Automated image analysis of lung branching morphogenesis from microscopic images of fetal rat explants

Background: Regulating mechanisms of branching morphogenesis of fetal lung rat explants have been an essential tool for molecular research. This work presents a new methodology to accurately quantify the epithelial, outer contour and peripheral airway buds of lung explants during cellular development from microscopic images. Methods: The outer contour was defined using an adaptive and multi-scale threshold algorithm whose level was automatically calculated based on an entropy maximization criterion. The inner lung epithelial was defined by a clustering procedure that groups small image regions according to the minimum description length principle and local statistical properties. Finally, the number of peripheral buds were counted as the skeleton branched ends from a skeletonized image of the lung inner epithelial. Results: The time for lung branching morphometric analysis was reduced in 98% in contrast to the manual method. Best results were obtained in the first two days of cellular development, with lesser standard deviations. Non-significant differences were found between the automatic and manual results in all culture days. Conclusions: The proposed method introduces a series of advantages related to its intuitive use and accuracy, making the technique suitable to images with different lightning characteristics and allowing a reliable comparison between different researchers.

Protecção contra descargas atmosféricas: aplicação informática de identificação das vulnerabilidades das edificações e de apoio à concepção da protecção

A concepção de instalações eléctricas deve garantir condições de segurança para as pessoas e equipamentos. Para tal é exigida, quer por força de regulamentação ou de normalização, a instalação de dispositivos que garantam a detecção e a protecção contra os defeitos mais comuns nas instalações eléctricas como, por exemplo, as sobreintensidades e as sobretensões. Susceptíveis de criar sobretensões perigosas nas instalações eléctricas, as descargas atmosféricas podem ainda causar danos estruturais elevados, o que, em algumas actividades económicas, torna fundamental a implementação de medidas de protecção contra este fenómeno natural. A protecção contra descargas atmosféricas directas consiste em identificar as vulnerabilidades das estruturas e, nesses locais, implementar dispositivos de captura, direccionamento e escoamento da descarga atmosférica à terra, em condições de segurança. O presente trabalho, desenvolvido no âmbito da dissertação de Mestrado em Engenharia Electrotécnica, visa desenvolver e implementar uma ferramenta computacional, baseada em programas de desenho assistido por computador (CAD) de utilização corrente na área de projecto de arquitectura e de engenharia, que permita, no âmbito de normas internacionais, a análise e implementação de sistemas de protecção em edifícios contra descargas atmosféricas de uma forma rápida e expedita. Baseado num programa CAD 3D, que permite a modelização tridimensional das estruturas a proteger, a ferramenta desenvolvida tentará identificar as suas vulnerabilidades das estruturas às descargas atmosféricas directas, com o intuito de implementar as medidas de protecção mais adequadas do ponto de vista técnico económico. Prevê-se que a ferramenta resultante deste estudo, o Simulador do Modelo Electrogeométrico (SIMODEL), possibilite aos projectistas e particularmente aos alunos das unidades curriculares na área do projecto de instalações eléctricas da Área Departamental de Engenharia de Sistemas e Potencia e Automação (ADESPA) do ISEL, estudar e implementar sistemas de protecção contra descargas atmosféricas (SPDA) baseados na normalização internacional do CENELEC e da IEC, nomeadamente as normas da série 62305.

Identification of tsunami-induced deposits using numerical modeling and rock magnetism techniques: Astudy case of the 1755 Lisbon tsunami in Algarve, Portugal (vol 182, pg 187, 2010)

