Towards a Variety of Family Models: Economic Contributions of Spouses and Family Power

In Western societies the increase in female employment (especially among married women) is seen as having brought about the crisis of the traditional model of the family, reinforcing the position of the "modern" model - the egalitarian family with two working spouses and a "dual-career" family. In contrast, the transitional situation in the post-communist countries during the 1990s is producing a crisis of the family with two working spouses (the basic type of the communist period) and leading to new power relations within the family. While the growth of dual-earner households in this century has implied modification of family models towards greater symmetry of responsibility for breadwinning and homemaking, there is considerable evidence that women's increased employment does not necessarily lead to a more egalitarian approach to gender roles within the family. The group set out to investigate the economic situation of families and economic power within the fame as a crucial factor in the transformation of families with two working spouses in order to reveal the specific patterns of gender contracts and power relations within the family that are emerging in response to the current political and economic transformation. They opted for a comparative approach, selecting the Czech Republic as a country where the very similar tendencies of a few years ago (almost 100% of women employed and the family as a realm of considerable private freedom where both women's and men's gender identities and the traditional distribution of family responsibilities were largely preserved) are combined with a very different experience in terms of economic inequalities during the 1990s to that of Russia. In the first stage of the study they surveyed 300 married couples (150 in each country) on the question of breadwinning. They then carried out in-depth interviews with 10 couples from each country (selected from among the educated layers of the population), focusing on the process of the social construction of gender, using breadwinning and homemaking as gender boundaries which distinguish men from women. By analysing changes in social position and the type of interpersonal interaction of spouses they distinguished two main types of family contracts: the neo-traditional "communal sharing" (with male breadwinner, traditional distribution of family chores and negotiated family power) and the modern one based on negotiated agreement. The most important pre-conditions of husband-wife agreement about breadwinning seemed to imply their overall gender ideology rather than the economic and/or family circumstances. In general, wives were more likely to express egalitarian views, supporting the blurring or even elimination of many gender boundaries. Husbands, on the other hand, more often gave responses calling for the continued maintenance of gender boundaries. The analysis showed that breadwinning is still an important gender boundary in these cultures, one that is assumed unless it is explicitly questioned and that is seen as part of what makes a man a "real man". The majority of respondents seemed to be committed to egalitarian ideology on gender roles and the distribution of family tasks, including decision making, but this is contradicted by the persistent idea of the husband as the breadwinner. This contradiction is more characteristic of the Russian situation than of the Czech. The quantitative study showed a difference in prevailing family models between the two countries, with a clearer shift towards the traditional family contract in the Russian case. The Czechs were more likely to consider their partnerships as based on negotiated agreement, while the Russians saw theirs as based on egalitarian contract, in both cases seeing this as the norm. The majority of couples said they felt satisfied with their marriage, although in both countries wives seemed to be less satisfied. There was however a difference in the issues that aroused dissatisfaction, with Czech women being more sensitive to issues such as self-realisation, personal independence, understanding and recognition in the family, and Russians to issues of love, understanding and recognition. The most disputed area for the majority of families was chores in the home, presumably because in many families both husband and wife were working hard outside the home and because a number of partners had differing views as to the ideal distribution of chores within the family. The distribution of power in the family seems to be linked to the level of well being. The analysis showed that in the dominant democratic model there is still an inverse connection between family leadership and well being: the more prominent the wife's position as head of the family is, the lower the level of family income. This may reflect both the husband's refusal to play the leading role in the family and even his rejection of any involvement in family issues in such a family. The qualitative research revealed that both men and women see the breadwinning role to be an essential part of masculine identity, a role which the female partner would take on temporarily to assist the male but not permanently since this would threaten the gender boundaries and the man's identity. At the same time, few breadwinners expressed a sense of job satisfaction and all considered their choice as imposed on them by the circumstances (i.e. having a family in difficult times). The group feel that family orientation and some loss of personal involvement in their profession is partly reflected in the fact that many of the men felt more comfortable and self-confident at home than at work. Women's work, on the other hand, was largely seen as a source of personal and self-realisation and social life. Eight out of ten of the Russian women interviewed were employed, although only two on a full-time basis, but none saw their jobs as adding substantially to the family budget. Both partners see the most important factor as the wife's wish to work or stay at home, and do not think it wise for the wife to work at the expense of her part of the "family contract", although husbands from the "egalitarian" relationships expressed more willingness to compromise. The analysis showed clearly that wives and husbands did not construct gender boundaries in isolation, with the interviews providing clear evidence of negotiation. At the same time, husbands' interpretations of their wives' employment were less susceptible to the influence of negotiation than were their gender attitudes and norms about breadwinning. One of the most interesting aspects of the spouses' negotiations was the extent to which they disagreed about what they seemed to have agreed upon. Most disagreements about the breadwinning boundaries, however, were over norms and were settled by changes in norms rather than in behavioural interpretation. Changes in norms were often a form of peace offering or were in response in changes in circumstances. The study did show, however, that many of the efforts at cooperation and compensation were more symbolic than real and the group found the plasticity of expressed gender ideology to be one of the most striking findings of their work. They conclude that the shift towards more traditional gednder distributions of incomes and domestic chores does not automatically mean the reestablishment of a patriarchal model of family power. On the contrary, it seems to be a compromise formation, relatively unstable, temporary and containing self-defeating forces as the split between the personal and professional value of work and its social value expressed in a money equivalent cannot be maintained for generations.

