Safety and Efficacy of Ranibizumab in Diabetic Macular Edema (RESOLVE Study): A 12-month, randomized, controlled, double-masked, multicenter phase II study

The expression of vascular endothelial growth factor (VEGF) is elevated in diabetic macular edema (DME). Ranibizumab binds to and inhibits multiple VEGF variants. We investigated the safety and efficacy of ranibizumab in DME involving the foveal center.

High-Spin Molecules: Synthesis, X-ray Characterization, and Magnetic Behavior of Two New Cyano-Bridged Ni II 9 Mo V 6 and Ni II 9 W V 6 Clusters with a S = 12 Ground State

The preparations, X-ray structures, and magnetic characterizations are presented for two new pentadecanuclear cluster compounds:  [NiII{NiII(MeOH)3}8(μ-CN)30{MV(CN)3}6]·xMeOH·yH2O (MV = MoV (1) with x = 17, y = 1; MV = WV (2) with x = 15, y = 0). Both compounds crystallize in the monoclinic space group C2/c, with cell dimensions of a = 28.4957(18) Å, b = 19.2583(10) Å, c = 32.4279(17) Å, β = 113.155(6)°, and Z = 4 for 1 and a = 28.5278(16) Å, b = 19.2008(18) Å, c = 32.4072(17) Å, β = 113.727(6)°, and Z = 4 for 2. The structures of 1 and 2 consist of neutral cluster complexes comprising 15 metal ions, 9 NiII and 6 MV, all linked by μ-cyano ligands. Magnetic susceptibilities and magnetization measurements of compounds 1 and 2 in the crystalline and dissolved state indicate that these clusters have a S = 12 ground state, originating from intracluster ferromagnetic exchange interactions between the μ-cyano-bridged metal ions of the type NiII−NC−MV. Indeed, these data show clearly that the cluster molecules stay intact in solution. Ac magnetic susceptibility measurements reveal that the cluster compounds exhibit magnetic susceptibility relaxation phenomena at low temperatures since, with nonzero dc fields, χ‘ ‘M has a nonzero value that is frequency dependent. However, there appears no out-of-phase (χ‘ ‘M) signal in zero dc field down to 1.8 K, which excludes the expected signature for a single molecule magnet. This finding is confirmed with the small uniaxial magnetic anisotropy value for D of 0.015 cm-1, deduced from the high-field, high-frequency EPR measurement, which distinctly reveals a positive sign in D. Obviously, the overall magnetic anisotropy of the compounds is too low, and this may be a consequence of a small single ion magnetic anisotropy combined with the highly symmetric arrangement of the metal ions in the cluster molecule.

II Congreso Internacional de Estudios Clásicos en México : La Antigüedad Clásica : Alcances interdisciplinarios de su estudio actual : Universidad Nacional Autónoma de México, México DF, 8 al 12 de septiembre de 2008

Fil: Galán, Lía Margarita. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

IIº Jornadas de Estudios Clásicos y Medievales, La Plata, 12 al 14 de abril de 2005

Fil: Vizzotti, Martín Miguel. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

II Congreso Internacional de Estudios Clásicos en México : La Antigüedad Clásica : Alcances interdisciplinarios de su estudio actual : Universidad Nacional Autónoma de México, México DF, 8 al 12 de septiembre de 2008

Fil: Galán, Lía Margarita. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

IIº Jornadas de Estudios Clásicos y Medievales, La Plata, 12 al 14 de abril de 2005

Fil: Vizzotti, Martín Miguel. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.