Hyperglycaemia but not hyperlipidaemia decreases serum amylase and increases neutrophils in the exocrine pancreas of cats

The goal of the study was to determine whether hyperglycaemia or hyperlipidaemia causes pancreatitis in cats and to assess the effect of excess serum glucose and lipids on amylase and lipase activity. Ten-day hyperglycaemic and hyperlipidaemic clamps were carried out in five and six healthy cats, respectively. Ten healthy cats received saline and served as controls. The activity of amylase was below the normal range in 4 of 5 hyperglycaemic cats by day 10. The activity of lipase did not vary in any of the cats. Samples of exocrine pancreas were normal on histological examination, but the number of tissue neutrophils was increased in hyperglycaemic cats (P<0.05). In a retrospective study 14 of 40 (35%) cats with naturally occurring diabetes mellitus had amylase activities below the reference range at the time of admission. Amylase activities normalised within 1 week of insulin therapy and subsequent glycaemic control. Lipase activity was increased in 26 of 40 (65%) diabetic cats and remained elevated despite glycaemic control. In conclusion, hyperglycaemia, but not hyperlipidaemia, increases pancreatic neutrophils in cats. However, because the histological morphology of the exocrine pancreas was normal, hyperglycaemia may play only a minor role in the pathogenesis of pancreatitis. Low amylase activities in diabetic cats may reflect an imbalance in glucose metabolism rather than pancreatitis.

An Ethical History of Photography in Combat and of Combat Photography in the United States during World War II

With the United States‘ entry into the Second World War, the word ?censorship? was seen largely as antithetical to, rather than a necessary counterpart to, victory among Americans. People did not want to be censored in their writing, photographs or speech,but it proved to be necessary even before the war began, in order to protect government secrets and the people on the home-front from scenes that were too disturbing. Even before the war had officially begun, there were problems with censorship among journalists and newspapers. The initial response of outrage in reference to censorship in the United States was common among journalists, newspapers, magazines, and radio news; nevertheless, there was a necessity for censorship among Americans, on the home frontand the front lines, and it would be tolerated throughout the war to ensure that enemies of America did not gain access to information that would assist in a defeat of the United States in the Second World War. The research I have conducted has dealt with the censorship of combat photography during World War II, in conjunction with the ethics that were in play at the time that affected the censors. Through exploring the work of three combat photographers — Tony Vaccaro, James R. Stephens and Charles E. Sumners — I wasable to effectively construct an explanatory ethical history of these three men. Research on the censorship and effects it had on the United States brought me to three distinctareas of censorship and ethics that would be explored: (1) the restrictions and limitations enforced by the Office of Censorship, (2) a general overview of war and photography as it influenced the soldiers and their families on the home-front, (3) and the combat photographers and personal and military censorship that influenced their work. Although their work was censored both by the military and the government, these men saw the war in a different light that remained with them long after the battles and war had ceased.Using the narratives of Tony Vaccaro, Charles E. Sumners and James R. Stephens as means for more in depth research, this thesis strives to create lenses through which to view the history and ethics of censorship that shaped combat photography during the Second World War and the images to which we refer as representative of that war today.

Cortisol levels and history of depression in acute coronary syndrome patients

BACKGROUND: Depressed mood following an acute coronary syndrome (ACS) is a risk factor for future cardiac morbidity. Hypothalamic-pituitary-adrenal (HPA) axis dysregulation is associated with depression, and may be a process through which depressive symptoms influence later cardiac health. Additionally, a history of depression predicts depressive symptoms in the weeks following ACS. The purpose of this study was to determine whether a history of depression and/or current depression are associated with the HPA axis dysregulation following ACS. METHOD: A total of 152 cardiac patients completed a structured diagnostic interview, a standardized depression questionnaire and a cortisol profile over the day, 3 weeks after an ACS. Cortisol was analysed using: the cortisol awakening response (CAR), total cortisol output estimated using the area under the curve method, and the slope of cortisol decline over the day. RESULTS: Total cortisol output was positively associated with history of depression, after adjustment for age, gender, marital status, ethnicity, smoking status, body mass index (BMI), Global Registry of Acute Cardiac Events (GRACE) risk score, days in hospital, medication with statins and antiplatelet compounds, and current depression score. Men with clinically diagnosed depression after ACS showed a blunted CAR, but the CAR was not related to a history of depression. CONCLUSIONS: Patients with a history of depression showed increased total cortisol output, but this is unlikely to be responsible for associations between depression after ACS and later cardiac morbidity. However, the blunted CAR in patients with severe depression following ACS indicates that HPA dysregulation is present.

