Der Prediger vom weißen Berg : Zur Rezeption der besseren Gerechtigkeit aus Mt 5 in Martin Luthers Predigtüberlieferung 1522 1546.

The purpose of this study is to examine the reception of Matthew 5 in Martin Luther s sermons; in other words to investigate how Luther interprets and applies Jesus teaching of the better righteousness and the law in Mt 5. The study applies the reception-historical approach and contributes to the history of effects and the history of interpretation in New Testament exegesis. The study shows that Luther understands the better righteousness of Mt 5 as good works and fulfillment of the law. Luther s interpretation coheres with the intention of the Evangelist, even if Luther s overall concept of righteousness is foreign to Matthew. In Luther s view righteousness is twofold: The greater righteousness of Mt 5 is the second and the actual righteousness (iustitia activa), which follows the first and the foreign righteousness (iustitia passiva). The first righteousness (faith) is for Luther the work of God, while the second righteousness (good works) is co-operation between a Christian and God. In this co-operation the law, as it is taught by Jesus, is not the opposite of the gospel, but the gospel itself in the sense of Christ as an example . The task of the law is to show the dependence of a Christian on God and to help one to love and to serve one s neighbour (brothers as well as enemies) properly. The study underlines a feature in Luther s thinking that has received little attention in Lutheran theology: Luther insists on preaching the law to Christians. In his view Mt 5 is directed to all Christians and particularly to pastors, for whom Jesus here gives an example of how to preach the law. Luther believes similarly to Matthew that Jesus reveals the real meaning of Mosaic Law and confirms its validity for Christians in Mt 5. Like Matthew, Luther insists on the practicability of the commandments of Mt 5 in his view Christians fulfil the law also with joy yet his interpretation of Mt 5 attenuates the radical nature of its commandments. Luther s reception of the individual pericopes of Mt 5 is considerably generative and occasionally contradictory, which is explained by the following factors, among others: Luther receives many ideas from tradition and reads them and his own theological concepts into Matthew s Gospel. He interprets Mt 5 through his understanding of some Old Testament passages as well as Paul. Most of all, Luther s reception of Mt 5 is shaped by his own experience as a preacher, by his relation to his religious enemies, rulers and to the congregation of Wittenberg. Here Luther shares with Matthew the experience of being opposed and concern about the upright living of the believers, which in both cases also explains the polemical tone of the paraenesis.

Metabolomic and proteomic analysis of breast cancer patient samples suggests that glutamate and 12-HETE in combination with CA15-3 may be useful biomarkers reflecting tumour burden

Evaluation of protein and metabolite expression patterns in blood using mass spectrometry and high-throughput antibody-based screening platforms has potential for the discovery of new biomarkers for managing breast cancer patient treatment. Previously identified blood-based breast cancer biomarkers, including cancer antigen 15.3 (CA15-3) are useful in combination with imaging (computed tomography scans, magnetic resonance imaging, X-rays) and physical examination for monitoring tumour burden in advanced breast cancer patients. However, these biomarkers suffer from insufficient levels of accuracy and with new therapies available for the treatment of breast cancer, there is an urgent need for reliable, non-invasive biomarkers that measure tumour burden with high sensitivity and specificity so as to provide early warning of the need to switch to an alternative treatment. The aim of this study was to identify a biomarker signature of tumour burden using cancer and non-cancer (healthy controls/non-malignant breast disease) patient samples. Results demonstrate that combinations of three candidate biomarkers from Glutamate, 12-Hydroxyeicosatetraenoic acid, Beta-hydroxybutyrate, Factor V and Matrix metalloproteinase-1 with CA15-3, an established biomarker for breast cancer, were found to mirror tumour burden, with AUC values ranging from 0.71 to 0.98 when comparing non-malignant breast disease to the different stages of breast cancer. Further validation of these biomarker panels could potentially facilitate the management of breast cancer patients, especially to assess changes in tumour burden in combination with imaging and physical examination.

