Biofilm formation at the solid-liquid and air-liquid interfaces by Acinetobacter species.

BACKGROUND The members of the genus Acinetobacter are Gram-negative cocobacilli that are frequently found in the environment but also in the hospital setting where they have been associated with outbreaks of nosocomial infections. Among them, Acinetobacter baumannii has emerged as the most common pathogenic species involved in hospital-acquired infections. One reason for this emergence may be its persistence in the hospital wards, in particular in the intensive care unit; this persistence could be partially explained by the capacity of these microorganisms to form biofilm. Therefore, our main objective was to study the prevalence of the two main types of biofilm formed by the most relevant Acinetobacter species, comparing biofilm formation between the different species. FINDINGS Biofilm formation at the air-liquid and solid-liquid interfaces was investigated in different Acinetobacter spp. and it appeared to be generally more important at 25°C than at 37°C. The biofilm formation at the solid-liquid interface by the members of the ACB-complex was at least 3 times higher than the other species (80-91% versus 5-24%). In addition, only the isolates belonging to this complex were able to form biofilm at the air-liquid interface; between 9% and 36% of the tested isolates formed this type of pellicle. Finally, within the ACB-complex, the biofilm formed at the air-liquid interface was almost 4 times higher for A. baumannii and Acinetobacter G13TU than for Acinetobacter G3 (36%, 27% & 9% respectively). CONCLUSIONS Overall, this study has shown the capacity of the Acinetobacter spp to form two different types of biofilm: solid-liquid and air-liquid interfaces. This ability was generally higher at 25°C which might contribute to their persistence in the inanimate hospital environment. Our work has also demonstrated for the first time the ability of the members of the ACB-complex to form biofilm at the air-liquid interface, a feature that was not observed in other Acinetobacter species.

Prototipação e usabilidade em interfaces para aplicações móveis

Como já é de conhecimento de todos as tecnologias móveis permitem aceder à informação em qualquer lugar e em qualquer altura. Por isso, essas tecnologias móveis podem facilitar o dia-a-dia dos utilizadores, e tornar mais eficiente e eficaz a prestação de serviços. Os profissionais da universidade necessitam de partilhar e aceder à informação adequada para auxiliar nos serviços frequentes do dia-a-dia. Assim a existência de uma interface que interage e disponibilize as diversas informações pode trazer grandes benefícios. Analisando ainda dentro desse contexto existe actualmente alguma falha no sector académico, visto que ainda existe dificuldades em aceder à informação a quem dela necessita, antes pelo contrário, originando atrasos nos afazeres do dia-a-dia. Em muitos casos a introdução de tecnologias pode evitar a ocorrência de problemas. No entanto os profissionais têm de estar preparados para a evolução dos actuais processos nos serviços académicos. Desenvolver um protótipo para aplicações móveis nesta área constitui um desafio, pois não basta somente conhecer os processos realizados pelos potenciais utilizadores, sendo igualmente necessário assegurar que funcionam do mesmo modo quando são executados através de um equipamento com características muito próprias, como os dispositivos de computação móvel.

Quantitative comparison of simulations of seismic wave propagation in heterogeneous poro-elastic media involving fluid-solid interfaces and in equivalent visco-elastic solids

There is increasing evidence to suggest that the presence of mesoscopic heterogeneities constitutes the predominant attenuation mechanism at seismic frequencies. As a consequence, centimeter-scale perturbations of the subsurface physical properties should be taken into account for seismic modeling whenever detailed and accurate responses of the target structures are desired. This is, however, computationally prohibitive since extremely small grid spacings would be necessary. A convenient way to circumvent this problem is to use an upscaling procedure to replace the heterogeneous porous media by equivalent visco-elastic solids. In this work, we solve Biot's equations of motion to perform numerical simulations of seismic wave propagation through porous media containing mesoscopic heterogeneities. We then use an upscaling procedure to replace the heterogeneous poro-elastic regions by homogeneous equivalent visco-elastic solids and repeat the simulations using visco-elastic equations of motion. We find that, despite the equivalent attenuation behavior of the heterogeneous poro-elastic medium and the equivalent visco-elastic solid, the seismograms may differ due to diverging boundary conditions at fluid-solid interfaces, where there exist additional options for the poro-elastic case. In particular, we observe that the seismograms agree for closed-pore boundary conditions, but differ significantly for open-pore boundary conditions. This is an interesting result, which has potentially important implications for wave-equation-based algorithms in exploration geophysics involving fluid-solid interfaces, such as, for example, wave field decomposition.

