998 resultados para Martin, Elisha May, 1809-1821.


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Here we describe an association between α3β1 integrin and transmembrane-4 superfamily (TM4SF) protein CD151. This association is maintained in relatively stringent detergents and thus is remarkably stable in comparison with previously reported integrin–TM4SF protein associations. Also, the association is highly specific (i.e., observed in vitro in absence of any other cell surface proteins), and highly stoichiometric (nearly 90% of α3β1 associated with CD151). In addition, α3β1 and CD151 appeared in parallel on many cell lines and showed nearly identical skin staining patterns. Compared with other integrins, α3β1 exhibited a considerably higher level of associated phosphatidylinositol-4-kinase (PtdIns 4-kinase) activity, most of which was removed upon immunodepletion of CD151. Specificity for CD151 and PtdIns 4-kinase association resided in the extracellular domain of α3β1, thus establishing a novel paradigm for the specific recruitment of an intracellular signaling molecule. Finally, antibodies to either CD151 or α3β1 caused a ∼88–92% reduction in neutrophil motility in response to f-Met-Leu-Phe on fibronectin, suggesting an functionally important role of these complexes in cell migration.

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This layer is a georeferenced raster image of the historic paper map entitled: Ancient ichnography of the city of Winchester, Js. Cave delineavit ad mentem J. Milner. It was published by Jas. Robbins, March 1st, 1809. Scale [ca. 1:3,800].The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'British National Grid' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, built-up areas and selected buildings, ground cover, parks, and more. Includes 2 insets: Ichnography of the environs of Winchester, Ichnography of the Cathedral Church.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

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This layer is a georeferenced raster image of the historic paper map entitled: Hindoostan, J. & G. Menzies sculp. It was published by Baldwin, Cradock & Joy in 1821. Scale [1: 7,000,000]. Covers India, Bangladesh, Nepal, Bhutan, and portions of Afghanistan, Pakistan, China, Sri Lanka, and Maldives.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Kalianpur 1975 India Zone III projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, territorial and administrative boundaries, shoreline features, and more. Relief shown by hachures. Includes inset: "Isle of Ceylon" ; scale [ca. 1: 4,500,000].This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

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This layer is a georeferenced raster image of the historic paper map entitled: A new map and profile of the proposed canal from Lake Erie to Hudson River in the state of New York, contracted by direction of the Canal Commissioners from the maps of the engineers. It was printed by W. A. Mercein in 1821. Scale [1:253,440]. This layer is image 1 of 2 total images of the two sheet source map, representing the eastern portion of the map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Universal Transverse Mercator (UTM) Zone 18N NAD83 projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, cities and towns, county boundaries, and more. Relief is shown by hachures. Includes inset profiles: A profile of the extent of the levels and of the places and lifts of the locks between Lake Erie and the Hudson -- A profile of the southern route west of the Genesee River. Includes table of distances. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

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This layer is a georeferenced raster image of the historic paper map entitled: A new map and profile of the proposed canal from Lake Erie to Hudson River in the state of New York, contracted by direction of the Canal Commissioners from the maps of the engineers. It was printed by W. A. Mercein in 1821. Scale [1:253,440]. This layer is image 2 of 2 total images of the two sheet source map, representing the western portion of the map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Universal Transverse Mercator (UTM) Zone 18N NAD83 projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, cities and towns, county boundaries, and more. Relief is shown by hachures. Includes inset profiles: A profile of the extent of the levels and of the places and lifts of the locks between Lake Erie and the Hudson -- A profile of the southern route west of the Genesee River. Includes table of distances. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.