GPR30 activation decreases anxiety in the open field test but not in the elevated plus maze test in female mice

The GPR30 is a novel estrogen receptor (ER) that is a candidate membrane ER based on its binding to 17beta estradiol and its rapid signaling properties such as activation of the extracellular-regulated kinase (ERK) pathway. Its distribution in the mouse limbic system predicts a role for this receptor in the estrogenic modulation of anxiety behaviors in the mouse. A previous study showed that chronic administration of a selective agonist to the GPR30 receptor, G-1, in the female rat can improve spatial memory, suggesting that GPR30 plays a role in hippocampal-dependent cognition. In this study, we investigated the effect of a similar chronic administration of G-1 on behaviors that denote anxiety in adult ovariectomized female mice, using the elevated plus maze (EPM) and the open field test as well as the activation of the ERK pathway in the hippocampus. Although estradiol benzoate had no effect on behaviors in the EPM or the open field, G-1 had an anxiolytic effect solely in the open field that was independent of ERK signaling in either the ventral or dorsal hippocampus. Such an anxiolytic effect may underlie the ability of G-1 to increase spatial memory, by acting on the hippocampus.

'Dig in' to social capital : community gardens as mechanisms for growing urban social connectedness

This article reports on research undertaken with members of a Melbourne urban community garden to explore the extent to which such a natural amenity provides opportunities for enhancing social capital. It is apparent even from this small qualitative study that membership of 'Dig In' community garden offers many benefits to its members. These benefits include increased social cohesion (the sharing of values enabling identification of common aims and the sharing of codes of behaviour governing relationships), social support (having people to turn to in times of crisis) and social connections (the development of social bonds and networks). However, the study indicates that, at least in the early stages of development, such benefits do not necessarily extend beyond the garden setting. This raises a question about the time required to develop high levels of social capital, and points to the need for further research into 'time' and 'space' aspects of community gardens.