84 resultados para pilling


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Pilling, J.C. Bibl. of the Eskimo language, 1887, p. 56.

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"Mr. Wilberforce Eames ... has contributed ... a number of special articles ... relating to the publications of the Apostle Eliot, the Indiane primer, Lykins, Mather, Mayhew, Meeker, Pierson, Quinney, Rawson, Sergeant, and Simerwell, besides many new titles, biographic material, etc."--Pref., p. iv.

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Title vignette.

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Dutch translation of: Missions de l'Orégon et voyages aux montagnes Rocheuses, which in turn is a translation of the author's Oregon missions and travels over the Rocky Mountains in 1845-46.

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"The manuscript of this work is in the library of the American philosophical society. It is a copy made by Mr. Duponceau, and forms no. xxvii of a collection made by him and recorded in a folio account book, of which it occupies pp. 114-119."--Pilling, Bibl. of the Algonquin languages, p. 227.

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The dynamics of fibre slippage within general non-bonded fibrous assemblies is studied in the situation where the assembly is subjected to general small cyclic loads. Two models are proposed. The first is applicable when the general cyclic loading is complemented by an occasional tugging force on one end of a fibre, which causes it to gradually withdraw from the assembly, such as might occur during the pilling of a textile. The second considers the situation in which the cyclic perturbations act around a constant background load applied to the assembly. The dynamics is reminiscent of self-organized critical behaviour. This model is applied to predict the progressive elongation of a single yarn during weaving.

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Synaptosomal-associated protein 23 (SNAP23) is a SNARE protein expressed abundantly in human skeletal muscle. Its established role is to mediate insulin-stimulated docking and fusion of glucose transporter 4 (GLUT4) with the plasma membrane. Recent in vitro research has proposed that SNAP23 may also play a role in the fusion of growing lipid droplets (LDs) and the channeling of LD-derived fatty acids (FAs) into neighboring mitochondria for β-oxidation. This study investigates the subcellular distribution of SNAP23 in human skeletal muscle using immunofluorescence microscopy to confirm that SNAP23 localization supports the three proposed metabolic roles. Percutaneous biopsies were obtained from the m. vastus lateralis of six lean, healthy males in the rested, overnight fasted state. Cryosections were stained with antibodies targeting SNAP23, the mitochondrial marker cytochrome c oxidase and the plasma membrane marker dystrophin, whereas intramuscular LDs were stained using the neutral lipid dye oil red O. SNAP23 displayed areas of intense punctate staining in the intracellular regions of all muscle fibers and continuous intense staining in peripheral regions of the cell. Quantitation of confocal microscopy images showed colocalization of SNAP23 with the plasma membrane marker dystrophin (Pearson's correlation coefficient r = 0.50 ± 0.01). The intense punctate intracellular staining colocalized primarily with the mitochondrial marker cytochrome C oxidase (r = 0.50 ± 0.012) and to a lesser extent with LDs (r = 0.21 ± 0.01) visualized with oil red O. We conclude that the observed subcellular distribution of SNAP23 in human skeletal muscle supports the three aforementioned metabolic roles.