Storm- and tsunami-deposits are generated by similar depositional mechanisms making their discrimination hard to establish using classic sedimentologic methods. Here we propose an original approach to identify tsunami-induced deposits by combining numerical simulation and rock magnetism. To test our method, we investigate the tsunami deposit of the Boca do Rio estuary generated by the 1755 earthquake in Lisbon which is well described in the literature. We first test the 1755 tsunami scenario using a numerical inundation model to provide physical parameters for the tsunami wave. Then we use concentration (MS. SIRM) and grain size (chi(ARM), ARM, B1/2, ARM/SIRM) sensitive magnetic proxies coupled with SEM microscopy to unravel the magnetic mineralogy of the tsunami-induced deposit and its associated depositional mechanisms. In order to study the connection between the tsunami deposit and the different sedimentologic units present in the estuary, magnetic data were processed by multivariate statistical analyses. Our numerical simulation show a large inundation of the estuary with flow depths varying from 0.5 to 6 m and run up of similar to 7 m. Magnetic data show a dominance of paramagnetic minerals (quartz) mixed with lesser amount of ferromagnetic minerals, namely titanomagnetite and titanohematite both of a detrital origin and reworked from the underlying units. Multivariate statistical analyses indicate a better connection between the tsunami-induced deposit and a mixture of Units C and D. All these results point to a scenario where the energy released by the tsunami wave was strong enough to overtop and erode important amount of sand from the littoral dune and mixed it with reworked materials from underlying layers at least 1 m in depth. The method tested here represents an original and promising tool to identify tsunami-induced deposits in similar embayed beach environments.

Lighting conditions and optical filters effects on visual performance of speleologists exposed to cave environments

The aim of this study is to evaluate lighting conditions and speleologists’ visual performance using optical filters when exposed to the lighting conditions of cave environments. A crosssectional study was conducted. Twenty-three speleologists were submitted to an evaluation of visual function in a clinical lab. An examination of visual acuity, contrast sensitivity, stereoacuity and flashlight illuminance levels was also performed in 16 of the 23 speleologists at two caves deprived of natural lightning. Two organic filters (450 nm and 550 nm) were used to compare visual function with and without filters. The mean age of the speleologists was 40.65 (± 10.93) years. We detected 26.1% participants with visual impairment of which refractive error (17.4%) was the major cause. In the cave environment the majority of the speleologists used a head flashlight with a mean illuminance of 451.0 ± 305.7 lux. Binocular visual acuity (BVA) was -0.05 ± 0.15 LogMAR (20/18). BVA for distance without filter was not statistically different from BVA with 550 nm or 450 nm filters (p = 0.093). Significant improved contrast sensitivity was observed with 450 nm filters for 6 cpd (p = 0.034) and 18 cpd (p = 0.026) spatial frequencies. There were no signs and symptoms of visual pathologies related to cave exposure. Illuminance levels were adequate to the majority of the activities performed. The enhancement in contrast sensitivity with filters could potentially improve tasks related with the activities performed in the cave.

Spatial analysis and investigation of fire events occurrences in the Valencian Community, Spain

Dissertation submitted in partial fulfillment of the requirements for the Degree of Master of Science in Geospatial Technologies.

Изменение концентрации приземного озона в селе Руиспири в грозовые и градовые дни

სოფელ რუისპირში (თელავის რაიონი) ჩატარებული მიწისპირა ოზონის კონცენტრაციის (მოკ) გაზომვების დიდი სტატისტიკური მასალის საფუძველზე გამოკვლეულ იქნა მოკ-ის ცვალებადობის ხასიათი კახეთში მიმდინარე ელჭექიან და სეტყვა-ელჭექიან დღეებში.

Stochastic effects and uncertainties in assessing electromagnetic interactions with control systems

Electromagnetic compatibility, lightning, crosstalk surge voltages, Monte Carlo simulation, accident initiator

Erstellung einer Blitzschutzrichtlinie für die Produktpalette der FAM im Auftrag der "Gesellschaft für Prozeßautomation mbH" (GPA)"

On the basis of the global use of the FAM installations and systems, their location, type and height, a lightning protection system is required, which protects humans and machines from danger of a lightning. At the beginning the development, the threat and the potential for destruction of lightning are described. Besides the resulting solid normative calculation models and tables are presented. Then, the product portfolio of the FAM is characterized. From this demonstration models are selected; on the one hand a model for the totality of all portable devices and the other hand a model which defines the power plants. Subsequently, the risk management and a strengths and weaknesses analysis are performed. After that, with graphical and mathematical models, these weaknesses as well as the functional equipotential bonding and grounding system and its dimensioning are investigated and solutions are demonstrated. The following is a coordination of lightning protection standard with other directives and standards in order to classify the resulting internal lightning protection and protective measures against electromagnetic pulse and to generate a uniform protection and application platform. Furthermore, problems of the economy of protective circuit is shown and a solution is given. Finally, the indicated possible solutions are replaced by definitions. The main classification and structure of lightning protection directive are shown and exemplarily applied.

