Long-term clinical and ultrasonographic evaluation of thrombophilic patients with deep venous thrombosis

OBJECTIVE:The purpose of this study was to evaluate the long term clinical and ultrasonographic outcomes of thrombophilic patients with deep venous thrombosis (DVT).METHOD:Cohort study, retrospective case-control with cross-sectional analysis. Thirty-nine thrombophilic patients and 25 non-thrombophilic patients were assessed 76.3 ± 45.8 months after diagnosis. Demographic and family data were collected, as well as data from clinical and therapeutic progress, and physical and ultrasound examinations of the limbs were performed. Groups were matched for age and gender and the variables studied were compared across groups.RESULTS:Deep venous thrombosis was more frequent in women. The most common thrombophilias were antiphospholipid syndrome and factor V Leiden mutation. There was no difference between groups in terms of the number of pregnancies or miscarriages and the majority of women did not become pregnant after DVT. Non-spontaneous DVT prevailed. Proximal DVT and DVT of the left lower limb were more frequent, and the main risk factor was use of oral contraceptives. All patients were treated with anticoagulation. There was a higher frequency of pulmonary embolism in non-thrombophilic patients. Most patients considered themselves to have a normal life after DVT and reported wearing elastic stockings over at least 2 years. Seventy-one percent of patients had CEAP > 3, with no difference between groups. Deep venous reflux was more frequent in thrombophilic patients.CONCLUSION:There were no significant differences between groups with respect to most of the variables studied, except for a higher frequency of pulmonary embolism in non-thrombophilic patients and greater frequency of deep venous reflux in thrombophilic patients.

Healing Patterns After Subgingival Placement of a Resin-Modified Glass-Ionomer Restoration: A Histometric Study in Dogs

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Salivary carriage of periodontal pathogens in generalized aggressive periodontitis families

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The Kallikrein Inhibitor from Bauhinia bauhinioides (BbKI) shows antithrombotic properties in venous and arterial thrombosis models

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

CrataBL, a lectin and Factor Xa inhibitor, plays a role in blood coagulation and impairs thrombus formation

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Factor V Arg306 → Thr (factor V Cambridge) and factor V Arg306 → Gly mutations in venous thrombotic disease

We investigated the prevalence of two reported mutations of the factor V gene (factor V Arg306 → Thr, or factor V Cambridge, and factor V Arg306 → Gly) in 104 relatively young patients with verified venous thrombosis and in 208 age-, sex- and race-matched controls, in order to establish whether the two mutations are associated with increased predisposition for venous thrombosis. PCR amplification followed by BstNI and MspI digestion was employed to determine the genotypes, and each mutation was confirmed by DNA sequencing. Among the controls, one individual was found to be heterozygous for the factor V Arg306 → Thr mutation and one heterozygous for the factor V Arg306 → Gly mutation; none of the patients carried either mutation. Our findings do not support factor V Cambridge and factor V Arg306 → Gly as risk factors for venous thrombosis.

Two new species of marsupial tree-frogs genus Gastrotheca Fitzinger, 1843 (Anura, Hemiphractidae) from the Brazilian Atlantic Forest

Two new species of Gastrotheca are described from northeastern Minas Gerais and southern Bahia, in the Atlantic Forest of Brazil. Data on morphology, calls, mitochondrial, and nuclear DNA are provided. Allied to G. fissipes and G. megacephala, the new taxa provide evidence for a higher diversity of species of Gastrotheca than previously thought at the Atlantic Forest. The data also suggest that G. pulchra, another Atlantic Forest taxon, is more closely related to non-Atlantic Forest species than to the remaining analyzed Brazilian Gastrotheca species. This implies that the Gastrotheca at the Brazilian coastal forests have at least two independent origins.