Plakoglobin deficiency protects keratinocytes from apoptosis

The armadillo family protein plakoglobin (Pg) is a well-characterized component of anchoring junctions, where it functions to mediate cell-cell adhesion and maintain epithelial tissue integrity. Although its closest homolog beta-catenin acts in the Wnt signaling pathway to dictate cell fate and promote proliferation and survival, the role of Pg in these processes is not well understood. Here, we investigate how Pg affects the survival of mouse keratinocytes by challenging both Pg-null cells and their heterozygote counterparts with apoptotic stimuli. Our results indicate that Pg deletion protects keratinocytes from apoptosis, with null cells exhibiting delayed mitochondrial cytochrome c release and activation of caspase-3. Pg-null keratinocytes also exhibit increased messenger RNA and protein levels of the anti-apoptotic molecule Bcl-X(L) compared to heterozygote controls. Importantly, reintroduction of Pg into the null cells shifts their phenotype towards that of the Pg+/- keratinocytes, providing further evidence that Pg plays a direct role in regulating cell survival. Taken together, our results suggest that in addition to its adhesive role in epithelia, Pg may also function in contrast to the pro-survival tendencies of beta-catenin, to potentiate death in cells damaged by apoptotic stimuli, perhaps limiting the potential for the propagation of mutations and cellular transformation.Journal of Investigative Dermatology advance online publication, 16 November 2006; doi:10.1038/sj.jid.5700615.

MODEL UPDATING AND STRUCTURAL HEALTH MONITORING OF HORIZONTAL AXIS WIND TURBINES VIA ADVANCED SPINNING FINITE ELEMENTS AND STOCHASTIC SUBSPACE IDENTIFICATION METHODS

Wind energy has been one of the most growing sectors of the nation’s renewable energy portfolio for the past decade, and the same tendency is being projected for the upcoming years given the aggressive governmental policies for the reduction of fossil fuel dependency. Great technological expectation and outstanding commercial penetration has shown the so called Horizontal Axis Wind Turbines (HAWT) technologies. Given its great acceptance, size evolution of wind turbines over time has increased exponentially. However, safety and economical concerns have emerged as a result of the newly design tendencies for massive scale wind turbine structures presenting high slenderness ratios and complex shapes, typically located in remote areas (e.g. offshore wind farms). In this regard, safety operation requires not only having first-hand information regarding actual structural dynamic conditions under aerodynamic action, but also a deep understanding of the environmental factors in which these multibody rotating structures operate. Given the cyclo-stochastic patterns of the wind loading exerting pressure on a HAWT, a probabilistic framework is appropriate to characterize the risk of failure in terms of resistance and serviceability conditions, at any given time. Furthermore, sources of uncertainty such as material imperfections, buffeting and flutter, aeroelastic damping, gyroscopic effects, turbulence, among others, have pleaded for the use of a more sophisticated mathematical framework that could properly handle all these sources of indetermination. The attainable modeling complexity that arises as a result of these characterizations demands a data-driven experimental validation methodology to calibrate and corroborate the model. For this aim, System Identification (SI) techniques offer a spectrum of well-established numerical methods appropriated for stationary, deterministic, and data-driven numerical schemes, capable of predicting actual dynamic states (eigenrealizations) of traditional time-invariant dynamic systems. As a consequence, it is proposed a modified data-driven SI metric based on the so called Subspace Realization Theory, now adapted for stochastic non-stationary and timevarying systems, as is the case of HAWT’s complex aerodynamics. Simultaneously, this investigation explores the characterization of the turbine loading and response envelopes for critical failure modes of the structural components the wind turbine is made of. In the long run, both aerodynamic framework (theoretical model) and system identification (experimental model) will be merged in a numerical engine formulated as a search algorithm for model updating, also known as Adaptive Simulated Annealing (ASA) process. This iterative engine is based on a set of function minimizations computed by a metric called Modal Assurance Criterion (MAC). In summary, the Thesis is composed of four major parts: (1) development of an analytical aerodynamic framework that predicts interacted wind-structure stochastic loads on wind turbine components; (2) development of a novel tapered-swept-corved Spinning Finite Element (SFE) that includes dampedgyroscopic effects and axial-flexural-torsional coupling; (3) a novel data-driven structural health monitoring (SHM) algorithm via stochastic subspace identification methods; and (4) a numerical search (optimization) engine based on ASA and MAC capable of updating the SFE aerodynamic model.

