Understanding Medical Device Patenting and Clinical Trials for Product Leadership

Unmet clinical needs remain the primary driving force for innovations in medical devices. While appropriate mechanisms to protect these innovative outcomes are essential, the performance of clinical trials to ensure safety is also mandated before the invention is ready for public use. Literature explaining the relationship between patenting activities and clinical trials of medical devices is scarce. Linking patent ownership to clinical trials may imply product leadership and value chain control. In this paper, we use patent data from Indian Patent Office (IPO), PCT, and data from Clinical Trials Registry of India (CTRI) to identify whether patent assignees have any role in leading as primary sponsors of clinical trials. A total of 42 primary sponsors are identified from the CTRI database in India. Number of patents awarded to these primary sponsors in the particular medical device, total number of patents awarded to the primary sponsor in all technologies, total number of patents in the specific medical device technology provides an indication of leadership and control in the value chain.

Review paper on the production trials of rice-cum fish culture - a transferable concept into Niger State, Nigeria

This paper reviews the production trials of rice-cum-fish culture. Rice and various fish species using rotation and concurrent methods of cultivation are used. The farming system is mostly practiced and researched in to in Southeast Asian countries. It addresses the problems of high external inputs, sustainable aquaculture, poverty and nutrition in the rural population, insect pests, use of insecticides, weeds control and under-utilization of agricultural lands. The production trials yields are summarized and a summary of annual income per hectare from rice and fish have been given. The yield however depends to a large extent on the species stocked, culture period, fertility of the soil and water, degree of supplemental feeding and culturing methods. The production results are discussed. Niger state is blessed with abundant wetlands/rice fields suitable for the practice. However, ecological differences from country to country and region to region, research and development trials are necessary to ensure a successful adoption of the technology to farmers in the State

Analysis of permanent magnets as elasmobranch bycatch reduction devices in hook-and-line and longline trials

Previous studies indicate that elasmobranch fishes (sharks, skates and rays) detect the Earth’s geomagnetic field by indirect magnetoreception through electromagnetic induction, using their ampullae of Lorenzini. Applying this concept, we evaluated the capture of elasmobranchs in the presence of permanent magnets in hook-and-line and inshore longline fishing experiments. Hooks with neodymium-iron-boron magnets significantly reduced the capture of elasmobranchs overall in comparison with control and procedural control hooks in the hook-and-line experiment. Catches of Atlantic sharpnose shark (Rhizoprionodon terraenovae) and smooth dogfish (Mustelus canis) were signif icantly reduced with magnetic hook-and-line treatments, whereas catches of spiny dogfish (Squalus acanthias) and clearnose skate (Raja eglanteria) were not. Longline hooks with barium-ferrite magnets significantly reduced total elasmobranch capture when compared with control hooks. In the longline study, capture of blacktip sharks (Carcharhinus limbatus) and southern stingrays (Dasyatis americana) was reduced on magnetic hooks, whereas capture of sandbar shark (Carcharhinus plumbeus) was not affected. Teleosts, such as red drum (Sciaenops ocellatus), Atlantic croaker (Micropogonias undulatus), oyster toadfish (Opsanus tau), black sea bass (Centropristis striata), and the bluefish (Pomatomas saltatrix), showed no hook preference in either hook-and-line or longline studies. These results indicate that permanent magnets, although eliciting species-specific capture trends, warrant further investigation in commercial longline and recreational fisheries, where bycatch mortality is a leading contributor to declines in elasmobranch populations.

Integrating fish into seasonally flooded rice fields: on-farm trials in Assam, India

In the State of Assam, floodplains cover 2.6 million ha of area that is traditionally rice growing. The ecosystem in the rice-growing areas has undergone major changes as a result of various developmental activities and adoption of modern farming technology. Rice fields were once the major source of fish for the rural farmers. There has been a sharp decline in fish population in rice field leading to a chronic shortage of fish in the State and a deterioration of the rice ecosystem. This paper describes two on-farm experiments for integrating rice cultivation and fish production with the intent of contributing to the understanding of how raising fish can improve rice yields, riceecosystems and farm incomes.

