College and university libraries and librarianship. An examination of their present status and some proposals for their future development /

Place and date of imprint on label mounted on t. p.

Cambridge University examination papers.

Vols. for 1874/75- called also vol. 4-

University education in Ireland and "ultramontanism" : being an examination of arguments lately published by James L. Whittle, A.B., Trinity College, Dublin, G.E. Cairnes, M.A., professor, Queen's College, Galway, and Sir Dominick Corrigan, Bart. /

Mode of access: Internet.

A letter to the Right Reverend John, Lord Bishop of Bristol, respecting an additional examination of students in the University of Cambridge ... [microform] /

Mode of access: Internet.

An examination of the charters and statutes of Trinity College, Dublin, in regard to the supposed distinction between the college and the university.

Mode of access: Internet.

College without classes: credit through examination in university adult education.

Mode of access: Internet.

University Museums entrance

Albert Kahn, architect. Spence Bros., contractor. Also called Natural History Museum

University Museums entrance. Door detail

Albert Kahn, architect. Spence Bros., contractor. Also called Natural History Museum

Pumas at entrance to University Museums Building

Albert Kahn, architect. Pumas by Carleton Watson Angell, 1940; black terrazzo

Annotated record of the detailed examination of Mn deposits in the submarine canyons off George Bank taken by the R/V ATlantis in 1939

New surveys were completed and data from the field sheets were kindly furnished by the U. S. Coast and Geodetic Survey to the Woods Hole Oceanographic Institution for use in dredging and coring operations. This field work, first reported in 1936, was continued from time to time until 1941 as new soundings became available. Rock dredging and coring has been carried out in every major canyon on the slope from Corsair Canyon at the tip of Georges Bank to Norfolk Canyon off the entrance to the Chesapeake. Numerous cores have also been taken from the areas in between; and while the whole slope from Georges to the Chesapeake has not been covered, it is believed that no significant areas have been missed. In the following report the tows and cores will be described by areas from Georges Bank southwards, as the same region was revisited in successive years. The various samples, however, will be referred to by number followed by the year in which they were taken. The material is in storage in the Woods Hole Oceanographic Institution and in the Museum of Comparative Zoology at Harvard University.

Annotated record of the detailed examination of ferromanganese concretions from the Bothnia Gulf, the Baltic Sea and the Barents sea collected by Boström, K. and Ingri, J. (Technical University of Lulea)

The collection of ferromanganese nodules at Naturhistoriska Riksmuseet, Stockholm, Sweden has been donated by Pr. Boström, K. and Ingri, J. from the Technical University of Lulea. They have been collected in the Bothnia Gulf, the Baltic Sea anfd the Barents sea from 1976 until 1985. In 1997 it is was put to the care custody of the Laboratory for Isotope Geology (LIG) of NRM. As part of the Access Project at LIG, Curt Boman has gone through the collection and established a database with detailed information about the samples it contains. Ferromanganese nodules typically display a rounded shape and are formed by redox processes at the interface between the seabed sediment and water. In addition to iron and manganese they also contain other metal elements. Nodules chemical composition reflects the substances found in the sediment to which they are associated. Since the nodules grow continuously, they reflect changes in the sedimentary environment chemistry on a yearly basis, which makes them very interesting as environmental archives. The nodules can be found locally in large quantities and due to their metal content they are also economically interesting as a source of raw materials.

Item and task difficulty in a B2 reading examination: perceptions of test-takers and CEFR alignment experts compared with psychometric measurements

The article presents a study of a CEFR B2-level reading subtest that is part of the Slovenian national secondary school leaving examination in English as a foreign language, and compares the test-taker actual performance (objective difficulty) with the test-taker and expert perceptions of item difficulty (subjective difficulty). The study also analyses the test-takers’ comments on item difficulty obtained from a while-reading questionnaire. The results are discussed in the framework of the existing research in the fields of (the assessment of) reading comprehension, and are addressed with regard to their implications for item-writing, FL teaching and curriculum development.

A re-examination of the Ghrelin and Ghrelin receptor genes

The last few years have seen dramatic advances in genomics, including the discovery of a large number of non-coding and antisense transcripts. This has revolutionised our understanding of multifaceted transcript structures found within gene loci and their roles in the regulation of development, neurogenesis and other complex processes. The recent and continuing surge of knowledge has prompted researchers to reassess and further dissect gene loci. The ghrelin gene (GHRL) gives rise to preproghrelin, which in turn produces ghrelin, a 28 amino acid peptide hormone that acts via the ghrelin receptor (growth hormone secretagogue receptor/GHSR 1a). Ghrelin has many important physiological and pathophysiological roles, including the stimulation of growth hormone (GH) release, appetite regulation, and cancer development. A truncated receptor splice variant, GHSR 1b, does not bind ghrelin, but dimerises with GHSR 1a, and may act as a dominant negative receptor. The gene products of ghrelin and its receptor are frequently overexpressed in human cancer While it is well known that the ghrelin axis (ghrelin and its receptor) plays a range of important functional roles, little is known about the molecular structure and regulation of the ghrelin gene (GHRL) and ghrelin receptor gene (GHSR). This thesis reports the re-annotation of the ghrelin gene, discovery of alternative 5’ exons and transcription start sites, as well as the description of a number of novel splice variants, including isoforms with a putative signal peptide. We also describe the discovery and characterisation of a ghrelin antisense gene (GHRLOS), and the discovery and expression of a ghrelin receptor (growth hormone secretagogue receptor/GHSR) antisense gene (GHSR-OS). We have identified numerous ghrelin-derived transcripts, including variants with extended 5' untranslated regions and putative secreted obestatin and C-ghrelin transcripts. These transcripts initiate from novel first exons, exon -1, exon 0 and a 5' extended 1, with multiple transcription start sites. We used comparative genomics to identify, and RT-PCR to experimentally verify, that the proximal exon 0 and 5' extended exon 1 are transcribed in the mouse ghrelin gene, which suggests the mouse and human proximal first exon architecture is conserved. We have identified numerous novel antisense transcripts in the ghrelin locus. A candidate non-coding endogenous natural antisense gene (GHRLOS) was cloned and demonstrates very low expression levels in the stomach and high levels in the thymus, testis and brain - all major tissues of non-coding RNA expression. Next, we examined if transcription occurs in the antisense orientation to the ghrelin receptor gene, GHSR. A novel gene (GHSR-OS) on the opposite strand of intron 1 of the GHSR gene was identified and characterised using strand-specific RT-PCR and rapid amplification of cDNA ends (RACE). GHSR-OS is differentially expressed and a candidate non-coding RNA gene. In summary, this study has characterised the ghrelin and ghrelin receptor loci and demonstrated natural antisense transcripts to ghrelin and its receptor. Our preliminary work shows that the ghrelin axis generates a broad and complex transcriptional repertoire. This study provides the basis for detailed functional studies of the the ghrelin and GHSR loci and future studies will be needed to further unravel the function, diagnostic and therapeutic potential of the ghrelin axis.