The IFITM5 mutation c.-14C > T results in an elongated transcript expressed in human bone; And causes varying phenotypic severity of osteogenesis imperfecta type V

Background The genetic mutation resulting in osteogenesis imperfecta (OI) type V was recently characterised as a single point mutation (c.-14C > T) in the 5' untranslated region (UTR) of IFITM5, a gene encoding a transmembrane protein with expression restricted to skeletal tissue. This mutation creates an alternative start codon and has been shown in a eukaryotic cell line to result in a longer variant of IFITM5, but its expression has not previously been demonstrated in bone from a patient with OI type V. Methods Sanger sequencing of the IFITM5 5' UTR was performed in our cohort of subjects with a clinical diagnosis of OI type V. Clinical data was collated from referring clinicians. RNA was extracted from a bone sample from one patient and Sanger sequenced to determine expression of wild-type and mutant IFITM5. Results: All nine subjects with OI type V were heterozygous for the c.-14C > T IFITM5 mutation. Clinically, there was heterogeneity in phenotype, particularly in the manifestation of bone fragility amongst subjects. Both wild-type and mutant IFITM5 mRNA transcripts were present in bone. Conclusions The c.-14C > T IFITM5 mutation does not result in an RNA-null allele but is expressed in bone. Individuals with identical mutations in IFITM5 have highly variable phenotypic expression, even within the same family.

Schoolman family papers, undated, 1889-1994

The Schoolman Papers reflect Dr. Albert P. and Mrs. Bertha Schoolmans' staunch dedication to Jewish education, Jewish causes, and Israel. Bertha Schoolman, a lifelong member of Hadassah, assisted thousands of Israeli youth as chairman of the Youth Aliyah Committee. Her diaries, photos, scrapbooks, and correspondence record her numerous visits to Israel on which she helped set up schools, met with Israeli dignitaries, and participated in Zionist Conferences and events. The collection includes a 1936 letter from Hadassah founder, Henrietta Szold, praising Mrs. Schoolman's work as well as a letter from the father of Anne Frank, thanking Mrs. Schoolman for naming a Youth Aliyah center the "Anne Frank Haven" after his later daughter.

Franks family papers, 1711-1821, [1965-1968].

Contains business correspondence, accounts and documents relating to Jacob Franks of New York, his two sons, Moses and David, a nephew, Isaac, and a John Franks of Halifax, possibly a member of the family.

Sapientia, 1950, Vol. V, nº 16 (número completo)

Contenido: El hombre desamparado / La Dirección – Los fundamentos de la educación en Santo Tomás de Aquino / José Todoli Duque -- La filosofía jurídica de Hans Kelsen/ Julio M. Ojea Quintana – El problema moral / Carlo Giacon – Notas y comentarios -- Bibliografía

[Discurso do Deputado Oscar Corrêa : Sessão da Câmara dos Deputados de 08 de setembro de 1965]

Critica os serviços prestados pelas companhias aéreas, que agem como forças contrárias à consolidação de Brasília. Cita especialmente a deficiência do transporte aéreo entre a Capital Federal e Belo Horizonte.

[Discurso do Deputado Eurico Oliveira : Sessão da Câmara dos Deputados de 17 de novembro de 1965]

Comentários sobre os editoriais do Jornal do Brasil e do Correio Braziliense sobre boatos de que o Governo Federal estaria disposto a impor ao Brasil duas capitais federais: Brasília e Rio de Janeiro.

Dados estatísticos : eleições federais e estaduais realizadas no Brasil em 1965 e 1966

Trata das eleições federais e estaduais nos anos de 1965 e 1966. A primeira parte se refere aos Senadores, Deputados Federais e Estaduais, eleitos em 15 de novembro de 1966. A segunda parte diz respeito aos Governadores eleitos em 3 de outubro de 1965 e aos eleitos indiretamente em 3 de setembro de 1966. A terceira parte apresenta o resultado das eleições de junho de 1965 e 3 de outubro do mesmo ano, decorrentes da necessidade do preenchimento de duas vagas na Câmara dos Deputados e uma no Senado Federal.

Cartas enviadas por Karin Wolf a Justo Garate entre 1965 y 1966

1 tarjeta postal y 2 cartas (mecanografiadas y manuscritas) ; entre 150x105mm y 210x297mm

Oceanographic observations from the eastern Pacific Ocean collected by the R/V Shoyo Maru, October 1963 – March 1964

ENGLISH: The Nankai Regional Fisheries Research Laboratory of Kochi, Japan conducted a long-line fishery exploration and hydrographic survey in the eastern Pacific Ocean aboard the R/V Shoyo Maru during October 1963- March 1964. An invitation to the Inter-American Tropical Tuna Commission to participate in the cruise gave its investigators the opportunity to make surface biological observations and to preserve water samples for subsequent analyses of nutrients. The result of this survey is a comprehensive body of physical, chemical and biological data covering a large portion of the eastern half of the Pacific Ocean. SPANISH: El Nankai Regional Fisheries Research Laboratory de Rochi, Japón, llevó a cabo una exploración pesquera con palangre y un reconocimiento hidrográfico en el Océano Pacífico oriental, a bordo del barco de investigación Shoyo Maru, desde octubre de 1963 hasta marzo de 1964. Una invitación dirigida a la Comisión Interamericana del Atún Tropical para participar en el crucero, confirió a sus investigadores la oportunidad de hacer observaciones biológicas superficiales y conservar muestras de agua para el subsiguiente análisis de los nutrientes. El resultado de este reconocimiento es un conjunto de datos físicos, químicos y biológicos que abarcan una gran parte del sector medio oriental del Océano Pacífico. (PDF contains 153 pages.)

Annaes do Parlamento Brazileiro. Tomo I [1878]

Anais do Parlamento Brasileiro, 1878.

Annaes do Parlamento Brazileiro. Tomo II [1878]

Anais do Parlamento Brasileiro, 1878.

Annaes do Parlamento Brazileiro. Tomo III [1878]

Anais do Parlamento Brasileiro, 1878.

Annaes do Parlamento Brazileiro. Tomo IV [1878]

Anais do Parlamento Brasileiro, 1878.