hospital Batista de Sousa. E Sendo que no atendimento pré-hospitalar em Cabo Verde, temos a participação apenas dos bombeiros e da polícia nacional de trânsito, foram entrevistados, cinco (5) bombeiros do corpo de bombeiros de São Vicente e mais quatro (4) policiais que trabalham na esquadra de trânsito. Na análise do conteúdo constatou-se que a organização do trabalho no atendimento pré-hospitalar segundos os entrevistados não se efetua de forma interdisciplinar, mas que na visão destes a inserção de enfermagem no ambiente pré-hospitalar seria essencial na prestação de cuidados às vitimas decorrentes de acidente de viação. A relação entre os atores envolvidos nessa abordagem constatou-se que se trata de uma relação muito superficial e que não se chega ao perto do profissionalismo, pelo não uso da linguagem técnica entre estes. E os dados analisados revelam a relevância do atendimento ás vitimas de acidentes de trânsito, mostrando a necessidade de aprofundar conhecimentos nessa área e investir em formações e qualificação dos atores, bem como a estruturação do trabalho baseado em interdisciplinaridade.

Caracterização e Factores que Influenciam o Desempenho dos Bombeiros Profissionais: estudo exploratório

É indubitável que a decisão está presente no dia-a-dia de todos nós, independentemente do tipo de actividade em que estamos envolvidos. Na vida organizacional, enfrentamos muitas situações que exigem uma resposta momentânea, aqui denominadas de imediatas, as quais não permitem uma recolha de informação adequada, tempo para reflexão, discussão e troca de ideias, entre outras restrições. Além das limitações já citadas por outros autores, como a própria capacidade cognitiva do indivíduo, faculdade de processamento, há outros elementos que influenciam o processo de tomada de decisão, especialmente em ambientes sob pressão e em constante mutação, como é o dos bombeiros. O presente trabalho procura conhecer quais os factores que influenciam a tomada de decisão de bombeiros profissionais com funções de chefia, em ocorrências de incêndios urbanos e acidentes de viação. Neste contexto, foram abordados alguns enquadramentos para a tomada de decisão, como o Modelo da Tomada de Decisão da Primeira Opção Identificada (TDPOI) de Gary Klein, entre outros. No sentido de aprofundar a nossa investigação, foram realizados dois estudos exploratórios através de entrevistas presenciais. A amostra é constituída por 14 profissionais do sector, entre eles bombeiros com funções de chefia, comandantes e delegados sindicais. Os resultados obtidos mostraram que a experiência e a formação são os factores que se evidenciam, e influenciam a decisão dos bombeiros. Constatamos que nos Bombeiros Portugueses a experiência é uma característica dos decisores, pois são eles que farão as opções de alto risco. Por outro lado, apesar de a formação visar a aquisição de competências profissionais, nomeadamente na área da decisão, esta carece de actualização, porque não satisfaz as necessidades dos bombeiros. Apresentam-se também as principais limitações do estudo e sugestões para investigações futuras. / Undoubtedly, the decision is present in day-to-day for us all, regardless of the type of activity we are involved. In organizational life, we face many situations that require a momentary response, here called the immediate, which do not allow collection of adequate information, time for reflection, discussion and exchange of ideas, among other restrictions. Besides the limitations already mentioned by other authors, as the individual's cognitive capacity, processing power, there are other factors that influence the decision-making process, especially in environments under pressure and constantly changing, as is the Fire. This paper seeks to know which factors influence the decision making of professional firefighters with leadership roles in urban fire occurrences and accidents. In this context, we discuss some frameworks for decision making, as the Recognition-Primed Decision (RPD) Model by Gary Klein, among others. In order to further our investigation, two exploratory studies were conducted through personal interviews. The sample consists of 14 professionals, including firefighters with executive functions, commanders and union representatives. The results showed that the experience and training are factors that are evident, and influence the decision of the firefighters. We note that the Portuguese Firemen experience is a characteristic of decision-makers because they are options that will make high-risk. On the other hand, although the training to aim at the acquisition of professional skills, particularly in the area of decision, it needs updating, because it meets the needs of firefighters. We present also the main limitations of the study and suggestions for future investigations.

