Unge mästerskidlöparen Markus Sahlberg 7.3.1958 Kurikka

Kirje

Taas Kaanaassa 2/6 -25

Kirje 2.6.1925

Nuori hiihtäjämestari Markus Sahlberg 7/3 1958

Kirje 7.3.1958

Iowa Lottery Action, April 18-29, 2007, vol. 14, no. 7.

Iowa Lottery newsletter for lottery retailers.

Efficacy of garenoxacin in treatment of experimental endocarditis due to Staphylococcus aureus or viridans group streptococci.

The activity of garenoxacin was investigated in rats with experimental endocarditis due to staphylococci and viridans group streptococci (VGS). The staphylococci tested comprised one ciprofloxacin-susceptible and methicillin-susceptible Staphylococcus aureus (MSSA) isolate (isolate 1112), one ciprofloxacin-susceptible but methicillin-resistant S. aureus (MRSA) isolate (isolate P8), and one ciprofloxacin-resistant mutant (grlA) of P8 (isolate P8-4). The VGS tested comprised one penicillin-susceptible isolate and one penicillin-resistant isolate (Streptococcus oralis 226 and Streptococcus mitis 531, respectively). To simulate the kinetics of drugs in humans, rats were infused intravenously with garenoxacin every 24 h (peak and trough levels in serum, 6.1 and 1.0 mg/liter, respectively; area under the concentration-time curve [AUC], 63.4 mg. h/liter) or levofloxacin every 12 h (peak and trough levels in serum, 7.3 and 1.5 mg/liter, respectively; AUC, 55.6 mg. h/liter) for 3 or 5 days. Flucloxacillin, vancomycin, and ceftriaxone were used as control drugs. Garenoxacin, levofloxacin, flucloxacillin, and vancomycin sterilized >/=70% of the vegetations infected with both ciprofloxacin-susceptible staphylococcal isolates (P < 0.05 versus the results for the controls). Garenoxacin and vancomycin also sterilized 70% of the vegetations infected with ciprofloxacin-resistant MRSA isolate P8-4, whereas treatment with levofloxacin failed against this organism (cure rate, 0%; P < 0.05 versus the results obtained with the comparator drugs). Garenoxacin did not select for resistant derivatives in vivo. In contrast, levofloxacin selected for resistant variants in four of six rats infected with MRSA isolate P8-4. Garenoxacin sterilized 90% of the vegetations infected with both penicillin-susceptible and penicillin-resistant isolates of VGS. Levofloxacin sterilized only 22 and 40% of the vegetations infected with penicillin-susceptible S. oralis 226 and penicillin-resistant S. mitis 531, respectively. Ceftriaxone sterilized only 40% of those infected with penicillin-resistant S. mitis 531 (P < 0.05 versus the results obtained with garenoxacin). No quinolone-resistant VGS were detected. In all the experiments successful quinolone treatment was predicted by specific pharmacodynamic criteria (D. R. Andes and W. A. Craig, Clin. Infect. Dis. 27:47-50, 1998). The fact that the activity of garenoxacin was equal or superior to those of the standard comparators against staphylococci and VGS indicates that it is a potential alternative for the treatment of infections caused by such bacteria.

Medical appropriateness of hospital utilization: an overview of the Swiss experience.

We present here the principal results of four concurrent hospital utilization reviews conducted in Switzerland in 1990 and 1991, based on an adapted Appropriateness Evaluation Protocol. The studies were performed on all the hospital days from a sample of patients admitted over a 6 month period. The level of inappropriate use ranged between 8 and 15% in terms of days and was consistently higher in medicine than in surgery. In comparison with other published studies, the low proportion of observed inappropriate days is probably due, at least partly, to differences in study design.

Tasavallan Presidentti Urho Kekkosen vierailu Tshekkoslovakiaan 1.-4.10.1969 (Tasavallan Presidentin radio- ja TV-haastattelu Romanian, Unkarin ja Tshekkoslovakian matkojen jälkeen 6.10.1969)

Haastattelu

Produtividade de soja e propriedades físicas de um Latossolo submetido a sistemas de manejo e compactação

Em solos sob plantio direto, o tráfego de máquinas pode imprimir ao solo estado de compactação restritivo ao rendimento de culturas. Este trabalho foi realizado na Universidade de Cruz Alta, no município de Cruz Alta (RS). O objetivo foi avaliar os efeitos de sistemas de manejo e estados de compactação do solo sob sistema plantio direto nas propriedades físicas e no rendimento de grãos de seis cultivares de soja. O experimento foi realizado em um Latossolo Vermelho distroférrico, com 427 g kg-1 de argila. Os tratamentos, estabelecidos em blocos ao acaso, com quatro repetições, constaram de sistemas de manejo e estados de compactação criados por um rolo compactador de 2 Mg, foram: plantio direto (PD) contínuo sem compactação adicional (PD-C0), PD com uma passada do rolo compactador (PD-C1), PD com três passadas do rolo compactador (PD-C2), PD com cinco passadas do rolo compactador (PD-C3) e PD escarificado sem preparo secundário (ESCAR). As propriedades físicas avaliadas foram resistência à penetração do solo (RP), densidade do solo (Ds), porosidade total (Pt), macroporosidade (Macro) e microporosidade (Micro). A compactação do solo causou menores valores de Ds, espaço poroso e RP do solo na camada de 0-0,10 m de profundidade. Houve relação direta entre a Ds, volume de Micro e a RP do solo e relação inversa entre a Ds e o volume de Macro, com o aumento do estado de compactação. Os cultivares de soja apresentaram comportamento semelhante para os diferentes estados de compactação do solo. A escarificação do solo em área manejada por oito anos sob sistema plantio direto não propiciou incremento no rendimento de grãos de soja. Quando os valores de RP foram de até 2,6 MPa, os de Ds de até 1,51 Mg m-3 e volume de Macro superiores a 0,10 dm³ dm-3, em condições de lavoura, não houve comprometimento do rendimento de grãos de soja.

Secure and Prepared Newsletter, July 15, 2010, Vol. 6, no. 14

A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management