Nos Pere Marti preuere sot sacrista d[e]la seu rege[n]t de Vicari G[e]neral ... aq[ue]st flagell de pestile[n]cia p[er] la sua special intercessio ... dona[ra] ... ... p[er] q[ue] sia special intercessor y aduocat n[ost]re co[n]tra aq[ue]st flagell de pestilencia ...

Texto datado: "Datis Vale[n]cia pr[incip]ia Julij M.D.X.X.X", tomado de final del texto

[Carta pastoral de] Don Andres Mayoral... Arzobispo de Valencia... A todos los fieles... eneste n[u]s[tro] Arzobispado... p[ara] q[ue] los enfermos pued[a]n com[e]r carne en dias de Ayuno guardando la Forma [Manuscrito]

Contiene: Breve de Papa Benedicto XIV dado en Roma el dia 12 de marzo de 1742, confirmando la licencia a los enfermos para poder comer carne los dias de ayuno preceptivo.

Soil P and cation availability and crop uptake in a forage rotation under conventional and reduced tillage

Long-term conservation tillage can modify vertical distribution of nutrients in soil profiles and alter nutrient availability and yields of crops.

Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury

Substance P, acting via the neurokinin 1 receptor (NK1R), plays an important role in mediating a variety of inflammatory processes. However, its role in acute pancreatitis has not been previously described. We have found that, in normal mice, substance P levels in the pancreas and pancreatic acinar cell expression of NK1R are both increased during secretagogue-induced experimental pancreatitis. To evaluate the role of substance P, pancreatitis was induced in mice that genetically lack NK1R by administration of 12 hourly injections of a supramaximally stimulating dose of the secretagogue caerulein. During pancreatitis, the magnitude of hyperamylasemia, hyperlipasemia, neutrophil sequestration in the pancreas, and pancreatic acinar cell necrosis were significantly reduced in NK1R−/− mice when compared with wild-type NK1R+/+ animals. Similarly, pancreatitis-associated lung injury, as characterized by intrapulmonary sequestration of neutrophils and increased pulmonary microvascular permeability, was reduced in NK1R−/− animals. These effects of NK1R deletion indicate that substance P, acting via NK1R, plays an important proinflammatory role in regulating the severity of acute pancreatitis and pancreatitis-associated lung injury.

Tyrosine replacement in P-selectin glycoprotein ligand-1 affects distinct kinetic and mechanical properties of bonds with P- and L-selectin

Selectins are adhesion molecules that initiate tethering and rolling of leukocytes on the vessel wall. Rolling requires rapid formation and breakage of selectin–ligand bonds that must have mechanical strength to resist premature dissociation by the forces applied in shear flow. P- and L-selectin bind to the N-terminal region of P-selectin glycoprotein ligand-1 (PSGL-1), a mucin on leukocytes. To define determinants on PSGL-1 that contribute to the kinetic and mechanical properties of bonds with selectins, we compared rolling of transfected preB cells expressing P- or L-selectin on transfected cell monolayers expressing wild-type PSGL-1 or PSGL-1 constructs with substitutions in targeted N-terminal residues. Rolling through P- or L-selectin required a Thr or Ser at a specific position on PSGL-1, the attachment site for an essential O-glycan, but required only one of three nearby Tyr residues, which are sites for Tyr-SO3 formation. The adhesive strengths and numbers of cells rolling through P- or L-selectin were similar on wild-type PSGL-1 and on each of the three PSGL-1 constructs containing only a single Tyr. However, the cells rolled more irregularly on the single-Tyr forms of PSGL-1. Analysis of the lifetimes of transient tethers on limiting densities of PSGL-1 revealed that L-selectin dissociated faster from single-Tyr than wild-type PSGL-1 at all shears examined. In sharp contrast, P-selectin dissociated faster from single-Tyr than wild-type PSGL-1 at higher shear but not at lower shear. Thus, tyrosine replacements in PSGL-1 affect distinct kinetic and mechanical properties of bonds with P- and L-selectin.

Oklahoma City ASAP - effectiveness and efficiency. Analytic study no. 1. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

An essay concerning the laws of nations, and the rights of soveraigns : with an account of what was said at the Council-board by the civilians upon the question, whether Their Majesties subjects taken at sea acting by the late king's commission, might not be looked on as pirates? : with reflections upon the arguments of Sir T.P. and Dr. Ol /

Signatures: 1 leaf unsigned, B-E⁴, F² (F2 missing)

The Tampa AID line experiment: extent of use and cost. Analytic study.

National Highway Traffic Safety Administration, Office of Alcohol Countermeasures, Washington, D.C.

An analysis of ASAP patrol activity and enforcement. Analytic study 3. Final study.

National Highway Traffic Safety Administration, Office of Driver and Pedestrian Programs, Washington, D.C.

ASAP public information and education. Analytic study number seven. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Public information and education. Analytic study no. 7. Final study.

National Highway Traffic Safety Administration, Office of Driver and Pedestrian Programs, Washington, D.C.