Lógicas y tendencias de la expansión residencial en áreas periurbanas. El Partido de La Plata, Buenos Aires, Argentina, entre 1990 y 2010

Con el propósito de contribuir al conocimiento de las lógicas y tendencias de la expansión residencial en áreas periurbanas y su impronta en la organización futura de las ciudades medias, tendiente al logro de una relación armónica entre la actividad residencial y las otras actividades socioeconómicas que se presentan en dichas áreas, en la presente Tesis doctoral se aborda el estudio del proceso de expansión residencial que se han venido desarrollando en el espacio periurbano del Partido de La Plata desde principios de los años '90 hasta nuestros días. Para tal fin, se profundiza en el estudio de espacios periurbanos, caracterizados por su dinamismo, heterogeneidad y complejidad. En relación a los espacios residenciales que se desarrollan en estas áreas periféricas del Partido, fueron reconocidas tres tendencias diferenciadas: a) el proceso de urbanización cerrada, con tendencias al aislamiento de viviendas y complejos habitacionales, b) la "producción de periferia" relacionada con los sectores de población que no consiguen acceder al mercado formal de la tierra y la vivienda, asociada por lo general a modalidades de asentamiento espontáneo; y c) la ocupación gradual de baldíos urbanos con escasa o nula provisión de servicios y redes de infraestructura. En la presente Tesis se profundizará en las dos primeras de estas modalidades expansivas, indagándose en las lógicas de los distintos actores -sociales, políticos y económicos- que intervienen en el proceso urbano expansivo que hemos denominado "formal cerrado" e "informal abierto", respectivamente. La hipótesis que guía nuestro trabajo plantea que la expansión urbana en el Partido de La Plata trae aparejada una competencia por el territorio entre diferentes usos del suelo y actividades, con el consecuente incremento en los precios de la tierra, abandono de los sectores de bajos ingresos como habitantes originales y disminución del uso de tierra rural. Para dar respuesta a los objetivos e hipótesis planteados en nuestra Tesis, los criterios metodológicos adoptados parten de considerar al territorio como un sistema complejo. En este marco, el abordaje desde una visión sistémica y de la complejidad de nuestro objeto de estudio necesita de un abordaje dialéctico y de la convergencia metodológica para obtener distintos puntos de vista sobre el mismo. En el desarrollo de esta Tesis se han utilizado como herramientas de investigación: el método del estudio de caso, la construcción tipológica, la realización de entrevistas semiestructuradas y en profundidad, la utilización de modelos y la construcción de escenarios urbanos. Finalmente, producto de estos años de investigación en la temática, se arribó a las siguientes conclusiones, que han sido estructuradas en cinco apartados principales en función de su carácter predominantemente teórico, empírico, metodológico y/o propositivo, a saber: 1. el periurbano: ¿espacio de competencia o complementariedad?; 2. la construcción de tipologías como camino explicativo en materia de espacios periurbanos; 3. las lógicas residenciales periféricas: la "privatópolis" y la "precariópolis"; 4. las tendencias residenciales periféricas y los desafíos de la planificación urbana, y 5. nuevos interrogantes y perspectivas surgidos de esta Tesis.

Career guidance in Quebec, Canadá

First, the guidance counselor profession in the province of Quebec will be described: the professional association to which it belongs, the required in- struction, the counselors' tasks and the institutions for which they work. There follows the description of the main current tendencies in career guidance devel- opment in this French-speaking area of Canada with about 7.2 million inhabit- ants, approximately one fourth of the total country population. Finally, a brief description of the Center for Research on Education and Labor of the University of Shebrooke as well as of some instruments that one of the teams is constructing will be provided.

