Effects of two-wheelers on saturation flow at signalized intersections in developing countries

Two-wheelers (TW) constitute a major proportion of urban traffic in developing countries and therefore their effect on the saturation flow at signalized intersections could be substantial. This paper attempts to study and analyze the effect of two-wheelers on the saturation flow of signalized intersections by collecting data at a few signalized intersections in Bangalore, India. A strong correlation is observed between the measured saturation flow and the proportion of two-wheeler traffic, which suggest that two-wheelers have significant impact and should be considered in the capacity analysis of signalized intersections. In this paper, the effect of two-wheelers on saturation flow rate is incorporated in a previous model by calibrating and introducing a new adjustment factor for two-wheelers. Results show that saturation flow measured using the modified HCM equation is closer to observed saturation flow values.

The MHP36 line of murine neural stem cells expresses functional CXCR1 chemokine receptors that initiate chemotaxis in vitro.

Chemokines help to establish cerebral inflammation after ischemia, which comprises a major component of secondary brain injury. The CXCR4 chemokine receptor system induces neural stem cell migration, and hence has been implicated in brain repair. We show that CXCR1 and interleukin-8 also stimulate chemotaxis in murine neural stem cells from the MHP36 cell line. The presence of CXCR1 was confirmed by reverse transcriptase PCR and immunohistochemistry. Interleukin-8 evoked intracellular calcium currents, upregulated doublecortin (a protein expressed by migrating neuroblasts), and elicited positive chemotaxis in vitro. Therefore, effectors of the early innate immune response may also influence brain repair mechanisms.

Anaesthetic impairment of immune function is mediated via GABA(A) receptors.

BACKGROUND: GABA(A) receptors are members of the Cys-loop family of neurotransmitter receptors, proteins which are responsible for fast synaptic transmission, and are the site of action of wide range of drugs. Recent work has shown that Cys-loop receptors are present on immune cells, but their physiological roles and the effects of drugs that modify their function in the innate immune system are currently unclear. We are interested in how and why anaesthetics increase infections in intensive care patients; a serious problem as more than 50% of patients with severe sepsis will die. As many anaesthetics act via GABA(A) receptors, the aim of this study was to determine if these receptors are present on immune cells, and could play a role in immunocompromising patients. PRINCIPAL FINDINGS: We demonstrate, using RT-PCR, that monocytes express GABA(A) receptors constructed of α1, α4, β2, γ1 and/or δ subunits. Whole cell patch clamp electrophysiological studies show that GABA can activate these receptors, resulting in the opening of a chloride-selective channel; activation is inhibited by the GABA(A) receptor antagonists bicuculline and picrotoxin, but not enhanced by the positive modulator diazepam. The anaesthetic drugs propofol and thiopental, which can act via GABA(A) receptors, impaired monocyte function in classic immunological chemotaxis and phagocytosis assays, an effect reversed by bicuculline and picrotoxin. SIGNIFICANCE: Our results show that functional GABA(A) receptors are present on monocytes with properties similar to CNS GABA(A) receptors. The functional data provide a possible explanation as to why chronic propofol and thiopental administration can increase the risk of infection in critically ill patients: their action on GABA(A) receptors inhibits normal monocyte behaviour. The data also suggest a potential solution: monocyte GABA(A) receptors are insensitive to diazepam, thus the use of benzodiazepines as an alternative anesthetising agent may be advantageous where infection is a life threatening problem.

Effect of nonlinear wave-current interaction on flow fields and hydrodynamic forces

A fifth-order theory for solving the problem of interaction between Stokes waves and exponential profile currents is proposed. The calculated flow fields are compared with measurements. Then the errors caused by the linear superposition method and approximate theory are discussed. It is found that the total wave-current field consists of pure wave, pure current and interaction components. The shear current not only directly changes the flow field, but also indirectly does sx, by changing the wave parameters due to wave-current interaction. The present theory can predict the wave kinematics on shear currents satisfactorily. The linear superposition method may give rise to more than 40% loading error in extreme conditions. When the apparent wave period is used and the Wheeler stretching method is adopted to extrapolate the current, application of the approximate theory is the best.

