Surb khorhrdoys vray ekeghetsʻwoy vkayutʻiwnnerě /

Issues called Tetrak (tract)

Services for activities in group editing 'sage'

The project described in this thesis investigates the needs of a group of people working cooperatively in an OSI environment, and recommends tools and services to meet these needs. The project looks specifically at Services for Activities in Group Editing, and is identified as the `SAGE' project. The project uses case studies to identify user requirements and to determine common functionalities for a variety of group editing activities. A prototype is implemented in an X.400 environment to help refine user requirements, as a source of new ideas and to test the proposed functionalities. The conceptual modelling follows current CCITT proposals, but a new classification of group activities is proposed: Informative, Objective and Supportive application groups. It is proposed that each of these application groups have their own Service Agent. Use of this classification allows the possibility of developing three sets of tools which will cover a wide range of group activities, rather than developing tools for individual activities. Group editing is considered to be in the Supportive application group. A set of additional services and tools to support group editing are proposed in the context of the CCITT draft on group communication, X.gc. The proposed services and tools are mapped onto the X.400 series of recommendations, with the Abstract Service Definition of the operational objects defined, along with their associated component files, by extending the X.420 protocol functionality. It is proposed that each of the Informative, Objective and Supportive application groups should be implemented as a modified X.420 inter-personal messaging system.

Maximization of a Linear Utility Function over the Set of the Housing Market Short-Term Equilibria

AMS subject classification: 90C05, 90A14.

Impact of the carrier relaxation paths on two-state operation in quantum dot lasers

We study InGaAs QD laser operating simultaneously at ground (GS) and excited (ES) states under 30ns pulsed-pumping and distinguish three regimes of operation depending on the pump current and the carrier relaxation pathways. An increased current leads to an increase in ES intensity and to a decrease in GS intensity (or saturation) for low pump range, as typical for the cascade-like pathway. Both the GS and ES intensities are steadily increased for high current ranges, which prove the dominance of the direct capture pathway. The relaxation oscillations are not pronounced for these ranges. For the mediate currents, the interplay between the both pathways leads to the damped large amplitude relaxation oscillations with significant deviation of the relaxation oscillation frequency from the initial value during the pulse.

Movement Effects on the Flow Physics and Nutrient Delivery in Engineered Valvular Tissues

Mechanical conditioning has been shown to promote tissue formation in a wide variety of tissue engineering efforts. However the underlying mechanisms by which external mechanical stimuli regulate cells and tissues are not known. This is particularly relevant in the area of heart valve tissue engineering (HVTE) owing to the intense hemodynamic environments that surround native valves. Some studies suggest that oscillatory shear stress (OSS) caused by steady flow and scaffold flexure play a critical role in engineered tissue formation derived from bone marrow derived stem cells (BMSCs). In addition, scaffold flexure may enhance nutrient (e.g. oxygen, glucose) transport. In this study, we computationally quantified the i) magnitude of fluid-induced shear stresses; ii) the extent of temporal fluid oscillations in the flow field using the oscillatory shear index (OSI) parameter, and iii) glucose and oxygen mass transport profiles. Noting that sample cyclic flexure induces a high degree of oscillatory shear stress (OSS), we incorporated moving boundary computational fluid dynamic simulations of samples housed within a bioreactor to consider the effects of: 1) no flow, no flexure (control group), 2) steady flow-alone, 3) cyclic flexure-alone and 4) combined steady flow and cyclic flexure environments. We also coupled a diffusion and convention mass transport equation to the simulated system. We found that the coexistence of both OSS and appreciable shear stress magnitudes, described by the newly introduced parameter OSI-t , explained the high levels of engineered collagen previously observed from combining cyclic flexure and steady flow states. On the other hand, each of these metrics on its own showed no association. This finding suggests that cyclic flexure and steady flow synergistically promote engineered heart valve tissue production via OSS, so long as the oscillations are accompanied by a critical magnitude of shear stress. In addition, our simulations showed that mass transport of glucose and oxygen is enhanced by sample movement at low sample porosities, but did not play a role in highly porous scaffolds. Preliminary in-house in vitro experiments showed that cell proliferation and phenotype is enhanced in OSI-t environments.

Sperimentazione di protocolli di routing su topologie di rete ibride

In questa tesi si è voluto interfacciare dispositivi di nuova generazione (Raspberry Pi), presenti in una topologia di rete già implementata, con dispositivi di vecchia generazione, come Router Cisco e Switch HP. Questi ultimi sono dispositivi fisici, mentre i Raspberry, tramite tool mininet e altre impostazioni, possono generare dispositivi virtuali. Si è quindi applicato un interfacciamento tra le due tipologie di apparati, creando una rete nuova, e adatta come caso a ricoprire le reti attuali, siccome questo è un esempio di come con poche modifiche si può intervenire su qualsiasi rete già operativa. Si sono quindi osservati i criteri generali su cui operano sia i router, che gli switch, e si sono osservati come questi interagiscono con un flusso di dati attraverso vari protocolli, alcuni rifacenti al modello ISO/OSI, altri all'OSPF.

