Anatomia foliar de cinco espécies de Polygala de restinga e cerrado

A plasticidade ecológica observada em plantas que ocupam diferentes formações vegetais é frequentemente acompanhada por variações morfológicas, sendo a folha o órgão vegetativo com a maior variação estrutural. Diante disso, cinco espécies de Polygala L. ocorrentes em restinga e cerrado do Estado de São Paulo tiveram a anatomia da folha analisada com o objetivo de efetuar um inventário dos seus principais caracteres e descrever sua estrutura, com o propósito de compará-las, e de avaliar se é possível evidenciar padrões estruturais comuns às condições ecológicas de ambas as formações vegetacionais. As espécies pesquisadas foram: P. cyparissias A.St. –Hil. & Moq., P. laureola A.St.-Hil. & Moq., P. paniculata L., encontradas em restinga; P. angulata DC. e P. violacea Aubl. emend. Marques, que ocorrem em campo cerrado e em margem de cerradão, respectivamente. A região mediana da lâmina foliar e a região proximal do pecíolo de cada folha foram processadas segundo as técnicas usuais para microscopia eletrônica de varredura e de luz. Os resultados obtidos evidenciam dois padrões estruturais comuns às espécies procedentes das formações de restinga e cerrado: características mesomórficas são observadas em P. laureola, P. paniculata e P. violacea, e xeromórficas em P. cyparissias e P. angulata.

Influência da atividade das mataloproteinases 2 e 9 na diminuiçao o colágeno tipo I miocárdico em ratos obesos

Pós-graduação em Fisiopatologia em Clínica Médica - FMB

Efeitos da flutamida na morfologia dos órgãos reprodutivos e fígado de Rhinella schneideri (Anura: Bufonidae)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Toxic heritage: maternal transfer of pyrethroid insecticides and sunscreen agents in dolphins from Brazil

Pyrethroids (PYR) and UV filters (UVF) were investigated in tissues of paired mother-fetus dolphins from Brazilian coast in order to investigate the possibility of maternal transfer of these emerging contaminants. Comparison of PYR and UVF concentrations in maternal and fetal blubber revealed Franciscana transferred efficiently both contaminants to fetuses (F/M > 1) and Guiana dolphin transferred efficiently PYR to fetuses (F/M > 1) different than UVF (F/M < 1). PYR and UVF concentrations in fetuses were the highest-ever reported in biota (up to 6640 and 11,530 ng/g lw, respectively). Muscle was the organ with the highest PYR and UVF concentrations (p < 0.001), suggesting that these two classes of emerging contaminants may have more affinity for proteins than for lipids. The high PYR and UVF concentrations found in fetuses demonstrate these compounds are efficiently transferred through placenta. This study is the first to report maternal transfer of pyrethroids and UV filters in marine mammals.

Histologia e ultraestrutura do rim e rim cefálico do pacu

O pacu, Piaractus mesopotamicus, é um teleósteo da Família Characidae, intensivamente cultivado no Brasil devido sua rusticidade, crescimento rápido e fácil adaptação. O conhecimento morfológico dos sistemas corpóreos, incluído órgãos linfóide, se faz necessário, para uma melhor produção no cultivo de peixes, fornecendo subsídios na manutenção dos estoques. O objetivo deste estudo foi descrever morfologicamente o rim e rim cefálico de Piaractus mesopotamicus, analisando os perfis celulares de cada órgão com o uso de microscopia de luz e microscopia eletrônica de transmissão. O resultado da análise macroscópica mostrou que a localização do rim e rim cefálico são as mesmas encontradas na maioria dos teleósteos. O rim apresentou uma forma em "H", onde a região média se expandia sobre a bexiga natatória. O rim cefálico se apresentou como uma dilatação na região cranial do rim, mostrando-se bem visível. Na microscopia eletrônica de transmissão também foram observadas similaridades ultraestruturais com outros teleósteos. Observando nossos resultados concluímos que histologicamente e ultraestruturalmente, os órgãos linfóides rim e rim cefálico de Piaractus mesopotamicus são similares aos de outros teleósteos.