Definições para o resultado de enfermagem comportamento de prevenção de quedas: uma revisão integrativa

Devido à necessidade de mensurar o risco de quedas em concordância à linguagem padronizada de enfermagem, foi selecionado o resultado de enfermagem Comportamento para Prevenção de Quedas da Nursing Outcomes Classification (NOC), com objetivo de identificar evidências sobre seus elementos, mensuração, comparação com indicadores existentes e construir definições constitutivas. Foi efetuada revisão integrativa entre abril e novembro de 2009, mediante identificação da questão, estabelecimento de critérios de inclusão/exclusão, extração das informações, avaliação, interpretação e síntese. Destacaram-se pesquisas transversais e perspectivas de especialistas. Os indicadores Uso de recursos de correção da visão e Uso de sapatos amarrados e do tamanho adequado foram considerados insuficientes para avaliar fatores de risco como déficits sensoriais e roupas/calçados inadequados. Percebe-se que algumas definições precisam ser melhor desenvolvidas e que esse resultado de enfermagem merece refinamento sobretudo referente aos indicadores. Foram identificados 22 indicadores e definições foram propostas baseadas nas evidências da literatura

Qualidade dos empregos e a carcinicultura marinha nos laboratórios da praia de Barreta/RN

To present research had for objective to study the quality of the employment in the maturation Laboratories and larviculture of the Beach of Barreta/RN, adopting for so much the criteria used by Reinecke(1999) to characterize a quality employment: surrender, benefits non salary, regularity and work reliability and of the wage, contractual status, social protection, work day, intensity of the work, risk of accidents and of occupational diseases, involvement in linked decisions to the section work, possibility for the development of professional qualifications. Of the exam of the data it was verified that the generated employments are considered employments of good quality. However, this result should be analyzed to the light of a context of extreme informality and of precarization of the work. Therefore, the results should be relativized. He/she/you imports to retain that one of the limitations of the study resides in the impossibility of generalizing the data for the whole section of the sea carcinicultura. In spite of that fact, he/she is considered that the objectives of the research were assisted fully and that the characterization of the profile of the employment generated by the section of the shrimpculture it is extremely important for the drawing of public politics gone back to foment this activity.

Descomposición de residuos, dinámica del fósforo y evolución de variables físicas de suelo en la secuencia soja / cultivos de cobertura en el oeste de la Región Pampeana

Los cultivos de cobertura (CC) constituyen una práctica conservacionista actualmente revalorizada a nivel local e internacional. En la Región Pampeana surgen como una alternativa para compensar, al menos parcialmente, los efectos negativos del monocultivo de soja. En siembra directa aún se desconocen los efectos de esta práctica sobre algunas propiedades y procesos físico-químicos y biológicos del suelo. En esta tesis se llevaron a cabo experimentos de campo en el Oeste de la Región Pampeana para evaluar la descomposición de biomasa y liberación de distintas fracciones de fósforo (P) desde los residuos y las propiedades físicas de suelo en distintos momentos de la secuencia Soja/CC. Los CC incrementaron el carbono orgánico, la actividad y biomasa microbiana (13-53 por ciento) de la capa superficial del suelo y estimularon la descomposición de residuos de soja (7,3 por ciento). Los residuos de los CC liberaron cantidades agronómicamente significativas de P (5-16 kg ha-1) durante el período de crecimiento de soja, a la vez que mantuvieron elevados niveles de cobertura (1200 - 4500 kg ha-1). Una parte importante del P liberado inicialmente (53-100) proviene de la fracción inorgánica, cuya liberación estaría parcialmente desacoplada del proceso de descomposición. Las tasas empíricas de liberación de las fracciones de P podrían ser incorporadas en modelos de predicción de la contribución del P de los residuos a la disponibilidad del P del suelo. Los CC cuyas raíces fueron más gruesas incrementaron la macroporosidad y la tasa de infiltración del suelo. Las propiedades físicas presentaron variaciones temporales independientemente del efecto de los tratamientos. La cantidad y calidad de los residuos aéreos, así como las características del sistema radical de cada especie de CC regularían su efectividad en el mantenimiento de la cobertura y el mejoramiento de las propiedades físicas del suelo, que, en última instancia, contribuyen a la conservación del recurso.