Elementos para la evaluación de interfaces de consulta de bases de datos

La interfaz de consulta de una base de datos en web sirve para establecer la comunicación entre personas que buscan información y los sistemas de recuperación de la información, siendo una de las partes más importantes del diseño conceptual de una base de datos. La interfaz de consulta está formada por un conjunto de páginas de las cuales podríamos destacar las siguientes: página de consulta, resultados, visualización del documento completo, información general y ayudas. El objetivo del texto consiste en determinar cuáles son los elementos básicos que han de estar presentes en cada una de las páginas antes citadas para contribuir a facilitar el proceso de recuperación de la información por parte de los usuarios.

La financiación del sistema de seguridad social en España: efectos dinámicos de una posible reforma

[spa] Este artículo analiza los efectos de dos posibles reformas en la financiación del actual sistema de Seguridad Social en España, y cuantifica los efectos de dichas reformas sobre los principales agregados macroeconómicos. El tipo de reformas que se analizan son la sustitución del actual régimen de financiación de cotizaciones, por imposición directa e indirecta, y los efectos de variaciones en plazo de cálculo de las pensiones de jubilación. Para este proposito se construye un modelo de equilibrio general de generaciones sucesivas con agentes heterogéneos, calibrado para obtener resultados cuantitativos para el caso español.

Growth of unstable interfaces in disordered media

The effects of a disordered medium in the growth of unstable interfaces are studied by means of two local models with multiplicative and additive quenched disorder, respectively. For short times and large pushing the multiplicative quenched disorder is equivalent to a time-dependent noise. In this regime, the linear dispersion relation contains a destabilizing contribution introduced by the noise. For long times, the interface always gets pinned. We model the systematics of the pinned shapes by means of an effective nonlinear model. These results show good agreement with numerical simulations. For the additive noise we find numerically that a depinning transition occurs.

Magnetoresistance at artificial interfaces in the itinerant SrRuO3 ferromagnet

The magnetoresistance across interfaces in the itinerant ferromagnetic oxide SrRuO3 have been studied. To define appropriately the interfaces, epitaxial thin films have been grown on bicrystalline and laser-patterned SrTiO3 substrates. Comparison is made with results obtained on similar experiments using the double-exchange ferromagnetic oxide La2/3Sr1/3MnO3. It is found that in SrRuO3, interfaces induce a substantial negative magnetoresistance, although no traces of the low-field spin tunneling magnetoresistance are found. We discuss these results on the basis of the distinct degree of spin polarization in ruthenates and manganites and the different nature of the surface magnetic layer formed at interfaces.

La financiación del sistema de seguridad social en España: efectos dinámicos de una posible reforma

[spa] Este artículo analiza los efectos de dos posibles reformas en la financiación del actual sistema de Seguridad Social en España, y cuantifica los efectos de dichas reformas sobre los principales agregados macroeconómicos. El tipo de reformas que se analizan son la sustitución del actual régimen de financiación de cotizaciones, por imposición directa e indirecta, y los efectos de variaciones en plazo de cálculo de las pensiones de jubilación. Para este proposito se construye un modelo de equilibrio general de generaciones sucesivas con agentes heterogéneos, calibrado para obtener resultados cuantitativos para el caso español.

Interfaces entre a ciência da informação e a ciência cognitiva

Estudo panorâmico sobre aspectos da ciência da informação (CI) e da ciência cognitiva (CC), apontando recentes contribuições em quatro de suas possíveis interseções: categorização, indexação, recuperação da informação (RI) e interação homem-computador.

Modelos dinámicos en finanzas

El problema de la modelización dinámica enfinanzas tiene mucho que ver con el tipo deproblema que se pretende estudiar. Es preciso teneren cuenta el subyacente así como las magnitudesque se pretende estimar para elegir el modeloadecuado.-