Aspekte der Melancholietherapie in Martin Luthers Trostbriefen

Pro gradu -tutkielmani tehtävänä on selvittää näkökulmia melankoliaterapiaan Martti Lutherin lohdutuskirjeissä. Lähteinä on ollut neljä lohdutuskirjettä sekä yksi kirje, joka muistuttaa sisällöltään lohdutuskirjettä. Metodina on ollut kirjeiden tyylillis-retorinen analyysi. Aihe on kiinnostava, koska Lutherin kirjeiden ja retoriikan tutkimus on ollut vähäistä verrattuna häntä koskevaan laajaan kansainväliseen tutkimukseen. Työn lähtökohtana on ollut, että yksi kirjallisuuden tärkeimmistä tehtävistä 1500-luvulla oli erilaisten melankolisten sairauksien parantaminen. Kirjallisuuden avulla voitiin torjua hengenvaarallisia melankolisia affekteja kuten epätoivoa, pelkoa, surua ja apatiaa. Lutherin lohdutuskirjeet soveltuvat hyvin melankoliaterapian tutkimiseen, koska ne on kirjoitettu lohtua tarvitseville ihmisille. Työn tutkimuskysymykset ovat: Mitä melankolian hoitokeinoja Luther mainitsee? Missä määrin Lutherin melankoliaterapia on sopusoinnussa 1500-luvulla vallinneiden hoitokäsitysten kanssa? Miten Luther hyödyntää retoriikan ja huumorin keinoja melankoliaterapiassaan? Työn teoriaosassa selvitetään 1500-luvun ihmiskäsitystä sekä teologisesta että lääketieteellisestä näkökulmasta ja esitellään ajalle tyypillisiä humoraaliopin mukaisia melankolian hoitokeinoja. Selvitetään myös retoriikan ja melankoliaterapian suhdetta toisiinsa. Analyysiosassa pääpaino on Lutherin käyttämissä retorisissa keinoissa, mutta siinä hyödynnetään myös teoriaosan havaintoja. Tutkielmassa kirjallisuustieteellinen ja teologinen näkökulma tukevat toisiaan. Kirjallisuustieteellisestä näkökulmasta lohdutuskirjeet on tutkittavissa retoriikan tarjoamien käsitteiden avulla, koska ne on kirjoitettu aikana, jolloin retoriikka oli tärkeä yliopistollinen oppiaine. Tutkielma huomioi myös aiheen teologisen näkökulman, koska ajan kieli on uskonnollisesti värittynyttä ja koska Lutherin melankoliaterapiaan kuuluu vahva hengellinen ulottuvuus. Ihmisen kyky lohduttaa rinnastuu Lutherilla Jumalan kykyyn lohduttaa ihmistä Raamatun sanan kautta. Lutherille Jumala on reetori, jonka työväline on Raamatun pyhä sana. Puhutulla ja kirjoitetulla sanalla on Lutherin melankoliaterapiassa erityisen keskeinen merkitys. Tutkielmani osoittaa, että sekä Lutherin käyttämät retoriset keinot että hänen melankoliaterapiansa ovat suuressa määrin sopusoinnussa 1500-luvun retoriikan ja lääketieteen oppien kanssa. Luther käyttää melankoliaterapiassaan laajasti apuna erilaisia retorisia keinoja kuten toistoa, variaatiota, metaforaa ja esimerkkikertomuksia. Lutherin mainitsemat hoitokeinot kuten esimerkiksi metsästys, ratsastus, syöminen ja juominen, pelien pelaaminen, leikinlasku ja ystävien kanssa seurustelu ovat sopusoinnussa ajan hoitokäsitysten kanssa. Kirjeissä esiintyy myös lääketieteellisestä ja uskonnollisesta näkökulmasta katsottuna kyseenalaisia hoitokeinoja kuten tyhjänpäiväisten juttujen kertominen ja paholaisen kiroileminen. Nämä neuvot ylittävät ajan melankoliaterapiaan kuuluvan kohtuullisuuden säännön, ja ne on ymmärrettävä niiden teologisesta merkityksestä käsin. Lutherille kohtuullisuuden säännön rikkominen on toisinaan sallittua, kun on kysymys vaikeasta paholaisen aiheuttamasta melankoliasta. Kristillinen usko näyttää Lutherille tarjoavan vapauden käyttää tiettyjä hoitokeinoja, joita vielä keskiajalla ei olisi hyväksytty. Toisinaan Luther näkee kirjeen vastaanottajaa kohdanneen vaikeuden Jumalan eikä paholaisen aikaansaannoksena. Tällaisissa tapauksissa melankolia nähdään Jumalan työnä ihmisessä, joka mahdollistaa hengellisen kääntymisen Jumalan, kaiken lohdutuksen Isän puoleen.

