Genetically Modified Food in the US and the UK: proponents, dissenters and media coverage

This research is a qualitative study examining the communication surrounding the issue of genetically modified food in the UK and the UK from October, 2011 through September, 2012. Material from biotechnology industry organizations, industry-funded non-profits, groups campaigning against the continued use of the technology, and mainstream media coverage of the issue in both countries during this time was examined using thematic analysis. The issue is analyzed through the lenses of Herman and Chomsky's propaganda model, agenda building and framing theory. The research finds support for agenda building as well as a modernized understanding of the propaganda model, which the researcher argues are complementary theories.

Complete works.

v. 1. Desperate remedies -- v. 2. Far from the madding crowd -- v. 3. A group of noble dames -- v. 4. The hand of Ethelberta -- v. 5-6. Jude, the obscure -- v. 7-8. A laodicean -- v. 9. Life's little ironies -- v. 10. The mayor of Casterbridge -- v. 11. A pair of blue eyes -- v. 12-13. The return of the native -- v. 14. Tess of the d'Urbervilles -- v. 15. The trumpet major -- v. 16. Two on a tower -- v. 17. Under the greenwood tree -- v. 18. The well-beloved -- v. 19. Wessex tales -- v. 20. The woodlanders.

The works of Thomas Hardy in prose and verse,

"Wessex edition."

The writings of Thomas Hardy in prose and verse

III. Novels of ingenuity: v. 14. Desperate remedies.--v. 15. The hand of Ethelberta.--v. 16. A Laodicean.--v. 17. A changed man, [The waiting supper, and other tales: concluding with the Romantic adventures of a milk-maid] Poetical works.--v. 18. Wessex poems and other verses; poems of the past and the present.--v. 19. The Dynasts; parts 1st and 2d.--v. 20. The Dynasts, part 3d. Time's laughingstocks.--v. 21. Satires of circumstance; Moments of vision and Miscellaneous verses.

An investigation to determine the influence of illumination sources on colour discrimination in normal subjects and smokers

Accurate colour vision testing requires using the correct illumination. With the plethora of 'daylight' lamps available, is there a cost-effective alternative to the discontinued MacBeth Easel lamp? Smoking is a known risk factor for macula degeneration. As the macula is responsible for colour discrimination, any toxin that affects it has the potential to influence colour discrimination. Aims: To find a costeffective light source for colour vision testing. To investigate the effect of smoking on colour discrimination. To explore how deuteranomalous trichromats compare with normal trichromats. Methods: Using the Ishihara colour vision test subjects were classified into the groups: 'Normal/Control', 'Smoker/Test', and 'Case Study' (subjects who failed the screening test and did not smoke). They completed the Farnsworth Munsell 100 Hue test under each of the three light sources: Phillips EcoHalo Twist (tungsten halogen - THL), Kosnic KCF07ALU/GU10-865 (compact fluorescent- CFL), and Deal Guardian Ltd. GU103X2WA4B-60 (light-emitting diode - LED) Results: 42 subjects took part in the study: 18 in the Normal/Control group, 18 in the Smoker/Test group, and 6 in the Case Study group. For the Normal/Control group the total error scores (TESs) were significantly lower with the CFL than with the THL (p = 0.017) as it was for the Case Study group (p = 0.009). No significant differences were found between the Normal/Control group and the Smoker/Test group for each light source. Decision tree analysis found pack years to be a significant variable for TES. Discussion: All three light sources were comparable with previous studies. The CFL provided better colour discrimination than the LED despite them both being 6500 K. Deuteranomalous trichromats showed a greatest deviation than normal trichromats using the LED. Conclusions: The Kosnic KCF07ALU/GU10-865 is a cost-effective alternative for colour vision testing. Smoking appears to have an effect on colour vision, but requires further investigation.

