O ato educativo numa perspectiva desconstrucionista: hospitalidade e experiência no espaço escolar

Pós-graduação em Educação Escolar - FCLAR

Comparison of drug retention rates and causes of drug discontinuation between anti-tumor necrosis factor agents in rheumatoid arthritis

OBJECTIVE: Tumor necrosis factor (TNF) inhibitors have revolutionized the treatment of severe rheumatoid arthritis (RA), yet drug discontinuation is common. The aim of this study was to compare treatment retention rates and specific causes of anti-TNF discontinuation in a population-based RA cohort. METHODS: All patients treated with etanercept, infliximab, or adalimumab within the Swiss Clinical Quality Management RA cohort between 1997 and 2006 were included in the study. Causes of treatment discontinuation were broadly categorized as adverse events (AEs) or nontoxic causes, and further subdivided into specific categories. Specific causes of treatment interruption were analyzed using a Cox proportional hazards model and adjusted for potential confounders. RESULTS: A total of 2,364 anti-TNF treatment courses met the inclusion criteria. Treatment discontinuation was reported 803 times: 309 with etanercept, 249 with infliximab, and 245 with adalimumab. Drug inefficacy represented the largest single cause of treatment discontinuation (55.8% of cases). The median time of receiving anti-TNF therapy was 37 months, but discontinuation rates differed between the 3 anti-TNF agents (P < 0.001), with shorter retention rates for infliximab (hazard ratio [HR] 1.24, 99% confidence interval [99% CI] 1.01-1.51). The specific causes of treatment discontinuation revealed an increased risk of AEs with infliximab (HR 1.4, 99% CI 1.003-1.96), mostly due to an increased risk of infusion or allergic reactions (HR 2.11, 99% CI 1.23-3.62). Other discontinuation causes were equally distributed between the anti-TNF agents. CONCLUSION: In this population, infliximab was associated with higher overall discontinuation rates compared with etanercept and adalimumab, which is mainly due to an increased risk of infusion or allergic reactions.

Aus Briefen an H. N.., ehmals Mitarbeiter am philantropischen Institut

Jean Jacques Du Toit

Aus Briefen an H. N.., ehmals Mitarbeiter am philantropischen Institut : (Beschluß)

Jean Jacques Du Toit

Scripturae sacrae cursus completus, ex commentariis omnium perfectissimis ubique habitis, et a magna parte episcoporum necnon theologorum Europae catholicae, universim ad hoc interrogatorum, designatis, unicè conflatus, plurimis annotantibus presbyteris ad docendos levitas pascendosve populos altè positis /

Text in Latin and French; commentary in Latin only.

Theologiae R.P. Fr. Suarez e Societate Jesu, summa, seu compendium /

Table of contents at end of each volume.

Scripturae Sacrae, cursus completus.

Includes index.

Le Droit raciste à l'assaut de la civilisation,

L'extermination des Juifs allemands par le régime hitlérien, par Ernest Hamburger.--La législation raciste en droit comparé, par Max Gottschalk.--L'application du droit raciste en France, par Paul Jacob.--Le droit raciste et la vraie signification du racisme, par Jacques Maritain.

Bulletin.

"Jubilé du soixante-quinzième anniversaire. Paris et Noyon, 8-10 juillet 1927": v. 76, 1927, p. [305]-389.

Patrologiae cursus completus; omnium SS. patrum, doctorum scriptorumque ecclesiasticorum, sive latinorum, sive graecorum. [Series graeca]

Greek and Latin translation in alternate columns.

Patrologiae cursus completus, seu, Bibliotheca universalis, integra, uniformis, commoda, oeconomica : omnium SS patrum, doctorum scriptorumque ecclesiasticorum ... : series græca, in qua prodeunt patres, doctores scriptoresque Ecclesiae græcae /

v. 11-54, 1857-61 issued under "Series Graeca ... A. S. Barnaba ad Photium"; v. 55-, 1861- issued under "Series Graeca posterior ... ab aevo Photiano ad Concilii usque Florentini tempora."

Patrologiae cursus completus, sive biblioteca universalis, integra, uniformis, commoda, oeconomica, omnium SS. Patrum, doctorum scriptorumque eccelesiasticorum qui ab aevo apostolico ad usque Innocentii III tempora floruerunt ... [Series Latina, in qua prodeunt Patres, doctores scriptoresque Ecclesiae Latinae, a Tertulliano ad Innocentium III]

Accompanied by "Supplementum. Accurante Adalberto Hamman" (. 28 cm.) published: Paris, Garnier, 1958- Some volumes issued in parts. Call no.: BR60.M412.

Œuvres complétes de A.-F. Ozanam.

Mode of access: Internet.