Les liliacees /par P.J. Redoute.

vol. 4

Les liliacees /par P.J. Redoute.

vol. 5

Les liliacees /par P.J. Redoute.

vol. 6

Les liliacees /par P.J. Redoute.

vol. 7

Les liliacees /par P.J. Redoute.

vol. 8

Comprehensive index to the Flora of Guatemala / Terua P. Williams.

v.24:pt.13(1977)

Amphibians and reptiles of the James Simpson-Roosevelt Asiatic expedition, by Karl P. Schmidt.

v.12:no.13(1926)

Nutrição mineral de plantas ornamentais XII: Deficiências de N, P, Ca, Mg, S e B em crisântemo (Chrysanthemum morifolium cv golden polaris)

Com o objetivo de determinar: Os sintomas de deficiência de macronutrientes e de boro, de modo a relacioná-los com a composição química da planta; Foi conduzido um experimento em casa-de-vegetação com plantas de crisântemo cultivadas em substrato de sílica e irrigadas com soluções nutritivas, submetidas aos tratamentos: completo, omissão e nitrogênio (-N), omissão de fósforo (-P), omissão de potássio (-K), omissão de cálcio (-Ca), omissio de magnésio (-Mg), omissão de enxofre (-S) e omissão de boro (-B). O desenvolvimento dos sintomas foi acompanhado e, ao final do ciclo, as plantas foram colhidas e separadas em folhas novas, folhas velhas, hastes e inflorescências para serem analisadas quanto a concentração dos nutrientes. Os autores concluiram que: A sintomatologia de carência de nutrientes aparece, em sequência, para os elementos N, B, S, K, Ca, P e Mg, sendo mais pronunciada nos tratamentos -N, -K, -B e -Ca. Os níveis de nutrientes nas folhas de plantas sadias, expressos em função da matéria seca, estão na faixa de:N-1,02% -2,25%; P-0,08%-0,13%; K-2,79%-2,87%; Ca -1,18%-1 ,68%; Mg-0,70%-0,93%; S- 0,93%-0,13% e B-56,5 ppm-67,25 ppm. Os níveis de nutrientes nas folhas de plantas com sintomas de carência, expressos na matéria seca, são: N-0,73%; P-0,03%; K-0,42%; Ca-0,46%; Mg-0,48%; S-0,10% e B-33 ppm.

Hemprich's coral snake : Micrurus hemprichi / Karl P. Schmidt.

v.34:no.13(1953)

A new toad from western China, by Karl P. Schmidt and Ch'eng-chao Liu.

v.24:no.13(1940)

Simultaneous LC-MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma.

BACKGROUND: An LC-MS/MS method has been developed for the simultaneous quantification of P-glycoprotein (P-gp) and cytochrome P450 (CYP) probe substrates and their Phase I metabolites in DBS and plasma. P-gp (fexofenadine) and CYP-specific substrates (caffeine for CYP1A2, bupropion for CYP2B6, flurbiprofen for CYP2C9, omeprazole for CYP2C19, dextromethorphan for CYP2D6 and midazolam for CYP3A4) and their metabolites were extracted from DBS (10 µl) using methanol. Analytes were separated on a reversed-phase LC column followed by SRM detection within a 6 min run time. RESULTS: The method was fully validated over the expected clinical concentration range for all substances tested, in both DBS and plasma. The method has been successfully applied to a PK study where healthy male volunteers received a low dose cocktail of the here described P-gp and CYP probes. Good correlation was observed between capillary DBS and venous plasma drug concentrations. CONCLUSION: Due to its low-invasiveness, simple sample collection and minimal sample preparation, DBS represents a suitable method to simultaneously monitor in vivo activities of P-gp and CYP.

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻S13; to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻&supl;³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.

IL-13 induces expression of CD36 in human monocytes through PPARgamma activation.

The class B scavenger receptor CD36 is a component of the pattern recognition receptors on monocytes that recognizes a variety of molecules. CD36 expression in monocytes depends on exposure to soluble mediators. We demonstrate here that CD36 expression is induced in human monocytes following exposure to IL-13, a Th2 cytokine, via the peroxisome proliferator-activated receptor (PPAR)gamma pathway. Induction of CD36 protein was paralleled by an increase in CD36 mRNA. The PPARgamma pathway was demonstrated using transfection of a PPARgamma expression plasmid into the murine macrophage cell line RAW264.7, expressing very low levels of PPARgamma, and in peritoneal macrophages from PPARgamma-conditional null mice. We also show that CD36 induction by IL-13 via PPARgamma is dependent on phospholipase A2 activation and that IL-13 induces the production of endogenous 15-deoxy-Delta12,14-prostaglandin J2, an endogenous PPARgamma ligand, and its nuclear localization in human monocytes. Finally, we demonstrate that CD36 and PPARgamma are involved in IL-13-mediated phagocytosis of Plasmodium falciparum-parasitized erythrocytes. These results reveal a novel role for PPARgamma in the alternative activation of monocytes by IL-13, suggesting that endogenous PPARgamma ligands, produced by phospholipase A2 activation, could contribute to the biochemical and cellular functions of CD36.

Jornades del moviment per la pau. Barcelona, 13 i 14 de novembre de 2009

Aquesta relatoria correspon a les Jornades del Moviment per la Pau coorganitzades per la Federació Catalana d’ONG per la Pau i l’Institut Català Internacional per la Pau, i que es van desenvolupar a Barcelona durant els dies 13 i 14 de novembre de 2009. L'objectiu era reflexionar i debatre sobre els plantejaments dels quals parteix el moviment, la identificació de noves realitats, els reptes de futur, i la possible adequació a nous enfocaments o estratègies per incrementar la incidència transformadora en el camp social i polític.

On p-optimal proof systems and logics for PTIME

"Vegeu el resum a l'inici del document del fitxer adjunt"