Cluster recognition in spatial-temporal sequences: The case of forest fires

Forest fire sequences can be modelled as a stochastic point process where events are characterized by their spatial locations and occurrence in time. Cluster analysis permits the detection of the space/time pattern distribution of forest fires. These analyses are useful to assist fire-managers in identifying risk areas, implementing preventive measures and conducting strategies for an efficient distribution of the firefighting resources. This paper aims to identify hot spots in forest fire sequences by means of the space-time scan statistics permutation model (STSSP) and a geographical information system (GIS) for data and results visualization. The scan statistical methodology uses a scanning window, which moves across space and time, detecting local excesses of events in specific areas over a certain period of time. Finally, the statistical significance of each cluster is evaluated through Monte Carlo hypothesis testing. The case study is the forest fires registered by the Forest Service in Canton Ticino (Switzerland) from 1969 to 2008. This dataset consists of geo-referenced single events including the location of the ignition points and additional information. The data were aggregated into three sub-periods (considering important preventive legal dispositions) and two main ignition-causes (lightning and anthropogenic causes). Results revealed that forest fire events in Ticino are mainly clustered in the southern region where most of the population is settled. Our analysis uncovered local hot spots arising from extemporaneous arson activities. Results regarding the naturally-caused fires (lightning fires) disclosed two clusters detected in the northern mountainous area.

Forest fires cluster detection with space-time scan statistics

Forest fires are defined as uncontrolled fires often occurring in wildland areas, but that can also affect houses or agricultural resources. Causes are both natural (e.g.,lightning phenomena) and anthropogenic (human negligence or arsons).Major environmental factors influencing the fire ignition and propagation are climate and vegetation. Wildfires are most common and severe during drought period and on windy days. Moreover, under water-stress conditions, which occur after a long hot and dry period, the vegetation is more vulnerable to fire. These conditions are common in the United State and Canada, where forest fires represent a big problem. We focused our analysis on the state of Florida, for which a big dataset on forest fires detection is readily available. USDA Forest Service Remote Sensing Application Center, in collaboration with NASA-Goddard Space Flight Center and the University of Maryland, has compiled daily MODIS Thermal Anomalies (fires and biomass burning images) produced by NASA using a contextual algorithm that exploits the strong emission of mid-infrared radiation from fires. Fire classes were converted in GIS format: daily MODIS fire detections are provided as the centroids of the 1 kilometer pixels and compiled into daily Arc/INFO point coverage.

Recuperação de 241Am de para-raios e detectores de fumaça

A method is described for recovering and purifying 241Am from lightning-conductors and smoke detectors. The method is based on the precipitation of silver, as AgCl, the main impurity, and extraction of americium with TBP. Further purification with ion-exchange resin is also used. The results have shown that by this method the americium is obtained with high purity.