Kinome-wide CRISPR-Cas9 screen to identify kinases involved in Taxol resistance in breast cancer

Breast cancer is the most frequently diagnosed cancer in women, accounting for over 25% of cancer diagnoses and 13% of cancer-related deaths in Canadian women. There are many types of therapies for treatment or management of breast cancer, with chemotherapy being one of the most widely used. Taxol (paclitaxel) is one of the most extensively used chemotherapeutic agents for treating cancers of the breast and numerous other sites. Taxol stabilizes microtubules during mitosis, causing the cell cycle to arrest until eventually the cell undergoes apoptosis. Although Taxol has had significant benefits in many patients, response rates range from only 25-69%, and over half of Taxol-treated patients eventually acquire resistance to the drug. Drug resistance remains one of the greatest barriers to effective cancer treatment, yet little has been discerned regarding resistance to Taxol, despite its widespread clinical use. Kinases are known to be heavily involved in cancer development and progression, and several kinases have been linked to resistance of Taxol and other chemotherapeutic agents. However, a systematic screen for kinases regulating Taxol resistance is lacking. Thus, in this study, a set of kinome-wide screens was conducted to interrogate the involvement of kinases in the Taxol response. Positive-selection and negative-selection CRISPR-Cas9 screens were conducted, whereby a pooled library of 5070 sgRNAs targeted 507 kinase-encoding genes in MCF-7 breast cancer cells that were Taxol-sensitive (WT) or Taxol-resistant (TxR) which were then treated with Taxol. Next generation sequencing (NGS) was performed on cells that survived Taxol treatment, allowing identification and quantitation of sgRNAs. STK38, Blk, FASTK and Nek3 stand out as potentially critical kinases for Taxol-induced apoptosis to occur. Furthermore, kinases CDKL1 and FRK may have a role in Taxol resistance. Further validation of these candidate kinases will provide novel pre-clinical data about potential predictive biomarkers or therapeutic targets for breast cancer patients in the future.

Receptive Vocabulary of CLIL and Non-CLIL Primary and Secondary School Learners

CLIL instruction has been reported to be beneficial for foreign language vocabulary learning since CLIL students show higher vocabulary profiles than students of their same age in traditional EFL contexts. However, to our knowledge, the receptive vocabulary knowledge of CLIL and non-CLIL learners at the end of primary and secondary education has not been examined yet. Hence, this study aims at comparing the receptive vocabulary size 79 CLIL primary learners with the receptive vocabulary knowledge of 331 non-CLIL learners at the end of primary and secondary school. Sex-based differences were also analysed. The 2k Vocabulary Levels Test (VLT) was used for the purposes of the study. Results revealed that learners’ receptive vocabulary sizes lie within the most frequent 1000 words, non-CLIL secondary school students throw better results than primary students but the differences between the secondary group and the CLIL group are not statistically significant. As for sex-based differences, we found no significant differences among the groups. These findings led us to believe that the CLIL approach offers a benefit for vocabulary acquisition since CLIL learners have been exposed to the foreign language for a shorter period of time and the results are quite similar to their non-CLIL secondary school partners.

Superconducting Transition-Edge Sensor Physics

Despite record-setting performance demonstrated by superconducting Transition Edge Sensors (TESs) and growing utilization of the technology, a theoretical model of the physics governing TES devices superconducting phase transition has proven elusive. Earlier attempts to describe TESs assumed them to be uniform superconductors. Sadleir et al. 2010 shows that TESs are weak links and that the superconducting order parameter strength has significant spatial variation. Measurements are presented of the temperature T and magnetic field B dependence of the critical current Ic measured over 7 orders of magnitude on square Mo/Au bilayers ranging in length from 8 to 290 microns. We find our measurements have a natural explanation in terms of a spatially varying order parameter that is enhanced in proximity to the higher transition temperature superconducting leads (the longitudinal proximity effect) and suppressed in proximity to the added normal metal structures (the lateral inverse proximity effect). These in-plane proximity effects and scaling relations are observed over unprecedentedly long lengths (in excess of 1000 times the mean free path) and explained in terms of a Ginzburg-Landau model. Our low temperature Ic(B) measurements are found to agree with a general derivation of a superconducting strip with an edge or geometric barrier to vortex entry and we also derive two conditions that lead to Ic rectification. At high temperatures the Ic(B) exhibits distinct Josephson effect behavior over long length scales and following functional dependences not previously reported. We also investigate how film stress changes the transition, explain some transition features in terms of a nonequilibrium superconductivity effect, and show that our measurements of the resistive transition are not consistent with a percolating resistor network model.