IL -12 inhibits the metastatic potential of osteosarcoma cells and induces tumor regression via a mechanism involving Fas /Fas ligand pathway

Despite multiple changes in the adjuvant chemotherapy regimens used to treat osteosarcoma (OS), the 2-year metastasis-free survival has remained at 65–70% for the past 10 years. Characterizing the molecular determinants that permit metastatic spread of tumor cells is a crucial element in developing new approaches for the treatment of osteosarcoma. Since OS metastasizes almost exclusively to the lung, an organ with constitutive Fas ligand (FasL) expression, we hypothesized that the expression of Fas (CD95, APO-1) by OS cells may play a role in the ability of these cells to form lung metastases. Fas expression was quantified in human SAOS-2 OS cells and selected variants (LM2, LM4, LM5, LM6, LM7). Using northern blot, FACS and RT-PCR analysis, low Fas expression was found to correlate with higher metastatic potential in these cell lines. The highly metastatic LM7 cell line was transfected with the full-length human Fas gene and injected into athymic nude mice. The median number of metastatic nodules per mouse fell from over 200 to 1.1 and the size of the nodules decreased from a range of 0.5–9.0 mm to less than 0.5 mm in the Fas-transfected cell line compared to the native LM7 cell line. Additionally, the subsequent incidence of lung metastases was lower in the Fas-expressing cell line. IL-12 was seen to upregulate Fas expression in the highly metastatic LM sublines in vitro. To visualize the effects of IL-12 in vivo, nude mice were injected with LM7 cells and treated biweekly for 4 weeks with Ad.mIL-12, saline control or Ad.βgal. Lung sections were analyzed via immunchistochemistry for Fas expression. A higher expression of Fas was found in tumors from mice receiving IL-12. To study the mechanism by which IL-12 upregulates Fas, LM7 cells were transfected with a luciferase reporter gene construct containing the full-length human fas promoter. Treatment with IL-12 increased luciferase activity. We therefore conclude that IL-12 influences the metastatic potential of OS cells by upregulating the fas promoter, resulting in increased cell surface Fas expression and susceptibility to Fas-induced cell death. ^

Lung structure at preterm and term birth

When lung development is not interrupted by premature birth and unaffected by genetic or environmental disturbances, all components develop with complex control to form a functional organ with a predictable timeline during fetal development. In this chapter we describe the relationship between morphological development and function in both physiological and pathological conditions in human lung development. Tree-like growth of the lung begins during the first few weeks postconception, with the embryonic stage characterized by branching morphogenesis in both the airways and blood vessels, separately in the left and right lung buds, which appear near day 26 postcoitus (p.c.). Branching continues through the embryonic stage, with proliferation of mesenchymal and epithelial cells and apoptosis near branch points and in the areas of new formation. The pseudoglandular stage (weeks 5–17 p.c.) is characterized by accelerated cellular proliferation and airway and vascular branching, with epithelial differentiation in proximal and distal airways. Further epithelial differentiation, angiogenesis of the parenchymal capillary network, and the first formation of the air–blood barrier characterize the canalicular stage (16–26 weeks p.c.), just before the completion of branching morphogenesis (saccular stage, weeks 24–38 p.c.) and the start of alveolarization (week 36 through adolescence).

Première rhapsodie pour orchestre avec clarinette principale en si♭.

Mode of access: Internet.

Lied der Walküre (The song of the Valkyr) ... Für eine höhere Singstimme mit Begleitung des Orchesters. Op. 36, Nr. 4. Partitur.

Pl. no.: Part.B.1834.

Aus fernen Welten. Vier Gesänge für eine mittlere Singstimme mit Begleitung des Orchesters

Sibley Music Library lacks no. 2.

L'invitation au voyage.

Reprinted from Rouart, Lerolle plates: R.L. 5060 et Cie.

Rondo brillant : für Pianoforte mit Begleitung des Orchesters, Op. 29 /

"Ignaz Moscheles gewidmet." -- P. 1.

Sechs Orchesterlieder, op. 8.

Mode of access: Internet.

Concertstück für Pianoforte mit Orchester. Op. 31a.

Pl. no.: 19291.

Concert-allegro : op. 46 /

Mode of access: Internet.