PICES Science: the first ten years and a look to the future

Introduction [pdf, 0.17 MB] Warren S. Wooster [pdf, 0.12 MB] PICES - the first decade, and beyond Paul H. LeBlond [pdf, 0.03 MB] The Physical Oceanography and Climate Committee: The first decade D.E. Harrison and Neville Smith [pdf, 0.04 MB] Ocean observing systems and prediction - the next ten years Tsutomu Ikeda and Patricia A. Wheeler [pdf, 0.85 MB] Ocean impacts from the bottom of the food web to the top: Biological Oceanography Committee (BIO) retrospective Timothy R. Parsons [pdf, 0.2 MB] Future needs for biological oceanographic studies in the Pacific Ocean Douglas E. Hay, Richard J. Beamish, George W. Boehlert, Vladimir I. Radchenko, Qi-Sheng Tang, Tokio Wada, Daniel W. Ware and Chang-Ik Zhang [pdf, 0.2 MB] Ten years FIS in PICES: An introspective, retrospective, critical and constructive review of fishery science in PICES Richard F. Addison, John E. Stein and Alexander V. Tkalin [pdf, 0.12 MB] Marine Environmental Committee in review Robie W. Macdonald, Brian Morton, Richard F. Addison and Sophia C. Johannessen [pdf, 1.89 MB] Marine environmental contaminant issues in the North Pacific: What are the dangers and how do we identify them? R. Ian Perry, Anne B. Hollowed and Takashige Sugimoto [pdf, 0.36 MB] The PICES Climate Change and Carrying Capacity Program: Why, how, and what next? List of acronyms [pdf, 0.07 MB] (Document contains 108 pages)

Proceedings of the 1998 Science Board Symposium on The Impacts of the 1997/98 El Niño Event on the North Pacific Ocean and Its Marginal Seas

Preface [pdf, 0.01 Mb] James J. O'Brien The big picture - The ENSO of 1997-98 [pdf, 0.01 Mb] James E. Overland, Nicholas A. Bond & Jennifer Miletta Adams Atmospheric anomalies in 1997: Links to ENSO? [pdf, 0.54 Mb] Vladimir I. Ponomarev, Olga Trusenkova, Serge Trousenkov, Dmitry Kaplunenko, Elena Ustinova & Antonina Polyakova The ENSO signal in the northwest Pacific [pdf, 0.47 Mb] Robert L. Smith, A. Huyer, P.M. Kosro & J.A. Barth Observations of El Niño off Oregon: July 1997 to present (October 1998) [pdf, 1.31 Mb] Patrica A. Wheeler & Jon Hill Biological effects of the 1997-1998 El Niño event off Oregon: Nutrient and chlorophyll distributions [pdf, 1.13 Mb] William T. Peterson Hydrography and zooplankton off the central Oregon coast during the 1997-1998 El Niño event [pdf, 0.26 Mb] William Crawford, Josef Cherniawsky, Michael Foreman & Peter Chandler El Niño sea level signal along the west coast of Canada [pdf, 1.25 Mb] Howard J. Freeland & Rick Thomson The El Niño signal along the west coast of Canada - temperature, salinity and velocity [pdf, 0.49 Mb] Frank A. Whitney, David L. Mackas, David W. Welch & Marie Robert Impact of the 1990s El Niños on nutrient supply and productivity of Gulf of Alaska waters [pdf, 0.06 Mb] Craig McNeil, David Farmer & Mark Trevorrow Dissolved gas measurements at Stn. P4 during the 97-98 El Niño [pdf, 0.13 Mb] Kristen L.D. Milligan, Colin D. Levings & Robert E. DeWreede Data compilation and preliminary time series analysis of abundance of a dominant intertidal kelp species in relation to the 1997/1998 El Niño event [pdf, 0.05 Mb] S.M. McKinnell, C.C. Wood, M. Lapointe, J.C. Woodey, K.E. Kostow, J. Nelson & K.D. Hyatt Reviewing the evidence that adult sockeye salmon strayed from the Fraser River and spawned in other rivers in 1997 [pdf,0.03 Mb] G.A. McFarlane & R.J. Beamish Sardines return to British Columbia waters [pdf, 0.34 Mb] Ken H. Morgan Impact of the 1997/98 El Niño on seabirds of the northeast Pacific [pdf, 0.06 Mb] Thomas C. Royer & Thomas Weingartner Coastal hydrographic responses in the northern Gulf of Alaska to the 1997-98 ENSO event [pdf, 0.76 Mb] John F. Piatt, Gary Drew, Thomas Van Pelt, Alisa Abookire, April Nielsen, Mike Shultz & Alexander Kitaysky Biological effects of the 1997/98 ENSO in Cook Inlet, Alaska [pdf, 0.22 Mb] H.J. Niebauer The 1997-98 El Niño in the Bering Sea as compared with previous ENSO events and the "regime shift" of the late 1970s [pdf, 0.10 Mb] A.S. Krovnin, G.P. Nanyushin, M.Yu. Kruzhalov, G.V. Khen, M.A. Bogdanov, E.I. Ustinova, V.V. Maslennikov, A.M. Orlov, B.N. Kotenev, V.V. Bulanov & G.P. Muriy The state of the Far East seas during the 1997/98 El Niño event [pdf, 0.15 Mb] Stacy Smith & Susan Henrichs Phytoplankton collected by a time-series sediment trap deployed in the southeast Bering Sea during 1997 [pdf, 0.21 Mb] Cynthia T. Tynan Redistributions of cetaceans in the southeast Bering Sea relative to anomalous oceanographic conditions during the 1997 El Niño [pdf, 0.02 Mb] Akihiko Yatsu, Junta Mori, Hiroyuki Tanaka, Tomowo Watanabe, Kazuya Nagasawa, Yikimasa Ishida, Toshimi Meguro, Yoshihiko Kamei & Yasunori Sakurai Stock abundance and size compositions of the neon flying squid in the central North Pacific Ocean during 1979-1998 [pdf, 0.11 Mb] O.B. Feschenko A new point of view concerning the El Niño mechanism [pdf, 0.01 Mb] Nathan Mantua 97/98 Ocean climate variability in the northeast Pacific: How much blame does El Niño deserve? [pdf, 0.01 Mb] Vadim P. Pavlychev Sharp changes of hydrometeorological conditions in the northwestern Pacific during the 1997/1998 El Niño event [pdf, 0.01 Mb] Jingyi Wang Predictability and forecast verification of El Niño events [pdf, 0.01 Mb] (Document contains 110 pages)