La Eneida en las Metamorfosis de Ovidio : Interpretaciones y parámetros metodológicos para una relectura

En este trabajo se presenta un status quaestionis de las principales tendencias críticas del siglo XX sobre la "Eneida ovidiana" y se proponen cuatro parámetros metodológicos para abordar la secuencia: en primer lugar, considerar las razones para la inclusión de una Odisea en la "Eneida ovidiana", en el marco de las discusiones "sobre" género e influencias de la década del 90; en segundo lugar, precisar las relaciones de la secuencia con el final romano de la obra y las posibilidades de que, aun sin un augusteísmo político, haya una afirmación de Roma; en tercer lugar, otorgarle a la idea de la apoteosis y a la apoteosis de Eneas un papel destacado en la secuencia y en el plan de la obra; por último, aportar algo a la discusión sobre la concepción de hombre en las Metamorfosis y sus diferencias y complemento respecto de Virgilio

Lógicas y tendencias de la expansión residencial en áreas periurbanas. El Partido de La Plata, Buenos Aires, Argentina, entre 1990 y 2010

Con el propósito de contribuir al conocimiento de las lógicas y tendencias de la expansión residencial en áreas periurbanas y su impronta en la organización futura de las ciudades medias, tendiente al logro de una relación armónica entre la actividad residencial y las otras actividades socioeconómicas que se presentan en dichas áreas, en la presente Tesis doctoral se aborda el estudio del proceso de expansión residencial que se han venido desarrollando en el espacio periurbano del Partido de La Plata desde principios de los años '90 hasta nuestros días. Para tal fin, se profundiza en el estudio de espacios periurbanos, caracterizados por su dinamismo, heterogeneidad y complejidad. En relación a los espacios residenciales que se desarrollan en estas áreas periféricas del Partido, fueron reconocidas tres tendencias diferenciadas: a) el proceso de urbanización cerrada, con tendencias al aislamiento de viviendas y complejos habitacionales, b) la "producción de periferia" relacionada con los sectores de población que no consiguen acceder al mercado formal de la tierra y la vivienda, asociada por lo general a modalidades de asentamiento espontáneo; y c) la ocupación gradual de baldíos urbanos con escasa o nula provisión de servicios y redes de infraestructura. En la presente Tesis se profundizará en las dos primeras de estas modalidades expansivas, indagándose en las lógicas de los distintos actores -sociales, políticos y económicos- que intervienen en el proceso urbano expansivo que hemos denominado "formal cerrado" e "informal abierto", respectivamente. La hipótesis que guía nuestro trabajo plantea que la expansión urbana en el Partido de La Plata trae aparejada una competencia por el territorio entre diferentes usos del suelo y actividades, con el consecuente incremento en los precios de la tierra, abandono de los sectores de bajos ingresos como habitantes originales y disminución del uso de tierra rural. Para dar respuesta a los objetivos e hipótesis planteados en nuestra Tesis, los criterios metodológicos adoptados parten de considerar al territorio como un sistema complejo. En este marco, el abordaje desde una visión sistémica y de la complejidad de nuestro objeto de estudio necesita de un abordaje dialéctico y de la convergencia metodológica para obtener distintos puntos de vista sobre el mismo. En el desarrollo de esta Tesis se han utilizado como herramientas de investigación: el método del estudio de caso, la construcción tipológica, la realización de entrevistas semiestructuradas y en profundidad, la utilización de modelos y la construcción de escenarios urbanos. Finalmente, producto de estos años de investigación en la temática, se arribó a las siguientes conclusiones, que han sido estructuradas en cinco apartados principales en función de su carácter predominantemente teórico, empírico, metodológico y/o propositivo, a saber: 1. el periurbano: ¿espacio de competencia o complementariedad?; 2. la construcción de tipologías como camino explicativo en materia de espacios periurbanos; 3. las lógicas residenciales periféricas: la "privatópolis" y la "precariópolis"; 4. las tendencias residenciales periféricas y los desafíos de la planificación urbana, y 5. nuevos interrogantes y perspectivas surgidos de esta Tesis.

Career guidance in Quebec, Canadá

First, the guidance counselor profession in the province of Quebec will be described: the professional association to which it belongs, the required in- struction, the counselors' tasks and the institutions for which they work. There follows the description of the main current tendencies in career guidance devel- opment in this French-speaking area of Canada with about 7.2 million inhabit- ants, approximately one fourth of the total country population. Finally, a brief description of the Center for Research on Education and Labor of the University of Shebrooke as well as of some instruments that one of the teams is constructing will be provided.