Cigarette smoke inhalation influences bone healing of post-extraction tooth socket: a histometric study in rats

The aim of this study was to evaluate, histometrically, the bone healing of the molar extraction socket just after cigarette smoke inhalation (CSI). Forty male Wistar rats were randomly assigned to a test group (animals exposed to CSI, starting 3 days before teeth extraction and maintained until sacrifice; n=20) and a control group (animals never exposed to CSI; n=20). Second mandibular molars were bilaterally extracted and the animals (n=5/group/period) were sacrificed at 3, 7, 10 and 14 days after surgery. Digital images were analyzed according to the following histometric parameters: osteoid tissue (OT), remaining area (RA), mineralized tissue (MT) and non-mineralized tissue (NMT) in the molar socket. Intergroup analysis showed no significant differences at day 3 (p>0.05) for all parameters. On the 7th day, CSI affected negatively (p<0.05) bone formation with respect to NMT and RA (MT: 36%, NMT: 53%, RA: 12%; and MT: 39%, NMT: 29%, RA: 32%, for the control and test groups, respectively). In contrast, no statistically significant differences (p>0.05) were found at days 10 and 14. It may be concluded that CSI may affect socket healing from the early events involved in the healing process, which may be critical for the amount and quality of new-bone formation in smokers.

Extrafiscalidade: análise da norma potiguar regulamentadora do imposto sobre propriedade veicular automotora à luz da tutela ambiental

From the second half of the twentieth century the state bega n to use exaction beyond your fiscalist character, also as a means of alignment deformities economic and social balance, influencing in different directions, according to economic, social and political policy. It is what is usually called the extrafiscalit y. It is in light of this phenomenon and the constitutional perspective, the present work aims to analyze item IV of article. 8 of Law n. 6.967/96, regulatory Property Tax Vehicle Automotive (property taxes) in the State of Rio Grande do Norte, in view of its possible incompatibility with the principles of the Basic Statute and with international guidelines for protection of the environment The problem of this research is Seated in art. 225 of the Constitution, which provides that everyone has the right to an ecologically balanced environment. From the reading of this standard, extracted it is the responsibility of the state protecting the environment, which requires the adoption of suitable actions to that end. However, we look to state law cited follows th e constitutional path, since it exempts the collection of property taxes automotive vehicles with over 10 years of manufacturing, which could encourage the conservation of a fleet of old vehicles, mostly more polluting and harmful to the environment and hu man health. Would the state legislature oblivious to the constitutional principles and the global trend of environmental preservation? Thus questions whether such an incentive for more polluting vehicles, emitting more gases in the atmosphere. Moreover, th e international community is already moving through important conventions in an attempt to minimize and control global warming and climate change. Predicting the theme in CF/88 demonstrates that the country is no stranger to the issue. Thus, the work is a retelling of Law No. 6.967/96 order to check whether it is compatible with the existing system. The methodology consists of a documentary, deductive, dialectical literature. At the end of the survey, it was found that provide a tax benefit to these vehicle s is encouraged to maintain them in circulation and contribute to the increase in air and noise pollution, in addition to the traffic problems generated. Thus, this potiguar anything standard can be expressed extrafiscality because the medium and long term there is encouragement and worsening environmental problem. Despite the ability to pay clause, but this remission is an affront to legally protected interests. Thus, this device goes in reverse order compared to the values of the legal system and in relat ion to sustainable development. Modern Tax Law should be used as a tool to achieve the purposes collimated by the State, and not otherwise. It was noticed that the vast majority of Brazilian states does not follow this rule, including Mato Grosso and Minas Gerais have no such exemption. Therefore, the RN State does not constitute a model for sustainable public policies, nor example of environmental protection by state law.

Produção animal no Brasil: caracterização, simulação de cenários para pastagens e alternativas de adaptação às mudanças climáticas.

2015

Atributos desejáveis para gramados a serem cultivados sob condições brasileiras: uma proposta.

2016

Avaliação do desempenho de gramíneas para paisagismo submetidas à diferentes níveis de fertilidades de solo.

2016

Diversidade da fauna de invertebrados associada a três genótipos de Paspalum notatum para uso como gramados.