Sistema de apoio no combate aos fogos florestais para o Concelho de Águeda

O presente trabalho pretende mostrar o desenvolvimento de um sistema de apoio à decisão no combate aos fogos florestais que assenta fundamentalmente em tecnologias da informação, em contraste com a dinâmica utilizada atualmente. O sistema é composto por três componentes: uma componente WebSig que disponibiliza a informação necessária à tomada de decisão no teatro de operações; uma componente para apoio às equipas terrestres; e, uma componente que serve de suporte aos meios de combate aéreos. Este sistema permite ainda a leitura dos dados provenientes da simulação de propagação de fogo proveniente do Farsite. Estas simulações são visualizados na aplicação WebSig. Uma das maiores preocupações em relação ao sistema é que todos os dados utilizados sejam certos e atualizados, mas também que as principais funcionalidades da aplicação sejam utilizadas em tempo real pelos principais agentes da proteção civil. Pelas validações efetuadas, conclui-se que a aplicação funciona conforme projetada tendo sido desenvolvido um sistema que se espera ser considerado uma mais-valia para a área de estudo e para a proteção civil.

Characterization of the glial scar tissue in a murine model of spinal cord compression, with focus on hyaluronan

Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of people each year. Although in recent decades significant progress has been made in relation to understanding the molecular and cellular events underlying the nervous damage, spinal cord injury is still a highly disabling condition for which there is no curative therapy. People affected by spinal cord injuries manifested dysfunction or loss, temporary or permanent, of motor, sensory and / or autonomic functions depending on the spinal lesion damaged. Currently, the incidence rate of this type of injury is approximately 15-40 cases per million people worldwide. At the origin of these lesions are: road accidents, falls, interpersonal violence and the practice of sports. In this work we placed the hypothesis that HA is one of the component of the scar tissue formed after a compressive SCI, that it is likely synthetised by the perilesional glial cells and that it might support the permeation of the glial scar during the late phase of SCI. Nowadays, much focus is drawn on the recovery of CNS function, made impossible after SCI due to the high content of sulfated proteoglycans in the extracellular matrix. Counterbalancing the ratio between these proteoglycans and hyaluronic acid could be one of the experimental therapy to re-permeate the glial scar tissue formed after SCI, making possible axonal regrowth and functional recovery. Therefore, we established a model of spinal cord compression in mice and studied the glial scar tissue, particularly through the characterization of the expression of enzymes related to the metabolism of HA and the subsequent concentration thereof at different distances of the lesion epicenter. Our results show that the lesion induced in mice shows results similar to those produced in human lesions, in terms of histologic similarities and behavioral results. but these animals demonstrate an impressive spontaneous reorganization mechanism of the spinal cord tissue that occurs after injury and allows for partial recovery of the functions of the CNS. As regards the study of the glial scar, changes were recorded at the level of mRNA expression of enzymes metabolizing HA i.e., after injury there was a decreased expression of HA synthases 1-2 (HAS 1-2) and an increase of the expression HAS3 synthase mRNA, as well as the enzymes responsible for the HA catabolism, HYAL 1-2. But the amount of HA measured through the ELISA test was found unchanged after injury, it is not possible to explain this fact only with the change of expression of enzymes. At two weeks and in response to SCI, we found synthesized HA by reactive astrocytes and probably by others like microglial cells as it was advanced by the HA/GFAP+ and HA/IBA1+ cells co-location.