La Eneida en las Metamorfosis de Ovidio : Interpretaciones y parámetros metodológicos para una relectura

En este trabajo se presenta un status quaestionis de las principales tendencias críticas del siglo XX sobre la "Eneida ovidiana" y se proponen cuatro parámetros metodológicos para abordar la secuencia: en primer lugar, considerar las razones para la inclusión de una Odisea en la "Eneida ovidiana", en el marco de las discusiones "sobre" género e influencias de la década del 90; en segundo lugar, precisar las relaciones de la secuencia con el final romano de la obra y las posibilidades de que, aun sin un augusteísmo político, haya una afirmación de Roma; en tercer lugar, otorgarle a la idea de la apoteosis y a la apoteosis de Eneas un papel destacado en la secuencia y en el plan de la obra; por último, aportar algo a la discusión sobre la concepción de hombre en las Metamorfosis y sus diferencias y complemento respecto de Virgilio

Lógicas y tendencias de la expansión residencial en áreas periurbanas. El Partido de La Plata, Buenos Aires, Argentina, entre 1990 y 2010

Con el propósito de contribuir al conocimiento de las lógicas y tendencias de la expansión residencial en áreas periurbanas y su impronta en la organización futura de las ciudades medias, tendiente al logro de una relación armónica entre la actividad residencial y las otras actividades socioeconómicas que se presentan en dichas áreas, en la presente Tesis doctoral se aborda el estudio del proceso de expansión residencial que se han venido desarrollando en el espacio periurbano del Partido de La Plata desde principios de los años '90 hasta nuestros días. Para tal fin, se profundiza en el estudio de espacios periurbanos, caracterizados por su dinamismo, heterogeneidad y complejidad. En relación a los espacios residenciales que se desarrollan en estas áreas periféricas del Partido, fueron reconocidas tres tendencias diferenciadas: a) el proceso de urbanización cerrada, con tendencias al aislamiento de viviendas y complejos habitacionales, b) la "producción de periferia" relacionada con los sectores de población que no consiguen acceder al mercado formal de la tierra y la vivienda, asociada por lo general a modalidades de asentamiento espontáneo; y c) la ocupación gradual de baldíos urbanos con escasa o nula provisión de servicios y redes de infraestructura. En la presente Tesis se profundizará en las dos primeras de estas modalidades expansivas, indagándose en las lógicas de los distintos actores -sociales, políticos y económicos- que intervienen en el proceso urbano expansivo que hemos denominado "formal cerrado" e "informal abierto", respectivamente. La hipótesis que guía nuestro trabajo plantea que la expansión urbana en el Partido de La Plata trae aparejada una competencia por el territorio entre diferentes usos del suelo y actividades, con el consecuente incremento en los precios de la tierra, abandono de los sectores de bajos ingresos como habitantes originales y disminución del uso de tierra rural. Para dar respuesta a los objetivos e hipótesis planteados en nuestra Tesis, los criterios metodológicos adoptados parten de considerar al territorio como un sistema complejo. En este marco, el abordaje desde una visión sistémica y de la complejidad de nuestro objeto de estudio necesita de un abordaje dialéctico y de la convergencia metodológica para obtener distintos puntos de vista sobre el mismo. En el desarrollo de esta Tesis se han utilizado como herramientas de investigación: el método del estudio de caso, la construcción tipológica, la realización de entrevistas semiestructuradas y en profundidad, la utilización de modelos y la construcción de escenarios urbanos. Finalmente, producto de estos años de investigación en la temática, se arribó a las siguientes conclusiones, que han sido estructuradas en cinco apartados principales en función de su carácter predominantemente teórico, empírico, metodológico y/o propositivo, a saber: 1. el periurbano: ¿espacio de competencia o complementariedad?; 2. la construcción de tipologías como camino explicativo en materia de espacios periurbanos; 3. las lógicas residenciales periféricas: la "privatópolis" y la "precariópolis"; 4. las tendencias residenciales periféricas y los desafíos de la planificación urbana, y 5. nuevos interrogantes y perspectivas surgidos de esta Tesis.