2016

Entrevista a Francisco Proaño Arandi: se trataba de crear en el lector una sensación de angustia frente a la realidad (Homenaje)

En este diálogo entre el escritor Francisco Proaño Arandi (Premio latinoamericano José María Arguedas, La Habana, 2010) y el lúcido crítico y ensayista Alejandro Moreano, se pasa revista a los años de formación del narrador, la década de los 60, los tzántzicos, la creación de la revista La bufanda del sol, el Frente Cultural en Quito. Proaño, hurgando en la memoria, reconstruye los diversos momentos de lo que fue el debate político y literario de esos años, el peso de la Revolución cubana, las ideas y las propuestas del compromiso del filósofo Jean-Paul Sartre, las luchas anticolonialistas en África, Mayo del 68 y su repercusión en la juventud del mundo, los escritores del boom de la narrativa latinoamericana, su experiencia como diplomático de carrera durante procesos y gobiernos que se sucedieron en el Ecuador en los años 80 y 90. El escritor también da cuenta de lo que es su universo narrativo, las obsesiones, la presencia de una ciudad como Quito en sus diversas novelas y cuentarios, así como la reflexión que a través de sus personajes realiza de las complejas relaciones de la pareja. Diálogo que no solo significó el encuentro de escritores de una misma generación, sino de dos amigos que han sabido compartir la pasión por la escritura de manera vital.

Diseño de un sistema de gestión administrativa para la Biblioteca Nacional Francisco Gavidia de la ciudad de San Salvador.

A través de los años, las diferentes administraciones en la Biblioteca Nacional Francisco Gavidia de El Salvador, no han implementado un sistema de gestión administrativa que integre las diferentes tareas y funciones institucionales en un todo, donde se elaboren objetivos que guíen el quehacer organizacional para obtener logros importantes que coadyuven al mejoramiento de los servicios que ofrece la Institución. Por tal razón, para eficientizar la administración en la BINAC se ha diseñado la presente propuesta que contiene herramientas administrativas necesarias, así como aspectos que contribuyen a la realización de una buena gestión. Para la realización de la investigación se describió, analizó e interpretó la situación problemática que acontece en la BINAC. En la elaboración del diagnóstico administrativo se utilizaron diferentes técnicas que permitieron recabar la información, entre ellos se encuentran: la entrevista, la encuesta y la observación. Posteriormente, se procesó la información por medio de un sistema manual utilizando hojas tabulares para facilitar el proceso de integración de la información. Los resultados obtenidos reflejaron deficiencias en las fases del proceso administrativo, lográndose de esta manera la determinación de la situación real y necesidades que demanda el quehacer administrativo de la BINAC, lo cual permitió establecer las siguientes conclusiones y recomendaciones: CONCLUSIONES: a. Los componentes de la planeación como visión, misión y objetivos de la BINAC son conocidos de manera general por los empleados. b. Con relación a la funciones de los colaboradores específicamente, conocen de manera general las actividades que desempeñan y muchas veces las conocen de manera empírica lo que ocasiona que no las tengan bien definidas. c. Referente a la comunicación dentro de las unidades administrativas, tanto de jefes como de colaboradores es deficiente, debido a que muchas de ellas se realizan de manera informal, ya que es de tipo verbal. d. No existen herramientas administrativas como: manual organización, de procedimientos y descripción de puestos que ayuden al buen funcionamiento de las actividades y que estandaricen las funciones. RECOMENDACIONES: a. Se debe realizar una adecuada planeación de la institución especialmente en la misión, visión y objetivos con el fin de actualizar los conceptos de manera que puedan ser completos, al mismo tiempo darlos a conocer a todos los empleados. b. Las diferentes unidades de la Biblioteca Nacional deben de contar con herramientas administrativas que describan las funciones generales de la unidad y funciones específicas de los puestos de trabajo tanto de jefaturas como de colaboradores, en la que se describan el conjunto de actividades a realizar. c. Es necesario que los empleados de las unidades deban entender que una comunicación efectiva es importante ya sea entre los jefes y sus colaboradores; todo esto debe formalizarse a través de un sistema de comunicación escrita que pueda coadyuvar al desarrollo de sus actividades. d. Elaborar manuales de organización, procedimientos, descripción de puestos para todas las unidades de la institución los cuales deberán ser difundidos, actualizados y revisados constantemente con el fin de lograr una eficiencia en todos los puestos.