不同脱乙酰度壳聚糖Mark-Houwink方程的订定

通过多步脱乙酰基反应和溶液超声波降解制备了脱乙酰度D.D在49—100％(wt),重均分子量在1.94—25.1×10~5的系列壳聚糖样品,在0.1mol/L CH_3COONa+0.2mol/L CH_3COOH溶剂中和30℃下,用光散射法首次订定出了不同D.D壳聚糖的M-H方程常数K和α值,结果如下:D.D(wt％) K×10~3(ml·g~(-)1) α69 0.104 1.1284 1.424 0.9691 6.589 0.88100 16.800 0.81导致K和α值差别的主要原因是由于壳聚糖大分子链上的胺基(—NH_2)被酸质子化后,失去了形成分子内氢键的能力,减弱了内旋转受阻程度,同时,质子化后形成的阳离子聚电解质分子链链段间以及链段与溶剂之间的相互作用增强,有效电荷密度的增加使得聚电解质溶液粘度增大。

Automating Mechanical FMEA Using Functional Models

Hughes, N., Chou E., Price, C. J. Lee M. H.(1999). Automating Mechanical FMEA Using Functional Models, Proceedings 12th Int. Florida AI Research Soc. Conf. (FLAIRS-99), AAAI Press, May 1999, pp. 394-398.

The Net and the Self: Colliding Views of Individuality and Nationhood in the Pre-Devolutionary plays of Mark Jenkins and Ed Thomas

Owen, Roger, 'The Net and the Self: Colliding Views of Individuality and Nationhood in the Pre-Devolutionary plays of Mark Jenkins and Ed Thomas', In: 'Cool Britannia: British Political Drama in the 1990s', Rebecca D'Mont? and Graham Saunders (eds), (Basingstoke: Palgrave Macmillan), pp.158-175, 2007 RAE2008

The church in Corea by Mark Napier Trollope, Bp. of Korea

http://www.archive.org/details/churchincorea00troluoft

A memorial of the dedication of monuments erected by the Moravian Historical Society : to mark the sites of ancient missionary stations in New York and Connecticut.

http://www.archive.org/details/memorialofdedica00moraiala

By canoe and dog-train among the Cree and Salteaux Indians / by Egerton Ryerson Young ; with an introduction by Mark Guy Pearse.

http://www.archive.org/details/bycanoedogtraina00younrich

All-optical modulation converter for on-off keying to duobinary and alternate-mark inversion at 42.6 Gbps

Advanced modulation formats have become increasingly important as telecoms engineers strive for improved tolerance to both linear and nonlinear fibre-based transmission impairments. Two important modulation schemes are Duobinary (DB) and Alternate-mark inversion (AMI) [1] where transmission enhancement results from auxiliary phase modulation. As advanced modulation formats displace Return-to-zero On-Off Keying (RZ-OOK), inter-modulation converters will become increasingly important. If the modulation conversion can be performed at high bitrates with a small number of operations per bit, then all-optical techniques may offer lower energy consumption compared to optical-electronic-optical approaches. In this paper we experimentally demonstrate an all-optical system incorporating a pair of hybrid-integrated semiconductor optical amplifier (SOA)-based Mach-Zehnder interferometer (MZI) gates which translate RZ-OOK to RZ-DB or RZ-AMI at 42.6 Gbps. This scheme includes a wavelength conversion to arbitrary output wavelength and has potential for high-level photonic integration, scalability to higher bitrates, and should exhibit regenerative properties [2].

Novel all-optical on-off-keyed to alternate-mark-inversion converter

We numerically investigate a novel 40 Gbps OOK to AMI all-optical modulation format converter employing an SOA-based Mach-Zehnder interferometer.  We demonstrate operation with a 27-1 PRBS and explain the phase modulation's relationship with patterning.

LPS-binding protein and IL-6 Mark paradoxical tuberculosis immune reconstitution inflammatory syndrome in HIV patients

Background: Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) remains a poorly understood complication in HIV-TB co-infected patients initiating antiretroviral therapy (ART). The role of the innate immune system in TB-IRIS is becoming increasingly apparent, however the potential involvement in TB-IRIS of a leaky gut and proteins that interfere with TLR stimulation by binding PAMPs has not been investigated before. Here we aimed to investigate the innate nature of the cytokine response in TB-IRIS and to identify novel potential biomarkers. Methods: From a large prospective cohort of HIV-TB co-infected patients receiving TB treatment, we compared 40 patients who developed TB-IRIS during the first month of ART with 40 patients matched for age, sex and baseline CD4 count who did not. We analyzed plasma levels of lipopolysaccharide (LPS)-binding protein (LBP), LPS, sCD14, endotoxin-core antibody, intestinal fatty acid-binding protein (I-FABP) and 18 pro-and anti-inflammatory cytokines before and during ART. Results: We observed lower baseline levels of IL-6 (p = 0.041), GCSF (p = 0.036) and LBP (p = 0.016) in TB-IRIS patients. At IRIS event, we detected higher levels of LBP, IL-1RA, IL-4, IL-6, IL-7, IL-8, G-CSF (p ≤ 0.032) and lower I-FABP levels (p = 0.013) compared to HIV-TB co-infected controls. Only IL-6 showed an independent effect in multivariate models containing significant cytokines from pre-ART (p = 0.039) and during TB-IRIS (p = 0.034). Conclusion: We report pre-ART IL-6 and LBP levels as well as IL-6, LBP and I-FABP levels during IRIS-event as potential biomarkers in TB-IRIS. Our results show no evidence of the possible contribution of a leaky gut to TB-IRIS and indicate that IL-6 holds a distinct role in the disturbed innate cytokine profile before and during TB-IRIS. Future clinical studies should investigate the importance and clinical relevance of these markers for the diagnosis and treatment of TB-IRIS. Copyright: © 2013 Goovaerts et al.