Career guidance in Quebec, Canadá

First, the guidance counselor profession in the province of Quebec will be described: the professional association to which it belongs, the required in- struction, the counselors' tasks and the institutions for which they work. There follows the description of the main current tendencies in career guidance devel- opment in this French-speaking area of Canada with about 7.2 million inhabit- ants, approximately one fourth of the total country population. Finally, a brief description of the Center for Research on Education and Labor of the University of Shebrooke as well as of some instruments that one of the teams is constructing will be provided.

La Eneida en las Metamorfosis de Ovidio : Interpretaciones y parámetros metodológicos para una relectura

En este trabajo se presenta un status quaestionis de las principales tendencias críticas del siglo XX sobre la "Eneida ovidiana" y se proponen cuatro parámetros metodológicos para abordar la secuencia: en primer lugar, considerar las razones para la inclusión de una Odisea en la "Eneida ovidiana", en el marco de las discusiones "sobre" género e influencias de la década del 90; en segundo lugar, precisar las relaciones de la secuencia con el final romano de la obra y las posibilidades de que, aun sin un augusteísmo político, haya una afirmación de Roma; en tercer lugar, otorgarle a la idea de la apoteosis y a la apoteosis de Eneas un papel destacado en la secuencia y en el plan de la obra; por último, aportar algo a la discusión sobre la concepción de hombre en las Metamorfosis y sus diferencias y complemento respecto de Virgilio

Extreme temperature events analyzed with Fast Fourier Transform

Extreme weather and climate events have received increased attention in the last few years, due to the often large loss of agriculture business and exponentially increasing costs associated with them and insurance planning. This increased attention raises the question as to whether extreme weather and climate events are truly increasing, whether this is only a perceived increase exacerbated by enhanced media coverage, or both. There are a number of ways extreme climate events can be defined, such as extreme daily temperatures, extreme daily rainfall amounts, and large areas experiencing unusually warm monthly temperatures, among others. In this study, we will focus our attention in frost and heatstroke events measuring it as the number of days under 0 ºC and number of days with daily maximum over 30ºC monthly respectively. We have studied the trends in these extreme events applying a Fast Fourier Transform to the series to clarify the tendency. Lack of long-term climate data suitable for analysis of extremes is the single biggest obstacle to quantifying whether extreme events have changed over the twentieth century, including high temporal and spatial resolution observations of temperatures. However, several series have been grouped in different ways: chosen the longest series independently, by provinces, by main watersheds and altitude. On the other hand, synthetic series generated by Luna and Balairón (AEMet) were also analyzed. The results obtained by different pooling data are discussed concluding the difficulties to assess the extreme events tendencies and high regional variation in the trends.

