999 resultados para État unitaire
Resumo:
Heinrich Mann
Resumo:
J. Uprimny
Resumo:
M. Henes
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Max Dienemann
Resumo:
Heinrich York-Steiner
Resumo:
Jakob Loewenberg
Resumo:
Arthur Schnitzler
Resumo:
Israel Reichert
Resumo:
publ. sous la dir. de Liebrechts. Par les soins du Th. Masui
Resumo:
par Pierre Kassai͏̈
Resumo:
par Gustave Moynier
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par H. Droogmans
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par Arthur Beugnot
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Signatur des Originals: S 36/F12056
Resumo:
The HIV-1 Tat protein is a potent chemoattractant for monocytes. We observed that Tat shows conserved amino acids corresponding to critical sequences of the chemokines, a family of molecules known for their potent ability to attract monocytes. Synthetic Tat and a peptide (CysL24–51) encompassing the “chemokine-like” region of Tat induced a rapid and transient Ca2+ influx in monocytes and macrophages, analogous to β-chemokines. Both monocyte migration and Ca2+ mobilization were pertussis toxin sensitive and cholera toxin insensitive. Cross-desensitization studies indicated that Tat shares receptors with MCP-1, MCP-3, and eotaxin. Tat was able to displace binding of β-chemokines from the β-chemokine receptors CCR2 and CCR3, but not CCR1, CCR4, and CCR5. Direct receptor binding experiments with the CysL24–51 peptide confirmed binding to cells transfected with CCR2 and CCR3. HIV-1 Tat appears to mimic β-chemokine features, which may serve to locally recruit chemokine receptor-expressing monocytes/macrophages toward HIV producing cells and facilitate activation and infection.