Ultraviolet radiation, but not γ radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

Polyclonal antibodies were produced and purified that selectively react with a p53 epitope containing the murine phosphoserine-389 or the human phosphoserine-392 residue, but not the unphosphorylated epitope. These antibodies, termed alpha-392, were employed to demonstrate that the phosphorylation of this serine-389 residue in the p53 protein occurs in vivo in response to ultraviolet radiation of cells containing the p53 protein. After ultraviolet radiation of cells in culture, p53 levels increase and concomitantly serine-389 is phosphorylated in these cells. By contrast, the serine-389 phosphorylation of the p53 protein was not detected by these antibodies in the increased levels of p53 protein made in response to γ radiation or the treatment of cells with etoposide. These results demonstrate an ultraviolet responsive and specific phosphorylation site at serine-389 of the mouse or serine-392 of the human p53 protein. Previous studies have demonstrated that this phosphorylation of p53 activates the protein for specific DNA binding. This study demonstrates in vivo a unique phosphorylation site in the p53 protein that responds to a specific type of DNA damage.

A new balance of power in the Council? Yes, but not yet… CEPS Commentary, 19 December 2014

On the 1st of November, the double majority system established by the Lisbon Treaty for qualified majority voting (QMV) in the Council entered into force. The shift in the balance of power, however, will not be effective before April 2017, given the possibility for member states to invoke the Nice rules until that date. While acknowledging that the new voting system in the Council promises to do away with the difficult negotiations of the past among member states to reallocate voting weights, this commentary finds that it is questionable whether it will achieve its ultimate aim to substantially improve democratic legitimacy and efficiency.

A bibliographical guide to the history of Christianity /

Bibliographies :p. 20-21.

The Nicaraguan Canal bill : the early completion of an Isthmian canal is of the utmost importance ... but the pending bill for the Nicaraguan Canal is not an effective measure for securing this object ... speech of Theodore E. Burton, of Ohio, in the House of Representatives, Tuesday, May 1, 1900, with remarks Wednesday, May 2, 1900.

Mode of access: Internet.

The history and antiquities of dissenting churches and meeting houses, in London, Westminster, and Southwark : including the lives of their ministers, from the rise of nonconformity to the present time : with an appendix on the origin, progress, and present state of Christianity in Britain /

Includes bibliographical references and index.

History of the Church of Scotland, from the introduction of Christianity to the period of the disruption, May 18, 1843; with an introductory essay on the principles and constitution of the Church of Scotland.

Mode of access: Internet.

An ecclesiastical history of Great Britain; chiefly of England, from the first planting of Christianity, to the end of the reign of King Charles the Second; with a brief account of the affairs of religion in Ireland. Collected from the best ancient historians, councils, and records,

Mode of access: Internet.

History of paganism in Caledonia, with an examination into the influence of Asiatic philosophy, and the gradual development of Christianity in Pictavia.

Mode of access: Internet.

Fox's book of martyrs; or, The acts and monuments of the Christian church : being a complete history of the lives, sufferings, and deaths of the Christian martyrs; from the commencement of Christianity to the present period. To which is added an account of the Inquisition, the Bartholomew massacre in France, the general persecution under Louis XIV, the massacres in the Irish rebellions in the years 1641, and 1798, rise, progress, and persecutions of the people commonly called Quakers, together with an account of the Western martyrology, or bloody assizes; with the lives of some of the early eminent reformers ... /

This edition first published 1829 by William Borradaile, New York (Cf. title page verso)

A history of the lives, sufferings, and triumphant deaths, of the primitive as well as the Protestant martyrs, from the commencement of Christianity to the latest periods of pagan and popish persecution. To which is added an account of the Inquisition; the Bartholomew massacre; the massacre in France, and general persecution under Louis XIV.; the massacres of the Irish rebellion in the year 1641; and the recent persecutions of Protestants in the South of France.

Mode of access: Internet.

The History of Christianity ...

Mode of access: Internet.