Paisaje de energías: conocimiento estético en el enfoque ambiental del proyecto

Desde hace ya varias décadas la praxis de la ecología ha venido reconociendo la necesidad de estudiar los múltiples sistemas de interacción del ser humano, como especie viva, y su entorno. Entidades espaciales como el paisaje geográfico son empleadas para delimitar sistemas territoriales operados por la sociedad, precisando campos concretos de su acción física, biológica y cultural. La ecología aborda así el conocimiento científico del territorio como asentamiento humano, rastrea sus patrones espaciales y analiza su compleja estructura funcional. En ese contexto, la transferencia de herramientas e instrumentos desde la ecología al ámbito proyectivo posee ya un bagaje de más de cinco décadas. Cada vez con más frecuencia el proyecto emplea parámetros, inventarios, fórmulas, indicadores y tecnologías que tratan de dar una respuesta ambientalmente adecuada a los condicionantes de contorno, por ejemplo aprovechando las condiciones climáticas en la optimización energética o proponiendo programas de usos del suelo que eviten perturbaciones en ecosistemas de interés. Con todo, en el momento presente surgen voces que, ante el dominio indiscutible de los enfoques netamente deterministas, tratan de recordar que los principios del pensamiento ecológico van más allá del mero control cuantitativo de los procesos biofísicos. Recuerdan que la etología demostró a principios del XX que el ser humano, como ser consciente, inviste una relación de intimidad con su entorno que supera tales perspectivas: a través de la correspondencia entre percepción y significación, entre lo físico y lo psíquico, entre interioridad y exterioridad, las personas abrazan la plenitud de aquello que les rodea en un acto de profunda conciliación afectiva. De tal ligadura de intimidad depende, sí o sí, y en toda su profundidad, la aceptación humana del entorno construido. A través de la noción de ambiente [Umwelt] se demuestra que la relación del hombre con su entorno es inseparable, bidireccional y coordinada y, por lo tanto, desde una posición coherente, la experiencia del espacio puede ser examinada a partir de la reciprocidad que constituyen, en continuidad, la persona y el lugar. De esta forma, la tesis dirige su objetivo principal a explorar y considerar, desde el proyecto, el significado y la influencia de la experiencia ambiental del espacio construido en la vida humana. Es más que probable que buena parte de los problemas de desafección del hombre con los paisajes transformados de su contemporaneidad tenga que ver con que tanto las intensidades de la experiencia y percepción humana, como la potestad interpretativa de sus productos culturales, incluyendo la arquitectura, han sido fuertemente reducidas. Ante este problema, la investigación toma como hipótesis la oportunidad que ofrece el pensamiento ecológico de reformular la experiencia estética como un acto de conocimiento, como un evento donde se da el encuentro físico y se construyen significados, donde se sancionan valores sociales y se mira hacia el futuro. Se ha de señalar que la presente tesis doctoral arranca en el Laboratorio de Paisaje del Grupo de Investigación Paisaje Cultural de la Universidad Politécnica de Madrid dirigido por Concha Lapayese y Darío Gazapo, y por tanto hace suyos para el estado del arte los principales conceptos e ideas bajo los que el trabajo teórico y práctico del grupo se viene orientando desde hace años: la consideración del paisaje como acontecimiento; la oscilación de la interpretación entre un paisaje específico y un paisaje genérico en un mundo globalizado; el reconocimiento de la experiencia estética del paisaje como una toma de conciencia social; y en definitiva, la reivindicación de la interioridad en el proyecto contemporáneo. La investigación profundiza en una línea de oportunidad que se abre al promover lo que se ha llamado un conocimiento por lo sentido como estrategia ambiental que permite contrarrestar mitos profundamente arraigados en las estructuras sociales. El primer paso en ese recorrido sería explorar ecológicamente el aporte de la experiencia estética; esto es, su consideración como forma de conocimiento específico. Resultaría pertinente impulsar la idea de la inmersión en el paisaje como fenómeno experiencial, sensual y corporal, y enfrentar, desde ahí, el problema de la aceptación social de lo nuevo y lo trasformado de acuerdo con el momento actual. La exploración sobre la afectividad en el ambiente no es, en cualquier caso, un asunto nuevo. Sin pretensiones de historiografía, dos momentos del siglo XX concentran el interés de la investigación. La primera se corresponde fundamentalmente con la segunda década del siglo, en relación a una serie de influencias que desde los avances científicos determinaron singulares aventuras del arte más experimental. La segunda se posiciona en el entorno de 1970, época en la que es conocido el interés que despertaron las cuestiones ambientales. En ambos casos se han estudiado aportaciones que desvelan conceptos determinantes en la definición de la experiencia estética como un evento de adquisición de conocimiento por lo sentido. Es conveniente adelantar el rol de centralidad que para la investigación tiene el concepto de energía, tal como el propio título subraya. La energía como realidad material y sensible es el sustrato que permite navegar por el principio de unidad epistemológica que subyace al pensamiento ecológico. Sus continuas referencias simbólicas, físicas y metafóricas entre los artistas estudiados no son un mero recurso iconográfico: mantienen inherente el principio de continuidad ambiental en el cual el ser humano y la inmensidad del cosmos navegan indisociables. Un discurso unificado y consistente sobre los aportes de la experiencia estética enfocada como forma de conocimiento por lo sentido hila la lectura histórica, conceptual y práctica de toda la investigación. Con ello se alcanza a hilvanar un diagrama conceptual, modelo de análisis proyectivo, que recoge ideas científicas, filosóficas y proyectivas. De alguna manera, el diagrama trata de dibujar, desde los principios del pensamiento ecológico, la correlación de continuidad que, vacilante, tensa, sutil y frágil se desplaza incesante e irresuelta entre interioridad y exterioridad. ABSTRACT Over the last few decades ecological practice has come to acknowledge a need for studying the multiple systems of interaction between the human being - inasmuch as it is a living species - and its environment. Spatial entities such as the geographic notion of landscape have been used to delimitate the territorial systems operated by society and to describe in