984 resultados para Lisa Ellis
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Unter dem Titel »Kanon und Hysterie« vertrete ich die These, dass bei den Spitzenstücken die öffentliche Rezeption eines Werkes zusammen mit dem Verhalten der Forschung in fast irrationale Verhaltensweisen abgleitet, die hier provisorisch mit dem nicht klinisch-pathologisch gemeinten Begriff der ›Hysterie‹ umschrieben werden. Das zeigt sich etwa dann, wenn sowohl von der Forschung als auch in der öffentlichen Wahrnehmung die Erkenntnisse der Quellenkritik sowie der Gattungs- und Funktionsgeschichte ebenso wie die der politischen Ikonographie sowie auch Fragen klassischer Inhaltsdeutung beinahe vollkommen ignoriert werden. Fallbeispiele für den Vortrag sind Sandro Botticellis Primavera, Leonardo da Vincis Mona Lisa und Michelangelos Deckenfresko in der Sixtinischen Kapelle.
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Ellis-van Creveld (EvC) syndrome is a human autosomal recessive disorder caused by a mutation in either the EVC or EVC2 gene, and presents with short limbs, polydactyly, and ectodermal and heart defects. The aim of this study was to understand the pathologic basis by which deletions in the EVC2 gene lead to chondrodysplastic dwarfism and to describe the morphologic, immunohistochemical, and molecular hallmarks of EvC syndrome in cattle. Five Grey Alpine calves, with a known mutation in the EVC2 gene, were autopsied. Immunohistochemistry was performed on bone using antibodies to collagen II, collagen X, sonic hedgehog, fibroblast growth factor 2, and Ki67. Reverse transcription polymerase chain reaction was performed to analyze EVC1 and EVC2 gene expression. Autopsy revealed long bones that were severely reduced in length, as well as genital and heart defects. Collagen II was detected in control calves in the resting, proliferative, and hypertrophic zones and in the primary and secondary spongiosa, with a loss of labeling in the resting zone of 2 dwarfs. Collagen X was expressed in hypertrophic zone in the controls but was absent in the EvC cases. In affected calves and controls, sonic hedgehog labeled hypertrophic chondrocytes and primary and secondary spongiosa similarly. FGF2 was expressed in chondrocytes of all growth plate zones in the control calves but was lost in most EvC cases. The Ki67 index was lower in cases compared with controls. EVC and EVC2 transcripts were detected. Our data suggest that EvC syndrome of Grey Alpine cattle is a disorder of chondrocyte differentiation, with accelerated differentiation and premature hypertrophy of chondrocytes, and could be a spontaneous model for the equivalent human disease.
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Theodor Vogelstein
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Solomon Small
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von J. A. Pflanz
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Signatur des Originals: S 36/F04556
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Signatur des Originals: S 36/F04579
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Signatur des Originals: S 36/F04580
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Signatur des Originals: S 36/F07208
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Signatur des Originals: S 36/F08901