Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release

Hypothalamic neuropeptide Y (NPY) is thought to be important in the regulation of feeding and also in the release of Adrenocorticotrophic hormone (ACTH). Intracerebroventricular administration of NPY to male rats significantly increased plasma ACTH 10 min after injection and stimulated 2-h food intake. A series of analogues of NPY that have a greatly reduced affinity for the Y1 [human pancreatic polypeptide (human PP), NPY(3–36)], the Y2 ([Pro34]NPY, human PP), the Y3 (peptide YY), and the Y6 (human PP) receptor, all markedly stimulated ACTH release. Rat PP, which binds with high affinity to the Y4 receptor, was unable to stimulate ACTH release. A novel analogue fragment [Pro34]NPY(13–36) was synthesized as a ligand with low Y1 and Y2 receptor affinity. Interestingly, neither [Pro34]NPY(13–36) nor the selective Y5 receptor agonist [d-Trp32]NPY stimulated food intake, whereas both significantly increased plasma ACTH. Thus the hypothalamic NPY receptor mediating increases in plasma ACTH has a fragment activation profile unlike the Y1–Y4 or Y6 receptors and appears distinct from the NPY receptor controlling food intake.

Role of the Y5 neuropeptide Y receptor in limbic seizures

Neuropeptide Y (NPY) is an inhibitory neuromodulator expressed abundantly in the central nervous system that is suspected of being an endogenous antiepileptic agent that can control propagation of limbic seizures. Electrophysiological and pharmacological data suggest that these actions of NPY are mediated by G protein-coupled NPY Y2 and NPY Y5 receptors. To determine whether the NPY Y5 receptor (Y5R) is required for normal control of limbic seizures, we examined hippocampal function and responsiveness to kainic acid-induced seizures in Y5R-deficient (Y5R−/−) mice. We report that Y5R−/− mice do not exhibit spontaneous seizure-like activity; however, they are more sensitive to kainic acid-induced seizures. Electrophysiological examination of hippocampal slices from mutant mice revealed normal function, but the antiepileptic effects of exogenously applied NPY were absent. These data demonstrate that Y5R has an important role in mediating NPY���s inhibitory actions in the mouse hippocampus and suggest a role for Y5R in the control of limbic seizures.

Analyzing the commercial activities of a street network by ranking their nodes: a case study in Murcia, Spain

Urban researchers and planners are often interested in understanding how economic activities are distributed in urban regions, what forces influence their special pattern and how urban structure and functions are mutually dependent. In this paper, we want to show how an algorithm for ranking the nodes in a network can be used to understand and visualize certain commercial activities of a city. The first part of the method consists of collecting real information about different types of commercial activities at each location in the urban network of the city of Murcia, Spain. Four clearly differentiated commercial activities are studied, such as restaurants and bars, shops, banks and supermarkets or department stores, but obviously we can study other. The information collected is then quantified by means of a data matrix, which is used as the basis for the implementation of a PageRank algorithm which produces a ranking of all the nodes in the network, according to their significance within it. Finally, we visualize the resulting classification using a colour scale that helps us to represent the business network.

Realizing the Commercial Potential of Hierarchical Zeolites: New Opportunities in Catalytic Cracking

Many approaches to mesoporous zeolites have been reported. The preparation of mesoporous zeolite Y, as the most widely used zeolite in catalysis, its properties, and its application in fluid catalytic cracking (FCC) and hydrocracking are reviewed. Finally, the scale-up and use of mesostrutured zeolite Y on an industrial scale are described, as the first commercial application of hierarchical zeolites.

Commercial feasibility of recovering tomato processing residuals for food use /

Mode of access: Internet.

Tables of the Bessel functions, Y₀(x), Y₁(x), K₀(x), K₁(x), 0 <̳ x <̳ 1.

Bibliography: p. ix.

Commercial use of space : a new economic strength for America.

Shipping list no.: 89-365-P.

Centers for the commercial development of space.

"PAM 525"--P. [4] of cover.

A new and accurate history of South-America : containing a particular account of some accidents leading to the discovery of the New World, of the discovery made by Columbus, and other adventures ... : with a full description of the spanish provinces of Chili, Paraguay, and Terra Firma : of Guiana, particularly of Surinam ..., and of Cayenne belonging to the french : of Brazil, subject to the Crown of Portugal : of that part of Paraguay possessed by the Jesuits, where they have established a new monarchy ... : including the geographical, natural, political, and commercial history of every province, with the religion, manners, and customs of the inhabitants : with Dissertations on the british, spanish, portuguese, french, dutch, and indian settlements /

Sabin,

South Kaibab Block interim timber management plan, Kaibab National Forest : October 1978, effective period F.Y. 1979 through F.Y. 1983.

Mode of access: Internet.

Final reports of the International business conference. Private interprise; raw materials and foodstuffs; encouragement and protection of investments; industrialization in new areas; currency relations among nations; transportation and communications; cartels; commercial policy of nations; also roster of attendance. Westchester country club, Rye, New York, November 10-18, 1944.

Cover-title.

Minimum standards for the commercial production of random bred and inbred laboratory mice (rev. Sept., 22, 1957)

Reprinted from the Journal of the National Cancer Institute, vol. 19, no. 6, Dec. 1957.

Report from the Secretary of the Treasury, transmitting returns of the Bank of the United States, in compliance with a resolution of the Senate of the 9th.

Mode of access: Internet.