Kysymys esineellisyydestä : Georg Lukácsin esineellistymisteoria ja Martin Heideggerin fundamentaaliontologia

Käsilläolevan tutkielman aiheena on esineellistymisen käsite. Sitä tarkastellaan yhtäältä sellaisena kuten se esitetään Georg Lukácsin (1885-1971) teoksessa Historia ja luokkatietoisuus (1923), toisaalta kuten sitä koskeva teoria on luettavissa esiin Martin Heideggerin (1889-1976) läpimurtoteoksesta Oleminen ja aika (1927). Molemmat ajattelijat pyrkivät teoksissaan rakentamaan kokonaisvaltaista tulkintaa länsimaisen ajattelun ja toiminnan taipumuksesta tulkita todellisuus esineellisenä (dinglich), so. eletystä elämästä ja toiminnasta irrallisena olioiden (Dinge) maailmana. Sekä Lukács että Heidegger pyrkivät osoittamaan, että esineellistyneen todellisuuden ontologisena perustana toimii inhimillisen praktisen toiminnan kenttä, josta käsin esineellistävät ja objektivoivat suhtautumistavat todellisuuteen voivat vasta jälkikäteisesti syntyä. Molemmille ajattelijoille esineellisyyden muodostuminen ontologiaa hallitsevaksi tulkinnaksi todellisuuden luonteesta edellyttää myös tietynlaisia sosiaalisen olemisen rakenteita. Tutkielmassa tehdään vertailevaa käsiteanalyysia Lukácsin ja Heideggerin teoreettisten diskurssien välillä. Tavoitteena on rakentaa mahdollisuutta lukea mainittuja filosofeja saman, modernille olemassaololle keskeisen ontologisen sekä eksistentiaalisen ongelman tarkastelijoina. Toisaalta vertaileva lähestymistapa pyrkii myös tuomaan esiin olennaisia ja perustavia eroja Lukácsin marxilaisen ja Heideggerin fundamentaaliontologisen orientaation välillä. Tutkielmassa pyritäänkin osoittamaan, että Heideggerin fundamentaaliontologia ei tarkastele kauppatavaran rakennetta eikä sosiaalisen vaihdon prosesseja marxilaisesta näkökulmasta riittävällä tavalla, kun taas Lukácsin teoreettinen projekti tulee edellyttäneeksi tuottavaan subjektiviteettiin pohjautuvan ontologisen perusasenteen. Tämä ontologinen positio voidaan puolestaan kritisoida hedelmällisesti heideggerilaisesta näkökulmasta. Viime kädessä tutkielma pyrkii avaamaan esineellistymisteorioiden vertailun kautta kysymyksen länsimarxilaisen materialistisen dialektiikan ja Heideggerin fenomenologisen ontologian välisestä suhteesta.

How smokers may react to cigarette taxes and price increases in Brazil: data from a national survey

Background: Despite being the third largest tobacco producer in the world, Brazil has developed a comprehensive tobacco control policy that includes a broad restriction on both advertising and smoking in indoor public places, compulsory pictorial warning labels, and a menthol cigarette ban. However, tax and pricing policies have been developed slowly and only very recently were stronger measures implemented. This study investigated the expected responses of smokers to hypothetical price increases in Brazil.Methods: We analyzed smokers' responses to hypothetical future price increases according to sociodemographic characteristics and smoking conditions in a multistage sample of Brazilian current cigarette smokers aged >= 14 years (n = 500). Logistic regression analysis was used to examine the relationship between possible responses and different predictors.Results: in most subgroups investigated, smokers most frequently said they would react to a hypothetical price increase by taking up alternatives that might have a positive impact on health, i.e., they would try to stop smoking (52.3%) or smoke fewer cigarettes (46.8%). However, a considerable percentage responded that they would use alternatives that would reduce the effect of price increases, such as the same brand with lower cost (48.1%). After controlling for sex age group (14-19, 20-39, 40-59, and >= 60 years), schooling level (>= 9 versus <= 9 years), number of cigarettes per day (>20 versus <= 20), and stage of change for smoking cessation (precontemplation, contemplation, and preparation), lower levels of dependence were positively associated with the response I would try to stop smoking (odds ratio [OR], 2.19). Young age was associated with I would decrease the number of cigarettes (OR, 3.44). A low schooling level was strongly associated with all responses.Conclusions: Taxes and prices increases have great potential to stimulate cessation or reduction of cigarette consumption further among two important vulnerable populations of smokers in Brazil: young smokers and those of low educational level. the results from the present study also suggest that seeking illegal products may reduce the impact of increased taxes, but does not eliminate it.

