Cognitive response control in writer's cramp

Disturbances of the motor and sensory system as well as an alteration of the preparation of movements have been reported to play a role in the pathogenesis of dystonias. However, it is unclear whether higher aspects of cortical – like cognitive – functions are also involved. Recently, the NoGo-anteriorization (NGA) elicited with a visual continuous performance test (CPT) during recording of a 21-channel electroencephalogram has been proposed as an electrophysiological standard-index for cognitive response control. The NGA consists of a more anterior location of the positive area of the brain electrical field associated with the inhibition (NoGo-condition) compared with that of the execution (Go-condition) of a prepared motor response in the CPT. This response control paradigm was applied in 16 patients with writer’s cramp (WC) and 14 age matched healthy controls. Topographical analysis of the associated event-related potentials revealed a significant (P < 0.05) NGA effect for both patients and controls. Moreover, patients with WC showed a significantly higher global field power value (P < 0.05) in the Go-condition and a significantly higher difference-amplitude (P < 0.05) in the NoGo-condition. A source location analysis with the low resolution electromagnetic tomography (LORETA) method demonstrated a hypoactivity for the Go-condition in the parietal cortex of the right hemisphere and a hyperactivity in the NoGo-condition in the left parietal cortex in patients with WC compared with healthy controls. These results indicate an altered response control in patients with WC in widespread cortical brain areas and therefore support the hypothesis that the pathogenesis of WC is not restricted to a pure sensory-motor dysfunction.

An Evening with Lisa Nicole Bell, Award-Winning Media Entrepreneur, Writer, Producer, and On Camera Talent

Lisa Bell is the founder and CEO of Inspired Life Media Group, a Los Angeles-based international content development and production company that works with a diverse cross-section of venture-backed startups, high profile individuals, and fortune 500 brands. Lisa, past content and business ventures are critically-acclaimed, diverse, and plentiful. She created, directed, and produced The American Dream Revised, a digital docuseries that follows a diverse group of young entrepreneurs. Lisa’s past business ventures include startups in technology, personal development, and original content.After launching her first company at 19 years old, she later started a for-profit social enterprise that reached more than 400,000 girls around the world with active programs in Liberia, England, Brazil, and the US.

A complete treatise on the geography of Ireland, on a new plan, never before attempted by any writer.

Mode of access: Internet.

The writer's index of good form and good English,

Mode of access: Internet.

Old times in Oildom, being a series of chapters in which are related the writer's many personal experiences, during fifty years of life in the oil regions,

Mode of access: Internet.

Things I remember; the recollections of a political writer in the capitals of Europe.

Mode of access: Internet.

Junius : including letters by the same writer, under other signatures (now first collected) : to which are added his confidential correspondence with Mr. Wilkes, and his private letters addressed to Mr. H.S. Woodfall : with a preliminary essay, notes, facsimiles, &c. : in three volumes.

Edited by John Mason Good (cf. NUC pre-1956).

Louvet : revolutionist & romance-writer /

Many of the portraits are accompanied by small illustrations designed and engraved by Duplessis Berteaux.

Junius, lord Chatham; a biography, setting forth the condition of English politics preceding and contemporary with the revolutionary Junian period, and showing the the greatest orator and statesman was also the greatest epistolary writer of his age.

An attempt to identify Junius with William Pitt, earl of Chatham.