Opportunistic Contact Graph Routing

L'ambiente di questa tesi è quello del Delay and Disruption Tolerant Networks (DTN), un'architettura di rete di telecomunicazioni avente come obiettivo le comunicazioni tra nodi di reti dette “challenged”, le quali devono affrontare problemi come tempi di propagazione elevati, alto tasso di errore e periodi di perdita delle connessioni. Il Bunde layer, un nuovo livello inserito tra trasporto e applicazione nell’architettura ISO/OSI, ed il protocollo ad esso associato, il Bundle Protocol (BP), sono stati progettati per rendere possibili le comunicazioni in queste reti. A volte fra la ricezione e l’invio può trascorrere un lungo periodo di tempo, a causa della indisponibilità del collegamento successivo; in questo periodo il bundle resta memorizzato in un database locale. Esistono varie implementazioni dell'architettura DTN come DTN2, implementazione di riferimento, e ION (Interplanetary Overlay Network), sviluppata da NASA JPL, per utilizzo in applicazioni spaziali; in esse i contatti tra i nodi sono deterministici, a differenza delle reti terrestri nelle quali i contatti sono generalmente opportunistici (non noti a priori). Per questo motivo all’interno di ION è presente un algoritmo di routing, detto CGR (Contact Graph Routing), progettato per operare in ambienti con connettività deterministica. È in fase di ricerca un algoritmo che opera in ambienti non deterministici, OCGR (Opportunistic Contact Graph Routing), che estende CGR. L’obiettivo di questa tesi è quello di fornire una descrizione dettagliata del funzionamento di OCGR, partendo necessariamente da CGR sul quale è basato, eseguire dei test preliminari, richiesti da NASA JPL, ed analizzarne i risultati per verificare la possibilità di utilizzo e miglioramento dell’algoritmo. Sarà inoltre descritto l’ambiente DTN e i principali algoritmi di routing per ambienti opportunistici. Nella parte conclusiva sarà presentato il simulatore DTN “The ONE” e l’integrazione di CGR e OCGR al suo interno.

SecAdvise : un aviseur de mécanismes de sécurité

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

SecAdvise - un aviseur de mécanismes de sécurité : implantation, validation et expérimentation du modèle proposé

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

SecAdvise : un aviseur de mécanismes de sécurité

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

SecAdvise - un aviseur de mécanismes de sécurité : implantation, validation et expérimentation du modèle proposé

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

Operational Stress Injuries: Impact on Family Mental Health and Well-being

This study was part of a larger scoping review and environmental scan conducted for Veterans Affairs Canada on the effects of operational stress injuries (OSIs) on the mental health and wellbeing of Veterans’ families. This paper focuses broadly on the relationships between combat (and/or deployment more generally), OSIs (primarily post-traumatic stress disorder (PTSD)), and the family. Based on the scoping review, the paper finds that existing research investigates the impacts of a Veteran’s OSI on the family, but also how various aspects of the family (such as family functioning, family support, etc.) can impact a Veteran living with an OSI.

IGF-1R inhibition sensitizes breast cancer cells to ATM-Related Kinase (ATR) inhibitor and cisplatin

The complexity of the IGF-1 signalling axis is clearly a roadblock in targeting this receptor in cancer therapy. Here, we sought to identify mediators of resistance, and potential co-targets for IGF-1R inhibition. By using an siRNA functional screen with the IGF-1R tyrosine kinase inhibitor (TKI) BMS-754807 in MCF-7 cells we identified several genes encoding components of the DNA damage response (DDR) pathways as mediators of resistance to IGF-1R kinase inhibition. These included ATM and Ataxia Telangiectasia and RAD3-related kinase (ATR). We also observed a clear induction of DDR in cells that were exposed to IGF-1R TKIs (BMS-754807 and OSI-906) as indicated by accumulation of γ-H2AX, and phosphorylated Chk1. Combination of the IGF-1R/IR TKIs with an ATR kinase inhibitor VE-821 resulted in additive to synergistic cytotoxicity compared to either drug alone. In MCF-7 cells with stably acquired resistance to the IGF-1R TKI (MCF-7-R), DNA damage was also observed, and again, dual inhibition of the ATR kinase and IGF-1R/IR kinase resulted in synergistic cytotoxicity. Interestingly, dual inhibition of ATR and IGF-1R was more effective in MCF-7-R cells than parental cells. IGF-1R TKIs also potentiated the effects of cisplatin in a panel of breast cancer cell lines. Overall, our findings identify induction of DDR by IGF-1R kinase inhibition as a rationale for co-targeting the IGF-1R with ATR kinase inhibitors or cisplatin, particularly in cells with acquired resistance to TKIs.