detail specific fields of its physical, biological and cultural action. Ecology has thus managed to address the scientific knowledge of the territory as a human settlement, tracking its spatial patterns and analysing its complex functional structure. In this context, the transfer of tools and instruments from the field of ecology to that of design has a tradition already going back more than fifty years. Increasingly more often, design makes use of parameters, inventories, formulas, indicators and technologies to give an environmentally sound response to contour conditions: for instance, taking advantage of the local climate for the optimisation of energy consumption or proposing land uses that avoid disturbing valuable ecosystems. Yet in the present day some voices have arisen that, against the uncontested domination of purely positivistic approaches, are trying to draw attention to the fact that the principles of ecological thought go beyond mere quantitative control of biophysical processes. They point out that, in the early 20th century, ethology proved that the human being, as a conscious entity, invests itself into a relationship of intimacy with its environment that surpasses such perspectives: through the correspondences between perception and signification, between physical and psychological or between inside and outside, people embrace the entirety of their surroundings in an action of deep affective conciliation. It is on this link of intimacy that - fully and unquestionably - human acceptance of the built environment depends. Through the notion of environment [Umwelt] it can be proven that the relationship between the human being and its environment is inseparable, bidirectional and coordinated; and that, therefore, from a coherent position the experience of space can be examined through the reciprocity constituted continuously by person and place. Thus, the main goal in this thesis is to explore and acknowledge, from the standpoint of design, the meaning and influence of the environmental experience in human life. It is extremely likely that many of the issues with mankind’s alienation from the transformed landscapes of the present day arise from the fact that both the intensity of human perception and experience and the interpretive capacity of its cultural products –including architecture - have been greatly reduced. Facing this issue, research has taken as hypothesis the opportunity offered by ecological thought of reformulating aesthetic experience as an act of knowledge – as an event where physical encounter takes place and meanings are constructed; where social values are sanctioned and the path towards the future is drawn. This notwithstanding, the present thesis began in the Landscape Laboratory of the Technical University of Madrid Cultural Landscape Research Group (GIPC-UPM), led by Concha Lapayese and Darío Gazapo; and has therefore appropriated for its state of the art the main concepts and ideas that have been orienting the practical and theoretical work of the latter: the understanding of landscape as an event, the oscillation of interpretation between a specific and a generic landscape within a globalised world; the acknowledgement of the aesthetic experience of landscape as a way of acquiring social awareness; and, all in all, a vindication of interiority in contemporary design. An exploration has been made of the line of opportunity that is opened when promoting what has been termed knowledge through the senses as an environmental strategy allowing to counter myths deeply rooted in social structures. The first step in this path would be an ecological exploration of the contribution of the aesthetic experience; that is, its consideration as a type of specific knowledge. It would be pertinent to further the idea of immersion into the landscape as an experiential, sensual and corporeal phenomenon and, from that point, to face the issue of social acceptance of what is new and transformed according to the values of the present day. The exploration of affectivity in the environment is not, at any rate, a new topic. Without aspiring to make a history of it, we can mark two points in the 20th century that have concentrated the interest of this research. The first coincides with the second decade of the century and relates to a number of influences that, arising from scientific progress, determined the singular adventures of the more experimental tendencies in art. The second is centred around 1970: a period in which the interest drawn by environmental matters is well known. In both cases, contributions have been studied that reveal crucial concepts in defining the aesthetic experience as an event for the acquisition of knowledge through the senses. It is necessary to highlight the role of centrality that the concept of energy has throughout this research, as is evident even in its title. Energy as a material, sensitive reality is the substrate making it possible to navigate through the principle of epistemological unity underlying ecological thought. The continuous symbolic, physical and metaphorical references to it among the artists studied here are not a mere iconographic source: they remind of the inherency of the principle of environmental continuity within which the human being and the immensity of cosmos travel indissociably. A unified, consistent discourse on the contributions of the aesthetic experience addressed as knowledge through the senses weaves together the historic, conceptual and practical reading of the whole research. With it, a conceptual diagram is constructed – a model of design analysis – gathering together scientific, philosophical and design ideas. Somehow, the diagram tries to draw from the principles of ecological thought the correlation of continuity that, vacillating, tense, subtle and fragile, shifts incessantly and unresolved between interiority and exteriority.

Proposed mechanism for stability of proteins to evolutionary mutations

It is shown that the sequence-ordering tendencies induced by design into different fast-folding, thermally stable native structures interfere. This interference results in a type of quasiorthogonality between optimal native structures, which divides sequence space into fast-folding, thermally stable families surrounded by slow-folding, low stability shells. A concrete example of this effect is provided by using a simple α carbon type model in which a complete correspondence is established between sequence and structure. It is speculated that gaps can occur in the space of protein-like sequences separating the sequence families and resulting in a mechanism for stability and diversity of protein sequence information.