Freshwater prawn farming trials in Bangladesh

Details are given of pond trials conducted in Bangladesh regarding the culture of freshwater prawn (Macrobrachium rosenbergii ). Integrated rice and prawn farming systems were also experimented and results indicated that the prawn could be a suitable species for such integration. Such systems, pond or integrated, are suggested to be best practiced in the southeastern and southwestern areas of the country where there is tidal water exchange and post-larvae are naturally available.

On-farm trials with rice fish cultivation in the west Kano rice irrigation scheme, Kenya

The viability of integrating rice farming with fish culture was studied in ten (10) rice plots. The on-farm research was done during one rice-growing season starting May 2003. The rice variety used was IR 2793-80-1 while the fish species was the Nile tilapia, Oreochromis niloticus. The fish culture period lasted 77 days. An average fish production of 132.4 kg/ha was obtained. The mean recovery rate of tilapia was 43 per cent. Total rice yield from the fields stocked with fish was lower than from unstocked fields. The net returns were not significantly different.

Feeding trials of green seaweed Ulva fasciata

For the nutritional evaluation of green seaweed Ulva fasciata, a feeding trial was performed in albino rats. The results indicated that the 20% replacement of seaweed U. fasciata instead of carrot or lettuce in rad diet causes no harmful effects, as evident by a non-significant change in blood constituents and serum enzyme levels. The weight gain observed in rats with U. fasciata diet was same as that of control diet. The true digestibility ratio of U. fasciata was 80.20% with carrot and 83.4% with lettuce. The data suggest that the green seaweed U. fasciata could be used as an alternative dietary component in animal fodder.

Preliminary trials on the toxicity of "Algistat" to fish and algae

Preliminary toxicity trials conducted with "Algistat" (an algicide) indicated that a dose of 0,66ppm of the compound was highly toxic to fish and 0.8ppm was the general lethal level for Spirogyra sp. The blue green algae, Oscillatoria sp., Mycrocystis sp. and Anabaena sp. were adversely affected by dosages higher than 0.5 ppm Euglena sp. was not affected even at 1.0 ppm.

Field trials on culture of Clarias batrachus

Culture of Magur, Clarias batrachus on an experimental basis was carried out for a total of 159 days in 6 earthen ponds each of 0.02 ha in area, singly in 2 ponds and in combination with Rohu, Labeo rohita in 4 ponds. Three different artificial feeds were used. Growth of Magur varied from 89 to 110 and survival form 93 to 100%. Out of the 3 feeds used, feed formulation 2 yielded better results. Length-weight relationship parameters were found as log W=0.4979067+1.878346 log L; -1.1116438+2.3511497 log L; and -1.238157+2.433125 log L indicating growth to be not isometric. Relative condition factor (K u) was close to or higher than 1.0 only in fishes higher than 200 mm of total length; K. values which were less than 1.0 up to January, reached values greater than 1.0 by March-April. Condition appears to be influenced by spawning rather than feeding.

Results of comparative fishing trials with rectangular flat and rectangular curved otter boards

The communication deals with the results of comparative fishing operations conducted to study the effectiveness of rectangular flat and rectangular curved otter boards. Based on the analysis of data gathered during the course of actual field trials, following conclusions have been drawn: the average catch per hour of trawling was more by 22 kg during attachment of rectangular curved otter boards. The average horizontal spread between rectangular curved otter boards in action was more by 13% and works out to 50% of the head-rope length of the net including sweeps. The towing resistance of the gear with horizontally curved otter boards was more by 10%.

On the results of preliminary fishing trials with shark long lines in Veraval waters

Experimental fishing operations with shark long lines were conducted in the sea off Veraval with a view to studying their efficiency and gathering information on the available resources of sharks to be used for planning the future gear investigations. The trials were undertaken in 1967, employing departmental fishing vessel "Fishtech No. IV" (10.9 m O.L. and 48 H.P. engine). A total of 5525 hooks were employed and 242 sharks weighing 8629 kg were landed. Data on composition of catch, weight of fishes landed, effectiveness of various baits in capture of different species of sharks and effectiveness of gear including its catch efficiency in this area were compiled. Bait preference was also observed in certain species of sharks caught. Chirocentrus dorab proved to be the cheapest and most effective bait in capture of all the three varieties of sharks landed.