Subsídios geológicos para o planejamento e gestão ambiental do turismo em estâncias: estudo de caso em Paraguaçu Paulista (SP)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Compartimentação morfoestrutural da região do Triângulo Mineiro (MG): aplicado a exploração de recursos hídricos subterrâneos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Zoneamento ecológico-econômico no Tocantins: contribuição metodológica e processual para sua execução

Pós-graduação em Geociências e Meio Ambiente - IGCE

Estudo comparativo das associações de macroinvertebrados bentônicos e do sedimento dos reservatórios de Chavantes e Salto Grande (rio Paranapanema, SP, PR) e avaliação toxicológica da água e sedimento

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Bandamento em cromossomos de peixes: discussão sobre o conceito de compartimentalização cromossômica

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Ecologia trófica das assembléias de peixes do reservatório de Chavantes (Medio rio Paranapanema. SP/PR)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Scattered organization of the histone multigene family and transposable elements in Synbranchus

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Glycosomal Targets for Anti-Trypanosomatid Drug Discovery

Glycosomes are peroxisome-related organelles found in all kinetoplastid protists, including the human pathogenic species of the family Trypanosomatidae: Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. Glycosomes are unique in containing the majority of the glycolytic/gluconeogenic enzymes, but they also possess enzymes of several other important catabolic and anabolic pathways. The different metabolic processes are connected by shared co-factors and some metabolic intermediates, and their relative importance differs between the parasites or their distinct life-cycle stages, dependent on the environmental conditions encountered. By genetic or chemical means, a variety of glycosomal enzymes participating in different processes have been validated as drug targets. For several of these enzymes, as well as others that are likely crucial for proliferation, viability or virulence of the parasites, inhibitors have been obtained by different approaches such as compound libraries screening or design and synthesis. The efficacy and selectivity of some initially obtained inhibitors of parasite enzymes were further optimized by structure-activity relationship analysis, using available protein crystal structures. Several of the inhibitors cause growth inhibition of the clinically relevant stages of one or more parasitic trypanosomatid species and in some cases exert therapeutic effects in infected animals. The integrity of glycosomes and proper compartmentalization of at least several matrix enzymes is also crucial for the viability of the parasites. Therefore, proteins involved in the assembly of the organelles and transmembrane passage of substrates and products of glycosomal metabolism offer also promise as drug targets. Natural products with trypanocidal activity by affecting glycosomal integrity have been reported.

Frações oxidáveis do carbono orgânico total e macrofauna edáfica em sistema de integração lavoura-pecuária

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Compartmentalized gene expression of toll-like receptors 2, 4 and 9 in the brain and peripheral lymphoid organs during canine visceral leishmaniasis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy

Hepatitis C virus (HCV) infection represents an important public health problem worldwide. Reduction of HCV morbidity and mortality is a current challenge owned to several viral and host factors. Virus molecular evolution plays an important role in HCV transmission, disease progression and therapy outcome. The high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures (e.g., host immune responses and antiviral therapy). HCV molecular evolution is shaped by different mechanisms including a high mutation rate, genetic bottlenecks, genetic drift, recombination, temporal variations and compartmentalization. These evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging manner. Remarkable advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against HCV. As a result, superior sustained viral responses have been attained. The rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer, more potent antivirals, bringing us one step closer to the interferon-free era. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

Gestão ambiental aplicada a prevenção, controle e recuperação de erosão linear acelerada no município de Ipeúna-SP

The erosion is a natural process of detachment, transport and deposition of soil and rock particles from one place to another. Human activities with no previous planning may accelerate this process, causing several damages to the environment and to society. In order to control the acceleration of these erosion processes caused by humans, prevention and improvement initiatives emerge. Regarding works which interfere directly in some of the natural resources, these initiatives must respect the intrinsic physical properties of the area of interest, if they aim to obtain effective results. Based on this scenario, this work proposes a few methods of accelerated linear erosion prevention, control and recovery in a specific area of the municipal district of Ipeúna (SP). For that matter, this study is based on a method of physiographic compartmentalization of the area, considering and integrating soil, relief, geology and the use and land cover properties of the study area. Plus, a flowchart with general orientations regarding management of eroded areas was produced, focused on the control and recovery of linear erosion. The result demonstrates the importance of careful erosion control, respecting the physical properties of each physiographic unit. The vegetative and mechanical conservationists methods, and the discipline of water flow, have found wide applicability in the study area.

