133 resultados para Sequencia de aminoacidos
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Pós-graduação em Química - IQ
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Pós-graduação em Aquicultura - FCAV
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Pós-graduação em Química - IQ
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Educação para a Ciência - FC
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Aquicultura - FCAV
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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O bulbo rostroventrolateral (RVL) é uma estrutura importante para o controle cardiovascular. Em ratos espontaneamente hipertensos (SHR), há evidências de que a transmissão glutamatérgica descendente do RVL aos neurônios pré-ganglionares simpáticos é maior quando comparada com os ratos Wistar Kyoto (WKY). A adrenomedulina (ADM) é um peptídeo de 52 aminoácidos que tem como funções: vasodilatação, broncodilatação e neurotransmissão no sistema nervoso central (SNC). Dados da literatura têm demonstrado que a ADM quando microinjetada no RVL de ratos normotensos anestesiados ou normotensos não anestesiados promove aumento da pressão arterial. Ademais, também já foi demonstrado que a microinjeção bilateral no RVL do antagonista de ADM (adrenomedulina 22-52) em SHR anestesiados foi capaz de reduzir significantemente a pressão arterial, enquanto que não foi observado alterações da pressão arterial em ratos normotensos. Uma vez que foi descrito que em SHR há um maior número de receptores de ADM no RVL quando comparado com ratos normotensos, esses dados obtidos são convergentes com a idéia de que maior número de receptores de ADM no RVL de SHR possam ser um dos fatores responsáveis pela hipertensão nestes animais. Entretanto, até o momento, não sabemos os efeitos da ADM no RVL de SHR não anestesiados, uma vez que a anestesia pode interferir com a resposta cardiovascular. Estudos anteriores demonstraram que o efeito pressor da ADM no RVL são dependentes de receptores glutamatérgicos, sugerindo uma interação entre a ADM e o glutamato (GLU). Assim, seria interessante estudar a interação entre ADM e a neurotransmissão glutamatérgica no RVL. Por isso, o presente estudo teve como objetivo estudar os efeitos da microinjeção de ADM no RVL e seu efeito sobre a resposta pressora do GLU em ratos normotensos e SHR conscientes... (Resumo completo, clicar acesso eletrônico abaixo)
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The area of this work is located along the Northern portion of the Pelotas´s basin. The onshore region extends from the Southern portion São Paulo State to the North of Rio Grande do Sul State, with a total area of 440 530 km ². The objective of the research is to characterize the main geological structures of the outcropping basement in the Paraná Basin and its correlation with the offshore portion of the Pelotas Basin. The characterization was performed through the integration of surface (SRTM images and outcrops) and subsurface data (seismic data and well logs), the method includes the use of remote sensing techniques and seismic interpretation. The main structures to be analyzed are the Tibagi Lineament and the “Torres Syncline in order to verify its influence on the geological evolution and deformation of the basin. As result, it was identified the continuity of the both structures inside the offshore basin (Pelotas Basin); but only the Tibagi Lineament represents an important structural feature in the offshore basin. In this sense, the Tibagi lineament shows a NW-SE direction along the both basins (Pelotas and Paraná) and it is defined by drainages and relief on the continental portion. It was classified as a graben structure limited by normal faults and it also was verified a trend of faults inside the lineament that cuts all the sedimentary package of Itararé Group from Paraná Basin. The Torres syncline is a structure that connects the arches of Ponta Grossa and Rio Grande, showing NW-SE orientation and a low angle dip in the NW direction. Its projection into the Pelotas Basin was not recognized by the methods applied in this work, because a preliminary analyze indicates that its projection corresponds to a structural high inside the Pelotas Basin
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The Roosevelt-Domain Aripuanã that by Filho et al 2004 is characterized by a metavolcanic sedimentary sequence, containing acidic to interemediary metavolcanic rocks and clastic and chemical sediments, deformed and metamorphosed at low grade, with U-Pb age of 1.743 +- 4 Ma, (by Granito Zé do Torno), and circumscribed bodies of granites late to post-orogenic (Aripuanã)...
Análise estrutural de treliças espaciais no software Excel utilizando o médodo dos elementos finitos
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The following paper means to develop a program to make structural analysis of space trusses. The program to be implemented was based on the concepts of the finite element method and used the programing resources of Visual Basic for Applications (VBA) for the Excel Software®. Being Excel® a software of easy access, low cost, capacity to make matrix calculations and with advanced resources of VBA programing, it is possible to develop an economic solution, efficient and precise for structural analysis of space trusses. Firstly is presented a finite elemento method and the space truss. Then is developed a few important algorithms to be used during the development of the program and also the use of a few resources of VBA. And to validate the quality, efficiency and precision of the results, these are compared with the established commercial software Ansys
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The study area is includes in the geological context of Arenópolis Magmatic Arc, a region where there are neoproterozoic associations of granodioritic and tonalitic composiotion. (Ortogneisses of the western Goiás) and sequences metavolcanic-sedimentary (Jaupaci Metavolcanic-sedimentary Sequence ). In the mapped area, both units are covered by a cover-laterite. The Ortogneisses from Goiás West consist of a source granodioritic gneisses, corresponding to the Biotite granodiorite gneisse, and also by tonalitic gneiss composition corresponding to Metatonalit. The Jaupaci Metavolcanic-sedimentary Sequence is formed by Chlorite Schist (Metabasalt), Biotite Schist (Metadacite) and Sericite Schist (Metarhyolite), and even intrusions Sin/Tardi e Post Tectonic, granite to diorite composition (Diorites), and alson tonalitic (Bacilandia Tonalite). Post tectonic intrusions are observed, wich were Hornblend Diorite Porphyry and Lamprophyres, Structural analysis allowed the identification of three deformational events, Dn-1, Dn and Post-Dn. The first event is associated with a bygone foliation, lineation which generates an intersectional event, generating the foliation Sn, this being the most important structure in the study area, generating even the type mineral lineation and stretch. The last deformational event is characterized by folds on different scales, affecting the Sn foliation. The rocks of the region have features s active hydrothermal and regional metamorphism, and are composed os assembly indicative of mineralogical facies metamorphism Green Schist, in chlotite zone, with evidence of retro metamorphism. Locally there are sulfides as pyrite, arsenopyrit and pyrhotite, and te mineralization is associated with the arsenopyrite