Mecenazgo, reforma y música en la catedral de Toledo (1523-1545)

El propósito de este trabajo de investigación es realizar una aproximación al papel que realizan como mecenas musicales y legisladores de la Iglesia dos arzobispos toledanos: Alonso de Fonseca (1475-1534) y Juan Pardo Tavera (1472-1545). El estudio se lleva a cabo a través tanto del análisis de su ámbito personal como del de su relación con la Santa Iglesia Catedral de Santa María de Toledo, y su ascendiente en las ceremonias musicales y litúrgicas que en ella tenían lugar. La franja cronológica escogida para el análisis comprende la etapa en la que gobernaron la archidiócesis primada: desde 1523 hasta 1545, un periodo que constituyó el punto culminante de sus carreras religiosas. El mismo año en que moría el cardenal Tavera, comenzaron las reuniones tridentinas en las que se debatieron y consideraron algunas de las polémicas musicales que se encuentran presentes en la documentación coetánea a los pontífices. Para la consecución de estos objetivos el estudio se divide en dos grandes bloques separados en tres capítulos cada uno, cuya estructura muestra la metodología utilizada. El primer capítulo del primer bloque se centra en las biografías de los dos arzobispos, su conexión con la música y su relación con la documentación central de esta investigación: los manuscritos BPR II/1778 y ACT 9; el segundo capítulo realiza un estudio crítico de estos textos para establecer su autenticidad, su origen y su datación, y el tercero describe brevemente el contenido de las fuentes relacionadas con los pontífices y las contextualiza dentro del gran fondo documental que genera la catedral toledana, para terminar planteando la función de los textos y las circunstancias sociales, estéticas y políticas en que se produjeron...

La tradición monódica hispana en las lamentaciones polifónicas del Renacimiento en España

Las lamentaciones son un género cultivado a lo largo de la historia de la música occidental, desde la Antigüedad al siglo XXI, pero su estudio ha sido tratado de un modo desigual en la historiografía musical religiosa. Todavía son muchas y variadas las cuestiones por resolver con respecto a la práctica de este género en la Edad Media y el Renacimiento. Por tanto, esta investigación de las lamentaciones, junto con los trabajos realizados por otros autores en otros repertorios1, tiene por objetivo contribuir a una reconstrucción más completa de la historia de la música española e hispanoamericana en la Edad Moderna. Esta tesis doctoral analiza la tradición cantollanística hispana en las lamentaciones polifónicas del Renacimiento en España, y su relación con el contexto europeo, estudio que no es posible sin un conocimiento previo de las melodías del canto llano. Casi la totalidad de los polifonistas españoles usaron cantos monódicos preexistentes en sus lamentaciones polifónicas, como hicieron también otros maestros renacentistas. Lo significativo es que los tonos empleados por los compositores españoles son diferentes de las melodías monódicas utilizadas en las lamentaciones polifónicas coetáneas europeas. Esta investigación parte de la hipótesis de que las lamentaciones polifónicas españolas de los siglos XV y XVI están basadas en una tradición monódica medieval de raíz hispana, probable pervivencia del antiguo rito hispano. Por consiguiente, antes de estudiar el corpus polifónico español, hay que desentrañar los rasgos textuales y melódicos de las lamentaciones hispanas en la España medieval, y la pervivencia, transformación y transferencia de este repertorio a los contextos litúrgicos pre- y postridentino —un tema importante que ha sido poco estudiado y a menudo mal comprendido...