Kunnan kiinteistöjen energiansäästöpotentiaali

Tämän diplomityön tarkoitus oli selvittää kolmen suomalaisen HINKU-kunnan, Mynämäen, Padasjoen ja Kuhmoisten kiinteistöjen energiansäästöpotentiaali. Työssä käytiin aluksi läpi kunnan kiinteistöjen perustiedot sekä kulutuslukemat, jonka jälkeen kiinteistöihin tutustuttiin kiinteistönhoitajan avustuksella. Tämän jälkeen pyrittiin identifioimaan säästötoimet muutamien yritysten sekä vuorovaikutteisesti kiinteistönhoitajien kanssa. Säästötoimien vaikuttavuuden arvioinnissa hyödynnettiin sähkön ja lämmön tuntimittarointia. Lopuksi tulokset esiteltiin kuntien johdolle. Säästöpotentiaalia löytyi lähes jokaiselta osa-alueelta. Perinteisesti suurin säästöpotentiaali on löytynyt ilmanvaihdosta, mutta tämän työn puitteissa suurimmat säästöt löydettiin valaistuksesta. Etenkin LED-tekniikan kehittyminen on muuttamassa valaistuksen tulevaisuutta. Yksittäisten kohteiden suurimmat säästömahdollisuudet olivat vanhojen öljylämmitysten muuttamisessa maa- ja kaukolämpöön. Myös ilmanvaihdosta löytyi hyvin merkittävä potentiaali useassa kohteessa. Mynämäellä säästöpotentiaalia löytyi kaikkiaan noin 17 % kunnan energialaskusta. Padasjoella ja Kuhmoisissa vastaava luku oli noin 12–13 % kummassakin. Työn laajentaminen muihin kuntiin ei pääosin ole suoraviivaista, koska kuntien rakennuskanta poikkeaa toisistaan ja lisäksi kaikki rakennukset ovat yksilöllisiä. Työ pystyi kuitenkin tuottamaan kohdekunnissa erilaista havaintoaineistoa ja toimenpide-ehdotuksia, jotka toimivat muissa kunnissa herättelijöinä, ideoiden antajina ja tarkistuslistana siihen, miten asiat on hoidettu ja minkälaisiin toimenpiteisiin tulisi ryhtyä.

The destinal question of language

How can we think the destinal place of language in the essentially historical condition of our existence if such historicity cannot be understood on the basis of the labor of negativity alone? The attempt is made here to think language in a more originary manner, as non-negative finitude, that affirms what is outside dialectical-speculative closure, what is to come. The notion of 'destinal' itself is thus transformed. No longer being merely a categorical grasp of "entities presently given", language is an originary exposure to the event of arrival in its lightning flash. Destiny appears as that of the messianic arrival of the 'not yet' which is not a telos that the immanent movement of historical reason reaches by an irresistible force of the negative. This essay reads Schelling, Heidegger and Kierkegaard to think language as a "place" of exposure to the non-teleological destiny that may erupt even today, here and now, without any given conditionality.

Yhdysvaltain ja Venäjän kehitteillä olevien viidennen sukupolven hävittäjien kehittämisaikataulu

Suomen F-18 Hornet -hävittäjät on määrä korvata uusilla hävittäjillä 2020-luvun puolivälin jälkeen. Suomi on osoittanut mielenkiintoa kehitteillä olevaan viidennen sukupolven F-35 Lightning II :een, joka on kiinnostuksen kohteena ympäri maailman. Myös Venäjän kehittelemä T-50 on maailmanlaajuisen mielenkiinnon kohteena. Tässä tutkimuksessa vertailtiin neljännen sukupolven hävittäjien kehittämisaikatauluja F- 35:n ja T-50:n kehittämisaikatauluihin. Vertailun perusteella laadittiin arvio F-35:n ja T- 50:n kehittämisaikataulujen tilasta sekä molempien alustavan operatiivisen käytettävyyden (Initial Operating Capability, IOC) saavuttamisajankohdasta. Tutkimuksen pääkysymys oli: Mikä on Yhdysvaltain ja Venäjän kehitteillä olevien viidennen sukupolven hävittäjien tilanne suhteessa edellisen sukupolven hävittäjien kehittämisaikajanaan? Tutkimus on kirjallisuustutkimukseen perustuva deskriptiivinen tulevaisuudentutkimus. Tutkimuksessa havaittiin, että neljännen sukupolven hävittäjien kehittäminen kesti noin 7½ vuodesta 26½ vuoteen. Neljännen sukupolven hävittäjien kehittämisen keskiarvoon nähden F-35A ja F-35C ovat kahdeksan vuotta, F-35B noin kuusi vuotta ja T-50 viisi vuotta jäljessä. Tutkimuksen perusteella voidaan arvioida, että F-35A ja F-35C saavuttavat IOC:n aikaisintaan vuonna 2018, F-35B vuonna 2016 ja T-50 vuonna 2019, mutta todennäköisesti vasta vuonna 2020.