Radio over fiber enabling PON fronthaul in a two-tiered cloud

Avec l’avènement des objets connectés, la bande passante nécessaire dépasse la capacité des interconnections électriques et interface sans fils dans les réseaux d’accès mais aussi dans les réseaux coeurs. Des systèmes photoniques haute capacité situés dans les réseaux d’accès utilisant la technologie radio sur fibre systèmes ont été proposés comme solution dans les réseaux sans fil de 5e générations. Afin de maximiser l’utilisation des ressources des serveurs et des ressources réseau, le cloud computing et des services de stockage sont en cours de déploiement. De cette manière, les ressources centralisées pourraient être diffusées de façon dynamique comme l’utilisateur final le souhaite. Chaque échange nécessitant une synchronisation entre le serveur et son infrastructure, une couche physique optique permet au cloud de supporter la virtualisation des réseaux et de les définir de façon logicielle. Les amplificateurs à semi-conducteurs réflectifs (RSOA) sont une technologie clé au niveau des ONU(unité de communications optiques) dans les réseaux d’accès passif (PON) à fibres. Nous examinons ici la possibilité d’utiliser un RSOA et la technologie radio sur fibre pour transporter des signaux sans fil ainsi qu’un signal numérique sur un PON. La radio sur fibres peut être facilement réalisée grâce à l’insensibilité a la longueur d’onde du RSOA. Le choix de la longueur d’onde pour la couche physique est cependant choisi dans les couches 2/3 du modèle OSI. Les interactions entre la couche physique et la commutation de réseaux peuvent être faites par l’ajout d’un contrôleur SDN pour inclure des gestionnaires de couches optiques. La virtualisation réseau pourrait ainsi bénéficier d’une couche optique flexible grâce des ressources réseau dynamique et adaptée. Dans ce mémoire, nous étudions un système disposant d’une couche physique optique basé sur un RSOA. Celle-ci nous permet de façon simultanée un envoi de signaux sans fil et le transport de signaux numérique au format modulation tout ou rien (OOK) dans un système WDM(multiplexage en longueur d’onde)-PON. Le RSOA a été caractérisé pour montrer sa capacité à gérer une plage dynamique élevée du signal sans fil analogique. Ensuite, les signaux RF et IF du système de fibres sont comparés avec ses avantages et ses inconvénients. Finalement, nous réalisons de façon expérimentale une liaison point à point WDM utilisant la transmission en duplex intégral d’un signal wifi analogique ainsi qu’un signal descendant au format OOK. En introduisant deux mélangeurs RF dans la liaison montante, nous avons résolu le problème d’incompatibilité avec le système sans fil basé sur le TDD (multiplexage en temps duplexé).

Dostęp do informacji jako wyznacznik polityczności

Artykuł dotyka problemu polityczności z punktu widzenia komunikacji, która – jako subdyscyplina politologii – stanowi integralną część programów nauczania przyszłych absolwentów tego kierunku, przez co konieczną wydaje się być dyskusja na temat umiejscowienia tego zagadnienia w ramach dyscypliny. Co ciekawe, dyskurs naukowy zdominowany przez zagadnienia związane z mediami i przesyłaniem danych kanałami informacyjnymi, często pomija kwestie komunikowania bezpośredniego i poziomego; tym odbywającą się między obywatelami, ale – przede wszystkim – samymi politykami. Informacja – jako podstawowa jednostka komunikacyjna – staje się tu jednym z elementów relacji o cesze polityczności oraz środkiem osiągania celów, wpisując się tym samym w dyskusję o podstawach teoretycznych dyscypliny i o granicach badań nad zjawiskami tradycyjnie podejmowanymi w swoich rozważaniach przez przedstawicieli nauk politycznych. The article takes up a problem of " the political " from communication point of view, which-as a sub-discipline of political science-is an integral part of the curriculum for future graduates of this discipline. It seems to be necessary to locate this issue in the branch of studies. Interestingly, scientific discourse dominated by media and information channels, often ignores direct and horizontal communication, especially between citizens and-above all-politicians themselves. Information, as the basic unit of communication, becomes the part of " political relations " and the specific form of meeting a political aim. Therefore, it " fits in " the discussion of theoretical foundations of this discipline and scope of research in the area of phenomenons traditionally analysed by representatives of political science.