Christology in the Epistle to the Hebrews: Martin Luther's Reception of John Chrysostom

Throughout the history of the Church, the Epistle to the Hebrews has been one of the most puzzling letters in the Canon, particularly regarding the implications of understanding the person of Jesus Christ. John Chrysostom, an important patristic writer, is acknowledged to have made significant contributions to the exegesis of this letter. Chrysostom's thought became the norm for traditional thinking and interpretation of this letter in the Middle Ages. Martin Luther's reception of Chrysostom's Homilies on Hebrews presents a unique interpretation that some scholars may describe as the "Reformation Discovery" on Hebrews. In tracing Luther's reception and appropriation of Chrysostom's exegesis of the letter to the Hebrews, there is a noticeable and significant shift in Christological interpretation. Whether or not these modifications were necessary is a matter of debate; however, they do reflect Luther's contextual and existential questions regarding faith, Christ and knowledge of God, which is evident in his Lectures on Hebrews.

An overview of online-research in information systems

As the Internet has changed communication, commerce, and the distribution of information, so it is changing Information Systems Research (ISR). The goal of this paper is to put the topic of application and reliability of online research into the focus of ISR by exploring the extension of online research methods (ORM) into its popular publication outlets. 513 articles from high ranked ISR publication outlets from the last decade have been analyzed using online content analysis. The findings show that in ISR online research methods are applied despite the missing discussion on the validity of the theories and methods that were defined offline within the new environment and the associated challenges.

A schizophrenia locus may be located in region 10p15-p11

In our genomic scan of 265 Irish families with schizophrenia, we have thus far generated modest evidence for the presence of vulnerability genes in three chromosomal regions, i.e., 5q21-q31, 6p24-p22, and 8p22-p21. Outside of those regions, of all markers tested to date, D10S674 produced one of the highest pairwise heterogeneity lod (H-LOD) scores, 3.2 (P = 0.0004), when initially tested on a subset of 88 families. We then tested a total of 12 markers across a region of 32 centimorgans in region 10p15-p11 of all 265 families. The strongest evidence for linkage occurred assuming an intermediate phenotypic definition, and a recessive genetic model. The largest pairwise H-LOD score was found with marker D10S2443 (maximum 1.95, P = 0.005). Using multipoint H-LODs, we found a broad peak (maximum 1.91, P = 0.006) extending over the 11 centimorgans from marker D10S674 to marker D10S1426. Multipoint nonparametric linkage analysis produced a much broader peak, but with the maximum in the same location near D10S2443 (maximum z = 1.88, P = 0.03). Based on estimates from the multipoint analysis, this putative vulnerability locus appears to be segregating in 5-15% of the families studied, but this estimate should be viewed with caution. When evaluated in the context of our genome scan results, the evidence suggests the possibility of a fourth vulnerability locus for schizophrenia in these Irish families, in region 10p15-p11.

Abstinence from alcohol may indeed be the best policy: 32 month longitudinal outcomes among adolescents in the United Kingdom.

The present study investigated the longitudinal relationship between alcohol consumption at age 13, and at age 16. Alcohol-specific measures were frequency of drinking, amount consumed at last use and alcohol related harms. Self-report data were gathered from 1113 high school students at T1, and 981 students at T2. Socio-demographic data were gathered, as was information on context of use, alcohol-related knowledge and attitudes, four domains of aggression and delay reward discounting. Results indicated that any consumption of alcohol, even supervised consumption, at T1 was associated with significantly poorer outcomes at T2. In other words, compared to those still abstinent at age 13, those engaging in alcohol use in any context reported significantly more frequent drinking, more alcohol-related harms and more units consumed at last use at age 16. Results also support the relationship between higher levels of physical aggression at T1 and a greater likelihood of more problematic alcohol use behaviours at T2. The findings support other evidence suggesting that abstinence in early adolescence has better longitudinal outcomes that supervised consumption of alcohol. These results suggest support for current guidance on adolescent drinking in the United Kingdom (UK).

Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity

Low-dose hyper-radiosensitivity (HRS) is the phenomenon whereby cells exposed to radiation doses of less than approximately 0.5 Gy exhibit increased cell killing relative to that predicted from back-extrapolating high-dose survival data using a linear-quadratic model. While the exact mechanism remains to be elucidated, the involvement of several molecular repair pathways has been documented. These processes in turn are also associated with the response of cells to O6-methylguanine (O6MeG) lesions. We propose a model in which the level of low-dose cell killing is determined by the efficiency of both pre-replicative repair by the DNA repair enzyme O6-methylguanine methyltransferase (MGMT) and post-replicative repair by the DNA mismatch repair (MMR) system. We therefore hypothesized that the response of cells to low doses of radiation is dependent on the expression status of MGMT and MMR proteins. MMR (MSH2, MSH6, MLH1, PMS1, PMS2) and MGMT protein expression signatures were determined in a panel of normal (PWR1E, RWPE1) and malignant (22RV1, DU145, PC3) prostate cell lines and correlated with clonogenic survival and cell cycle analysis. PC3 and RWPE1 cells (HRS positive) were associated with MGMT and MMR proficiency, whereas HRS negative cell lines lacked expression of at least one (MGMT or MMR) protein. MGMT inactivation had no significant effect on cell survival. These results indicate a possible role for MMR-dependent processing of damage produced by low doses of radiation.

The Contemporary Group, May 28, 1969

Concert program for The Contemporary Group, May 28, 1969

Stravinsky Festival, May 8, 1972

Concert program for Stravinsky Festival, May 8, 1972

Recueil concernant les comtes de Quercy, les évêques de Tarbe, les reliques de S. Martin de Tours, les bénéfices du diocèse de Langres, les couvents de l'ordre de Fontevrauld, les confréries de S.-Martin et de S.-Germain d'Argentan, les rues de Paris.

Contient : 1 « Memoire des anciens comtes du païs de Quercy et du comté de Cahors », par « MARC ANTOINE DOMINICI » ; 2 « Diptyche ou catalogue, en forme d'histoire, des eveques de Tarbe » ; 3 « Proces verbal fait par GERVAIS GOYET, lieutenant particulier au bailliage de Touraine, en presence du procureur du roy et quelques chanoines, des bagues, joyaux, reliquaires et ornemens de S. Martin de Tours, lesquelles M. le prince de Condé avoit commendé estre fondues et mises en lingots pour lui estre portées à Orleans, et envoyé Mre François, comte de La Rochefoucault, François de Hangest, Sr de Genli, et François Du Fou, Sr Du Vigean, pour le faire executer. Ledit proces verbal fait au mois de may 1562 » ; 4 « Liber, sive rotulus omnium beneficiorum episcopatus lingonensis, in quo designantur eorum archidiaconatus, decanatus, abbatiae, prioratus, parochiales ecclesiae, hospitalia et eorum valores, ac etiam qui sint patroni et in quibus dominus episcopus habet visitationem et procurationem simul et procurationem tantum. 1604 ». En latin ; 5 « Couvents de l'ordre de Fontevrauld, qui subsistent actuellement, selon l'ordre de la reformation » ; 6 « Confrairie de la paroisse de S. Martin d'Argentan, etablie l'an 1539 ». En latin ; 7 « Propositions d'erreur sur les memoires d'Anjou par François Balduin » ; 8 « Compte original rendu par l'administrateur de la confrairie du S. Sacrement, etablie dans l'eglise de S. Germain d'Argentan. 1703 » ; 9 « C'est le dit du tout et entierement de tous les roys de France, et les noms et le nombre du regne de chascun » ; 10 « Les noms des rues de la ville de Paris et la despence d'icelle » ; 11 « La calculation et denombrement des bons et mauvais anges »

Decision-making theory applied to India's explosion of a nuclear device in May, 1974

This essay reviews the decision-making process that led to India exploding a nuclear device in May, 1974. An examination of the Analytic, Cybernetic and Cognitive Theories of decision, will enable a greater understanding of the events that led up to the 1974 test. While each theory is seen to be only partially useful, it is only by synthesising the three theories that a comprehensive account of the 1974 test can be given. To achieve this analysis, literature on decision-making in national security issues is reviewed, as well as the domestic and international environment in which involved decisionmakers operated. Finally, the rationale for the test in 1974 is examined. The conclusion revealed is that the explosion of a nuclear device by India in 1974 was primarily related to improving Indian international prestige among Third World countries and uniting a rapidly disintegrating Indian societal consensus. In themselves, individual decision-making theories were found to be of little use, but a combination of the various elements allowed a greater comprehension of the events leading up to the test than might otherwise have been the case.