障碍物扰动对半开口管道中火焰传播特性的影响

自从1926年Chanman和Wheeler率先开创有障碍物管道中的火焰传播研究工作以来，管道中障碍物扰动引起的火焰加速现象引起了广泛的关注。由于这类现象在燃烧科学上的学术意义及其在生产中诸如安全问题等方面的实际意义，人们相继进行了一系列的研究工作。归纳起来，可以分为两大类：1）封闭管道的火焰传播。人们在不同形状的管道或容器中研究了障碍物对火焰加速的影响，在理论分析和数值计算方面也作了一些有益的工作；2）开口管道的火焰传播。相对于闭口管道，开口管道中的火焰传播研究则逊色得多。这方面尚缺乏系统的实验数据，理论方面的分析也欠缺得多。但当前在实际中，并不乏开口体系的应用，如，现已广泛应用于电力系统的一种燃气除灰装置，是一燃烧气体燃料的半开口系统。因此，研究半开口管道中非稳态燃烧的加速机制具有重要意义。在本论文工作中，通过大量的实验研究，比较系统地研究了障碍物的扰动对预混火焰传播特性的影响。实验在一长L=5m、内径D＝80mm的一端封闭、一端开口的火焰传播管内进行，管内均匀布置障碍物，通过改变障碍物的形状、间距、阻塞比大小，同时选用五种不同的可燃气体，探索了障碍物结构对预混湍流火焰加速和管内压力上升的影响。实验表明，对于敏感气体如氢气和乙炔，由于障碍物扰动产生的影响，火焰不断加速，并最终达到一准稳定状态；在适当的条件下，火焰传播状态可由爆燃向爆轰转变，此时火焰速度发生跃变；而对干不敏感气体如甲烷，则爆燃转爆轰现象不容易发生。在不同的火焰传播状态，障碍物结构特性对火焰速度和压力产生的影响各不相同。在缓燃态，随着阻塞比的变化，最大火焰速度先上升后下降，在BR=0.3～0.4之间存在一最大值；在銮塞态，最大火焰速度受阻塞比变化的影响不明显，略低于燃烧产物的声速；在阻塞比BR＝0.5附近，压力达到最大值。而在爆轰态，随着阻塞比的增加，最大火焰速度和压力逐渐降低，爆燃转爆轰的浓度范围变小。由于在有障碍物的管道中，火焰速度很容易达到声速（变塞态）或超声速（爆轰态），必须考虑流体的马赫数效应。本文在前人研究成果的基础上，给出了湍流马赫数修正的可压缩性两方程湍流模型，模拟了半开口狭长管道中重复布置的障碍物引起的湍流火焰加速现象。最大火焰速度和管内压力的计算结果与实验测量值吻合良好，这表明用修正后的湍流模型能够比较真实地模拟障碍物管内预混火焰的发展过程。通过对管道内障碍物扰动引起的燃烧波加速的机理和技术研究，对流场扰动对燃烧波产生和发展的影响规律有了比较全面的了解，研究结果对气脉冲除灰技术的完善具有直接的指导意义。

A note on the shallow ponds on the gravel ridge of Epping Forest, Essex

In a recent study in Freshwater Forum on Speakman's Pond (also known as Nursery Pond) the impression was given that it had been a permanent water-filled pond which had recently dried out due to exceptionally low rainfall. In fact, Nursery Pond was created by the extraction of gravel and was never more than 50 cm deep, until the creation of trenches in 1989 to provide a refuge for aquatic life. The Nursery Pond followed a seasonal pattern of filling with winter rain and slowly drying out between 1940 to 1970. It had no established aquatic vegetation, no fish, and only rarely amphibians. Permanent water was present only from about 1979 until 1995 due to leakage from a Thames water storage reservoir.

