Life-patterns on the periphery : a humanities base for development imperatives and their application in the Chicago city-region

Life-Patterns on the Periphery: A Humanities Base for Development Imperatives and their Application in the Chicago City-Region is informed by the need to bring diverse fields together in order to tackle issues related to the contemporary city-region. By honouring the long-term economic, social, political, and ecological imperatives that form the fabric of healthy, productive, sustainable communities, it becomes possible to setup political structures and citizen will to develop distinct places that result in the overlapping of citizen life patterns, setting the stage for citizen action and interaction. Based in humanities scholarship, the four imperatives act as checks on each other so that no one imperative is solely honoured in development. Informed by Heidegger, Arendt, deCerteau, Casey, and others, their foundation in the humanities underlines their importance, while at the same time creating a stage where all fields can contribute to actualizing this balance in practice. For this project, theoretical assistance has been greatly borrowed from architecture, planning theory, urban theory, and landscape urbanism, including scholarship from Saskia Sassen, John Friedmann, William Cronon, Jane Jacobs, Joel Garreau, Alan Berger, and many others. This project uses the Chicago city-region as a site, specifically the Interstate 80 and 88 corridors extending west from Chicago. Both transportation corridors are divided into study regions, providing the opportunity to examine a broad variety of population and development densities. Through observational research, a picture of each study region can be extrapolated, analyzed, and understood with respect to the four imperatives. This is put to use in this project by studying region-specific suggestions for future development moves, culminating in some universal steps that can be taken to develop stronger communities and set both the research site specifically and North American city-regions in general on a path towards healthy, productive, sustainable development.

Strategies to advance translational research into brain barriers

There is a paucity of therapies for most neurological disorders--from rare lysosomal storage diseases to major public health concerns such as stroke and Alzheimer's disease. Advances in the targeting of drugs to the CNS are essential for the future success of neurotherapeutics; however, the delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by the blood-brain barrier, the blood-CSF barrier, or other specialised CNS barriers. These brain barriers are now recognised as a major obstacle to the treatment of most brain disorders. The challenge to deliver therapies to the CNS is formidable, and the solution will require concerted international efforts among academia, government, and industry. At a recent meeting of expert panels, essential and high-priority recommendations to propel brain barrier research forward in six topical areas were developed and these recommendations are presented here.

The history of the hebrew nation : from its first origin to the present time

by J. W. Brooks

Developmental disorder associated with increased cellular nucleotidase activity

Four unrelated patients are described with a syndrome that included developmental delay, seizures, ataxia, recurrent infections, severe language deficit, and an unusual behavioral phenotype characterized by hyperactivity, short attention span, and poor social interaction. These manifestations appeared within the first few years of life. Each patient displayed abnormalities on EEG. No unusual metabolites were found in plasma or urine, and metabolic testing was normal except for persistent hypouricosuria. Investigation of purine and pyrimidine metabolism in cultured fibroblasts derived from these patients showed normal incorporation of purine bases into nucleotides but decreased incorporation of uridine. De novo synthesis of purines and cellular phosphoribosyl pyrophosphate content also were moderately decreased. The distribution of incorporated purines and pyrimidines did not reveal a pattern suggestive of a deficient enzyme activity. Assay of individual enzymes in fibroblast lysates showed no deficiencies. However, the activity of cytosolic 5′-nucleotidase was elevated 6- to 10-fold. Based on the possibility that the observed increased catabolic activity and decreased pyrimidine salvage might be causing a deficiency of pyrimidine nucleotides, the patients were treated with oral pyrimidine nucleoside or nucleotide compounds. All patients showed remarkable improvement in speech and behavior as well as decreased seizure activity and frequency of infections. A double-blind placebo trial was undertaken to ascertain the efficacy of this supplementation regimen. Upon replacement of the supplements with placebo, all patients showed rapid regression to their pretreatment states. These observations suggest that increased nucleotide catabolism is related to the symptoms of these patients, and that the effects of this increased catabolism are reversed by administration of uridine.

University of Michigan Football Team, 1904

Top Row: assistant coach William Cole, Ted Stuart, James De Pree, Paul Magoffin, Walter Graham, Harry Patrick,

Middle Row: Hal Weeks, Harry Hammond, Thomas Jefferson Smull, Charles Briggs, Adolph "Germany" Schulz, Jay Mack Love, John Garrels, William Dennison Clark, Walter Rheinschild, Edward Hammond, Walter Becker

Front Row: trainer Keene Fitzpatrick, Tom Hammond, John Curtis, Henry Schulte, captain Willie Heston, , Frank Longman, Charles Carter, coach Fielding Yost, student mngr. Albert H. Montgomery

Seated in front: Fred Norcross

1906 University of Michigan Baseball Team

Top Row:mngr. Dell Dawes Dutton, Edward Dunne, Frank Sanger, John Loell, William Patterson, Maxwell Emmerman

Middle Row: Henry Taft, John Sullivan, Fred DeNeffe, Carmel Martin

Front Row: Falconer O'Brien, captain Roswell Wendell, George Kelly

Commercial tariffs and regulations of the several states of Europe and America : together sith the commercial treaties between England and foreign countries /

Report on Mexico made to the British Lords of the Committee of Privy Council for Trade and Plantations, containing treaties of commerce and navigation between Great Britain and Mexico, customs' tariff, commercial regulations, monies, weights, measures, and reports on trade, navigation, manufactures, finances, mining, Indian population, etc. The majority of this work relates to California, New Mexico, Oregon Territory and Russian America.

Plant uptake of cadmium from phosphate fertilizer /

Mode of access: Internet.

White heather : a novel /

Mode of access: Internet.

Mr. Fortescue : an Andean romance /

Mode of access: Internet.

Charles James Fox. A political study

Mode of access: Internet.

The Fitzwilliam virginal book /

"Erroneously known as 'Queen Elizabeth's virginal book'."

Strength out of weakness : or A glorious manifestation of the further progress of the gospel among the Indians in New England /

Includes letters from John Eliot, John Wilson, William Leverich, Anthony Bessey, Thomas Mayhew, John Endecott, William French and Thomas Allen. The Epistle dedicatory is signed by William Steele. "To the reader" signed: William Gouge [and seventeen others].

Scottish national melodies /

Mode of access: Internet.