Mapeamento geológico-geontécnico de trecho da estrada vicinal na Serra de Itaqueri, Charqueada (SP)

Geological-geotechnical problems affecting escarps as well as embankment and fill slopes of roads and motorways may generate different types of unsteadiness, which are mainly arisen from the deficient knowledge about the physical environment. This results in unsuitable engineering projects and inadequate executions, which can be worsened by an occasional inappropriate maintenance of the construction. A geologically-geotechnically characterization of escarps and slopes is crucial in order to prevent these problems. This work deals with a geological-geotechnical study of 1:10.000 scale mapping in a stretch of a local road (CHQ-40) at the Serra de Itaqueri, Charqueada town, State of São Paulo. The stretch is known by several physical problems as erosion and mass movement. The methods of study were based on an integrative analysis of the diverse elements of the physical environment by using aerial photographs - to obtain the physiographic compartmentalization of terrain units - as well as field work - to accomplish the evaluation of the units by employing sketch lists. To achieve this, we selected several techniques in order to identify and classify different types of existing problems as erosion, landslide in embankments and fill slopes, rockfall, block rolling, among others. We also included the analysis of soil horizon, thickness and composition. The geological-geotechnical mapping resulted in six units: 1- Sandstones in cuesta’s backhill; 2 – Basalts in cuesta’s front; 3- Sandstones in cuesta’s front; 4 – Talus and colluvial deposits at cuesta’s foothill; 5- Sandstones of the Piramboia Formation in hillside; and 6 – Colluvial soil in the hill top. A characterization of the geological-geotechnical units is detailed, coupled to the cartographic material. Other cartographic products elaborated for this study included 1:10.000 maps of hypsometry, slope and curvature

Mapeamento geológico-geotécnico na rodovia Amparo - Morungaba (SP - 360)

The work depicts the study of geological and geotechnical characteristics presents, together with an analysis of the physical environment components and evaluation of its units, along a marginal stretch at Rodovia Amparo-Morungaba (SP-360) in order to present a geological and geotechnical map, 1:25.000 scale (one of the objectives of the work). There was also a geotechnical assessment of the present geological processes and the development of corrective measures necessary to establish safe conditions for road traffic. The method for the characterization of geological and geotechnical analysis was integrated the physical components associated with photo interpretation (another objective of this work) based on Google Earth´s air images along the referred highway. In addition, field studies were made that helped in the distribution and compartmentalization of the six geological and geotechnical units and profiles of each specific alteration were also made. The finals results present the above mentioned map, a detailed description of each of the six units and a a geotechnical assessment of the present geological processes and the development of corrective measures necessary to establish safe conditions for road traffic. Also, had success at photo interpretation based on Google Earth´s air images, obtaining stereoscopy

Análise de condicionantes geológico-geotécnicos para o rompimento de pequenas e médias barragens de terra: estudo de caso na bacia do rio Jaguari Mirim no município de São João da Boa Vista, SP

The act of containing water is one of the most practiced by the civilizations along history, in the will to increase the offer of water to many uses. The raise of environmental worries surround many human activities has given a big attention to dams. Indeed, the environmental consequences about dams are proporcional to their size, what gives to the big dams a more detailed Project and a bigger political concerning that increases the built, estability and maintenance of them. Then, the projects of medium and small dams are weak, limitaded to handbooks, textbooks and empirical recommendations, while the constructions of small dams are growing everytime more. With that being said, the present work intends to analise the geological and geotechnical conditionants that can cause break of small earth dams by making a case study in the Jaguari Mirim Watershed, located in the city of São João da Boa Vista (SP), and can be used to encourage the concern with small dams. In the area of study were identificaded, from satellite images, 248 dams. The map of physiographical compartmentalization defined by Pilachevsky (2013) was used to define the locations in the study área that would have bigger risk to the break of dams. Then, 9 of this dams were analised in field research, using references made by Cerri, Reis e Giordano (2011) and the risk of the analised dams were defined. A study about this type of structure is highly necessary to avoid big damages. An analysis of the geological and geotechnical conditionants that can cause break of dams guides the project in a way to avoid adverse consequences, especially when integrated with locacional conditions observed in the place of the dam’s building