Asymmetric Total Synthesis of (+)-Inthomycin C Via O-Directed Free Radical Alkyne Hydrostannation with Ph3SnH and Catalytic Et3B: Reinstatement of the Zeeck-Taylor (3R)-Structure for (+)-Inthomycin C

A new pathway to (+)-inthomycin C is reported that exploits an O-directed free radical hydrostannation reaction on (−)-12 and a Stille cross-coupling as key steps. Significantly, the latter process was effected on 19 where a gauche-pentane repulsive interaction could interfere. Our stereochemical studies on the alkynol (−)-12 and the enyne (+)-7 confirm that Ryu and Hatakeyama’s (3S)-stereochemical revision of (+)-inthomycin C is invalid and that Zeeck and Taylor’s original (3R)-stereostructure for (+)-inthomycin C is correct.

An Association of Cancer Physicians' strategy for improving services and outcomes for cancer patients

The Association of Cancer Physicians in the United Kingdom has developed a strategy to improve outcomes for cancer patients and identified the goals and commitments of the Association and its members.

Summer School Band/Summer School Chorus, July 18, 1939

Concert program for Summer School Band/Summer School Chorus, July 18, 1939

Capitaine Taylor : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58530

Capitaine Taylor du [sous-marin britannique] M3 : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58610

Bertram ou Le château de St-Aldobrand : tragédie en 5 actes / traduite librement de l'anglois du Rév. R.C. Maturin, par MM. Taylor et Ch. Nodier

Titre original : Bertram or the Castel of St Aldobrand