Mechanism and applications of the photochemistry of Bis(η^5-cyclopentadienyl)titanacyclobutanes

The photochemically induced reductive elimination of cyclopropanes from bis(η⁵-cyclopentadienyl)titanacyclobutanes has been examined. Stereochemical labelling studies indicate that the cyclopropane is initially formed in a 6±1:1, ratio favoring retention of stereochemistry. The starting titanacyclobutane is isomerized during the course of the reaction. The isomerization of the starting material results from metal-carbon bond homolysis to yield a 1,4-biradical, which can either close to give the starting material or generate cyclopropane. The 1,4-biradical can be observed through a cyclopropyl carbinyl rearrangement employing 2-bis(η⁵- cyclopentadienyl)titana-5,5-dimethylbicyclo[2.1.0]pentane, to give the titanium alkylidene, 1-bis(η⁵-cyclopentadienyl)titana-3,3-dimethyl-1,4- pentadiene, which can be observed directly by NMR at low temperature.

The oxidation of titanacyclobutanes by chemical and electrochemical methods also yields cyclopropanes. Reduction of the metal center does not yield cyclopropanes. Depending on the oxidant, stereochemically labelled titanacyclobutanes yield cyclopropanes that are between 7:1 and 100:1 retention:isomerization. The fragmentation reaction resembles the photochemically induced reductive elimination. Both result from formal oxidation of a metal-carbon bond, which then results in very rapid formation of cyclopropane.

The titanocene generated photochemically reacts with a variety of substrates even at low temperature. Titanocene can be generated in a glass at 77 K. The titanocene can be trapped in noncoordinating solvents in high yield with bulky internal acetylenes to give monoacetylene adducts of titanocene. Less bulky acetylenes give the titanacyclopentadienes. The titanocene can be trapped with olefins to give less stable adducts, which appear by NMR analysis to be intermediate in structure between a titanacyclopropane and an η² olefin adduct of titanocene. Reaction of titanocene with butadiene gives a stable product, which appears to be the s-trans butadiene adduct of titanocene. It does not isomerize on heating. Titanocene reacts with epoxides to give titanocene-µ-oxo polymer and olefin. Stereochemically labelled epoxides and episulfides yield isomerized olefin upon deoxygenation by titanocene. The observations are rationalized as a result of a 1,4-biradical formed by stepwise insertion of titanocene into a carbon-oxygen bond.

Some theorems in classical elastodynamic

This investigation is concerned with various fundamental aspects of the linearized dynamical theory for mechanically homogeneous and isotropic elastic solids. First, the uniqueness and reciprocal theorems of dynamic elasticity are extended to unbounded domains with the aid of a generalized energy identity and a lemma on the prolonged quiescence of the far field, which are established for this purpose. Next, the basic singular solutions of elastodynamics are studied and used to generate systematically Love's integral identity for the displacement field, as well as an associated identity for the field of stress. These results, in conjunction with suitably defined Green's functions, are applied to the construction of integral representations for the solution of the first and second boundary-initial value problem. Finally, a uniqueness theorem for dynamic concentrated-load problems is obtained.

Kiribilen kosmologia kuantikorako sarrera

Gradu amaierako lan hau kiribilen kosmologia kuantikorako sarrera bat da. Lan honek 4 kapi- tulu ditu. Lehenengoan, sarrera bezala grabitazio kuantikoak izan duen bilakaera historikoa jaso da, halako teoria bat garatzeko motibazioak eta zailtasunak, eta honen garapenean kosmologia kuantikoak duen papera azalduz. Lanean, oro har, grabitazio kuantikoaren teoria bat eraikitzeko formalismo “kanonikoa” jarraitu da, alegia, erlatibitate orokorraren formulazio hamiltondarra era- biliz teoria kuantikoa garatzea. Bigarren kapituluan grabitazioaren teoria klasikoaren formulazio hamiltondarra garatu da, lehenik Arnowitt-Deser-Misner formalismoaren (Einstein-en geometro- dinamika bezala ere ezaguna denaren) bidez eta ondoren Ashtekar-en aldagaiak erabiliz. Bietan hamiltondar guztiz lotua lortzen da, hots, loturen konbinazio lineala den hamiltondarra. Lotu- ren bidezko formulazio hauen kuantizazioaren eta kribilen adierazpenaren oinarrizko aspektuak jaso dira bigarren kapituluan. Hirugarren kapituluan kosmologiaren teoria klasikoa Friedmann- Lemaˆ ıtre-Robertson-Walker metrika laua erabiliz azaltzen da era laburrean lehenik, eta ondoren Wheeler-DeWitt teoria kuantikoa eta kiribilen kosmologia kuantikoa eta hauek erabiliz lorturiko zenbait emaitza aipatzen dira. Azkenik, ondorioen atalarekin amaitzen da lana. Lana euskaraz idatzita dago.