Eleanor Misener

Eleanor Misener was Ralph Misener's mother and it is she that the Aquatic Centre is named after. Ralph Misener was the fourth Chancellor of Brock University.

Eleanor Ostrander Land Grant, 1801

Eleanor Ostrander, daughter of John Clark, and wife of Jacob Ostrander, petitioned for land on March 28, 1797. In her petition she describes herself as the daughter of a loyalist, John Clark, someone who served in “His Majesty’s Service” and that she came into the Province in 1788. Upon this information, Eleanor was granted 200 acres of land in Thorold Township, comprising of lots 115 and 169. Eleanor Clark (b. 1777) and Jacob Ostrander were married 5 October 1794 in St. Mark’s Church, Niagara-on-the-Lake, Ont.

Land Grant for Eleanor Ostrander

This is a land grant for Eleanor Ostrander for 200 acres, Lots 115 and 169, in the Township of Thorold, County of Lincoln, District of Niagara.

Indenture between Samuel Street and Eunice Price

Indenture (vellum) of bargain and sale between Samuel Street of Stamford and Eunice Price widow of the late David Price of Willoughby regarding a part of Lot no. 15 in the 5th Concession in Humberstone - instrument no. 1141, June 14, 1842.

Indenture between William Binkley and Eleanor Binkley to Charles Pierson

Indenture of bargain and sale between William Binkley and Eleanor Binkley of the Township of Crowland to Charles Pierson of the Town of Clifton regarding Lot no. 10 in Block E on Clifton Avenue in the Town of Clifton - instrument no. 7687. July 11, 1859.

Indenture of mortgage between Robert and Eunice Telfer of the Township of London to Ira Spaulding of the Township of Stamford

Indenture of mortgage between Robert and Eunice Telfer of the Township of London to Ira Spaulding of the Township of Stamford for Lot 17 in Block U in the Village of Komoka, Middlesex – instrument no. 1044. This was recorded on Dec. 21, 1857 in Liber B, folio 945, Apr. 7, 1857.

A model for stretch-bend interactions in molecular force fields

Interaction force constants between bond-stretching and angle-bending co-ordinates in polyatomic molecules have been attributed, by some authors, to changes of hybridization due to orbital-following of the bending co-ordinate, and consequent changes of bond length due to the change of hybridization. A method is described for using this model quantitatively to reduce the number of independent force constants in the potential function of a polyatomic molecule, by relating stretch-bend interaction constants to the corresponding diagonal stretching constants. It is proposed to call this model the Hybrid Orbital Force Field. The model is applied to the tetrahedral four co-ordinated carbon atom (as in methane) and to the trigonal planar three coordinated carbon atom (as in formaldehyde).

Overtone bandshapes and IVR: CH stretch overtones in CHCl3

The intracavity photoacoustic dye laser spectrum of CHCl3 in the gas phase at 16 350 cm−1 is reported. The v=6–0 overtone of the CH stretch is observed, and found to exhibit a rotational band contour closely analogous to the v=1–0 fundamental. The implication of this result for intramolecular vibrational energy redistribution is discussed.

Modulation of stretch-induced myocyte remodeling and gene expression by nitric oxide: a novel role for lipoma preferred partner in myofibrillogenesis

Prolonged hemodynamic load as a result of hypertension eventually leads to maladaptive cardiac adaptation and heart failure. The signalling pathways that underlie these changes are still poorly understood. The adaptive response to mechanical load is mediated by mechanosensors which convert the mechanical stimuli into a biological response. We examined the effect of cyclic mechanical stretch on myocyte adaptation using neonatal rat ventricular myocytes with 10% (adaptive) or 20% (maladaptive) maximum strain, 1Hz for 48 hours to mimic in vivo mechanical stress. Cells were also treated with and without L-NAME, a general nitric oxide synthase (NOS) inhibitor to suppress NO production. Maladaptive 20% mechanical stretch led to a significant loss of intact sarcomeres which was rescued by LNAME (P<0.05, n≥5 cultures). We hypothesized that the mechanism was through NOinduced alteration of myocyte gene expression. L-NAME up-regulated the mechanosensing proteins Muscle LIM protein (MLP (by 100%, p<0.05, n=4 cultures)) and lipoma preferred partner, a novel cardiac protein (LPP (by 80%, p<0.05, n=4 cultures)). L-NAME also significantly altered the subcellular localisation of LPP and MLP in a manner that favoured growth and adaptation. These findings suggest that NO participates in stretch-mediated adaptation. The use of isoform selective NOS inhibitors indicated a complex interaction between iNOS and nNOS isoforms regulate gene expression. LPP knockdown by siRNA led to formation of α-actinin aggregates and Z-bodies showing that myofibrillogenesis was impaired. There was an up-regulation of E3 ubiquitin ligase (MUL1) by 75% (P<0.05, n=5 cultures). This indicates that NO contributes to stretch-mediated adaptation via the upregulation of proteins associated mechansensing and myofibrillogenesis, thereby presenting potential therapeutic targets during the progression of heart failure. Keywords: Mechanotransduction, heart failure, stretch, heart, hypertrophy

State-resolved gas-surface reactivity of methane in the symmetric C-H stretch vibration on Ni(100)

The state-resolved reactivity of CH4 in its totally symmetric C-H stretch vibration (�1) has been measured on a Ni(100) surface. Methane molecules were accelerated to kinetic energies of 49 and 63:5 kJ=mol in a molecular beam and vibrationally excited to �1 by stimulated Raman pumping before surface impact at normal incidence. The reactivity of the symmetric-stretch excited CH4 is about an order of magnitude higher than that of methane excited to the antisymmetric stretch (�3) reported by Juurlink et al. [Phys. Rev. Lett. 83, 868 (1999)] and is similar to that we have previously observed for the excitation of the first overtone (2�3). The difference between the state-resolved reactivity for �1 and �3 is consistent with predictions of a vibrationally adiabatic model of the methane reaction dynamics and indicates that statistical models cannot correctly describe the chemisorption of CH4 on nickel.

Mode-specific reactivity of CH4 on Pt(110)-(1Ã2): The concerted role of stretch and bend excitation

The state-resolved reaction probability of CH4 on Pt�110-�1�2 was measured as a function of CH4 translational energy for four vibrational eigenstates comprising different amounts of C-H stretch and bend excitation. Mode-specific reactivity is observed both between states from different polyads and between isoenergetic states belonging to the same polyad of CH4. For the stretch/bend combination states, the vibrational efficacy of reaction activation is observed to be higher than for either pure C-H stretching or pure bending states, demonstrating a concerted role of stretch and bend excitation in C-H bond scission. This concerted role, reflected by the nonadditivity of the vibrational efficacies, is consistent with transition state structures found by ab initio calculations and indicates that current dynamical models of CH4 chemisorption neglect an important degree of freedom by including only C-H stretching motion.